Search Results - "Jahangiri, Kathy G"

First-in-Class Pan Caspase Inhibitor Developed for the Treatment of Liver Disease by Linton, Steven D, Aja, Teresa, Armstrong, Robert A, Bai, Xu, Chen, Long-Shiuh, Chen, Ning, Ching, Brett, Contreras, Patricia, Diaz, Jose-Luis, Fisher, Craig D, Fritz, Lawrence C, Gladstone, Patricia, Groessl, Todd, Gu, Xin, Herrmann, Julia, Hirakawa, Brad P, Hoglen, Niel C, Jahangiri, Kathy G, Kalish, Vincent J, Karanewsky, Donald S, Kodandapani, Lalitha, Krebs, Joseph, McQuiston, Jeff, Meduna, Steven P, Nalley, Kip, Robinson, Edward D, Sayers, Robert O, Sebring, Kristen, Spada, Alfred P, Ternansky, Robert J, Tomaselli, Kevin J, Ullman, Brett R, Valentino, Karen L, Weeks, Suzanne, Winn, David, Wu, Joe C, Yeo, Pauline, Zhang, Cheng-zhi

“…A series of oxamyl dipeptides were optimized for pan caspase inhibition, anti-apoptotic cellular activity and in vivo efficacy. This structure−activity…”
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Oxamyl dipeptide caspase inhibitors developed for the treatment of stroke by Linton, Steven D., Aja, Teresa, Allegrini, Peter R., Deckwerth, Thomas L., Diaz, Jose-Luis, Hengerer, Bastian, Herrmann, Julia, Jahangiri, Kathy G., Kallen, Joerg, Karanewsky, Donald S., Meduna, Steven P., Nalley, Kip, Robinson, Edward D., Roggo, Silvio, Rovelli, Giorgio, Sauter, Andre, Sayers, Robert O., Schmitz, Albert, Smidt, Robert, Ternansky, Robert J., Tomaselli, Kevin J., Ullman, Brett R., Wiessner, Christoph, Wu, Joe C.

“…Structural modifications were made to a previously described acyl dipeptide caspase inhibitor, leading to the oxamyl dipeptide series. Subsequent SAR studies…”
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Acyl dipeptides as reversible caspase inhibitors. Part 2: Further optimization by LINTON, Steven D, KARANEWSKY, Donald S, WU, Joe C, PHAM, Brian, KODANDAPANI, Lalitha, SMIDT, Robert, DIAZ, Jose-Luis, FRITZ, Lawrence C, VON KROSIGK, U, ROGGO, Silvio, SCHMITZ, Albert, TOMASELLI, Kevin J, TERNANSKY, Robert J, NING CHEN, GUO, Xian, JAHANGIRI, Kathy G, KALISH, Vincent J, MEDUNA, Steven P, ROBINSON, Edward D, ULLMAN, Brett R

“…A new structural class of broad spectrum caspase inhibitors was optimized for its activity against caspases 1, 3, 6, 7, and 8. The most potent compound had low…”
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A novel mesoionic ring system: unusual cyclization of thio- and amino-acid derivatives of 6-azauracil by Lakner, Frederick J., Xia, Haiji, Pervin, Azra, Hammaker, Jeffrey R., Jahangiri, Kathy G., Dalton, Michael K., Khvat, Alexander, Kiselyov, Alexander, Ivachtchenko, Alexandre V.

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