Search Results - "Jakupciak, John P."

Clinical implications and utility of field cancerization by Dakubo, Gabriel D, Jakupciak, John P, Birch-Machin, Mark A, Parr, Ryan L

“…Cancer begins with multiple cumulative epigenetic and genetic alterations that sequencially transform a cell, or a group of cells in a particular organ. The…”
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Breakpoints of Gross Deletions Coincide with Non-B DNA Conformations by Bacolla, Albino, Jaworski, Adam, Larson, Jacquelynn E., Jakupciak, John P., Chuzhanova, Nadia, Abeysinghe, Shaun S., O'Connell, Catherine D., Cooper, David N., Wells, Robert D., Modrich, Paul L.

“…Genomic rearrangements are a frequent source of instability, but the mechanisms involved are poorly understood. A 2.5-kbp poly(purine·pyrimidine) sequence from…”
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The pseudo-mitochondrial genome influences mistakes in heteroplasmy interpretation by Parr, Ryan L, Maki, Jennifer, Reguly, Brian, Dakubo, Gabriel D, Aguirre, Andrea, Wittock, Roy, Robinson, Kerry, Jakupciak, John P, Thayer, Robert E

“…Nuclear mitochondrial pseudogenes (numts) are a potential source of contamination during mitochondrial DNA PCR amplification. This possibility warrants careful…”
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Performance of mitochondrial DNA mutations detecting early stage cancer by Jakupciak, John P, Maragh, Samantha, Markowitz, Maura E, Greenberg, Alissa K, Hoque, Mohammad O, Maitra, Anirban, Barker, Peter E, Wagner, Paul D, Rom, William N, Srivastava, Sudhir, Sidransky, David, O'Connell, Catherine D

“…Mutations in the mitochondrial genome (mtgenome) have been associated with cancer and many other disorders. These mutations can be point mutations or…”
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An optimized microchip electrophoresis system for mutation detection by tandem SSCP and heteroduplex analysis for p53 gene exons 5-9 by Hestekin, Christa N., Jakupciak, John P., Chiesl, Thomas N., Kan, Cheuk Wai, O'Connell, Catherine D., Barron, Annelise E.

“…With the complete sequencing of the human genome, there is a growing need for rapid, highly sensitive genetic mutation detection methods suitable for clinical…”
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Facile whole mitochondrial genome resequencing from nipple aspirate fluid using MitoChip v2.0 by Jakupciak, John P, Maggrah, Andrea, Maragh, Samantha, Maki, Jennifer, Reguly, Brian, Maki, Katrina, Wittock, Roy, Robinson, Kerry, Wagner, Paul D, Thayer, Robert E, Gehman, Ken, Gehman, Teresa, Srivastava, Sudhir, Ngom, Alioune, Dakubo, Gabriel D, Parr, Ryan L

“…Mutations in the mitochondrial genome (mtgenome) have been associated with many disorders, including breast cancer. Nipple aspirate fluid (NAF) from…”
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Population-Sequencing as a Biomarker of Burkholderia mallei and Burkholderia pseudomallei Evolution through Microbial Forensic Analysis by Wells, Jeffrey M., Jakupciak, John P., Karalus, Richard J., Pawlowski, David R., Lin, Jeffrey S., Feldman, Andrew B.

“…Large-scale genomics projects are identifying biomarkers to detect human disease. B. pseudomallei and B. mallei are two closely related select agents that…”
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Multiple strand displacement amplification of mitochondrial DNA from clinical samples by Maragh, Samantha, Jakupciak, John P, Wagner, Paul D, Rom, William N, Sidransky, David, Srivastava, Sudhir, O'Connell, Catherine D

“…Whole genome amplification (WGA) methods allow diagnostic laboratories to overcome the common problem of insufficient DNA in patient specimens. Further, body…”
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Biological agent detection technologies by JAKUPCIAK, JOHN P, COLWELL, RITA R

“…The challenge for first responders, physicians in the emergency room, public health personnel, as well as for food manufacturers, distributors and retailers is…”
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Mitochondria and Cancer by Parr, Ryan, Harbottle, Andrew, Jakupciak, John P., Singh, Gurmit

“…Ryan Parr 1 and Andrew Harbottle 2 and John P. Jakupciak 3 and Gurmit Singh 4, 5 1, Mitomics Inc., Suite 1000, 290 Munro Street, Thunder Bay, ON, P7A 7T1,…”
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Population-Sequencing as a Biomarker for Sample Characterization by Jakupciak, John P.

“…Sequencing is accepted as the “gold” standard for genetic analysis and continues to be used as a validation and reference tool. The idea of using sequence…”
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Blinded study determination of high sensitivity and specificity microchip electrophoresis-SSCP/HA to detect mutations in the p53 gene by Hestekin, Christa N., Lin, Jennifer S., Senderowicz, Lionel, Jakupciak, John P., O'Connell, Catherine, Rademaker, Alfred, Barron, Annelise E.

“…Knowledge of the genetic changes that lead to disease has grown and continues to grow at a rapid pace. However, there is a need for clinical devices that can…”
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Mitochondrial Genome Deletion Aids in the Identification of False-and True-Negative Prostate Needle Core Biopsy Specimens by MAKI, Jennifer, ROBINSON, Kerry, THAYER, Robert E, KENT FROBERG, M, WILSON, Michael J, MARAGH, Samantha, JAKUPCIAK, John P, WAGNER, Paul D, SRIVASTAVA, Sudhir, DAKUBO, Gabriel D, PARR, Ryan L, REGULY, Brian, ALEXANDER, Jude, WITTOCK, Roy, AGUIRRE, Andrea, DIAMANDIS, Eleftherios P, ESCOTT, Nicholas, SKEHAN, Anthony, PROWSE, Owen

“…We report the usefulness of a 3.4-kb mitochondrial genome deletion (3.4 mtdelta) for molecular definition of benign, malignant, and proximal to malignant (PTM)…”
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Genetic Instabilities in (CTG·CAG) Repeats Occur by Recombination by Jakupciak, John P., Wells, Robert D.

“…The expansion of triplet repeat sequences (TRS) associated with hereditary neurological diseases is believed from prior studies to be due to DNA replication…”
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Mitochondrial DNA as a Cancer Biomarker by Jakupciak, John P, Wang, Wendy, Markowitz, Maura E, Ally, Delphine, Coble, Michael, Srivastava, Sudhir, Maitra, Anirban, Barker, Peter E, Sidransky, David, O'Connell, Catherine D

“…As part of a national effort to identify biomarkers for the early detection of cancer, we developed a rapid and high-throughput sequencing protocol for the…”
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3.4 kb mitochondrial genome deletion serves as a surrogate predictive biomarker for prostate cancer in histopathologically benign biopsy cores by Reguly, Brian, Jakupciak, John P, Parr, Ryan L

“…Recently, we described a 3.4-kb mitochondrial genome deletion having significance for identifying malignant and benign prostate tissues (p < 0.001). This…”
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Preparation and Characterization of Candidate Reference Materials for Telomerase Assays by Jakupciak, John P, Barker, Peter E, Wang, Wendy, Srivastava, Sudhir, Atha, Donald H

“…Telomerase has been measured in body fluids of cancer patients, and clinical tests for telomerase may have utility as noninvasive, cost-effective methods for…”
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Real-time telomerase activity measurements for detection of cancer by Jakupciak, John P

“…Since the hallmark report of the PCR-based telomeric repeat amplification protocol (TRAP) in 1994, there has been a flurry of investigations of telomerase…”
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Development of genomic reference materials for Huntington disease genetic testing by Kalman, Lisa, Johnson, Monique A, Beck, Jeanne, Berry-Kravis, Elizabeth, Buller, Arlene, Casey, Brett, Feldman, Gerald L, Handsfield, James, Jakupciak, John P, Maragh, Samantha, Matteson, Karla, Muralidharan, Kasinathan, Richie, Kristy L, Rohlfs, Elizabeth M, Schaefer, Frederick, Sellers, Tina, Spector, Elaine, Richards, C Sue

“…Diagnostic and predictive testing for Huntington disease requires an accurate measurement of CAG repeats in the HD (IT15) gene. However, precise repeat sizing…”
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Real-time telomerase assay of less-invasively collected esophageal cell samples by McGruder, Brenna M., Atha, Donald H., Wang, Wendy, Huppi, Konrad, Wei, Wen-Qiang, Abnet, Christian C., Qiao, You-Lin, Dawsey, Sanford M., Taylor, Philip R., Jakupciak, John P.

“…Genomic and proteomic efforts have discovered a complex list of biomarkers that identify human disease, stratify risk of disease within populations, and…”
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