Search Results - "Jaisser, Frederic"

Mineralocorticoid receptor antagonists in diabetic kidney disease — mechanistic and therapeutic effects by Barrera-Chimal, Jonatan, Lima-Posada, Ixchel, Bakris, George L., Jaisser, Frederic

“…Chronic kidney disease (CKD) is the leading complication in type 2 diabetes (T2D) and current therapies that limit CKD progression and the development of…”
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Roles of Mineralocorticoid Receptors in Cardiovascular and Cardiorenal Diseases by Barrera-Chimal, Jonatan, Bonnard, Benjamin, Jaisser, Frederic

“…Mineralocorticoid receptor (MR) activation in the heart and vessels leads to pathological effects, such as excessive extracellular matrix accumulation,…”
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Mineralocorticoid receptor is involved in rat and human ocular chorioretinopathy by Zhao, Min, Célérier, Isabelle, Bousquet, Elodie, Jeanny, Jean-Claude, Jonet, Laurent, Savoldelli, Michèle, Offret, Olivier, Curan, Antoine, Farman, Nicolette, Jaisser, Frédéric, Behar-Cohen, Francine

“…Central serous chorioretinopathy (CSCR) is a vision-threatening eye disease with no validated treatment and unknown pathogeny. In CSCR, dilation and leakage of…”
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Benefit of Mineralocorticoid Receptor Antagonism in AKI: Role of Vascular Smooth Muscle Rac1 by Barrera-Chimal, Jonatan, André-Grégoire, Gwennan, Nguyen Dinh Cat, Aurelie, Lechner, Sebastian M, Cau, Jérôme, Prince, Sonia, Kolkhof, Peter, Loirand, Gervaise, Sauzeau, Vincent, Hauet, Thierry, Jaisser, Frédéric

“…AKI is a frequent complication in hospitalized patients. Unfortunately, there is no effective pharmacologic approach for treating or preventing AKI. In…”
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Vascular Smooth Muscle Mineralocorticoid Receptor Contributes to Coronary and Left Ventricular Dysfunction After Myocardial Infarction by Gueret, Alexandre, Harouki, Najah, Favre, Julie, Galmiche, Guillaume, Nicol, Lionel, Henry, Jean-Paul, Besnier, Marie, Thuillez, Christian, Richard, Vincent, Kolkhof, Peter, Mulder, Paul, Jaisser, Frédéric, Ouvrard-Pascaud, Antoine

“…Mineralocorticoid receptor (MR) antagonists slow down the progression of heart failure after myocardial infarction (MI), but the cell-specific role of MR in…”
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Steroidal and Novel Non-steroidal Mineralocorticoid Receptor Antagonists in Heart Failure and Cardiorenal Diseases: Comparison at Bench and Bedside by Kolkhof, Peter, Jaisser, Frederic, Kim, So-Young, Filippatos, Gerasimos, Nowack, Christina, Pitt, Bertram

“…Characterization of mice with cell-specific deletion or overexpression of the mineralocorticoid receptor (MR) shed a new light on its role in health and…”
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Cutaneous Wound Healing in Diabetic Mice Is Improved by Topical Mineralocorticoid Receptor Blockade by Nguyen, Van Tuan, Farman, Nicolette, Palacios-Ramirez, Roberto, Sbeih, Maria, Behar-Cohen, Francine, Aractingi, Sélim, Jaisser, Frederic

“…Skin ulcers resulting from impaired wound healing are a serious complication of diabetes. Unresolved inflammation, associated with the dysregulation of both…”
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Differentiation between emerging non-steroidal and established steroidal mineralocorticoid receptor antagonists: head-to-head comparisons of pharmacological and clinical characteristics by Barrera-Chimal, Jonatan, Kolkhof, Peter, Lima-Posada, Ixchel, Joachim, Alexandre, Rossignol, Patrick, Jaisser, Frederic

“…Mineralocorticoid receptor (MR) antagonists (MRAs) provide cardiorenal protection. However steroidal MRAs might induce hyperkalemia and sex hormone-related…”
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Adipocyte Mineralocorticoid Receptor Activation Leads to Metabolic Syndrome and Induction of Prostaglandin D2 Synthase by Urbanet, Riccardo, Nguyen Dinh Cat, Aurelie, Feraco, Alessandra, Venteclef, Nicolas, El Mogrhabi, Soumaya, Sierra-Ramos, Catalina, Alvarez de la Rosa, Diego, Adler, Gail K, Quilliot, Didier, Rossignol, Patrick, Fallo, Francesco, Touyz, Rhian M, Jaisser, Frédéric

“…Metabolic syndrome is a major risk factor for the development of diabetes mellitus and cardiovascular diseases. Pharmacological antagonism of the…”
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Mineralocorticoid receptor antagonism limits experimental choroidal neovascularization and structural changes associated with neovascular age-related macular degeneration by Zhao, Min, Mantel, Irmela, Gelize, Emmanuelle, Li, Xinxin, Xie, Xiaoyue, Arboleda, Alejandro, Seminel, Marie, Levy-Boukris, Rinath, Dernigoghossian, Marilyn, Prunotto, Andrea, Andrieu-Soler, Charlotte, Rivolta, Carlo, Canonica, Jérémie, Naud, Marie-Christine, Lechner, Sebastian, Farman, Nicolette, Bravo-Osuna, Irene, Herrero-Vanrell, Rocio, Jaisser, Frederic, Behar-Cohen, Francine

“…Choroidal neovascularization (CNV) is a major cause of visual impairment in patients suffering from wet age-related macular degeneration (AMD), particularly…”
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CT-1 (Cardiotrophin-1)-Gal-3 (Galectin-3) Axis in Cardiac Fibrosis and Inflammation: Mechanistic Insights and Clinical Implications by Martínez-Martínez, Ernesto, Brugnolaro, Cristina, Ibarrola, Jaime, Ravassa, Susana, Buonafine, Mathieu, López, Begoña, Fernández-Celis, Amaya, Querejeta, Ramón, Santamaria, Enrique, Fernández-Irigoyen, Joaquín, Rábago, Gregorio, Moreno, María U, Jaisser, Frédéric, Díez, Javier, González, Arantxa, López-Andrés, Natalia

“…Myocardial fibrosis is a main contributor to the development of heart failure (HF). CT-1 (cardiotrophin-1) and Gal-3 (galectin-3) are increased in HF and…”
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Preclinical pharmacology of AZD9977: A novel mineralocorticoid receptor modulator separating organ protection from effects on electrolyte excretion by Bamberg, Krister, Johansson, Ulrika, Edman, Karl, William-Olsson, Lena, Myhre, Susanna, Gunnarsson, Anders, Geschwindner, Stefan, Aagaard, Anna, Björnson Granqvist, Anna, Jaisser, Frédéric, Huang, Yufeng, Granberg, Kenneth L, Jansson-Löfmark, Rasmus, Hartleib-Geschwindner, Judith

“…Excess mineralocorticoid receptor (MR) activation promotes target organ dysfunction, vascular injury and fibrosis. MR antagonists like eplerenone are used for…”
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Galectin-3 Blockade Inhibits Cardiac Inflammation and Fibrosis in Experimental Hyperaldosteronism and Hypertension by Martínez-Martínez, Ernesto, Calvier, Laurent, Fernández-Celis, Amaya, Rousseau, Elodie, Jurado-López, Raquel, Rossoni, Luciana V, Jaisser, Frederic, Zannad, Faiez, Rossignol, Patrick, Cachofeiro, Victoria, López-Andrés, Natalia

“…Hypertensive cardiac remodeling is accompanied by molecular inflammation and fibrosis, 2 mechanisms that finally affect cardiac function. At cardiac level,…”
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Nonepithelial mineralocorticoid receptor activation as a determinant of kidney disease by Nakamura, Toshifumi, Girerd, Sophie, Jaisser, Frederic, Barrera-Chimal, Jonatan

“…Chronic kidney disease is a major global health challenge, and mineralocorticoid receptor (MR) signaling is thought to play a role in disease progression. The…”
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Epithelial Sodium Channel in Aldosterone-Induced Endothelium Stiffness and Aortic Dysfunction by Jia, Guanghong, Habibi, Javad, Aroor, Annayya R, Hill, Michael A, Yang, Yan, Whaley-Connell, Adam, Jaisser, Frederic, Sowers, James R

“…Enhanced activation of the endothelial mineralocorticoid receptor contributes to the development of arterial stiffness, which is an independent predictor of…”
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Rapid glycemic regulation in poorly controlled patients living with diabetes, a new associated factor in the pathophysiology of Charcot's acute neuroarthropathy by Dardari, Dured, Van, Georges Ha, M'Bemba, Jocelyne, Laborne, Francois-Xavier, Bourron, Olivier, Davaine, Jean Michel, Phan, Franck, Foufelle, Fabienne, Jaisser, Frédéric, Penfornis, Alfred, Hartemann, Agnes

“…Aggressive antidiabetic therapy and rapid glycemic control are associated with diabetic neuropathy. Here we investigated if this is also the case for Charcot…”
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Mineralocorticoid receptor activation and blockade: an emerging paradigm in chronic kidney disease by Bertocchio, Jean-Philippe, Warnock, David G., Jaisser, Frederic

“…Slowing the progression of chronic kidney diseases (CKDs) requires new and effective treatment approaches. Aldosterone classically acts on the distal nephron:…”
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Endothelial Mineralocorticoid Receptors Differentially Contribute to Coronary and Mesenteric Vascular Function Without Modulating Blood Pressure by Mueller, Katelee Barrett, Bender, Shawn B, Hong, Kwangseok, Yang, Yan, Aronovitz, Mark, Jaisser, Frederic, Hill, Michael A, Jaffe, Iris Z

“…Arteriolar vasoreactivity tightly regulates tissue-specific blood flow and contributes to systemic blood pressure (BP) but becomes dysfunctional in the setting…”
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Epithelial sodium channels in endothelial cells mediate diet-induced endothelium stiffness and impaired vascular relaxation in obese female mice by Sowers, James R., Habibi, Javad, Aroor, Annayya R., Yang, Yan, Lastra, Guido, Hill, Michael A., Whaley-Connell, Adam, Jaisser, Frederic, Jia, Guanghong

“…Mineralocorticoid receptor activation of the epithelial sodium channel in endothelial cells (ECs) (EnNaC) is accompanied by aldosterone induced endothelial…”
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Epithelial Sodium Channel Stiffens the Vascular Endothelium In Vitro and in Liddle Mice by Jeggle, Pia, Callies, Chiara, Tarjus, Antoine, Fassot, Celine, Fels, Johannes, Oberleithner, Hans, Jaisser, Frederic, Kusche-Vihrog, Kristina

“…Liddle syndrome, an inherited form of hypertension, is caused by gain-of-function mutations in the epithelial Na channel (ENaC), the principal mediator of Na…”
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