Search Results - "Jaisser, Fréderic"

Differential Effect of Aldosterone or Mineralocorticoid Receptor Overexpression on Retinal Inflammation by Leclercq, Bastien, Mejlachowicz, Dan, Zhu, Linxin, Jonet, Laurent, Mehanna, Chadi, Berdugo, Marianne, Irinopoulou, Theano, Jaisser, Fréderic, Zhao, Min, Behar-Cohen, Francine

“…Overactivation of the mineralocorticoid receptor (MR) pathway is proinflammatory and contributes to the pathogenesis of diabetic retinopathy and of age-related…”
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Aldosterone-Specific Activation of Cardiomyocyte Mineralocorticoid Receptor In Vivo by Messaoudi, Smail, Gravez, Basile, Tarjus, Antoine, Pelloux, Véronique, Ouvrard-Pascaud, Antoine, Delcayre, Claude, Samuel, Janelise, Launay, Jean-Marie, Sierra-Ramos, Catalina, de la Rosa, Diego Alvarez, Clément, Karine, Farman, Nicolette, Jaisser, Fréderic

“…Inappropriate mineralocorticoid receptor (MR) activation is involved in cardiac diseases. Whether and how aldosterone is involved in the deleterious effects of…”
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Pathophysiologic mechanisms in diabetic kidney disease: A focus on current and future therapeutic targets by Barrera‐Chimal, Jonatan, Jaisser, Frédéric

“…Diabetic kidney disease (DKD) is the primary cause of chronic kidney disease around the globe and is one of the main complications in patients with type 1 and…”
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Mineralocorticoid Receptor Activation and Mineralocorticoid Receptor Antagonist Treatment in Cardiac and Renal Diseases by Bauersachs, Johann, Jaisser, Frédéric, Toto, Robert

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Mineralocorticoid Receptor and Cardiovascular Disease by Buonafine, Mathieu, Bonnard, Benjamin, Jaisser, Frédéric

“…Abstract Activation of the mineralocorticoid receptor (MR) in the distal nephron by its ligand, aldosterone, plays an important role in sodium reabsorption and…”
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Endothelial mineralocorticoid receptor activation enhances endothelial protein C receptor and decreases vascular thrombosis in mice by Lagrange, Jérémy, Li, Zhenlin, Fassot, Céline, Bourhim, Mustapha, Louis, Huguette, Cat, Aurélie Nguyen Dinh, Parlakian, Ara, Wahl, Denis, Lacolley, Patrick, Jaisser, Fréderic, Regnault, Véronique

“…ABSTRACT Previous studies have shown that aldosterone, which activates the mineralocorticoid receptor (MR), promotes thrombosis in animal models. Our objective…”
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Conditional FKBP12.6 overexpression in mouse cardiac myocytes prevents triggered ventricular tachycardia through specific alterations in excitation-contraction coupling by Gellen, Barnabas, Fernández-Velasco, María, Briec, François, Vinet, Laurent, LeQuang, Khai, Rouet-Benzineb, Patricia, Bénitah, Jean-Pierre, Pezet, Mylène, Palais, Gael, Pellegrin, Noémie, Zhang, Andy, Perrier, Romain, Escoubet, Brigitte, Marniquet, Xavier, Richard, Sylvain, Jaisser, Fréderic, Gómez, Ana María, Charpentier, Flavien, Mercadier, Jean-Jacques

“…Ca(2+) release from the sarcoplasmic reticulum via the ryanodine receptor (RyR2) activates cardiac myocyte contraction. An important regulator of RyR2 function…”
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Central serous chorioretinopathy: Recent findings and new physiopathology hypothesis by Daruich, Alejandra, Matet, Alexandre, Dirani, Ali, Bousquet, Elodie, Zhao, Min, Farman, Nicolette, Jaisser, Frédéric, Behar-Cohen, Francine

“…Central serous chorioretinopathy (CSCR) is a major cause of vision threat among middle-aged male individuals. Multimodal imaging led to the description of a…”
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Aldosterone promotes cardiac endothelial cell proliferation in vivo by Gravez, Basile, Tarjus, Antoine, Pelloux, Véronique, Ouvrard-Pascaud, Antoine, Delcayre, Claude, Samuel, Janelise, Clément, Karine, Farman, Nicolette, Jaisser, Fréderic, Messaoudi, Smail

“…Experimentally, aldosterone in association with NaCl induces cardiac fibrosis, oxidative stress, and inflammation through mineralocorticoid receptor…”
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Mineralocorticoid receptor antagonists in diabetic kidney disease — mechanistic and therapeutic effects by Barrera-Chimal, Jonatan, Lima-Posada, Ixchel, Bakris, George L., Jaisser, Frederic

“…Chronic kidney disease (CKD) is the leading complication in type 2 diabetes (T2D) and current therapies that limit CKD progression and the development of…”
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MR (Mineralocorticoid Receptor) in Endothelial Cells: A Major Contributor in Pulmonary Arterial Hypertension Remodeling by Barrera-Chimal, Jonatan, Jaisser, Frédéric

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Roles of Mineralocorticoid Receptors in Cardiovascular and Cardiorenal Diseases by Barrera-Chimal, Jonatan, Bonnard, Benjamin, Jaisser, Frederic

“…Mineralocorticoid receptor (MR) activation in the heart and vessels leads to pathological effects, such as excessive extracellular matrix accumulation,…”
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Immunosuppressive therapy after solid organ transplantation and the gut microbiota: Bidirectional interactions with clinical consequences by Gabarre, Paul, Loens, Christopher, Tamzali, Yanis, Barrou, Benoit, Jaisser, Frédéric, Tourret, Jérôme

“…Our understanding of the involvement of the gut microbiota (GM) in human health has expanded exponentially over the last few decades, particularly in the…”
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The myeloid mineralocorticoid receptor controls inflammatory and fibrotic responses after renal injury via macrophage interleukin-4 receptor signaling by Barrera-Chimal, Jonatan, Estrela, Gabriel R, Lechner, Sebastian M, Giraud, Sébastien, El Moghrabi, Soumaya, Kaaki, Shiem, Kolkhof, Peter, Hauet, Thierry, Jaisser, Frédéric

“…Acute kidney injury induced by ischemia/reperfusion is an independent risk factor for chronic kidney disease. Macrophage recruitment plays an essential role…”
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Mineralocorticoid receptor antagonists in kidney transplantation: time to consider? by Girerd, Sophie, Jaisser, Frédéric

“…Although patient survival is significantly improved by kidney transplantation (KT) in comparison with dialysis, it remains significantly lower than that…”
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Letter to the Editor From Behar-Cohen et al.: "The Cortisol Response of Male and Female Choroidal Endothelial Cells: Implications for Central Serous Chorioretinopathy" by Behar-Cohen, Francine, Jaisser, Frédéric, Zhao, Min

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Mineralocorticoid receptor is involved in rat and human ocular chorioretinopathy by Zhao, Min, Célérier, Isabelle, Bousquet, Elodie, Jeanny, Jean-Claude, Jonet, Laurent, Savoldelli, Michèle, Offret, Olivier, Curan, Antoine, Farman, Nicolette, Jaisser, Frédéric, Behar-Cohen, Francine

“…Central serous chorioretinopathy (CSCR) is a vision-threatening eye disease with no validated treatment and unknown pathogeny. In CSCR, dilation and leakage of…”
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Emerging fields for therapeutic targeting of the aldosterone–mineralocorticoid receptor signaling pathway by Lother, Achim, Jaisser, Frédéric, Wenzel, Ulrich O.

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Myocardial fibrosis: biomedical research from bench to bedside by Gyöngyösi, Mariann, Winkler, Johannes, Ramos, Isbaal, Do, Quoc‐Tuan, Firat, Hüseyin, McDonald, Kenneth, González, Arantxa, Thum, Thomas, Díez, Javier, Jaisser, Frédéric, Pizard, Anne, Zannad, Faiez

“…Myocardial fibrosis refers to a variety of quantitative and qualitative changes in the interstitial myocardial collagen network that occur in response to…”
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Benefit of Mineralocorticoid Receptor Antagonism in AKI: Role of Vascular Smooth Muscle Rac1 by Barrera-Chimal, Jonatan, André-Grégoire, Gwennan, Nguyen Dinh Cat, Aurelie, Lechner, Sebastian M, Cau, Jérôme, Prince, Sonia, Kolkhof, Peter, Loirand, Gervaise, Sauzeau, Vincent, Hauet, Thierry, Jaisser, Frédéric

“…AKI is a frequent complication in hospitalized patients. Unfortunately, there is no effective pharmacologic approach for treating or preventing AKI. In…”
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