Search Results - "Jain, Parag N."

Integrated PERSEVERE and endothelial biomarker risk model predicts death and persistent MODS in pediatric septic shock: a secondary analysis of a prospective observational study by Atreya, Mihir R, Cvijanovich, Natalie Z, Fitzgerald, Julie C, Weiss, Scott L, Bigham, Michael T, Jain, Parag N, Schwarz, Adam J, Lutfi, Riad, Nowak, Jeffrey, Allen, Geoffrey L, Thomas, Neal J, Grunwell, Jocelyn R, Baines, Torrey, Quasney, Michael, Haileselassie, Bereketeab, Lindsell, Christopher J, Alder, Matthew N, Wong, Hector R

“…Abstract Background Multiple organ dysfunction syndrome (MODS) is a critical driver of sepsis morbidity and mortality in children. Early identification of…”
Get full text

Prognostic and predictive value of endothelial dysfunction biomarkers in sepsis-associated acute kidney injury: risk-stratified analysis from a prospective observational cohort of pediatric septic shock by Atreya, Mihir R, Cvijanovich, Natalie Z, Fitzgerald, Julie C, Weiss, Scott L, Bigham, Michael T, Jain, Parag N, Schwarz, Adam J, Lutfi, Riad, Nowak, Jeffrey, Allen, Geoffrey L, Thomas, Neal J, Grunwell, Jocelyn R, Baines, Torrey, Quasney, Michael, Haileselassie, Bereketeab, Alder, Matthew N, Goldstein, Stuart L, Stanski, Natalja L

“…Sepsis-associated acute kidney injury (SA-AKI) is associated with high morbidity, with no current therapies available beyond continuous renal replacement…”
Get full text

Altered metabolic and inflammatory transcriptomics after cardiac surgery in neonates with congenital heart disease by Jain, Parag N., Robertson, Matthew, Lasa, Javier J., Shekerdemian, Lara, Guffey, Danielle, Zhang, Yuhao, Lingappan, Krithika, Checchia, Paul, Coarfa, Cristian

“…The study examines the whole blood transcriptome profile before and after cardiopulmonary bypass (CPB) in neonates with hypoplastic left heart syndrome (HLHS),…”
Get full text

Detrimental effects of PCSK9 loss-of-function in the pediatric host response to sepsis are mediated through independent influence on Angiopoietin-1 by Atreya, Mihir R, Cvijanovich, Natalie Z, Fitzgerald, Julie C, Weiss, Scott L, Bigham, Michael T, Jain, Parag N, Schwarz, Adam J, Lutfi, Riad, Nowak, Jeffrey, Allen, Geoffrey L, Thomas, Neal J, Grunwell, Jocelyn R, Baines, Torrey, Quasney, Michael, Haileselassie, Bereketeab, Alder, Matthew N, Lahni, Patrick, Ripberger, Scarlett, Ekunwe, Adesuwa, Campbell, Kyle R, Walley, Keith R, Standage, Stephen W

“…Sepsis is associated with significant mortality. Yet, there are no efficacious therapies beyond antibiotics. PCSK9 loss-of-function (LOF) and inhibition,…”
Get full text

Revisiting Post-ICU Admission Fluid Balance Across Pediatric Sepsis Mortality Risk Strata: A Secondary Analysis of a Prospective Observational Cohort Study by Atreya, Mihir R, Cvijanovich, Natalie Z, Fitzgerald, Julie C, Weiss, Scott L, Bigham, Michael T, Jain, Parag N, Abulebda, Kamal, Lutfi, Riad, Nowak, Jeffrey, Thomas, Neal J, Baines, Torrey, Quasney, Michael, Haileselassie, Bereketeab, Sahay, Rashmi, Zhang, Bin, Alder, Matthew N, Stanski, Natalja L, Goldstein, Stuart L

“…Post-ICU admission cumulative positive fluid balance (PFB) is associated with increased mortality among critically ill patients. We sought to test whether this…”
Get full text

Using ChatGPT to Provide Patient-Specific Answers to Parental Questions in the PICU by Hunter, R Brandon, Thammasitboon, Satid, Rahman, Sreya S, Fainberg, Nina, Renuart, Andrew, Kumar, Shelley, Jain, Parag N, Rissmiller, Brian, Sur, Moushumi, Mehta, Sanjiv

“…To determine if ChatGPT can incorporate patient-specific information to provide high-quality answers to parental questions in the PICU. We hypothesized that…”
Get full text

PERSEVERE Biomarkers Predict Severe Acute Kidney Injury and Renal Recovery in Pediatric Septic Shock by Stanski, Natalja L, Stenson, Erin K, Cvijanovich, Natalie Z, Weiss, Scott L, Fitzgerald, Julie C, Bigham, Michael T, Jain, Parag N, Schwarz, Adam, Lutfi, Riad, Nowak, Jeffrey, Allen, Geoffrey L, Thomas, Neal J, Grunwell, Jocelyn R, Baines, Torrey, Quasney, Michael, Haileselassie, Bereketeab, Wong, Hector R

“…Acute kidney injury (AKI), a common complication of sepsis, is associated with substantial morbidity and mortality and lacks definitive disease-modifying…”
Get full text

Envisioning Distinctive Professional Identity for Critical Care Advanced Practice Providers: Fostering Integrative Transformation Beyond Orientation by Jain, Parag N., Jones, Melissa B., Thammasitboon, Satid

“…The roles played by nurse practitioners and physician assistants have expanded exponentially during the last decade. Although existing professional advancement…”
Get full text

Risk Factors for Perioperative Morbidity in Adults Undergoing Cardiac Surgery at Children’s Hospitals by Jain, Parag N., Salciccioli, Katherine B., Guffey, Danielle, Byun, Jinyoung, Cotts, Timothy B., Ermis, Peter, Gaies, Michael, Ghanayem, Nancy, Kim, Francis, Lasa, Javier J., Smith, Andrew, Fuller, Stephanie

“…Increasing numbers of adults with congenital heart disease (ACHD) undergo cardiac surgical procedures in children’s hospitals, yet surgical outcomes data are…”
Get full text

Serum renin and prorenin concentrations predict severe persistent acute kidney injury and mortality in pediatric septic shock by Stanski, Natalja L., Pode Shakked, Naomi, Zhang, Bin, Cvijanovich, Natalie Z., Fitzgerald, Julie C., Jain, Parag N., Schwarz, Adam J., Nowak, Jeffrey, Weiss, Scott L., Allen, Geoffrey L., Thomas, Neal J., Haileselassie, Bereketeab, Goldstein, Stuart L.

“…Background Studies in critically ill adults demonstrate associations between serum renin concentrations (a proposed surrogate for renin–angiotensin–aldosterone…”
Get full text

Serum Soluble Endoglin in Pediatric Septic Shock Associated Multiple Organ Dysfunction Syndrome by Atreya, Mihir R., Cvijanovich, Natalie Z., Fitzgerald, Julie C., Weiss, Scott L., Bigham, Michael T., Jain, Parag N., Schwarz, Adam J., Lutfi, Riad, Nowak, Jeffrey, Thomas, Neal J., Quasney, Michael, Haileselassie, Bereketeab, Baines, Torrey D., Zingarelli, Basilia

“…Background: Endothelial activation is a key driver of multiple organ dysfunction syndrome (MODS). Soluble endoglin (sENG) is expressed by mature and progenitor…”
Get full text

SERUM HUMANIN IN PEDIATRIC SEPTIC SHOCK-ASSOCIATED MULTIPLE-ORGAN DYSFUNCTION SYNDROME by Atreya, Mihir R, Piraino, Giovanna, Cvijanovich, Natalie Z, Fitzgerald, Julie C, Weiss, Scott L, Bigham, Michael T, Jain, Parag N, Schwarz, Adam J, Lutfi, Riad, Nowak, Jeffrey, Thomas, Neal J, Baines, Torrey, Haileselassie, Bereketeab, Zingarelli, Basilia

“…Background: Multiple-organ dysfunction syndrome disproportionately contributes to pediatric sepsis morbidity. Humanin (HN) is a small peptide encoded by…”
Get full text

Severe acute kidney injury is independently associated with mortality in children with septic shock by Stanski, Natalja L., Cvijanovich, Natalie Z., Fitzgerald, Julie C., Bigham, Michael T., Wong, Hector R.

Get full text

External validation of the modified sepsis renal angina index for prediction of severe acute kidney injury in children with septic shock by Stanski, Natalja L, Basu, Rajit K, Cvijanovich, Natalie Z, Fitzgerald, Julie C, Bigham, Michael T, Jain, Parag N, Schwarz, Adam J, Lutfi, Riad, Thomas, Neal J, Baines, Torrey, Haileselassie, Bereketeab, Weiss, Scott L, Atreya, Mihir R, Lautz, Andrew J, Zingarelli, Basilia, Standage, Stephen W, Kaplan, Jennifer, Chawla, Lakhmir S, Goldstein, Stuart L

“…Acute kidney injury (AKI) occurs commonly in pediatric septic shock and increases morbidity and mortality. Early identification of high-risk patients can…”
Get full text

Identification and transcriptomic assessment of latent profile pediatric septic shock phenotypes by Atreya, Mihir R, Huang, Min, Moore, Andrew R, Zheng, Hong, Hasin-Brumshtein, Yehudit, Fitzgerald, Julie C, Weiss, Scott L, Cvijanovich, Natalie Z, Bigham, Michael T, Jain, Parag N, Schwarz, Adam J, Lutfi, Riad, Nowak, Jeffrey, Thomas, Neal J, Quasney, Michael, Dahmer, Mary K, Baines, Torrey, Haileselassie, Bereketeab, Lautz, Andrew J, Stanski, Natalja L, Standage, Stephen W, Kaplan, Jennifer M, Zingarelli, Basilia, Sahay, Rashmi, Zhang, Bin, Sweeney, Timothy E, Khatri, Purvesh, Sanchez-Pinto, L Nelson, Kamaleswaran, Rishikesan

“…Sepsis poses a grave threat, especially among children, but treatments are limited owing to heterogeneity among patients. We sought to test the clinical and…”
Get full text

Postoperative physiological parameters associated with severe acute kidney injury after pediatric heart transplant by Alali, Alexander, Acosta, Sebastian, Ahmed, Mubbasheer, Spinner, Joseph, Akcan‐Arikan, Ayse, Morris, Shaine A., Jain, Parag N.

“…Background The primary objective was to evaluate associations between perioperative clinical variables and postoperative hemodynamic indices after HT with the…”
Get full text

Comparison of Laboratory and Hemodynamic Time Series Data Across Original, Alpha, and Delta Variants in Patients With Multisystem Inflammatory Syndrome in Children by Jain, Parag N., Acosta, Sebastian, Annapragada, Ananth, Checchia, Paul A., Moreira, Axel, Muscal, Eyal, Sartain, Sarah E., Tejtel, S. Kristen Sexson, Vogel, Tiphanie P., Shekerdemian, Lara, Rusin, Craig G.

“…To compare the clinical, laboratory, and hemodynamic parameters during hospitalization for patients with multisystem inflammatory syndrome in children (MIS-C),…”
Get full text

Diagnostic Validation of the Updated Pediatric Sepsis Biomarker Risk II for Acute Kidney Injury Prediction Model in Pediatric Septic Shock by Stanski, Natalja L, Zhang, Bin, Cvijanovich, Natalie Z, Fitzgerald, Julie C, Bigham, Michael T, Jain, Parag N, Schwarz, Adam J, Lutfi, Riad, Allen, Geoffrey L, Thomas, Neal J, Baines, Torrey, Haileselassie, Bereketeab, Weiss, Scott L, Atreya, Mihir R, Lautz, Andrew J, Zingarelli, Basilia, Standage, Stephen W, Kaplan, Jennifer, Goldstein, Stuart L

“…We previously derived the updated Pediatric Sepsis Biomarker Risk for Acute Kidney Injury (PERSEVERE-II AKI) prediction model, which had robust diagnostic test…”
Get full text

Implementation of an extracorporeal cardiopulmonary resuscitation simulation program reduces extracorporeal cardiopulmonary resuscitation times in real patients by Su, Lillian, Spaeder, Michael C, Jones, Melissa B, Sinha, Pranava, Nath, Dilip S, Jain, Parag N, Berger, John T, Williams, Lisa, Shankar, Venkat

“…To determine if development of an extracorporeal cardiopulmonary resuscitation simulation program reduced extracorporeal cardiopulmonary resuscitation times in…”
Get full text

Hyperchloremia is associated with acute kidney injury in pediatric patients with septic shock by Stenson, Erin K., Cvijanovich, Natalie Z., Allen, Geoffrey L., Thomas, Neal J., Bigham, Michael T., Weiss, Scott L., Fitzgerald, Julie C., Jain, Parag N., Meyer, Keith, Quasney, Michael, Hall, Mark, Gedeit, Rainer, Freishtat, Robert J., Nowak, Jeffrey, Lutfi, Riad, Gertz, Shira, Grunwell, Jocelyn R., Wong, Hector R., Anas, Nick

Get full text