Search Results - "Jallat, Sophie"
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Adenovirus-Mediated Transfer of a Recombinant α1-Antitrypsin Gene to the Lung Epithelium in Vivo
Published in Science (American Association for the Advancement of Science) (19-04-1991)“…The respiratory epithelium is a potential site for somatic gene therapy for the common hereditary disorders α1-antitrypsin (α1AT) deficiency and cystic…”
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Synthesis in E. coli of α1-antitrypsin variants of therapeutic potential for emphysema and thrombosis
Published in Nature (London) (1985)Get full text
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Altered chloride ion channel kinetics associated with the ΔF508 cystic fibrosis mutation
Published in Nature (London) (26-12-1991)“…Cystic fibrosis is associated with a defect in epithelial chloride ion transport which is caused by mutations in a membrane protein called CFTR (cystic…”
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cDNA cloning and expression of a hamster α-thrombin receptor coupled to Ca2+ mobilization
Published in FEBS letters (19-08-1991)“…The serine protease α-thrombin (thrombin) potently stimulates G-protein-coupled signaling pathways and DNA synthesis in CCL39 hamster lung fibroblasts. To…”
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Characterization of recombinant human factor IX expressed in transgenic mice and in derived transimmortalized hepatic cell lines
Published in The EMBO journal (01-01-1990)“…Transgenic mice were generated in which 5 kb of the 5' flanking promoter region of the human Factor IX (FIX) gene fused to various FIX constructs (gene,…”
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cDNA cloning and expression of a hamster α‐thrombin receptor coupled to Ca 2+ mobilization
Published in FEBS letters (19-08-1991)“…The serine protease α‐thrombin (thrombin) potently stimulates G‐protein‐coupled signaling pathways and DNA synthesis in CCL39 hamster lung fibroblasts. To…”
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Sulphation of hirudin in BHK cells
Published in FEBS letters (26-11-1990)“…Hirudin, a thrombin inhibitor of the leech, was expressed in BHK cells; the α 1-antitrypsin signal peptide was used to direct secretion into the culture…”
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RNA structural elements for expression in Escherichia coli
Published in FEBS letters (24-11-1986)“…Analysis of a series of λ cII::α1‐antitrypsin (α1AT) gene fusions of different sizes showed that increased α1AT expression correlated with the stabilisation of…”
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RNA structural elements for expression in Escherichia coli: α 1-Antitrypsin synthesis using translation control elements based on the cII ribosome-binding site of phage λ
Published in FEBS letters (24-11-1986)“…Analysis of a series of λ cII::α 1-antitrypsin (α 1AT) gene fusions of different sizes showed that increased α 1AT expression correlated with the stabilisation…”
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Adenovirus-mediated transfer of a recombinant alpha 1-antitrypsin gene to the lung epithelium in vivo
Published in Science (American Association for the Advancement of Science) (19-04-1991)“…The respiratory epithelium is a potential site for somatic gene therapy for the common hereditary disorders alpha 1-antitrypsin (alpha 1AT) deficiency and…”
Get full text
Journal Article -
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Synthesis in E. coli of α 1 -antitrypsin variants of therapeutic potential for emphysema and thrombosis
Published in Nature (London) (10-01-1985)“…The primary function of alpha 1-antitrypsin (alpha 1-AT), an antiprotease produced by the liver, is the inhibition of neutrophil elastase, a protease capable…”
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