Search Results - "Jain, Nina K."

Deep diversification of an AAV capsid protein by machine learning by Bryant, Drew H., Bashir, Ali, Sinai, Sam, Jain, Nina K., Ogden, Pierce J., Riley, Patrick F., Church, George M., Colwell, Lucy J., Kelsic, Eric D.

“…Modern experimental technologies can assay large numbers of biological sequences, but engineered protein libraries rarely exceed the sequence diversity of…”
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Comprehensive mutagenesis maps the effect of all single-codon mutations in the AAV2 rep gene on AAV production by Jain, Nina K, Ogden, Pierce J, Church, George M

“…Recombinant adeno-associated viruses (rAAVs) are the predominant gene therapy vector. Several rAAV vectored therapies have achieved regulatory approval, but…”
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Synthetic small intestinal scaffolds for improved studies of intestinal differentiation by Costello, Cait M., Hongpeng, Jia, Shaffiey, Shahab, Yu, Jiajie, Jain, Nina K., Hackam, David, March, John C.

“…ABSTRACT In vitro intestinal models can provide new insights into small intestinal function, including cellular growth and proliferation mechanisms, drug…”
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3‑D Intestinal Scaffolds for Evaluating the Therapeutic Potential of Probiotics by Costello, Cait M, Sorna, Rachel M, Goh, Yih-Lin, Cengic, Ivana, Jain, Nina K, March, John C

“…Biomimetic in vitro intestinal models are becoming useful tools for studying host–microbial interactions. In the past, these models have typically been limited…”
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A high density CHO-S transient transfection system: Comparison of ExpiCHO and Expi293 by Jain, Nina K., Barkowski-Clark, Susan, Altman, Richard, Johnson, Krista, Sun, Fang, Zmuda, Jonathan, Liu, Chao Yan, Kita, Adriana, Schulz, Ryan, Neill, Alyssa, Ballinger, Robert, Patel, Rekha, Liu, Jian, Mpanda, Alinafe, Huta, Brian, Chiou, Henry, Voegtli, Walter, Panavas, Tadas

“…Chinese Hamster Ovary (CHO) cells are the principal mammalian host used for stable cell line generation and biotherapeutic protein production. Until recently,…”
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Large‐scale functional LIPA variant characterization to improve birth prevalence estimates of lysosomal acid lipase deficiency by Angel, Guillermo, Hutchinson, Andrew T., Jain, Nina K., Forbes, Chris D., Reynders, John

“…Lysosomal acid lipase (LAL) deficiency is an autosomal recessive disorder caused by LIPA gene mutations that disrupt LAL activity. We performed in vitro…”
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Comprehensive mutagenesis maps the effect of all single-codon mutations in the AAV2 rep gene on AAV production by Jain, Nina K, Ogden, Pierce J, Church, George M

“…Recombinant adeno-associated viruses (rAAVs) are the predominant gene therapy vector. Several rAAV vectored therapies have achieved regulatory approval, but…”
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Factors Affecting AAV Production: Mutagenesis of AAV2 rep and AAV Transgenes by Jain, Nina K

“…Recombinant adeno-associated viruses (rAAVs) are the predominant gene therapy vector. Previous work in the AAV field focused on capsid engineering to enable…”
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