Search Results - "Jalani, Hitesh B."

Carbonyl-Assisted Iridium-Catalyzed C–H Amination Using 2,2,2-Trichloroethoxycarbonyl Azide by Dong, Xunqing, Shang, Mingzhou, Chen, Shuguang, Zhang, Tao, Jalani, Hitesh B., Lu, Hongjian

“…The carbonyl-directed, mono C–H amination of arenes has been achieved using [Cp*Ir­(III)­Cl2]2 as the catalyst and 2,2,2-trichloroethoxycarbonyl (Troc) azide…”
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Iridium-Catalyzed C-H Amination of Weinreb Amides: A Facile Pathway toward Anilines and Quinazolin-2,4-diones by Dong, Xunqing, Ma, Panpan, Zhang, Tao, Jalani, Hitesh B, Li, Guigen, Lu, Hongjian

“…C-H amination of arenes directed by weakly coordinating Weinreb amides has been achieved with an iridium catalyst and 2,2,2-trichloroethoxycarbonyl (Troc)…”
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Iridium-Catalyzed Aryl C–H Sulfonamidation and Amide Formation Using a Bifunctional Nitrogen Source by Yu, Meng, Zhang, Tao, Jalani, Hitesh B, Dong, Xunqing, Lu, Hongjian, Li, Guigen

“…A new strategy for the sequential formation of aryl and amidyl C–N bonds is reported. Using trichloroethoxysulfonyl azide as a bifunctional nitrogen source,…”
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One‐pot synthesis of indolizin‐1‐yl‐pyrimidines from ethyl 3‐( 3‐ethoxy‐3‐oxopropanoyl ) indolizine‐1‐carboxylate , DMF‐DMA and amidines by Lee, Ju‐Young, Jalani, Hitesh B., Jeong, Jin‐Hyun

“…Abstract We have described herein a metal‐free one‐pot synthesis of indolizin‐1‐yl‐pyrimidines from ethyl 3‐(3‐ethoxy‐3‐oxopropanoyl) indolizine‐1‐carboxylate,…”
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Exploration of flexible phenylpropylurea scaffold as novel cardiac myosin activators for the treatment of systolic heart failure by Manickam, Manoj, Jalani, Hitesh B., Pillaiyar, Thanigaimalai, Sharma, Niti, Boggu, Pulla Reddy, Venkateswararao, Eeda, Lee, You-Jung, Jeon, Eun-Seok, Jung, Sang-Hun

“…A series of flexible urea derivatives have been synthesized and demonstrated as selective cardiac myosin ATPase activator. Among them…”
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Recent Development on the Heterocycles Derived From In Situ Formation of Aryl Glyoxals by Iodine/DMSO Mediated Oxidation of Methyl Ketones by Jalani, Hitesh B.

“…ABSTRACT Controlled oxidation of methyl‐ketones to aryl glyoxals using Selenium dioxide and iodine is one of the useful transformation. Regardless the…”
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Copper‐Catalyzed One‐pot Synthesis of Pyrimidines from Amides, N,N′‐dimethylformamide dimethylacetal, and Enamines by Jalani, Hitesh B., Cai, Wangshui, Lu, Hongjian

“…A versatile copper catalyzed one‐pot synthesis of diversely substituted pyrimidines directly from amides, N,N′‐dimethylformamide dimethylacetal (DMF−DMA) and…”
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Iridium-Catalyzed C–H Amination/Cyclization for Medium to Large N‑Heterocycle-Fused Dihydroquinazolinones by Zhang, Tao, Dong, Xunqing, Jalani, Hitesh B, Zou, Jiaqi, Li, Guigen, Lu, Hongjian

“…A practical iridium-catalyzed cascade/stepwise synthesis of dihydroquinazolinones (DHQs) and bis-DHQs fused to medium to large N-heterocyclic rings is…”
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Rh-Catalyzed Chemoselective [4 + 1] Cycloaddition Reaction toward Diverse 4‑Methyleneprolines by Cai, Wangshui, Wu, Junxian, Zhang, Haowei, Jalani, Hitesh B, Li, Guigen, Lu, Hongjian

“…An efficient synthesis of 4-methyleneproline derivatives has been developed through an Rh-catalyzed [4 + 1] cycloaddition strategy using 3-methyleneazetidines…”
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Oxidative Cascade Reaction of N‑Aryl-3-alkylideneazetidines and Carboxylic Acids: Access to Fused Pyridines by Cai, Wangshui, Wang, Shuang, Jalani, Hitesh B, Wu, Junxian, Lu, Hongjian, Li, Guigen

“…A versatile silver-promoted oxidative cascade reaction of N-aryl-3-alkylideneazetidines with carboxylic acids is reported, providing a very efficient pathway…”
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Stereospecific Electrophilic Fluorocyclization of α,β-Unsaturated Amides with Selectfluor by Fei, Haiyang, Xu, Zheyuan, Wu, Hongmiao, Zhu, Lin, Jalani, Hitesh B, Li, Guigen, Fu, Yao, Lu, Hongjian

“…An efficient fluorocyclization of α,β-unsaturated amides through a formal halocyclization process is developed. The reaction proceeds under…”
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Iodine‐Promoted One‐pot Synthesis of Highly Substituted 4‐Aminopyrroles and Bis‐4‐aminopyrrole from Aryl Methyl Ketones, Arylamines, and Enamines by Jalani, Hitesh B., Mali, Jyotirling R., Park, Hyejun, Lee, Jae Kyun, Lee, Kiho, Lee, Kyeong, Choi, Yongseok

“…An iodine‐promoted one‐pot synthesis of functionally diverse and highly substituted 4‐aminopyrroles directly from aryl methyl ketones, arylamines, and enamines…”
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Metal/catalyst/alkyne/alkene‐free one‐pot synthesis of indolizines from 2‐(pyridin‐2‐yl)acetate, DMF‐DMA and α‐halomethylenes by Jalani, Hitesh B., Lee, Doha, Lee, Ju‐Young, Jeong, Jin‐Hyun

“…We have described a simple and robust one‐pot synthesis of 1,3‐disubstitued‐indolizines from 2‐(pyridin‐2‐yl)acetate, DMF‐DMA and α‐halomethylenes without…”
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Improvement of Aqueous Solubility of Lapatinib-Derived Analogues: Identification of a Quinolinimine Lead for Human African Trypanosomiasis Drug Development by Bachovchin, Kelly A, Sharma, Amrita, Bag, Seema, Klug, Dana M, Schneider, Katherine M, Singh, Baljinder, Jalani, Hitesh B, Buskes, Melissa J, Mehta, Naimee, Tanghe, Scott, Momper, Jeremiah D, Sciotti, Richard J, Rodriguez, Ana, Mensa-Wilmot, Kojo, Pollastri, Michael P, Ferrins, Lori

“…Lapatinib, an approved epidermal growth factor receptor inhibitor, was explored as a starting point for the synthesis of new hits against Trypanosoma brucei,…”
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Arylation of 2‐Chloro‐3‐(4,6‐Diaryl‐1,3,5‐Triazin‐2‐yl) Quinolines: Formal Synthesis of 3‐(4,6‐Diaryl‐1,3,5‐Triazin‐2‐yl)‐2‐Substituted Quinolines by Suzuki–Miyaura Reaction by Jeon, Joo‐Hyun, Lee, Han‐Joo, Kim, Jin‐Hee, Hawsawi, Mohammed B., Jalani, Hitesh B., Jeong, Jin‐Hyun

“…ABSTRACT We have described herein a simple and formal two‐step synthesis of 3‐(4,6‐diaryl‐1,3,5‐triazin‐2‐yl)‐2‐aryl quinolines from…”
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Exploration of diphenylalkyloxadiazoles as novel cardiac myosin activator by Manickam, Manoj, Boggu, Pulla Reddy, Pillaiyar, Thanigaimalai, Sharma, Niti, Jalani, Hitesh B., Venkateswararao, Eeda, Jung, Sang-Hun

“…[Display omitted] •The diphenylalkyl oxadiazoles were identified as novel cardiac myosin ATPase activator.•Three carbon spacer between oxadiazole core and one…”
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Novel thiazole–thiophene conjugates as adenosine receptor antagonists: Synthesis, biological evaluation and docking studies by Pandya, Dhaivat H., Sharma, Jayesh A., Jalani, Hitesh B., Pandya, Amit N., Sudarsanam, V., Kachler, Sonja, Klotz, Karl Norbert, Vasu, Kamala K.

“…[Display omitted] Here we report novel thiazole–thiophene conjugates as adenosine receptor antagonists. All the molecules were evaluated for their binding…”
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Discovery of a novel series of N-hydroxypyridone derivatives protecting astrocytes against hydrogen peroxide-induced toxicity via improved mitochondrial functionality by Singh, Sarbjit, Goo, Ja-Il, Noh, Hyojin, Lee, Sung Jae, Kim, Myoung Woo, Park, Hyejun, Jalani, Hitesh B., Lee, Kyeong, Kim, Chunsook, Kim, Won-Ki, Ju, Chung, Choi, Yongseok

“…[Display omitted] Astrocytes play a key role in brain homeostasis, protecting neurons against neurotoxic stimuli such as oxidative stress. Therefore, the…”
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Discovery of enantioselectivity of urea inhibitors of soluble epoxide hydrolase by Manickam, Manoj, Pillaiyar, Thanigaimalai, Boggu, PullaReddy, Venkateswararao, Eeda, Jalani, Hitesh B., Kim, Nam-Doo, Lee, Seul Ki, Jeon, Jang Su, Kim, Sang Kyum, Jung, Sang-Hun

“…Soluble epoxide hydrolase (sEH) hydrolyzes epoxyeicosatrienoic acids (EETs) in the metabolic pathway of arachidonic acid and has been considered as an…”
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Design and synthesis of sulfonamidophenylethylamides as novel cardiac myosin activator by Manickam, Manoj, Pillaiyar, Thanigaimalai, Namasivayam, Vigneshwaran, Boggu, Pulla Reddy, Sharma, Niti, Jalani, Hitesh B., Venkateswararao, Eeda, Lee, You-Jung, Jeon, Eun-Seok, Son, Min-Jeong, Woo, Sun-Hee, Jung, Sang-Hun

“…[Display omitted] •N-Phenethyl-5-phenylpentanamides were explored as novel cardiac myosin activators.•Selective cardiac myosin ATPase activation of 13 and 27…”
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