Search Results - "Jakowski, Amy"

Islet-selectivity of G-protein coupled receptor ligands evaluated for PET imaging of pancreatic β-cell mass by Cline, Gary W., Zhao, Xiaojian, Jakowski, Amy B., Soeller, Walter C., Treadway, Judith L.

“…► We screened G-protein coupled receptors for imaging pancreatic. ► Database mining and immunohistochemistry identified GPCRs enriched in β-cells. ► In vitro…”
Get full text

PF-03814735, an orally bioavailable small molecule aurora kinase inhibitor for cancer therapy by Jani, Jitesh P, Arcari, Joel, Bernardo, Vincent, Bhattacharya, Samit K, Briere, David, Cohen, Bruce D, Coleman, Kevin, Christensen, James G, Emerson, Erling O, Jakowski, Amy, Hook, Kenneth, Los, Gerrit, Moyer, James D, Pruimboom-Brees, Ingrid, Pustilnik, Leslie, Rossi, Ann Marie, Steyn, Stefan J, Su, Chunyan, Tsaparikos, Konstantinos, Wishka, Donn, Yoon, Kwansik, Jakubczak, John L

“…The Aurora family of highly related serine/threonine kinases plays a key role in the regulation of mitosis. Aurora1 and Aurora2 play important but distinct…”
Get full text

Coordinated Expression of Multidrug Resistance-Associated Proteins (Mrps) in Mouse Liver during Toxicant-Induced Injury by Aleksunes, Lauren M., Scheffer, George L., Jakowski, Amy B., Pruimboom-Brees, Ingrid M., Manautou, José E.

“…Following acute chemical injury, hepatocytes are generally more resistant to toxicant re-exposure. Alterations in expression of hepatobiliary transport systems…”
Get full text

Induction of Hepatobiliary Efflux Transporters in Acetaminophen-Induced Acute Liver Failure Cases by BARNES, Sarah N, ALEKSUNES, Lauren M, AUGUSTINE, Lisa, SCHEFFER, George L, GOEDKEN, Michael J, JAKOWSKI, Amy B, PRUIMBOOM-BREES, Ingrid M, CHERRINGTON, Nathan J, MANAUTOU, José E

“…Alterations in transporter expression may represent a compensatory mechanism of damaged hepatocytes to reduce accumulation of potentially toxic compounds. The…”
Get full text

Hyperphosphorylated Tau and Neurofilament and Cytoskeletal Disruptions in Mice Overexpressing Human p25, an Activator of cdk5 by Ahlijanian, M K, Barrezueta, N X, Williams, R D, Jakowski, A, Kowsz, K P, McCarthy, S, Coskran, T, Carlo, A, Seymour, P A, Burkhardt, J E, Nelson, R B, McNeish, J D

“…Hyperphosphorylation of microtubule-associated proteins such as tau and neurofilament may underlie the cytoskeletal abnormalities and neuronal death seen in…”
Get full text

Pharmacological Effects of Nicotine on Norepinephrine Metabolism in Rat Brown Adipose Tissue: Relevance to Nicotinic Therapies for Smoking Cessation by Brees, Dominique J., Elwell, Michael R., Tingley, F. David, Sands, Steven B., Jakowski, Amy B., Shen, Amy C., Cai, Jenny Hon, Finkelstein, Martin B.

“…In a two-year carcinogenicity study with administration of high doses of the partial nicotinic agonist varenicline (recently approved for smoking cessation),…”
Get full text

Islet-selectivity of G-protein coupled receptor ligands evaluated for PET imaging of pancreatic {beta}-cell mass by Cline, Gary W., Zhao, Xiaojian, Jakowski, Amy B., Soeller, Walter C., Treadway, Judith L.

“…Highlights: {yields} We screened G-protein coupled receptors for imaging pancreatic. {yields} Database mining and immunohistochemistry identified GPCRs…”
Get full text

A poorly differentiated germ cell tumor (seminoma) in a Long Evans rat by Kerlin, R L, Roesler, A R, Jakowski, A B, Boucher, G G, Krull, D L, Appel, W H

“…A large neoplasm that replaced 1 testis of a Long Evans Rat was noted at the final necropsy of a dietary 2-yr study. By light microscopy, the morphological…”
Get more information