Search Results - "Jakupciak, JP"

Breakpoints of Gross Deletions Coincide with Non-B DNA Conformations by Bacolla, Albino, Jaworski, Adam, Larson, Jacquelynn E., Jakupciak, John P., Chuzhanova, Nadia, Abeysinghe, Shaun S., O'Connell, Catherine D., Cooper, David N., Wells, Robert D., Modrich, Paul L.

“…Genomic rearrangements are a frequent source of instability, but the mechanisms involved are poorly understood. A 2.5-kbp poly(purine·pyrimidine) sequence from…”
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Genetic Instabilities in (CTG·CAG) Repeats Occur by Recombination by Jakupciak, John P., Wells, Robert D.

“…The expansion of triplet repeat sequences (TRS) associated with hereditary neurological diseases is believed from prior studies to be due to DNA replication…”
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Mitochondrial DNA as a Cancer Biomarker by Jakupciak, John P, Wang, Wendy, Markowitz, Maura E, Ally, Delphine, Coble, Michael, Srivastava, Sudhir, Maitra, Anirban, Barker, Peter E, Sidransky, David, O'Connell, Catherine D

“…As part of a national effort to identify biomarkers for the early detection of cancer, we developed a rapid and high-throughput sequencing protocol for the…”
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Gene Conversion (Recombination) Mediates Expansions of CTG·CAG Repeats by Jakupciak, John P., Wells, Robert D.

“…Genetic recombination is a robust mechanism for expanding CTG·CAG triplet repeats involved in the etiology of hereditary neurological diseases (Jakupciak, J…”
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Real-time telomerase activity measurements for detection of cancer by Jakupciak, John P

“…Since the hallmark report of the PCR-based telomeric repeat amplification protocol (TRAP) in 1994, there has been a flurry of investigations of telomerase…”
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Genetic Instabilities of Triplet Repeat Sequences by Recombination by Jakupciak, John P., Wells, Robert D.

“…The expansion of triplet repeat sequences is an initial step in the disease etiology of a number of hereditary neurological disorders in humans. Diseases such…”
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Analytical Validation of Telomerase Activity for Cancer Early Detection: TRAP/PCR-CE and hTERT mRNA Quantification Assay for High-Throughput Screening of Tumor Cells by Jakupciak, John P, Wang, Wendy, Barker, Peter E, Srivastava, Sudhir, Atha, Donald H

“…Activation of telomerase plays a critical role in unlimited proliferation and immortalization of cells. Telomerase activity has been shown to correlate with…”
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Standardization of PCR amplification for fragile X trinucleotide repeat measurements by O'Connell, CD, Atha, DH, Jakupciak, JP, Amos, JA, Richie, Kl

“…To provide the clinical diagnostics community with accurate protocols and measurements for the detection of genetic disorders, we have established a…”
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Improved methods and standards for telomerase detection: quantitative histopathology using antibody staining by Jakupciak, J P, Gallant, N D, Smith, A H, Becker, M L, Tona, A, Atha, D H

“…Evaluation of telomerase as an early detection biomarker for cancer has been hindered by a lack of reliable methods and standards for in situ histochemical…”
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