Search Results - "Jain, Jugnu"

The landscape of actionable genomic alterations in lung adenocarcinomas in India by Sharma, Rakesh, Kamireddy, Aruna Priya, Hussaini, Syed Meera, Chatterjee, Soma, Hasan, Qurratulain, Jain, Jugnu

“…Lung adenocarcinoma (LUAD), the most prevalent form of non-small cell lung cancer (NSCLC), remains a leading cause of cancer-related death globally, including…”
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Establishment and Characterization of Brain Cancer Primary Cell Cultures From Patients to Enable Phenotypic Screening for New Drugs by dePadua, Michelle, Kulothungan, Preethi, Lath, Rahul, Prasad, Ravikanti, Madamchetty, Kranthi, Atmakuri, Shravya, Ragamouni, Sravanthi, Gandhari, Mukesh, Khandrika, Lakshmipathi, Jain, Jugnu

“…Desmoplastic infantile ganglioglioma (DIG), is a rare tumor arising mainly during the first 2 years of life. Molecular characterization of these benign yet…”
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A Multi-centric retrospective study into the epidemiological distribution of breast cancer patients in India by Reddy, Vijay Anand, Sarin, Ramesh, Panda, Dipanjan, Hanitha, Rnm, Jain, Jugnu, Chatterjee, Soma, Annapurneswari, S, Saipillai, Mohamed Zehran, Gupta, Shaikat, Khan, Enamuddin, Bhattacharya, Jibak, Bhandari, Trilok Prasad Singh, Prasad, S V S S, Swain, Meenakshi

“…A multicentric private hospital-based retrospective study was conducted to understand the epidemiology of breast cancer in terms of demographics and clinical…”
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Determination of ROS1 positivity by immunohistochemistry in a multicentric cohort of 426 non-small-cell lung cancer cases in India by Jugnu Jain, Deepthi Chinta, Umeshnandan B Jayaraman, Neha Pathak, Manpreet Kaur, Soma Chatterjee, Meenakshi Swain, Vijay Anand Reddy

“…Introduction: ROS1 is a receptor tyrosine kinase of the insulin receptor family that acts as a driver oncogene in 1%–2% of non-small cell lung carcinoma…”
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A study on the impact of CYP2C19 genotype and platelet reactivity assay on patients undergoing PCI by Rath, P.C, Chidambaram, Sundar, Rath, Pallavi, Dikshit, Byomakesh, Naik, Sudhir, Sahoo, Prashant K, Das, Brajraj, Mahalingam, Mohanshankar, Khandrika, Lakshmipathi, Jain, Jugnu

“…Abstract Background A thorough understanding of the patient's genotype and their functional response to a medication is necessary for improving event free…”
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Novel inosine monophosphate dehydrogenase inhibitor VX-944 induces apoptosis in multiple myeloma cells primarily via caspase-independent AIF/Endo G pathway by Ishitsuka, Kenji, Hideshima, Teru, Hamasaki, Makoto, Raje, Noopur, Kumar, Shaji, Podar, Klaus, Le Gouill, Steven, Shiraishi, Norihiko, Yasui, Hiroshi, Roccaro, Aldo M, Tai, Yu-Zu, Chauhan, Dharminder, Fram, Robert, Tamura, Kazuo, Jain, Jugnu, Anderson, Kenneth C

“…Inosine monophosphate dehydrogenase (IMPDH) is a rate-limiting enzyme required for the de novo synthesis of guanine nucleotides from IMP. VX-944 (Vertex…”
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Regulation of inosine monophosphate dehydrogenase type I and type II isoforms in human lymphocytes by Jain, Jugnu, Almquist, Susan J., Ford, Pamella J., Shlyakhter, Dina, Wang, Yongping, Nimmesgern, Elmar, Germann, Ursula A.

“…The enzyme inosine monophosphate dehydrogenase (IMPDH) catalyzes the rate-limiting step in the de novo biosynthesis of guanine nucleotides. Inhibition of IMPDH…”
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Targeted Disruption of the Inosine 5′-Monophosphate Dehydrogenase Type I Gene in Mice by Gu, Jing Jin, Tolin, Amy K., Jain, Jugnu, Huang, Hai, Santiago, Lalaine, Mitchell, Beverly S.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Isolation of the Cyclosporin-Sensitive T Cell Transcription Factor NFATp by McCaffrey, Patricia G., Luo, Chun, Kerppola, Tom K., Jain, Jugnu, Badalian, Tina M., Ho, Andrew M., Burgeon, Emmanuel, Lane, William S., Lambert, John N., Curran, Tom, Verdine, Gregory L., Rao, Anjana, Hogan, Patrick G.

“…Nuclear factor of activated T cells (NFAT) is a transcription factor that regulates expression of the cytokine interleukin-2 (IL-2) in activated T cells. The…”
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Author Reply to Chadha KG, et al by Jain, Jugnu

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Author Reply to Chadha KG, et al by Jugnu Jain

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Analysis of the preexisting and nuclear forms of nuclear factor of activated T cells by Jain, J, Miner, Z, Rao, A

“…The nuclear factor of activated T cells (NF-AT)3 is an inducible DNA-binding protein that is essential for transcriptional induction of the IL-2 gene during T…”
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Characterization of pharmacological efficacy of VX-148, a new, potent immunosuppressive inosine 5'-monophosphate dehydrogenase inhibitor by Jain, Jugnu, Almquist, Susan J, Heiser, Angela D, Shlyakhter, Dina, Leon, Eduardo, Memmott, Christine, Moody, Cameron Stuver, Nimmesgern, Elmar, Decker, Caroline

“…Inosine 5'-monophosphate dehydrogenase (IMPDH) enzyme catalyzes the rate-limiting step in the de novo biosynthesis of guanine nucleotides. Proliferation of…”
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A Similar DNA-binding Motif in NFAT Family Proteins and the Rel Homology Region by Jain, J, Burgeon, E, Badalian, T M, Hogan, P G, Rao, A

“…The cyclosporin-sensitive factor NFATp cooperates with Fos and Jun family proteins to regulate transcription of the interleukin 2 gene in activated T cells. We…”
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Analysis of the AP-1 sites in the IL-2 promoter by Jain, J, Valge-Archer, VE, Rao, A

“…We have investigated the role of the two AP-1 sites, located at approximately -150 and -180 bp relative to the transcription start site, in induction of the…”
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Abstract 492: A Novel QUATRAMER sustained injectable suspension for the intracellular delivery of Salinomycin, a stem cell inhibitor (HSB-1216), for the treatment of triple negative breast cancer by Kharbanda, Surender M., Mohammad, Anees, Gupta, Bhawana, Appajosyula, Sireesh, Laumas, Sandeep, Jain, Jugnu, Kufe, Donald, Singh, Harpal

“…Abstract Triple-negative breast cancer (TNBC) accounts for approximately 15-20 % of all breast cancers, is an aggressive disease with a poor prognosis, and…”
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The IMPDH Inhibitor VX-944 Demonstrates In Vivo Efficacy in an Aggressive Leukemia Model by Jain, Jugnu, Ma, Jianguo, Furey, Brinley, Recher, Christian, Demur, Cecile, Poondru, Srinivasu, Zhang, Jianbo, Li, Shaolan, Firestone, Brant, Olson, Karen, Murphy, Maura, Taylor, Jennifer, Henkel, Greg, Ball, Edward, Yao, Yung-Mae, Almquist, Susan, Hoover, Russell

“…VX-944 is a small molecule, orally bioavailable, specific inhibitor of inosine monophosphate dehydrogenase (IMPDH), an essential rate-limiting enzyme in de…”
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Normal peripheral T-cell function in c-Fos-deficient mice by Jain, J, Nalefski, E A, McCaffrey, P G, Johnson, R S, Spiegelman, B M, Papaioannou, V, Rao, A

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Isolated polycystic disease of pancreas by Jain, Vishal Kumar, Jain, Jugnu, Singh, Rajesh, Gupta, Swati

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Transcriptional regulation of the IL-2 gene by Jain, J, Loh, C, Rao, A

“…The past two years have seen significant advances in our understanding of IL-2 gene transcription. Many of the relevant transcription factors have been…”
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