Search Results - "Jalil, Jorge E."

Counter-regulatory renin–angiotensin system in cardiovascular disease by Paz Ocaranza, Maria, Riquelme, Jaime A., García, Lorena, Jalil, Jorge E., Chiong, Mario, Santos, Robson A. S., Lavandero, Sergio

“…The renin–angiotensin system is an important component of the cardiovascular system. Mounting evidence suggests that the metabolic products of angiotensin I…”
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Recent insights and therapeutic perspectives of angiotensin-(1-9) in the cardiovascular system by Ocaranza, Maria Paz, Michea, Luis, Chiong, Mario, Lagos, Carlos F, Lavandero, Sergio, Jalil, Jorge E

“…Chronic RAS (renin-angiotensin system) activation by both AngII (angiotensin II) and aldosterone leads to hypertension and perpetuates a cascade of…”
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New Mechanisms to Prevent Heart Failure with Preserved Ejection Fraction Using Glucagon-like Peptide-1 Receptor Agonism (GLP-1 RA) in Metabolic Syndrome and in Type 2 Diabetes: A Review by Jalil, Jorge E, Gabrielli, Luigi, Ocaranza, María Paz, MacNab, Paul, Fernández, Rodrigo, Grassi, Bruno, Jofré, Paulina, Verdejo, Hugo, Acevedo, Monica, Cordova, Samuel, Sanhueza, Luis, Greig, Douglas

“…This review examines the impact of obesity on the pathophysiology of heart failure with preserved ejection fraction (HFpEF) and focuses on novel mechanisms for…”
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ACE2 and vasoactive peptides: novel players in cardiovascular/renal remodeling and hypertension by Mendoza-Torres, Evelyn, Oyarzún, Alejandra, Mondaca-Ruff, David, Azocar, Andrés, Castro, Pablo F, Jalil, Jorge E, Chiong, Mario, Lavandero, Sergio, Ocaranza, María Paz

“…The renin-angiotensin system (RAS) is a key component of cardiovascular physiology and homeostasis due to its influence on the regulation of electrolyte…”
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Enalapril Attenuates Downregulation of Angiotensin-Converting Enzyme 2 in the Late Phase of Ventricular Dysfunction in Myocardial Infarcted Rat by Ocaranza, María Paz, Godoy, Ivan, Jalil, Jorge E, Varas, Manuel, Collantes, Patricia, Pinto, Melissa, Roman, Maritza, Ramirez, Cristián, Copaja, Miguel, Diaz-Araya, Guillermo, Castro, Pablo, Lavandero, Sergio

“…The early and long-term effects of coronary artery ligation on the plasma and left ventricular angiotensin-converting enzyme (ACE and ACE2) activities, ACE and…”
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Rho kinase cascade activation in circulating leukocytes in patients with diabetes mellitus type 2 by Ocaranza, Maria Paz, Valderas, Patricio, Moya, Jackeline, Gabrielli, Luigi, Godoy, Iván, Córdova, Samuel, Nab, Paul Mac, García, Lorena, Farías, Luis, Jalil, Jorge E

“…The intracellular ROCK signaling pathway is an important modulator of blood pressure and of cardiovascular and renal remodeling when Rho-kinase activity is…”
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Reverse Remodeling in Human Heart Failure after Cardiac Resynchronization Therapy Is Associated With Reduced RHO-Kinase Activation by Ocaranza, Maria Paz, Jalil, Jorge E, Altamirano, Rodrigo, de León, Ana, Moya, Jackeline, Lonis, Alejandra, Gabrielli, Luigi, Nab, Paul Mac, Córdova, Samuel, Paredes, Alejandro, Vergara, Ismael, Bittner, Alex, Sabat, Karime, Pastorini, Karla

“…Reverse remodeling is a clinically relevant endpoint in heart failure with reduced ejection fraction (HFrEF). Rho-kinase (ROCK) signaling cascade activation…”
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Protection of the myocardium against ischemia/reperfusion injury by angiotensin-(1–9) through an AT2R and Akt-dependent mechanism by Mendoza-Torres, Evelyn, Riquelme, Jaime A., Vielma, Alejandra, Sagredo, Andrea Ramirez, Gabrielli, Luigi, Bravo-Sagua, Roberto, Jalil, Jorge E., Rothermel, Beverly A., Sanchez, Gina, Ocaranza, Maria Paz, Lavandero, Sergio

“…[Display omitted] Angiotensin-(19), a peptide of the non-classical renin angiotensin system, has been shown to prevent and revert hypertension and cardiac…”
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Protective Role of the ACE2/Ang-(1-9) Axis in Cardiovascular Remodeling by Ocaranza, María Paz, Jalil, Jorge E.

“…Despite reduction in cardiovascular (CV) events and end-organ damage with the current pharmacologic strategies, CV disease remains the primary cause of death…”
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Circulating Vascular Cell Adhesion Molecule-1 (sVCAM-1) Is Associated With Left Atrial Remodeling in Long-Distance Runners by Contreras-Briceño, Felipe, Herrera, Sebastián, Vega-Adauy, Julian, Salinas, Manuel, Ocaranza, María Paz, Jalil, Jorge E., Mandiola, Jorge, García, Lorena, Chiong, Mario, Castro, Pablo F., Lavandero, Sergio, Gabrielli, Luigi

“…Introduction: An increased risk of atrial fibrillation (AF) has been demonstrated in high-performance athletes. Soluble vascular adhesion molecule-1 (sVCAM-1),…”
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Left Cardiac Remodelling Assessed by Echocardiography Is Associated with Rho-Kinase Activation in Long-Distance Runners by Contreras-Briceño, Felipe, Vega, Julián, Mandiola, Jorge, Ocaranza, María Paz, Herrera, Sebastián, Salinas, Manuel, Fernández, Rodrigo, Jalil, Jorge E., Lavandero, Sergio, Chiong, Mario, Godoy, Paz, Castro, Pablo F., Sitges, Marta, Gabrielli, Luigi

“…This single-blind and cross-sectional study evaluated the role of Rho-kinase (ROCK) as a biomarker of the cardiovascular remodelling process assessed by…”
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Effects of Trimetazidine in Nonischemic Heart Failure: A Randomized Study by Winter, José Luis, MD, Castro, Pablo F., MD, Quintana, Juan Carlos, MD, Altamirano, Rodrigo, MD, Enriquez, Andres, MD, Verdejo, Hugo E., MD, PhD, Jalil, Jorge E., MD, Mellado, Rosemarie, PhD, Concepción, Roberto, MD, Sepúlveda, Pablo, MD, Rossel, Victor, MD, Sepúlveda, Luis, MD, Chiong, Mario, PhD, García, Lorena, PhD, Lavandero, Sergio, PhD

“…Abstract Objectives Heart failure (HF) is associated with changes in myocardial metabolism that lead to impairment of contractile function. Trimetazidine (TMZ)…”
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Markedly increased Rho-kinase activity in circulating leukocytes in patients with chronic heart failure by Ocaranza, María Paz, PhD, Gabrielli, Luigi, MD, Mora, Italo, Bq, Garcia, Lorena, PhD, McNab, Paul, MD, Godoy, Iván, MD, Braun, Sandra, MD, Córdova, Samuel, MD, Castro, Pablo, MD, Novoa, Ulises, PhD, Chiong, Mario, PhD, Lavandero, Sergio, PhD, Jalil, Jorge E., MD

“…Background The small guanosine triphosphatase Rho and its target Rho-kinase have significant roles in experimental remodeling and ventricular dysfunction, but…”
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Angiotensin-(1-9) reduces cardiovascular and renal inflammation in experimental renin-independent hypertension by Gonzalez, Leticia, Novoa, Ulises, Moya, Jackeline, Gabrielli, Luigi, Jalil, Jorge E., García, Lorena, Chiong, Mario, Lavandero, Sergio, Ocaranza, María Paz

“…Schematic representation on beneficial outcome after Ang-(1-9) treatment in renin-independent hypertension. [Display omitted] Hypertension-induced…”
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Elevated Systemic Inflammatory Burden and Cardiovascular Risk in Young Adults with Endodontic Apical Lesions by Garrido, Mauricio, Cárdenas, Angélica M., Astorga, Jessica, Quinlan, Francisca, Valdés, Macarena, Chaparro, Alejandra, Carvajal, Paola, Pussinen, Pirkko, Huamán-Chipana, Patricia, Jalil, Jorge E., Hernández, Marcela

“…The aim of this study was to assess whether apical lesions are associated with inflammatory serum markers of cardiovascular risk, especially high-sensitivity…”
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Protection of the myocardium against ischemia/reperfusion injury by angiotensin-(1-9) through an AT 2 R and Akt-dependent mechanism by Mendoza-Torres, Evelyn, Riquelme, Jaime A, Vielma, Alejandra, Sagredo, Andrea Ramirez, Gabrielli, Luigi, Bravo-Sagua, Roberto, Jalil, Jorge E, Rothermel, Beverly A, Sanchez, Gina, Ocaranza, Maria Paz, Lavandero, Sergio

“…Angiotensin-(19), a peptide of the non-classical renin angiotensin system, has been shown to prevent and revert hypertension and cardiac hypertrophy. We…”
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On Endogenous Angiotensin II Antagonism in Hypertension: The Role of Dipeptidyl Peptidase III by Ocaranza, María Paz, Jalil, Jorge E

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2022 World Hypertension League, Resolve To Save Lives and International Society of Hypertension dietary sodium (salt) global call to action by Campbell, Norm R. C., Whelton, Paul K., Orias, Marcelo, Wainford, Richard D., Cappuccio, Francesco P., Ide, Nicole, Neal, Bruce, Cohn, Jennifer, Cobb, Laura K., Webster, Jacqui, Trieu, Kathy, He, Feng J., McLean, Rachael M., Blanco-Metzler, Adriana, Woodward, Mark, Khan, Nadia, Kokubo, Yoshihiro, Nederveen, Leo, Arcand, JoAnne, MacGregor, Graham A., Owolabi, Mayowa O., Lisheng, Liu, Parati, Gianfranco, Lackland, Daniel T., Charchar, Fadi J., Williams, Bryan, Tomaszewski, Maciej, Romero, Cesar A., Champagne, Beatriz, L’Abbe, Mary R., Weber, Michael A., Schlaich, Markus P., Fogo, Agnes, Feigin, Valery L., Akinyemi, Rufus, Inserra, Felipe, Menon, Bindu, Simas, Marcia, Neves, Mario Fritsch, Hristova, Krassimira, Pullen, Carolyn, Pandeya, Sanjay, Ge, Junbo, Jalil, Jorge E., Wang, Ji-Guang, Wideimsky, Jiri, Kreutz, Reinhold, Wenzel, Ulrich, Stowasser, Michael, Arango, Manuel, Protogerou, Athanasios, Gkaliagkousi, Eugenia, Fuchs, Flávio Danni, Patil, Mansi, Chan, Andy Wai-Kwong, Nemcsik, János, Tsuyuki, Ross T., Narasingan, Sanjeevi Nathamuni, Sarrafzadegan, Nizal, Ramos, María Eugenia, Yeo, Natalie, Rakugi, Hiromi, Ramirez, Agustin J., Álvarez, Guillermo, Berbari, Adel, Kim, Cho-il, Ihm, Sang-Hyun, Chia, Yook-Chin, Unurjargal, Tsolmon, Park, Hye Kyung, Wahab, Kolawole, McGuire, Helen, Dashdorj, Naranjargal J., Ishaq, Mohammed, Ona, Deborah Ignacia D., Mercado-Asis, Leilani B., Prejbisz, Aleksander, Leenaerts, Marianne, Simão, Carla, Pinto, Fernando, Almustafa, Bader Ali, Spaak, Jonas, Farsky, Stefan, Lovic, Dragan, Zhang, Xin-Hua

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Rho kinase activation in circulating leukocytes is related to hypertensive myocardial remodeling by Ocaranza, Maria P, Fierro, Camila, Jalil, Jorge E, Moya, Jackeline, Gonzalez, Leticia, Molina, Cristián, Mancilla, Cristián

“…Rho-kinase has relevant functions in blood pressure modulation and cardiovascular remodeling. Rho-kinase activity is determined in circulating leukocytes…”
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Angiotensin-(1–9) reverses experimental hypertension and cardiovascular damage by inhibition of the angiotensin converting enzyme/Ang II axis by Ocaranza, Maria Paz, Moya, Jackeline, Barrientos, Victor, Alzamora, Rodrigo, Hevia, Daniel, Morales, Cristobal, Pinto, Melissa, Escudero, Nicolás, García, Lorena, Novoa, Ulises, Ayala, Pedro, Díaz-Araya, Guillermo, Godoy, Ivan, Chiong, Mario, Lavandero, Sergio, Jalil, Jorge E., Michea, Luis

“…BACKGROUND:Little is known about the biological effects of angiotensin-(1–9), but available evidence shows that angiotensin-(1–9) has beneficial effects in…”
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