Search Results - "Jain, Sidharth"

GEMINI: a variational Bayesian approach to identify genetic interactions from combinatorial CRISPR screens by Zamanighomi, Mahdi, Jain, Sidharth S, Ito, Takahiro, Pal, Debjani, Daley, Timothy P, Sellers, William R

“…Systems for CRISPR-based combinatorial perturbation of two or more genes are emerging as powerful tools for uncovering genetic interactions. However,…”
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Deconvolution of immune cell composition and biological age of hepatocellular carcinoma using DNA methylation by Jain, Sidharth S., McNamara, Megan E., Varghese, Rency S., Ressom, Habtom W.

“…•DNA methylation allows for cell-type deconvolution and biological age estimation.•Cell-type deconvolution reveals NK cell deficiency in hepatocellular…”
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The Role of Aging and Senescence in Immune Checkpoint Inhibitor Response and Toxicity by Jain, Sidharth S, Burton Sojo, Giselle, Sun, Harry, Friedland, Benjamin N, McNamara, Megan E, Schmidt, Marcel O, Wellstein, Anton

“…Cellular senescence accumulates with age and has been shown to impact numerous physiological and pathological processes, including immune function. The role of…”
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A Review of Recent Research on Rare Earth Particulate Composite Materials and Structures with Their Applications by Srikant, Sharma, Vipin Kumar, Kumar, Vinod, Joshi, Ravinder Singh, Jain, Sidharth, Kumar, Pardeep

“…Rare earth particulates are known as the “seed of technology.” Due to this in the last few years, the research based on rare earth particulate composite…”
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Molecular basis for substrate recruitment to the PRMT5 methylosome by Mulvaney, Kathleen M., Blomquist, Christa, Acharya, Nischal, Li, Ruitong, Ranaghan, Matthew J., O’Keefe, Meghan, Rodriguez, Diego J., Young, Michael J., Kesar, Devishi, Pal, Debjani, Stokes, Matthew, Nelson, Alissa J., Jain, Sidharth S., Yang, Annan, Mullin-Bernstein, Zachary, Columbus, Josie, Bozal, Fazli K., Skepner, Adam, Raymond, Donald, LaRussa, Salvatore, McKinney, David C., Freyzon, Yelena, Baidi, Yossef, Porter, Dale, Aguirre, Andrew J., Ianari, Alessandra, McMillan, Brian, Sellers, William R.

“…PRMT5 is an essential arginine methyltransferase and a therapeutic target in MTAP-null cancers. PRMT5 uses adaptor proteins for substrate recruitment through a…”
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Circulating cell-free methylated DNA reveals tissue-specific, cellular damage from radiation treatment by McNamara, Megan E, Loyfer, Netanel, Kiliti, Amber J, Schmidt, Marcel O, Shabi-Porat, Sapir, Jain, Sidharth S, Martinez Roth, Sarah, McDeed Iv, A Patrick, Shahrour, Nesreen, Ballew, Elizabeth, Lin, Yun-Tien, Li, Heng-Hong, Deslattes Mays, Anne, Rudra, Sonali, Riegel, Anna T, Unger, Keith, Kaplan, Tommy, Wellstein, Anton

“…Radiation therapy is an effective cancer treatment although damages to healthy tissues are common. Here we analyzed cell-free, methylated DNA released from…”
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RNASeq profiling of COVID19‐infected patients identified an EIF2AK2 inhibitor as a potent SARS‐CoV‐2 antiviral by Jain, Sidharth, Rego, Samantha, Park, Steven, Liu, Yiran, Parn, Simone, Savsani, Kush, Perlin, David S., Dakshanamurthy, Sivanesan

“…At an individual gene-level analysis, multiple ribosomal proteins were significantly downregulated in each data set (Figure 1B). The combination treatment of…”
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Integrative Analysis of DNA Methylation and microRNA Expression Reveals Mechanisms of Racial Heterogeneity in Hepatocellular Carcinoma by Varghese, Rency S, Barefoot, Megan E, Jain, Sidharth, Chen, Yifan, Zhang, Yunxi, Alley, Amber, Kroemer, Alexander H, Tadesse, Mahlet G, Kumar, Deepak, Sherif, Zaki A, Ressom, Habtom W

“…Pathologic alterations in epigenetic regulation have long been considered a hallmark of many cancers, including hepatocellular carcinoma (HCC). In a healthy…”
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Low Dose Chronic Angiotensin II Induces Selective Senescence of Kidney Endothelial Cells by Khan, Irfan, Schmidt, Marcel O, Kallakury, Bhaskar, Jain, Sidharth, Mehdikhani, Shaunt, Levi, Moshe, Mendonca, Margarida, Welch, William, Riegel, Anna T, Wilcox, Christopher S, Wellstein, Anton

“…Angiotensin II can cause oxidative stress and increased blood pressure that result in long term cardiovascular pathologies. Here we evaluated the contribution…”
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Prosthetic Rehabilitation of Ocular Defect Using Digital Photography: A Case Report by Jain, Sidharth, Makkar, Sumit, Gupta, Sharad, Bhargava, Akshay

“…The fundamental objective in restoring a congenital as well as acquired defect of eye with an ocular prosthesis is to enable the patient to cope better with…”
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Immune characterization and profiles of SARS-CoV-2 infected patients reveals potential host therapeutic targets and SARS-CoV-2 oncogenesis mechanism by Policard, Martine, Jain, Sidharth, Rego, Samantha, Dakshanamurthy, Sivanesan

“…•We studied how coronavirus hijacks the host immune system to develop therapeutic strategies to combat current and future coronavirus outbreaks.•We…”
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Cell-type Deconvolution and Age Estimation Using DNA Methylation Reveals NK Cell Deficiency in the Hepatocellular Carcinoma Microenvironment by Jain, Sidharth S., Barefoot, Megan E., Varghese, Rency S., Ressom, Habtom W.

“…Hepatocellular carcinoma (HCC) has been an approved indication for the administration of immunotherapy since 2017, but biomarkers that predict therapeutic…”
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Vulval elephantiasis as a result of tubercular lymphadenitis: two case reports and a review of the literature by Chintamani, Singh, Jp, Tandon, Megha, Khandelwal, Rohan, Aeron, Tushar, Jain, Sidharth, Narayan, Nikhil, Bamal, Rahul, Kumar, Yashwant, Srinivas, S, Saxena, Sunita

“…Elephantiasis as a result of chronic lymphedema is characterized by gross enlargement of the arms, legs or genitalia, and occurs due to a variety of…”
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ODP526 Thyrotoxic Periodic Paralysis in Graves’ Disease: A rare presentation in an African American male by Ghoweba, Mohamed, Jain, Sidharth, Patel, Nisargi

“…Abstract INTRODUCTION: Thyrotoxic Periodic Paralysis is a rare but life-threatening manifestation of hyperthyroidism characterized by hypokalemia, acute…”
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Abstract B005: Investigating distinct methylation signatures characteristic of breast cancer subtypes in residual disease via cell free DNA methylation by Alley, Amber, McNamara, Megan, Jain, Sidharth, Wellstein, Anton

“…Abstract Breast cancer is the most common type of cancer in females and recurrence increases over time, unlike many other cancers. Treatment for recurrent…”
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TCF7L1 Modulates Colorectal Cancer Growth by Inhibiting Expression of the Tumor-Suppressor Gene EPHB3 by Murphy, Matthew, Chatterjee, Sujash S., Jain, Sidharth, Katari, Manpreet, DasGupta, Ramanuj

“…Dysregulation of the Wnt pathway leading to accumulation of β-catenin (CTNNB1) is a hallmark of colorectal cancer (CRC). Nuclear CTNNB1 acts as a…”
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Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers by Ito, Takahiro, Young, Michael J., Li, Ruitong, Jain, Sidharth, Wernitznig, Andreas, Krill-Burger, John M., Lemke, Christopher T., Monducci, Davide, Rodriguez, Diego J., Chang, Liang, Dutta, Sanjukta, Pal, Debjani, Paolella, Brenton R., Rothberg, Michael V., Root, David E., Johannessen, Cory M., Parida, Laxmi, Getz, Gad, Vazquez, Francisca, Doench, John G., Zamanighomi, Mahdi, Sellers, William R.

“…Although single-gene perturbation screens have revealed a number of new targets, vulnerabilities specific to frequently altered drivers have not been…”
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Abstract B063: DiMMER: A robust computational pipeline for differential methylation marker evaluation in R of cell-free DNA fragments by McDeed, Arthur P, Jain, Sidharth S, McNamara, Megan E, Alley, Amber, Wellstein, Anton, Ahn, Jaeil

“…Abstract Background: Decoding the origins of cell-free DNA (cfDNA) released from dying cells in a liquid biopsy sample offers the potential to provide insight…”
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Equity's stake in wind energy by Jain, Sidharth, Kapoor, Rahul

“…SINCE 2006-07, new wind markets have emerged in Eastern Europe due to high potential and favorable policies. These markets collectively represent significant…”
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End-to-end Triplet Loss based Emotion Embedding System for Speech Emotion Recognition by Kumar, Puneet, Jain, Sidharth, Raman, Balasubramanian, Roy, Partha Pratim, Iwamura, Masakazu

“…In this paper, an end-to-end neural embedding system based on triplet loss and residual learning has been proposed for speech emotion recognition. The proposed…”
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