Search Results - "Jahr, H"

Additively manufactured biodegradable porous magnesium by Li, Y., Zhou, J., Pavanram, P., Leeflang, M.A., Fockaert, L.I., Pouran, B., Tümer, N., Schröder, K.-U., Mol, J.M.C., Weinans, H., Jahr, H., Zadpoor, A.A.

“…[Display omitted] An ideal bone substituting material should be bone-mimicking in terms of mechanical properties, present a precisely controlled and fully…”
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Additively manufactured biodegradable porous zinc by Li, Y., Pavanram, P., Zhou, J., Lietaert, K., Taheri, P., Li, W., San, H., Leeflang, M.A., Mol, J.M.C., Jahr, H., Zadpoor, A.A.

“…Additively manufacturing (AM) opens up the possibility for biodegradable metals to possess uniquely combined characteristics that are desired for bone…”
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Additively manufactured biodegradable porous iron by Li, Y., Jahr, H., Lietaert, K., Pavanram, P., Yilmaz, A., Fockaert, L.I., Leeflang, M.A., Pouran, B., Gonzalez-Garcia, Y., Weinans, H., Mol, J.M.C., Zhou, J., Zadpoor, A.A.

“…[Display omitted] Additively manufactured (AM) topologically ordered porous metallic biomaterials with the proper biodegradation profile offer a unique…”
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Additively manufactured functionally graded biodegradable porous iron by Li, Y., Jahr, H., Pavanram, P., Bobbert, F.S.L., Puggi, U., Zhang, X.-Y., Pouran, B., Leeflang, M.A., Weinans, H., Zhou, J., Zadpoor, A.A.

“…[Display omitted] Additively manufactured (AM) functionally graded porous metallic biomaterials offer unique opportunities to satisfy the contradictory design…”
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Physiomimetic biocompatibility evaluation of directly printed degradable porous iron implants using various cell types by Li, Y., Pavanram, P., Bühring, J., Rütten, S., Schröder, K-U., Zhou, J., Pufe, T., Wang, L-N., Zadpoor, A.A., Jahr, H.

“…Additively manufactured (AM) degradable porous metallic biomaterials offer unique opportunities for satisfying the design requirements of an ideal bone…”
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Additively manufactured functionally graded biodegradable porous zinc by Li, Y, Pavanram, P, Zhou, J, Lietaert, K, Bobbert, F S L, Kubo, Yusuke, Leeflang, M A, Jahr, H, Zadpoor, A A

“…Topological design provides additively manufactured (AM) biodegradable porous metallic biomaterials with a unique opportunity to adjust their biodegradation…”
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Identification of tissue-dependent proteins in knee OA synovial fluid by Timur, U.T., Jahr, H., Anderson, J., Green, D.C., Emans, P.J., Smagul, A., van Rhijn, L.W., Peffers, M.J., Welting, T.J.M.

“…For many proteins from osteoarthritic synovial fluid, their intra-articular tissue of origin remains unknown. In this study we performed comparative proteomics…”
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Full regeneration of segmental bone defects using porous titanium implants loaded with BMP-2 containing fibrin gels by van der Stok, J, Koolen, M K E, de Maat, M P M, Yavari, S Amin, Alblas, J, Patka, P, Verhaar, J A N, van Lieshout, E M M, Zadpoor, A A, Weinans, H, Jahr, H

“…Regeneration of load-bearing segmental bone defects is a major challenge in trauma and orthopaedic surgery. The ideal bone graft substitute is a biomaterial…”
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Chondrogenically differentiated mesenchymal stromal cell pellets stimulate endochondral bone regeneration in critical-sized bone defects by van der Stok, J, Koolen, M K E, Jahr, H, Kops, N, Waarsing, J H, Weinans, H, van der Jagt, O P

“…Grafting bone defects or atrophic non-unions with mesenchymal stromal cells (MSCs)-based grafts is not yet successful. MSC-based grafts typically use…”
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Non-invasive T1ρ mapping of the human cartilage response to loading and unloading by Nebelung, S., Sondern, B., Jahr, H., Tingart, M., Knobe, M., Thüring, J., Kuhl, C., Truhn, D.

“…To define the physiological response to sequential loading and unloading in histologically intact human articular cartilage using serial T1ρ mapping, as T1ρ is…”
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FK506 protects against articular cartilage collagenous extra-cellular matrix degradation by Siebelt, M, van der Windt, A.E, Groen, H.C, Sandker, M, Waarsing, J.H, Müller, C, de Jong, M, Jahr, H, Weinans, H

“…Summary Objective Osteoarthritis (OA) is a non-rheumatologic joint disease characterized by progressive degeneration of the cartilage extra-cellular matrix…”
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Corrigendum to “Additively manufactured functionally graded biodegradable porous iron” [Acta Biomaterialia 96 (2019) 646–661] by Li, Y., Jahr, H., Pavanram, P., Bobbert, F.S.L., Paggi, U., Zhang, X.-Y., Pouran, B., Leeflang, M.A., Weinans, H., Zhou, J., Zadpoor, A.A.

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In vitro expansion affects the response of chondrocytes to mechanical stimulation by Das, R.H.J., M.Sc, Jahr, H., Ph.D, Verhaar, J.A.N., M.D., Ph.D, van der Linden, J.C., Ph.D, van Osch, G.J.V.M., Ph.D, Weinans, H., Ph.D

“…Summary Objective Expansion of autologous chondrocytes is a common step in procedures for cartilage defect repair. Subsequent dedifferentiation can alter…”
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Ghrelin and unacylated ghrelin stimulate human osteoblast growth via mitogen-activated protein kinase (MAPK)/phosphoinositide 3-kinase (PI3K) pathways in the absence of GHS-R1a by Delhanty, P J D, van der Eerden, B C J, van der Velde, M, Gauna, C, Pols, H A P, Jahr, H, Chiba, H, van der Lely, A J, van Leeuwen, J P T M

“…Recent studies demonstrate widespread expression of ghrelin among tissues and have uncovered its pleiotropic nature. We have examined gene expression of…”
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Glucosamine decreases expression of anabolic and catabolic genes in human osteoarthritic cartilage explants by Uitterlinden, E.J., Jahr, H., Koevoet, J.L.M., Jenniskens, Y.M., Bierma-Zeinstra, S.M.A., DeGroot, J., Verhaar, J.A.N., Weinans, H., van Osch, G.J.V.M.

“…To investigate the effect of glucosamine (GlcN) in a human osteoarthritic explant model on expression of genes involved in anabolic and catabolic activities of…”
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TGF-β2 is involved in the preservation of the chondrocyte phenotype under hypoxic conditions by Das, R., Timur, U.T., Edip, S., Haak, E., Wruck, C., Weinans, H., Jahr, H.

“…Culturing chondrocytes under oxygen tension closely resembling their in vivo environment has been shown to have positive effects on matrix synthesis. In…”
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Effects of individual control of pH and hypoxia in chondrocyte culture by Das, R.H.J., van Osch, G.J.V.M., Kreukniet, M., Oostra, J., Weinans, H., Jahr, H.

“…Effects of oxygen tension (pO2) and pH on gene and protein expression and metabolic activity of human chondrocytes were independently assessed. Chondrocytes…”
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Fibroblast growth factor-2 in serum-free medium is a potent mitogen and reduces dedifferentiation of human ear chondrocytes in monolayer culture by Mandl, E.W., Jahr, H., Koevoet, J.L.M., van Leeuwen, J.P.T.M., Weinans, H., Verhaar, J.A.N., van Osch, G.J.V.M.

“…The loss of the differentiated phenotype (dedifferentiation) during the expansion culture of donor chondrocytes remains a large problem in cartilage tissue…”
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Biochemical and functional modulation of the cartilage collagen network by IGF1, TGFβ2 and FGF2 by Jenniskens, Y.M., Koevoet, W., de Bart, A.C.W., Weinans, H., Jahr, H., Verhaar, J.A.N., DeGroot, J., van Osch, G.J.V.M.

“…Examine effects of insulin-like growth factor 1 (IGF1), transforming growth factor β2 (TGFβ2) and fibroblast growth factor 2 (FGF2) on proteoglycan and…”
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Unfocused Extracorporeal Shock Waves Induce Anabolic Effects in Rat Bone by van der Jagt, O.P, Piscaer, T.M, Schaden, W, Li, J, Kops, N, Jahr, H, van der Linden, J.C, Waarsing, J.H, Verhaar, J.A.N, de Jong, M, Weinans, H

“…BACKGROUND:Extracorporeal shock waves are known to stimulate the differentiation of mesenchymal stem cells toward osteoprogenitors and induce the expression of…”
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