Search Results - "Jakobsche, Charles E"

Incorporating an Intelligent Tutoring System into the DiscoverOChem Learning Platform by Jakobsche, Charles E., Kongsomjit, Pitipat, Milson, Conor, Wang, Wenxing, Ngan, Chun-Kit

“…The current work develops intelligent tutoring aspects for the DiscoverOChem learning platform. Intelligent tutoring systems are technology-based learning…”
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Functional Analysis of an Aspartate-Based Epoxidation Catalyst with Amide-to-Alkene Peptidomimetic Catalyst Analogues by Jakobsche, Charles E, Peris, Gorka, Miller, Scott J

“…Subtle exchange: Replacement of an amide function with alkene or fluoroalkene groups provides a new class of epoxidation catalysts (see scheme). The…”
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Aspartate-Catalyzed Asymmetric Epoxidation Reactions by Peris, Gorka, Jakobsche, Charles E, Miller, Scott J

“…We report enantioselective epoxidation reactions that are catalyzed by aspartic acid-containing peptides. The strategy involves the transient conversion of the…”
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Bistability in Organic Magnetic Materials: A Comparative Study of the Key Differences between Hysteretic and Non‐hysteretic Spin Transitions in Dithiazolyl Radicals by Vela, Sergi, Reardon, Michael B., Jakobsche, Charles E., Turnbull, Mark M., Ribas‐Arino, Jordi, Novoa, Juan J.

“…Dithiazolyl (DTA)‐based radicals have furnished many examples of organic spin‐transition materials, some of them occurring with hysteresis and some others…”
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Exploring Binding and Effector Functions of Natural Human Antibodies Using Synthetic Immunomodulators by Jakobsche, Charles E, Parker, Christopher G, Tao, Ran N, Kolesnikova, Mariya D, Douglass, Eugene F, Spiegel, David A

“…The ability to profile the prevalence and functional activity of endogenous antibodies is of vast clinical and diagnostic importance. Serum antibodies are an…”
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How to Identify–with as Little as One Question–Students Who Are Likely to Struggle in Undergraduate Organic Chemistry by Jakobsche, Charles E.

“…Our goal as educators should be to help our students become well positioned to achieve future success. To develop effective strategies for accomplishing this…”
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Comparing hydrazine-derived reactive groups as inhibitors of quinone-dependent amine oxidases by Burke, Ashley A., Severson, Elizabeth S., Mool, Shreya, Solares Bucaro, Maria J., Greenaway, Frederick T., Jakobsche, Charles E.

“…Lysyl oxidase has emerged as an important enzyme in cancer metastasis. Its activity has been reported to become upregulated in several types of cancer, and…”
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Differential Effects of Polyphenols on Insulin Proteolysis by the Insulin-Degrading Enzyme by Zheng, Qiuchen, Kebede, Micheal T, Lee, Bethany, Krasinski, Claire A, Islam, Saadman, Wurfl, Liliana A, Kemeh, Merc M, Ivancic, Valerie A, Jakobsche, Charles E, Spratt, Donald E, Lazo, Noel D

“…The insulin-degrading enzyme (IDE) possesses a strong ability to degrade insulin and Aβ42 that has been linked to the neurodegeneration in Alzheimer's disease…”
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An Organic Chemistry Activity to Improve Student Understanding of Molecules as 3‑Dimensional Objects by Jakobsche, Charles E., Le, Anh-Vy

“…This report describes an activity that helps organic chemistry students to better understand organic molecules as 3-dimensional objects. To accomplish this…”
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Biomolecular Effects of Dance and Dance/Movement Therapy: A Review by Lopez-Nieves, Ivana, Jakobsche, Charles E.

“…The positive health impacts of dance and dance/movement therapy can be seen all the way down to the molecular level. This narrative-style review illustrates…”
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n → π Interaction and n)(π Pauli Repulsion Are Antagonistic for Protein Stability by Jakobsche, Charles E, Choudhary, Amit, Miller, Scott J, Raines, Ronald T

“…In many common protein secondary structures, such as α-, 310, and polyproline II helices, an n → π* interaction places the adjacent backbone amide carbonyl…”
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Bifunctional Molecular Probes for Activity‐Based Visualization of Quinone‐Dependent Amine Oxidases by Burke, Ashley A., Barrows, Luke, Solares, Maria J., Wall, Alexander D., Jakobsche, Charles E.

“…The design, synthesis, and evaluation of two bifunctional molecular probes that can be used to visualize quinone‐dependent amine oxidase enzymes in an…”
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A regio- and stereo-selective annulation to form the ‘inside-out’ trans-bicyclo[9.2.1]tetradecane ring system by Reardon, Michael B., Yasgur, Brooke C., Jakobsche, Charles E.

“…[Display omitted] •The macrocyclization proceeds with complete stereocontrol.•The shape of the precursor controls the alkylation’s regioselectivity.•The…”
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6-Hydroxynorleucine: Syntheses and Applications of a Versatile Building Block by MacArthur, Nicholas S., Jakobsche, Charles E.

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Long-Range Reactivity Modulations in Geranyl Chloride Derivatives by Reardon, Michael B, Xu, Muyun, Tan, Qingzhe, Baumgartel, P. George, Augur, Danielle J, Huo, Shuanghong, Jakobsche, Charles E

“…Derivatives of geraniol are versatile synthetic intermediates that are useful for synthesizing a variety of terpenoid natural products; however, the results…”
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Using N-Nitrosodichloroacetamides to Conveniently Convert Linear Primary Amines into Alcohols by MacArthur, Nicholas S., Wang, Linshu, McCarthy, Blaine G., Jakobsche, Charles E.

“…The reported rearrangement of N-nitrosodichloroacetamides provides a practicalmethod for converting primary amines into primary alcohols. The reaction sequence…”
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Reprogramming Urokinase into an Antibody-Recruiting Anticancer Agent by Jakobsche, Charles E, McEnaney, Patrick J, Zhang, Andrew X, Spiegel, David A

“…Synthetic compounds for controlling or creating human immunity have the potential to revolutionize disease treatment. Motivated by challenges in this arena, we…”
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Contrasting solution-state properties within a family of amyloid-binding molecular tools by Le, Anh-Vy, Xu, Muyun, Yang, Tianyi, Barrows, Luke, Fontaine, Devon F.A., Huo, Shuanghong, Jakobsche, Charles E.

“…Rational modification to the molecular structure of a family of amyloid-binding bifunctional molecular tools improves their hydrophilicity and aqueous…”
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A simple synthesis of 6-hydroxynorleucine based on the rearrangement of an N-nitrosodichloroacetamide by McCarthy, Blaine G., MacArthur, Nicholas S., Jakobsche, Charles E.

“…[Display omitted] 6-Hydroxynorleucine is a versatile chemical intermediate that has found broad use in target-oriented syntheses of numerous biologically…”
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Selective partial reduction of quinolines: Hydrosilylation vs. transfer hydrogenation by Voutchkova, Adelina M., Gnanamgari, Dinakar, Jakobsche, Charles E., Butler, Chase, Miller, Scott J., Parr, Jonathan, Crabtree, Robert H.

“…Two mild catalytic routes for regioselective hydrogenation of the heterocyclic ring of quinoline derivatives are presented. The first route occurs through…”
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