Search Results - "Jain, Rakesh K"

Antiangiogenesis Strategies Revisited: From Starving Tumors to Alleviating Hypoxia by Jain, Rakesh K.

“…Ten antiangiogenic drugs targeting VEGF or its receptors are approved for cancer treatment. However, these agents, intended to block tumors’ blood supply, may…”
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Normalizing Tumor Microenvironment to Treat Cancer: Bench to Bedside to Biomarkers by JAIN, Rakesh K

“…For almost four decades, my work has focused on one challenge: improving the delivery and efficacy of anticancer therapeutics. Working on the hypothesis that…”
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Molecular mechanisms and clinical applications of angiogenesis by Carmeliet, Peter, Jain, Rakesh K.

“…Blood vessels deliver oxygen and nutrients to every part of the body, but also nourish diseases such as cancer. Over the past decade, our understanding of the…”
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Physical traits of cancer by Nia, Hadi T., Munn, Lance L., Jain, Rakesh K.

“…Physical traits of cancer The biological and physical properties of tumors contribute to their growth and to treatment outcome. Although intense research…”
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Combining two strategies to improve perfusion and drug delivery in solid tumors by Stylianopoulos, Triantafyllos, Jain, Rakesh K.

“…Blood perfusion in tumors can be significantly lower than that in the surrounding normal tissue owing to the leakiness and/or compression of tumor blood…”
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Normalizing Function of Tumor Vessels: Progress, Opportunities, and Challenges by Martin, John D, Seano, Giorgio, Jain, Rakesh K

“…Abnormal blood and lymphatic vessels create a hostile tumor microenvironment characterized by hypoxia, low pH, and elevated interstitial fluid pressure. These…”
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Enhancing cancer immunotherapy using antiangiogenics: opportunities and challenges by Fukumura, Dai, Kloepper, Jonas, Amoozgar, Zohreh, Duda, Dan G., Jain, Rakesh K.

“…The aberrant tumour vasculature and the associated angiogenic factors have been implicated in tumour immune evasion and progression. Herein, the authors…”
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Design considerations for nanotherapeutics in oncology by Stylianopoulos, Triantafyllos, PhD, Jain, Rakesh K., PhD

“…Abstract Nanotherapeutics have improved the quality of life of cancer patients, primarily by reducing the adverse effects of chemotherapeutic agents, but…”
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Vessel co-option in glioblastoma: emerging insights and opportunities by Seano, Giorgio, Jain, Rakesh K.

“…Vessel co-option is the movement of cancer cells towards and along the pre-existing vasculature and is an alternative to angiogenesis to gain access to…”
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Improving cancer immunotherapy using nanomedicines: progress, opportunities and challenges by Martin, John D., Cabral, Horacio, Stylianopoulos, Triantafyllos, Jain, Rakesh K.

“…Multiple nanotherapeutics have been approved for patients with cancer, but their effects on survival have been modest and, in some examples, less than those of…”
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The role of mechanical forces in tumor growth and therapy by Jain, Rakesh K, Martin, John D, Stylianopoulos, Triantafyllos

“…Tumors generate physical forces during growth and progression. These physical forces are able to compress blood and lymphatic vessels, reducing perfusion rates…”
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Delivery of molecular and cellular medicine to solid tumors by Jain, Rakesh K.

“…To reach cancer cells in a tumor, a blood-borne therapeutic molecule or cell must make its way into the blood vessels of the tumor and across the vessel wall…”
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Challenges and Key Considerations of the Enhanced Permeability and Retention Effect for Nanomedicine Drug Delivery in Oncology by PRABHAKAR, Uma, MAEDA, Hiroshi, JAIN, Rakesh K, SEVICK-MURACA, Eva M, ZAMBONI, William, FAROKHZAD, Omid C, BARRY, Simon T, GABIZON, Alberto, GRODZINSKI, Piotr, BLAKEY, David C

“…Enhanced permeability of the tumor vasculature allows macromolecules to enter the tumor interstitial space, whereas the suppressed lymphatic filtration allows…”
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Role of vascular normalization in benefit from metronomic chemotherapy by Mpekris, Fotios, Baish, James W., Stylianopoulos, Triantafyllos, Jain, Rakesh K.

“…Metronomic dosing of chemotherapy—defined as frequent administration at lower doses—has been shown to be more efficacious than maximum tolerated dose treatment…”
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Reengineering the Physical Microenvironment of Tumors to Improve Drug Delivery and Efficacy: From Mathematical Modeling to Bench to Bedside by Stylianopoulos, Triantafyllos, Munn, Lance L, Jain, Rakesh K

“…Physical forces have a crucial role in tumor progression and cancer treatment. The application of principles of engineering and physical sciences to oncology…”
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Normalization of Tumor Vasculature: An Emerging Concept in Antiangiogenic Therapy by Jain, Rakesh K

“…Solid tumors require blood vessels for growth, and many new cancer therapies are directed against the tumor vasculature. The widely held view is that these…”
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Vascular Normalization as an Emerging Strategy to Enhance Cancer Immunotherapy by YUHUI HUANG, GOEL, Shom, DUDA, Dan G, FUKUMURA, Dai, JAIN, Rakesh K

“…The recent approval of Provenge has brought new hope for anticancer vaccine therapies. However, the immunosuppressive tumor microenvironment seems to impair…”
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Combining microenvironment normalization strategies to improve cancer immunotherapy by Mpekris, Fotios, Voutouri, Chrysovalantis, Baish, James W., Duda, Dan G., Munn, Lance L., Stylianopoulos, Triantafyllos, Jain, Rakesh K.

“…Advances in immunotherapy have revolutionized the treatment of multiple cancers. Unfortunately, tumors usually have impaired blood perfusion, which limits the…”
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Understanding the tumor immune microenvironment (TIME) for effective therapy by Binnewies, Mikhail, Roberts, Edward W., Kersten, Kelly, Chan, Vincent, Fearon, Douglas F., Merad, Miriam, Coussens, Lisa M., Gabrilovich, Dmitry I., Ostrand-Rosenberg, Suzanne, Hedrick, Catherine C., Vonderheide, Robert H., Pittet, Mikael J., Jain, Rakesh K., Zou, Weiping, Howcroft, T. Kevin, Woodhouse, Elisa C., Weinberg, Robert A., Krummel, Matthew F.

“…The clinical successes in immunotherapy have been both astounding and at the same time unsatisfactory. Countless patients with varied tumor types have seen…”
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Tumor microenvironment abnormalities: Causes, consequences, and strategies to normalize by Fukumura, Dai, Jain, Rakesh K.

“…A solid tumor is an organ‐like entity comprised of neoplastic cells and non‐transformed host stromal cells embedded in an extracellular matrix. The expression…”
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