Search Results - "Jakubowski, J"

Cytochrome P450 3A Inhibition by Ketoconazole Affects Prasugrel and Clopidogrel Pharmacokinetics and Pharmacodynamics Differently by Farid, N A, Payne, C D, Small, D S, Winters, K J, Ernest, C S, Brandt, J T, Darstein, C, Jakubowski, J A, Salazar, D E

“…Prasugrel and clopidogrel inhibit platelet aggregation through active metabolite formation. Prasugrel's active metabolite (R‐138727) is formed primarily by…”
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Detection of driver fatigue symptoms using transfer learning by J. Jakubowski, J. Chmielińska

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The greater in vivo antiplatelet effects of prasugrel as compared to clopidogrel reflect more efficient generation of its active metabolite with similar antiplatelet activity to that of clopidogrel’s active metabolite by SUGIDACHI, A., OGAWA, T., KURIHARA, A., HAGIHARA, K., JAKUBOWSKI, J.A., HASHIMOTO, M., NIITSU, Y., ASAI, F.

“…Summary Background and methods: Prasugrel is a novel orally active thienopyridine prodrug with potent and long‐lasting antiplatelet effects. Platelet…”
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Reversibility of platelet P2Y12 inhibition by platelet supplementation: ex vivo and in vitro comparisons of prasugrel, clopidogrel and ticagrelor by Bertling, A., Fender, A. C., Schüngel, L., Rumpf, M., Mergemeier, K., Geißler, G., Sibrowski, W., Kelsch, R., Waltenberger, J., Jakubowski, J. A., Kehrel, B. E.

“…Essentials Successful outcome of platelet transfusion depends on specific antiplatelet therapy in use. We assessed if ticagrelor, clopidogrel or prasugrel…”
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In the presence of strong P2Y12 receptor blockade, aspirin provides little additional inhibition of platelet aggregation by ARMSTRONG, P. C. J., LEADBEATER, P. D., CHAN, M. V., KIRKBY, N. S., JAKUBOWSKI, J. A., MITCHELL, J. A., WARNER, T. D.

“…Background: Aspirin and antagonists of platelet ADP P2Y12 receptors are often coprescribed for protection against thrombotic events. However, blockade of…”
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The reversible P2Y antagonist cangrelor influences the ability of the active metabolites of clopidogrel and prasugrel to produce irreversible inhibition of platelet function by Dovlatova, N L, Jakubowski, J A, Sugidachi, A, Heptinstall, S

“…Agents that act as antagonists at P2Y(12) ADP receptors on platelets are in use (clopidogrel), and in development for use (cangrelor and prasugrel), in…”
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Platelet function normalization after a prasugrel loading‐dose: time‐dependent effect of platelet supplementation by ZAFAR, M. U., SANTOS‐GALLEGO, C., VORCHHEIMER, D. A., VILES‐GONZALEZ, J. F., ELMARIAH, S., GIANNARELLI, C., SARTORI, S., SMALL, D. S., JAKUBOWSKI, J. A., FUSTER, V., BADIMON, J. J.

“…Background: Hemostatic benefits of platelet transfusions in thienopyridine‐treated acute coronary syndrome (ACS) patients may be compromised by residual…”
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The Markov consistency of Archimedean survival processes by Jakubowski, J., Pytel, A.

“…In this paper we connect Archimedean survival processes (ASPs) with the theory of Markov copulas. ASPs were introduced by Hoyle and Mengütürk (2013) to model…”
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Interaction of the active metabolite of prasugrel, R‐138727, with cysteine 97 and cysteine 175 of the human P2Y12 receptor by ALGAIER, I., JAKUBOWSKI, J. A., ASAI, F., VON KÜGELGEN, I.

“…Background: The P2Y12 receptor plays a crucial role in platelet aggregation and is the target of platelet aggregation inhibitors, including the thienopyridine…”
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A comparison of the pharmacological profiles of prasugrel and ticagrelor assessed by platelet aggregation, thrombus formation and haemostasis in rats by Sugidachi, A, Ohno, K, Ogawa, T, Jakubowski, JA, Hashimoto, M, Tomizawa, A

“…Background and Purpose Prasugrel is a third‐generation thienopyridine prodrug and ticagrelor is a non‐competitive P2Y12 receptor antagonist. In their phase 3…”
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Incomplete reversibility of platelet inhibition following prolonged exposure to ticagrelor by Gerrits, A. J., Jakubowski, J. A., Sugidachi, A., Michelson, A. D., Frelinger, A. L.

“…Essentials Irreversible platelet inhibition persists after reversibly‐binding ticagrelor is discontinued. Reversibility of platelet inhibition by ticagrelor…”
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Descriptive statistical analysis of TBM performance at Abu Hamour Tunnel Phase I by Stypulkowski, J. B., Bernardeau, F. G., Jakubowski, J.

“…The Abu Hamour Surface and Ground Water Drainage Tunnel Phase I is a 9.5-km-long, 3.7-m-inside-diameter storm water tunnel about 30 m below ground surface…”
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Incomplete reversibility of platelet inhibition following prolonged exposure to ticagrelor: reply by Gerrits, A. J., Jakubowski, J. A., Michelson, A. D., Frelinger, A. L.

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Surgical ciliated cyst of the maxilla secondary to a prior sinus exposure- case report and literature review by Amin, N, Pustylnik, T, Jakubowski, J

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Over 4,500 years of trepanation in Poland: From the unknown to therapeutic advisability by Lorkiewicz, W., Mietlińska, J., Karkus, J., Żądzińska, E., Jakubowski, J. K., Antoszewski, B.

“…This paper discusses 6 trepanned skulls from central Poland, dating from the late Neolithic (3,000–2,800 BC) to early modern times (18th century AD). Four of…”
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Agrobacterium tumefaciens VirB6 Protein Participates in Formation of VirB7 and VirB9 Complexes Required for Type IV Secretion by Jakubowski, Simon J, Krishnamoorthy, Vidhya, Christie, Peter J

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Agrobacterium tumefaciens VirB6 Domains Direct the Ordered Export of a DNA Substrate Through a Type IV Secretion System by Jakubowski, Simon J., Krishnamoorthy, Vidhya, Cascales, Eric, Christie, Peter J.

“…The Agrobacterium tumefaciens VirB/D4 type IV secretion system (T4SS) translocates DNA and protein substrates across the bacterial cell envelope. Six…”
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Theoretical analysis of shunting effect in resistance spot welding (RSW) of AA2219 by Jafari Vardanjani, M., Araee, A., Senkara, J., Jakubowski, J., Godek, J.

“…Shunting effect is the loss of electrical current via the secondary circuit provided due to existence of previous nugget in a series of welding spots. This…”
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Induction of Diabetes Abolishes the Antithrombotic Effect of Clopidogrel in Apolipoprotein E-Deficient Mice by Sugidachi, A, Ohno, K, Jakubowski, J A, Ito, Y, Tomizawa, A, Mizuno, M

“…Patients with acute coronary syndrome with diabetes mellitus (DM) exhibit an impaired platelet inhibitory response to clopidogrel which is only partially…”
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Agrobacterium tumefaciens VirB9, an Outer-Membrane-Associated Component of a Type IV Secretion System, Regulates Substrate Selection and T-Pilus Biogenesis by JAKUBOWSKI, Simon J, CASCALES, Eric, KRISHNAMOORTHY, Vidhya, CHRISTIE, Peter J

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