Multi-center prospective survey of inflammatory bowel diseases in Kerala: More than 2000 cases

Background Inflammatory bowel disease (IBD) is considered uncommon in Asia. The aim of this study was to document the demographic characteristics and clinical aspects of ulcerative colitis (UC) and Crohn’s disease (CD) in Kerala, India. Methods A survey of IBD in Kerala was performed. All gastroente...

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Published in:	Indian journal of gastroenterology Vol. 36; no. 6; pp. 459 - 467
Main Authors:	Philip, Mathew, Augustine, Philip, Thomas, Varghese, Ramesh, G. N., Vinayakumar, K. R., Ramachandran, T. M., Siyad, Ismail, Mukkada, Roy J., Devi, R. Sobhana, Chettupuzha, Antony P., Jaison, Varghese A., Ramesh, M., Mahadevan, P., Koshy, Abraham
Format:	Journal Article
Language:	English
Published:	New Delhi Springer India 01-11-2017
Subjects:	Gastroenterology Hepatology Medicine Medicine & Public Health Original Article Inflammatory bowel disease Colitis Ulcerative Epidemiology Crohn’s disease
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Summary:	Background Inflammatory bowel disease (IBD) is considered uncommon in Asia. The aim of this study was to document the demographic characteristics and clinical aspects of ulcerative colitis (UC) and Crohn’s disease (CD) in Kerala, India. Methods A survey of IBD in Kerala was performed. All gastroenterologists in the region were invited. From May 2013 to October 2015, data were collected in a standardized pro-forma. Results Forty-seven doctors in 34 centers contributed data. A total of 2142 patients were analyzed. This is the largest state-wide survey of IBD in India. Ulcerative colitis was diagnosed in 1112 (38 new), Crohn’s disease in 980 (53 new), and 50 were unclassified (5 new). The district-wise distribution of IBD cases correlated with the District-wise Gross State Domestic Product ( r = 0.69, p < 0.01). Three percent was below the age of 18. Patients with UC had more diarrhea (73% vs. 51%), bleeding PR (79% vs. 34%), and intermittent flares (35% vs. 13%) (all p < 0.01). Patients with CD had more abdominal pain (62% vs. 46%), weight loss (53% vs. 40%), fever (28% vs. 18%), and history of antituberculosis treatment (21% vs. 5%) (all p < 0.01). Compared to adults, children (below 18 years) were more likely to have extensive UC (58% vs. 34%, p < 0.01) and unclassified IBD (15% vs. 2%, p < 0.01). Conclusion Inflammatory bowel disease is common in Kerala, India. The disease characteristics of patients with IBD are almost similar to those from other parts of the country. Both UC and CD were seen in equal proportion in Kerala.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0254-8860 0975-0711
DOI:	10.1007/s12664-017-0809-6