Search Results - "Jaiswal, Sonal Nagarkar"

A library of MiMICs allows tagging of genes and reversible, spatial and temporal knockdown of proteins in Drosophila by Nagarkar-Jaiswal, Sonal, Lee, Pei-Tseng, Campbell, Megan E, Chen, Kuchuan, Anguiano-Zarate, Stephanie, Gutierrez, Manuel Cantu, Busby, Theodore, Lin, Wen-Wen, He, Yuchun, Schulze, Karen L, Booth, Benjamin W, Evans-Holm, Martha, Venken, Koen J T, Levis, Robert W, Spradling, Allan C, Hoskins, Roger A, Bellen, Hugo J

“…Here, we document a collection of ∼7434 MiMIC (Minos Mediated Integration Cassette) insertions of which 2854 are inserted in coding introns. They allowed us to…”
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Single-cell analysis of transcription kinetics across the cell cycle by Skinner, Samuel O, Xu, Heng, Nagarkar-Jaiswal, Sonal, Freire, Pablo R, Zwaka, Thomas P, Golding, Ido

“…Transcription is a highly stochastic process. To infer transcription kinetics for a gene-of-interest, researchers commonly compare the distribution of mRNA…”
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Bendless is essential for PINK1-Park mediated Mitofusin degradation under mitochondrial stress caused by loss of LRPPRC by Cheramangalam, Rajit Narayanan, Anand, Tarana, Pandey, Priyanka, Balasubramanian, Deepa, Varghese, Reshmi, Singhal, Neha, Jaiswal, Sonal Nagarkar, Jaiswal, Manish

“…Cells under mitochondrial stress often co-opt mechanisms to maintain energy homeostasis, mitochondrial quality control and cell survival. A mechanistic…”
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A genetic toolkit for tagging intronic MiMIC containing genes by Nagarkar-Jaiswal, Sonal, DeLuca, Steven Z, Lee, Pei-Tseng, Lin, Wen-Wen, Pan, Hongling, Zuo, Zhongyuan, Lv, Jiangxing, Spradling, Allan C, Bellen, Hugo J

“…Previously, we described a large collection of Minos-Mediated Integration Cassettes (MiMICs) that contain two phiC31 recombinase target sites and allow the…”
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A voltage-gated calcium channel regulates lysosomal fusion with endosomes and autophagosomes and is required for neuronal homeostasis by Tian, Xuejun, Gala, Upasana, Zhang, Yongping, Shang, Weina, Nagarkar Jaiswal, Sonal, di Ronza, Alberto, Jaiswal, Manish, Yamamoto, Shinya, Sandoval, Hector, Duraine, Lita, Sardiello, Marco, Sillitoe, Roy V, Venkatachalam, Kartik, Fan, Hengyu, Bellen, Hugo J, Tong, Chao

“…Autophagy helps deliver sequestered intracellular cargo to lysosomes for proteolytic degradation and thereby maintains cellular homeostasis by preventing…”
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Stereotyped terminal axon branching of leg motor neurons mediated by IgSF proteins DIP-α and Dpr10 by Venkatasubramanian, Lalanti, Guo, Zhenhao, Xu, Shuwa, Tan, Liming, Xiao, Qi, Nagarkar-Jaiswal, Sonal, Mann, Richard S

“…For animals to perform coordinated movements requires the precise organization of neural circuits controlling motor function. Motor neurons (MNs), key…”
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Transsynaptic interactions between IgSF proteins DIP-α and Dpr10 are required for motor neuron targeting specificity by Ashley, James, Sorrentino, Violet, Lobb-Rabe, Meike, Nagarkar-Jaiswal, Sonal, Tan, Liming, Xu, Shuwa, Xiao, Qi, Zinn, Kai, Carrillo, Robert A

“…The larval neuromuscular system provides an ideal context in which to study synaptic partner choice, because it contains a small number of pre- and…”
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DYRK1A interacts with the tuberous sclerosis complex and promotes mTORC1 activity by Wang, Pinhua, Sarkar, Sunayana, Zhang, Menghuan, Xiao, Tingting, Kong, Fenhua, Zhang, Zhe, Balasubramanian, Deepa, Jayaram, Nandan, Datta, Sayantan, He, Ruyu, Wu, Ping, Chao, Peng, Zhang, Ying, Washburn, Michael, Florens, Laurence A, Nagarkar-Jaiswal, Sonal, Jaiswal, Manish, Mohan, Man

“…DYRK1A, a ubiquitously expressed kinase is linked to the dominant intellectual developmental disorder, microcephaly, and Down syndrome in humans. It regulates…”
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A cell cycle-independent, conditional gene inactivation strategy for differentially tagging wild-type and mutant cells by Nagarkar-Jaiswal, Sonal, Manivannan, Sathiya N, Zuo, Zhongyuan, Bellen, Hugo J

“…Here, we describe a novel method based on intronic MiMIC insertions described in Nagarkar-Jaiswal et al. (2015) to perform conditional gene inactivation in …”
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Functional dissection of the Drosophila melanogaster condensin subunit Cap-G reveals its exclusive association with condensin I by Herzog, Sabine, Nagarkar Jaiswal, Sonal, Urban, Evelin, Riemer, Anna, Fischer, Sina, Heidmann, Stefan K

“…The heteropentameric condensin complexes have been shown to participate in mitotic chromosome condensation and to be required for unperturbed chromatid…”
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Ig Superfamily Ligand and Receptor Pairs Expressed in Synaptic Partners in Drosophila by Tan, Liming, Zhang, Kelvin Xi, Pecot, Matthew Y., Nagarkar-Jaiswal, Sonal, Lee, Pei-Tseng, Takemura, Shin-ya, McEwen, Jason M., Nern, Aljoscha, Xu, Shuwa, Tadros, Wael, Chen, Zhenqing, Zinn, Kai, Bellen, Hugo J., Morey, Marta, Zipursky, S. Lawrence

“…Information processing relies on precise patterns of synapses between neurons. The cellular recognition mechanisms regulating this specificity are poorly…”
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Control of Synaptic Connectivity by a Network of Drosophila IgSF Cell Surface Proteins by Carrillo, Robert A., Özkan, Engin, Menon, Kaushiki P., Nagarkar-Jaiswal, Sonal, Lee, Pei-Tseng, Jeon, Mili, Birnbaum, Michael E., Bellen, Hugo J., Garcia, K. Christopher, Zinn, Kai

“…We have defined a network of interacting Drosophila cell surface proteins in which a 21-member IgSF subfamily, the Dprs, binds to a nine-member subfamily, the…”
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The cohesin subunit Rad21 is required for synaptonemal complex maintenance, but not sister chromatid cohesion, during Drosophila female meiosis by Urban, Evelin, Nagarkar-Jaiswal, Sonal, Lehner, Christian F, Heidmann, Stefan K

“…Replicated sister chromatids are held in close association from the time of their synthesis until their separation during the next mitosis. This association is…”
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The E3 ligase Ubr3 regulates Usher syndrome and MYH9 disorder proteins in the auditory organs of Drosophila and mammals by Li, Tongchao, Giagtzoglou, Nikolaos, Eberl, Daniel F, Jaiswal, Sonal Nagarkar, Cai, Tiantian, Godt, Dorothea, Groves, Andrew K, Bellen, Hugo J

“…Myosins play essential roles in the development and function of auditory organs and multiple myosin genes are associated with hereditary forms of deafness…”
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Flip-flop Mediated Conditional Gene Inactivation in Drosophila by Manivannan, Sathiya N, Pandey, Priyanka, Nagarkar-Jaiswal, Sonal

“…Mosaic analysis in , an important tool to assess cellular phenotypes of mutants in an otherwise heterozygous background, relies on mitosis. Hence, it cannot be…”
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Neuron-Subtype-Specific Expression, Interaction Affinities, and Specificity Determinants of DIP/Dpr Cell Recognition Proteins by Cosmanescu, Filip, Katsamba, Phinikoula S., Sergeeva, Alina P., Ahlsen, Goran, Patel, Saurabh D., Brewer, Joshua J., Tan, Liming, Xu, Shuwa, Xiao, Qi, Nagarkar-Jaiswal, Sonal, Nern, Aljoscha, Bellen, Hugo J., Zipursky, S. Lawrence, Honig, Barry, Shapiro, Lawrence

“…Binding between DIP and Dpr neuronal recognition proteins has been proposed to regulate synaptic connections between lamina and medulla neurons in the…”
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Loss of Nardilysin, a Mitochondrial Co-chaperone for α-Ketoglutarate Dehydrogenase, Promotes mTORC1 Activation and Neurodegeneration by Yoon, Wan Hee, Sandoval, Hector, Nagarkar-Jaiswal, Sonal, Jaiswal, Manish, Yamamoto, Shinya, Haelterman, Nele A., Putluri, Nagireddy, Putluri, Vasanta, Sreekumar, Arun, Tos, Tulay, Aksoy, Ayse, Donti, Taraka, Graham, Brett H., Ohno, Mikiko, Nishi, Eiichiro, Hunter, Jill, Muzny, Donna M., Carmichael, Jason, Shen, Joseph, Arboleda, Valerie A., Nelson, Stanley F., Wangler, Michael F., Karaca, Ender, Lupski, James R., Bellen, Hugo J.

“…We previously identified mutations in Nardilysin (dNrd1) in a forward genetic screen designed to isolate genes whose loss causes neurodegeneration in…”
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DYRK1A interacts with the tuberous sclerosis complex and promotes mTORC1 activity by Wang, Pinhua, Sarkar, Sunayana, Zhang, Menghuan, Xiao, Tingting, Kong, Fenhua, Zhang, Zhe, Balasubramanian, Deepa, Jayaram, Nandan, Datta, Sayantan, He, Ruyu, Wu, Ping, Chao, Peng, Zhang, Ying, Washburn, Michael, Florens, Laurence A, Nagarkar-Jaiswal, Sonal, Jaiswal, Manish, Mohan, Man

“…DYRK1A, a ubiquitously expressed kinase , is linked to the dominant intellectual developmental disorder, microcephaly, and Down syndrome in humans. It…”
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Ari-1 Regulates Myonuclear Organization Together with Parkin and Is Associated with Aortic Aneurysms by Tan, Kai Li, Haelterman, Nele A., Kwartler, Callie S., Regalado, Ellen S., Lee, Pei-Tseng, Nagarkar-Jaiswal, Sonal, Guo, Dong-Chuan, Duraine, Lita, Wangler, Michael F., Bamshad, Michael J., Nickerson, Deborah A., Lin, Guang, Milewicz, Dianna M., Bellen, Hugo J.

“…Nuclei are actively positioned and anchored to the cytoskeleton via the LINC (Linker of Nucleoskeleton and Cytoskeleton) complex. We identified mutations in…”
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Stereotyped terminal axon branching of leg motor neurons mediated by IgSF proteins DIP-[alpha] and Dpr10 by Venkatasubramanian, Lalanti, Guo, Zhenhao, Xu, Shuwa, Tan, Liming, Xiao, Qi, Nagarkar-Jaiswal, Sonal, Mann, Richard S

“…For animals to perform coordinated movements requires the precise organization of neural circuits controlling motor function. Motor neurons (MNs), key…”
Get full text