Search Results - "Jakobsson, Tomas"

Liver X receptor biology and pharmacology: new pathways, challenges and opportunities by Jakobsson, Tomas, Treuter, Eckardt, Gustafsson, Jan-Åke, Steffensen, Knut R

“…Nuclear receptors (NRs) are master regulators of transcriptional programs that integrate the homeostatic control of almost all biological processes. Their…”
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Hepatocyte-specific loss of GPS2 in mice reduces non-alcoholic steatohepatitis via activation of PPARα by Liang, Ning, Damdimopoulos, Anastasius, Goñi, Saioa, Huang, Zhiqiang, Vedin, Lise-Lotte, Jakobsson, Tomas, Giudici, Marco, Ahmed, Osman, Pedrelli, Matteo, Barilla, Serena, Alzaid, Fawaz, Mendoza, Arturo, Schröder, Tarja, Kuiper, Raoul, Parini, Paolo, Hollenberg, Anthony, Lefebvre, Philippe, Francque, Sven, Van Gaal, Luc, Staels, Bart, Venteclef, Nicolas, Treuter, Eckardt, Fan, Rongrong

“…Obesity triggers the development of non-alcoholic fatty liver disease (NAFLD), which involves alterations of regulatory transcription networks and epigenomes…”
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The Nuclear Receptor-Co-repressor Complex in Control of Liver Metabolism and Disease by Liang, Ning, Jakobsson, Tomas, Fan, Rongrong, Treuter, Eckardt

“…Hepatocytes are the major cell-type in the liver responsible for the coordination of metabolism in response to multiple signaling inputs. Coordination occurs…”
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Gene Editing Correction of a Urea Cycle Defect in Organoid Stem Cell Derived Hepatocyte-like Cells by Zabulica, Mihaela, Jakobsson, Tomas, Ravaioli, Francesco, Vosough, Massoud, Gramignoli, Roberto, Ellis, Ewa, Rooyackers, Olav, Strom, Stephen C

“…Urea cycle disorders are enzymopathies resulting from inherited deficiencies in any genes of the cycle. In severe cases, currently available therapies are…”
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Correction of a urea cycle defect after ex vivo gene editing of human hepatocytes by Zabulica, Mihaela, Srinivasan, Raghuraman C., Akcakaya, Pinar, Allegri, Gabriella, Bestas, Burcu, Firth, Mike, Hammarstedt, Christina, Jakobsson, Tomas, Jakobsson, Towe, Ellis, Ewa, Jorns, Carl, Makris, Georgios, Scherer, Tanja, Rimann, Nicole, van Zuydam, Natalie R., Gramignoli, Roberto, Forslöw, Anna, Engberg, Susanna, Maresca, Marcello, Rooyackers, Olav, Thöny, Beat, Häberle, Johannes, Rosen, Barry, Strom, Stephen C.

“…Ornithine transcarbamylase deficiency (OTCD) is a monogenic disease of ammonia metabolism in hepatocytes. Severe disease is frequently treated by orthotopic…”
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Nuclear receptor ligands induce TREM-1 expression on dendritic cells: analysis of their role in tumors by Fontana, Raffaella, Raccosta, Laura, Rovati, Lucrezia, Steffensen, Knut R., Paniccia, Aida, Jakobsson, Tomas, Melloni, Giulio, Bandiera, Alessandro, Mangili, Giorgia, Bergamini, Alice, Maggioni, Daniela, Doglioni, Claudio, Crocchiolo, Roberto, Cella, Marina, Mattioli, Michela, Battaglia, Cristina, Colonna, Marco, Russo, Vincenzo

“…Dendritic cells (DCs) initiate adaptive immune responses after their migration to secondary lymphoid organs. The LXR ligands/oxysterols and the RXR ligand…”
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Molecular basis for repression of liver X receptor-mediated gene transcription by receptor-interacting protein 140 by Jakobsson, Tomas, Osman, Waffa, Gustafsson, Jan-Ake, Zilliacus, Johanna, Wärnmark, Anette

“…Similarities in physiological roles of LXR (liver X receptors) and co-repressor RIP140 (receptor-interacting protein 140) in regulating energy homoeostasis and…”
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Transcriptional repression in macrophages—basic mechanisms and alterations in metabolic inflammatory diseases by Treuter, Eckardt, Fan, Rongrong, Huang, Zhiqiang, Jakobsson, Tomas, Venteclef, Nicolas

“…Macrophage differentiation and signal responses are coordinated by closely linked transcriptional and epigenomic mechanisms that trigger gene expression. In…”
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Potential Role of Thyroid Receptor β Agonists in the Treatment of Hyperlipidemia by Jakobsson, Tomas, Vedin, Lise-Lotte, Parini, Paolo

“…Thyroid hormones have important effects on cellular development, growth, and metabolism and are necessary for the healthy function of almost all tissues…”
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The corepressors GPS2 and SMRT control enhancer and silencer remodeling via eRNA transcription during inflammatory activation of macrophages by Huang, Zhiqiang, Liang, Ning, Goñi, Saioa, Damdimopoulos, Anastasios, Wang, Cheng, Ballaire, Raphaelle, Jager, Jennifer, Niskanen, Henri, Han, Hongya, Jakobsson, Tomas, Bracken, Adrian P., Aouadi, Myriam, Venteclef, Nicolas, Kaikkonen, Minna U., Fan, Rongrong, Treuter, Eckardt

“…While the role of transcription factors and coactivators in controlling enhancer activity and chromatin structure linked to gene expression is well…”
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Metabolic nuclear receptor signaling and the inflammatory acute phase response by Venteclef, Nicolas, Jakobsson, Tomas, Steffensen, Knut R, Treuter, Eckardt

“…The acute phase response (APR) classically refers to the rapid reprogramming of gene expression and metabolism in response to inflammatory cytokine signaling…”
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GPS2-dependent corepressor/SUMO pathways govern anti-inflammatory actions of LRH-1 and LXRβ in the hepatic acute phase response by Venteclef, Nicolas, Jakobsson, Tomas, Ehrlund, Anna, Damdimopoulos, Anastasios, Mikkonen, Laura, Ellis, Ewa, Nilsson, Lisa-Mari, Parini, Paolo, Jänne, Olli A., Gustafsson, Jan-Åke, Steffensen, Knut R., Treuter, Eckardt

“…The orphan receptor LRH-1 and the oxysterol receptors LXRα and LXRβ are established transcriptional regulators of lipid metabolism that appear to control…”
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Generation of new hepatocyte-like in vitro models better resembling human lipid metabolism by Pramfalk, Camilla, Jakobsson, Tomas, Verzijl, Cristy R.C., Minniti, Mirko E., Obensa, Clara, Ripamonti, Federico, Olin, Maria, Pedrelli, Matteo, Eriksson, Mats, Parini, Paolo

“…In contrast to human hepatocytes in vivo, which solely express acyl-coenzyme A:cholesterol acyltransferase (ACAT) 2, both ACAT1 and ACAT2 (encoded by SOAT1 and…”
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Lipidomic analysis of human primary hepatocytes following LXR activation with GW3965 identifies AGXT2L1 as a main target associated to changes in phosphatidylethanolamine by Santinha, Deolinda, Klopot, Anna, Marques, Igor, Ellis, Ewa, Jorns, Carl, Johansson, Helene, Melo, Tânia, Antonson, Per, Jakobsson, Tomas, Félix, Vítor, Gustafsson, Jan-Åke, Domingues, Maria Rosário, Mode, Agneta, Helguero, Luisa A.

“…•GW3965 increases the ratio of monounsaturated / saturated fatty acid ratio.•GW3965 promotes phosphatidylethanolamine and phosphatidylcholine remodeling.•LXR…”
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Targeting liver X receptors in inflammation by Steffensen, Knut R, Jakobsson, Tomas, Gustafsson, Jan-Åke

“…The two oxysterol receptors, 'liver X receptors (LXRs)' LXRα and LXRβ, are amongst the emerging newer drug targets within the nuclear receptor family and…”
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GPS2 Is Required for Cholesterol Efflux by Triggering Histone Demethylation, LXR Recruitment, and Coregulator Assembly at the ABCG1 Locus by Jakobsson, Tomas, Venteclef, Nicolas, Toresson, Gudrun, Damdimopoulos, Anastasios E., Ehrlund, Anna, Lou, Xiaohua, Sanyal, Sabyasachi, Steffensen, Knut R., Gustafsson, Jan-Åke, Treuter, Eckardt

“…Transcriptional coregulators, rather than ligand signals, are suspected to confer context and pathway specificity to nuclear receptor signaling, but the…”
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Oxysterol Receptors LXRs and Coregulators in Cholesterol Metabolism and Inflammatory Transrepression Pathways by Jakobsson, Tomas

“…The LXRs are important sensors and regulators of cholesterol homeostasis in several metabolic tissues including liver, intestine and macrophages. They regulate…”
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RAP250 Is a Coactivator in the Transforming Growth Factor β Signaling Pathway That Interacts with Smad2 and Smad3 by Per Antonson, Tomas Jakobsson, Tova Almlöf, Karolin Guldevall, Knut R. Steffensen, Jan-Åke Gustafsson

“…RAP250 is a coactivator for nuclear receptors as well as other transcription factors. Recent studies have established RAP250 as an essential coactivator for…”
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RAP250 Is a Coactivator in the Transforming Growth Factor β Signaling Pathway That Interacts with Smad2 and Smad3 by Antonson, Per, Jakobsson, Tomas, Almlöf, Tova, Guldevall, Karolin, Steffensen, Knut R., Gustafsson, Jan-Åke

“…RAP250 is a coactivator for nuclear receptors as well as other transcription factors. Recent studies have established RAP250 as an essential coactivator for…”
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GPS2-dependent corepressor/SUMO pathways govern anti-inflammatory actions of LRH-1 and LXRbeta in the hepatic acute phase response by Venteclef, Nicolas, Jakobsson, Tomas, Ehrlund, Anna, Damdimopoulos, Anastasios, Mikkonen, Laura, Ellis, Ewa, Nilsson, Lisa-Mari, Parini, Paolo, Jänne, Olli A, Gustafsson, Jan-Ake, Steffensen, Knut R, Treuter, Eckardt

“…The orphan receptor LRH-1 and the oxysterol receptors LXRalpha and LXRbeta are established transcriptional regulators of lipid metabolism that appear to…”
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