Search Results - "Jakt, Lars Martin"

Necdin restricts proliferation of hematopoietic stem cells during hematopoietic regeneration by Kubota, Yasushi, Osawa, Masatake, Jakt, Lars Martin, Yoshikawa, Kazuaki, Nishikawa, Shin-Ichi

“…Hematopoietic stem cell (HSC) proliferation is tightly regulated by a poorly understood complex of positive and negative cell-cycle regulatory mechanisms…”
Get full text

Intron size minimisation in teleosts by Jakt, Lars Martin, Dubin, Arseny, Johansen, Steinar Daae

“…Spliceosomal introns are parts of primary transcripts that are removed by RNA splicing. Although introns apparently do not contribute to the function of the…”
Get full text

DNA chip databases, omics, and gene fishing: Commentary by Jakt, Lars Martin, Nishikawa, Shinichi

“…(Cancer Sci 2008; 99: 829–835)…”
Get full text

Longitudinal Analysis of DNA Methylation in CD34+ Hematopoietic Progenitors in Myelodysplastic Syndrome by Wong, Yan-Fung, Micklem, Chris N., Taguchi, Masataka, Itonaga, Hidehiro, Sawayama, Yasushi, Imanishi, Daisuke, Nishikawa, Shinichi, Miyazaki, Yasushi, Jakt, Lars Martin

“…Myelodysplastic syndrome (MDS) is a disorder of hematopoietic stem cells (HSCs) that is often treated with DNA methyltransferase 1 (DNMT1) inhibitors…”
Get full text

Parental micronutrient deficiency distorts liver DNA methylation and expression of lipid genes associated with a fatty-liver-like phenotype in offspring by Skjærven, Kaja H., Jakt, Lars Martin, Fernandes, Jorge M. O., Dahl, John Arne, Adam, Anne-Catrin, Klughammer, Johanna, Bock, Christoph, Espe, Marit

“…Micronutrient status of parents can affect long term health of their progeny. Around 2 billion humans are affected by chronic micronutrient deficiency. In this…”
Get full text

Profiling DNA methylation patterns of zebrafish liver associated with parental high dietary arachidonic acid by Adam, Anne-Catrin, Lie, Kai Kristoffer, Whatmore, Paul, Jakt, Lars Martin, Moren, Mari, Skjærven, Kaja Helvik

“…Diet has been shown to influence epigenetic key players, such as DNA methylation, which can regulate the gene expression potential in both parents and…”
Get full text

Embryonic stem-cell culture as a tool for developmental cell biology by Nishikawa, Shin-Ichi, Jakt, Lars Martin, Era, Takumi

“…The cell biology of the early processes of mammalian embryogenesis, such as germ-layer formation, has been technically challenging to study owing to the size…”
Get full text

A continuum of transcriptional identities visualized by combinatorial fluorescent in situ hybridization by Jakt, Lars Martin, Moriwaki, Satoko, Nishikawa, Shinichi

“…Oligonucleotide-based fluorescent in situ hybridization (FISH) coupled with high-resolution high-sensitivity microscopy allows the visualization of single RNA…”
Get full text

Induction and monitoring of definitive and visceral endoderm differentiation of mouse ES cells by Nishikawa, Shin-Ichi, Yasunaga, Masahiro, Tada, Shinsuke, Torikai-Nishikawa, Satomi, Nakano, Yoko, Okada, Mitsuhiro, Jakt, Lars Martin, Nishikawa, Satomi, Chiba, Tsutomu, Era, Takumi

“…Preparation of specific lineages at high purities from embryonic stem (ES) cells requires both selective culture conditions and markers to guide and monitor…”
Get full text

Effective generation of iPS cells from CD34+ cord blood cells by inhibition of p53 by Takenaka, Chiemi, Nishishita, Naoki, Takada, Nozomi, Jakt, Lars Martin, Kawamata, Shin

“…Objective Cord blood banks provide fully human leukocyte antigen−typed cells, from which a set of standard induced pluripotent stem (iPS) cells for use in…”
Get full text

Generation and Profiling of 2,135 Human ESC Lines for the Systematic Analyses of Cell States Perturbed by Inducing Single Transcription Factors by Nakatake, Yuhki, Ko, Shigeru B.H., Sharov, Alexei A., Wakabayashi, Shunichi, Murakami, Miyako, Sakota, Miki, Chikazawa, Nana, Ookura, Chiaki, Sato, Saeko, Ito, Noriko, Ishikawa-Hirayama, Madoka, Mak, Siu Shan, Jakt, Lars Martin, Ueno, Tomoo, Hiratsuka, Ken, Matsushita, Misako, Goparaju, Sravan Kumar, Akiyama, Tomohiko, Ishiguro, Kei-ichiro, Oda, Mayumi, Gouda, Norio, Umezawa, Akihiro, Akutsu, Hidenori, Nishimura, Kunihiro, Matoba, Ryo, Ohara, Osamu, Ko, Minoru S.H.

“…Transcription factors (TFs) play a pivotal role in determining cell states, yet our understanding of the causative relationship between TFs and cell states is…”
Get full text

DNA methylation restricts lineage-specific functions of transcription factor Gata4 during embryonic stem cell differentiation by Oda, Masaaki, Kumaki, Yuichi, Shigeta, Masaki, Jakt, Lars Martin, Matsuoka, Chisa, Yamagiwa, Akiko, Niwa, Hitoshi, Okano, Masaki

“…DNA methylation changes dynamically during development and is essential for embryogenesis in mammals. However, how DNA methylation affects developmental gene…”
Get full text

Early hematopoietic and vascular development in the chick by Nagai, Hiroki, Shin, Masahiro, Weng, Wei, Nakazawa, Fumie, Jakt, Lars Martin, Alev, Cantas, Sheng, Guojun

“…The field of hematopoietic and vascular developmental research owes its origin to the chick embryo. Many key concepts, such as the hematopoietic stem cell,…”
Get full text

The mitochondrial transcriptome of the anglerfish Lophius piscatorius by Dubin, Arseny, Jørgensen, Tor Erik, Jakt, Lars Martin, Johansen, Steinar Daae

“…Analyze key features of the anglerfish Lophius piscatorius mitochondrial transcriptome based on high-throughput total RNA sequencing. We determined the…”
Get full text

Arhgef15 promotes retinal angiogenesis by mediating VEGF-induced Cdc42 activation and potentiating RhoJ inactivation in endothelial cells by Kusuhara, Sentaro, Fukushima, Yoko, Fukuhara, Shigetomo, Jakt, Lars Martin, Okada, Mitsuhiro, Shimizu, Yuri, Hata, Masayuki, Nishida, Kohji, Negi, Akira, Hirashima, Masanori, Mochizuki, Naoki, Nishikawa, Shin-Ichi, Uemura, Akiyoshi

“…Drugs inhibiting vascular endothelial growth factor (VEGF) signaling are globally administered to suppress deregulated angiogenesis in a variety of eye…”
Get full text

Prolonged treatment with DNMT inhibitors induces distinct effects in promoters and gene-bodies by Wong, Yan-Fung, Jakt, Lars Martin, Nishikawa, Shin-Ichi

“…Treatment with the demethylating drugs 5-azacytidine (AZA) and decitabine (DAC) is now recognised as an effective therapy for patients with Myelodysplastic…”
Get full text

A competitive protein interaction network buffers Oct4‐mediated differentiation to promote pluripotency in embryonic stem cells by Muñoz Descalzo, Silvia, Rué, Pau, Faunes, Fernando, Hayward, Penelope, Jakt, Lars Martin, Balayo, Tina, Garcia‐Ojalvo, Jordi, Martinez Arias, Alfonso

“…Pluripotency in embryonic stem cells is maintained through the activity of a small set of transcription factors centred around Oct4 and Nanog, which control…”
Get full text

In Vitro Modeling of Paraxial and Lateral Mesoderm Differentiation Reveals Early Reversibility by Sakurai, Hidetoshi, Era, Takumi, Jakt, Lars Martin, Okada, Mitsuhiro, Nakai, Shigeru, Nishikawa, Satomi, Nishikawa, Shin‐Ichi

“…Endothelial cells (ECs) are thought to be derived mainly from the vascular endothelial growth factor receptor 2 (VEGFR‐2)+ lateral mesoderm during early…”
Get full text

The novel protein kinase Vlk is essential for stromal function of mesenchymal cells by Kinoshita, Masaki, Era, Takumi, Jakt, Lars Martin, Nishikawa, Shin-Ichi

“…From a list of protein kinases (PKs) that are newly induced upon differentiation of mouse embryonic stem cells to mesendoderm, we identified a previously…”
Get full text

Mitochondrial genome variation of Atlantic cod by Jørgensen, Tor Erik, Karlsen, Bård Ove, Emblem, Åse, Breines, Ragna, Andreassen, Morten, Rounge, Trine B, Nederbragt, Alexander J, Jakobsen, Kjetill S, Nymark, Marianne, Ursvik, Anita, Coucheron, Dag H, Jakt, Lars Martin, Nordeide, Jarle T, Moum, Truls, Johansen, Steinar D

“…The objective of this study was to analyse intraspecific sequence variation of Atlantic cod mitochondrial DNA, based on a comprehensive collection of…”
Get full text