Search Results - "Jakob, Steffen"

Comparative Analytical Evaluation of the Proposed Biosimilar FYB206 and its Reference Medicinal Product Keytruda by Stüber, Jakob C., Uhland, Kerstin, Reiter, Alwin, Jakob, Steffen, Wolschin, Florian

“…Background and Objective Biological medicinal products improve patients’ lives, but access is limited, mainly due to high costs. Patents for many existing…”
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Impact of two neighbouring ribosomal protein clusters on biogenesis factor binding and assembly of yeast late small ribosomal subunit precursors by Linnemann, Jan, Pöll, Gisela, Jakob, Steffen, Ferreira-Cerca, Sébastien, Griesenbeck, Joachim, Tschochner, Herbert, Milkereit, Philipp

“…Many of the small ribosomal subunit proteins are required for the stabilisation of late small ribosomal subunit (SSU) precursors and for final SSU rRNA…”
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Analysis of the In Vivo Assembly Pathway of Eukaryotic 40S Ribosomal Proteins by Ferreira-Cerca, Sébastien, Pöll, Gisela, Kühn, Holger, Neueder, Andreas, Jakob, Steffen, Tschochner, Herbert, Milkereit, Philipp

“…In eukaryotes, in vivo formation of the two ribosomal subunits from four ribosomal RNAs (rRNAs) and approximately 80 ribosomal proteins (r-proteins) involves…”
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rRNA Maturation in Yeast Cells Depleted of Large Ribosomal Subunit Proteins by Pöll, Gisela, Braun, Tobias, Jakovljevic, Jelena, Neueder, Andreas, Jakob, Steffen, Woolford, John L. Jr, Tschochner, Herbert, Milkereit, Philipp

“…The structural constituents of the large eukaryotic ribosomal subunit are 3 ribosomal RNAs, namely the 25S, 5.8S and 5S rRNA and about 46 ribosomal proteins…”
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Interrelationships between yeast ribosomal protein assembly events and transient ribosome biogenesis factors interactions in early pre-ribosomes by Jakob, Steffen, Ohmayer, Uli, Neueder, Andreas, Hierlmeier, Thomas, Perez-Fernandez, Jorge, Hochmuth, Eduard, Deutzmann, Rainer, Griesenbeck, Joachim, Tschochner, Herbert, Milkereit, Philipp

“…Early steps of eukaryotic ribosome biogenesis require a large set of ribosome biogenesis factors which transiently interact with nascent rRNA precursors…”
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Local Role for the Small Ribosomal Subunit Primary Binder rpS5 in Final 18S rRNA Processing in Yeast by Neueder, Andreas, Jakob, Steffen, Pöll, Gisela, Linnemann, Jan, Deutzmann, Rainer, Tschochner, Herbert, Milkereit, Philipp

“…In vivo depletion of the yeast small ribosomal subunit (SSU) protein S5 (rpS5) leads to nuclear degradation of nascent SSUs and to a perturbed global assembly…”
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The Noc-domain containing C-terminus of Noc4p mediates both formation of the Noc4p-Nop14p submodule and its incorporation into the SSU processome by Kühn, Holger, Hierlmeier, Thomas, Merl, Juliane, Jakob, Steffen, Aguissa-Touré, Almass-Houd, Milkereit, Philipp, Tschochner, Herbert

“…Noc1p, Noc3p and Noc4p are eukaryotic proteins which play essential roles in yeast ribosome biogenesis and contain a homologous stretch of about 45 aminoacids…”
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Site specific phosphorylation of yeast RNA polymerase I by Gerber, Jochen, Reiter, Alarich, Steinbauer, Robert, Jakob, Steffen, Kuhn, Claus-Dieter, Cramer, Patrick, Griesenbeck, Joachim, Milkereit, Philipp, Tschochner, Herbert

“…All nuclear RNA polymerases are phosphoprotein complexes. Yeast RNA polymerase I (Pol I) contains approximately 15 phosphate groups, distributed to 5 of the 14…”
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Communication with the Exon-Junction Complex and Activation of Nonsense-Mediated Decay by Human Upf Proteins Occur in the Cytoplasm by Singh, Guramrit, Jakob, Steffen, Kleedehn, Mark G., Lykke-Andersen, Jens

“…The nonsense-mediated mRNA decay (NMD) pathway rids eukaryotic cells of mRNAs with premature termination codons. There is contradictory evidence as to whether…”
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Analysis of ribosome biogenesis factor-modules in yeast cells depleted from pre-ribosomes by Merl, Juliane, Jakob, Steffen, Ridinger, Katrin, Hierlmeier, Thomas, Deutzmann, Rainer, Milkereit, Philipp, Tschochner, Herbert

“…Formation of eukaryotic ribosomes requires more than 150 biogenesis factors which transiently interact with the nascent ribosomal subunits. Previously, many…”
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