Search Results - "Jagtap, Pravin Kumar Ankush"

Identification of phenothiazine derivatives as UHM-binding inhibitors of early spliceosome assembly by Jagtap, Pravin Kumar Ankush, Kubelka, Tomáš, Soni, Komal, Will, Cindy L., Garg, Divita, Sippel, Claudia, Kapp, Tobias G., Potukuchi, Harish Kumar, Schorpp, Kenji, Hadian, Kamyar, Kessler, Horst, Lührmann, Reinhard, Hausch, Felix, Bach, Thorsten, Sattler, Michael

“…Interactions between U2AF homology motifs (UHMs) and U2AF ligand motifs (ULMs) play a crucial role in early spliceosome assembly in eukaryotic gene regulation…”
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Structure, dynamics and roX2-lncRNA binding of tandem double-stranded RNA binding domains dsRBD1,2 of Drosophila helicase Maleless by Ankush Jagtap, Pravin Kumar, Müller, Marisa, Masiewicz, Pawel, von Bülow, Sören, Hollmann, Nele Merret, Chen, Po-Chia, Simon, Bernd, Thomae, Andreas W, Becker, Peter B, Hennig, Janosch

“…Abstract Maleless (MLE) is an evolutionary conserved member of the DExH family of helicases in Drosophila. Besides its function in RNA editing and presumably…”
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Regulation and mechanisms of action of RNA helicases by Lang, Nina, Jagtap, Pravin Kumar Ankush, Hennig, Janosch

“…RNA helicases are an evolutionary conserved class of nucleoside triphosphate dependent enzymes found in all kingdoms of life. Their cellular functions range…”
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Upstream of N-Ras C-terminal cold shock domains mediate poly(A) specificity in a novel RNA recognition mode and bind poly(A) binding protein by Hollmann, Nele Merret, Jagtap, Pravin Kumar Ankush, Linse, Johanna-Barbara, Ullmann, Philip, Payr, Marco, Murciano, Brice, Simon, Bernd, Hub, Jochen S, Hennig, Janosch

“…RNA binding proteins (RBPs) often engage multiple RNA binding domains (RBDs) to increase target specificity and affinity. However, the complexity of target…”
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Structural model of the dimeric Parkinson’s protein LRRK2 reveals a compact architecture involving distant interdomain contacts by Guaitoli, Giambattista, Raimondi, Francesco, Gilsbach, Bernd K., Gómez-Llorente, Yacob, Deyaert, Egon, Renzi, Fabiana, Li, Xianting, Schaffner, Adam, Jagtap, Pravin Kumar Ankush, Boldt, Karsten, von Zweydorf, Felix, Gotthardt, Katja, Lorimer, Donald D., Yue, Zhenyu, Burgin, Alex, Janjic, Nebojsa, Sattler, Michael, Versées, Wim, Ueffing, Marius, Ubarretxena-Belandia, Iban, Kortholt, Arjan, Gloeckner, Christian Johannes

“…Leucine-rich repeat kinase 2 (LRRK2) is a large, multidomain protein containing two catalytic domains: a Ras of complex proteins (Roc) G-domain and a kinase…”
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Structural basis for specific RNA recognition by the alternative splicing factor RBM5 by Soni, Komal, Jagtap, Pravin Kumar Ankush, Martínez-Lumbreras, Santiago, Bonnal, Sophie, Geerlof, Arie, Stehle, Ralf, Simon, Bernd, Valcárcel, Juan, Sattler, Michael

“…The RNA-binding motif protein RBM5 belongs to a family of multi-domain RNA binding proteins that regulate alternative splicing of genes important for apoptosis…”
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Molecular basis of mRNA transport by a kinesin-1-atypical tropomyosin complex by Dimitrova-Paternoga, Lyudmila, Jagtap, Pravin Kumar Ankush, Cyrklaff, Anna, Vaishali, Lapouge, Karine, Sehr, Peter, Perez, Kathryn, Heber, Simone, Löw, Christian, Hennig, Janosch, Ephrussi, Anne

“…Kinesin-1 carries cargos including proteins, RNAs, vesicles, and pathogens over long distances within cells. The mechanochemical cycle of kinesins is well…”
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Scalable synthesis and structural characterization of reversible KLK6 inhibitors by Baumann, Andreas, Isak, Daniel, Lohbeck, Jasmin, Jagtap, Pravin Kumar Ankush, Hennig, Janosch, Miller, Aubry K

“…Scalable asymmetric syntheses of two kallikrein-related protease 6 (KLK6) inhibitors are reported. The inhibitors are assembled by linking enantiomerically…”
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Transcriptional regulation of the Nε‐fructoselysine metabolism in Escherichia coli by global and substrate‐specific cues by Graf von Armansperg, Benedikt, Koller, Franziska, Gericke, Nicola, Hellwig, Michael, Jagtap, Pravin Kumar Ankush, Heermann, Ralf, Hennig, Janosch, Henle, Thomas, Lassak, Jürgen

“…Thermally processed food is an important part of the human diet. Heat‐treatment, however, promotes the formation of so‐called Amadori rearrangement products,…”
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Selective Inhibitors of FKBP51 Employ Conformational Selection of Dynamic Invisible States by Jagtap, Pravin Kumar Ankush, Asami, Sam, Sippel, Claudia, Kaila, Ville R. I., Hausch, Felix, Sattler, Michael

“…The recently discovered SAFit class of inhibitors against the Hsp90 co‐chaperone FKBP51 show greater than 10 000‐fold selectivity over its closely related…”
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Correction: Scalable synthesis and structural characterization of reversible KLK6 inhibitors by Baumann, Andreas, Isak, Daniel, Lohbeck, Jasmin, Jagtap, Pravin Kumar Ankush, Hennig, Janosch, Miller, Aubry K

“…Correction for 'Scalable synthesis and structural characterization of reversible KLK6 inhibitors' by Andreas Baumann et al. , RSC Adv. , 2022, 12 ,…”
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Structure, dynamics and RNA binding of the multi-domain splicing factor TIA-1 by Wang, Iren, Hennig, Janosch, Jagtap, Pravin Kumar Ankush, Sonntag, Miriam, Valcárcel, Juan, Sattler, Michael

“…Alternative pre-messenger ribonucleic acid (pre-mRNA) splicing is an essential process in eukaryotic gene regulation. The T-cell intracellular antigen-1…”
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Segmental, Domain‐Selective Perdeuteration and Small‐Angle Neutron Scattering for Structural Analysis of Multi‐Domain Proteins by Sonntag, Miriam, Jagtap, Pravin Kumar Ankush, Simon, Bernd, Appavou, Marie‐Sousai, Geerlof, Arie, Stehle, Ralf, Gabel, Frank, Hennig, Janosch, Sattler, Michael

“…Multi‐domain proteins play critical roles in fine‐tuning essential processes in cellular signaling and gene regulation. Typically, multiple globular domains…”
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Mechanism of Mg2+-Accompanied Product Release in Sugar Nucleotidyltransferases by Vithani, Neha, Ankush Jagtap, Pravin Kumar, Verma, Sunil Kumar, Tripathi, Ravi, Awasthi, Shalini, Nair, Nisanth N., Prakash, Balaji

“…The nucleotidyl transfer reaction, catalyzed by sugar nucleotidyltransferases (SNTs), is assisted by two active site Mg2+ ions. While studying this reaction…”
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Corrigendum: Selective Inhibitors of FKBP51 Employ Conformational Selection of Dynamic Invisible States by Jagtap, Pravin Kumar Ankush, Asami, Sam, Sippel, Claudia, Kaila, Ville R. I., Hausch, Felix, Sattler, Michael

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Structure and dynamics of the quaternary hunchback mRNA translation repression complex by Macošek, Jakub, Simon, Bernd, Linse, Johanna-Barbara, Jagtap, Pravin Kumar Ankush, Winter, Sophie L, Foot, Jaelle, Lapouge, Karine, Perez, Kathryn, Rettel, Mandy, Ivanović, Miloš T, Masiewicz, Pawel, Murciano, Brice, Savitski, Mikhail M, Loedige, Inga, Hub, Jochen S, Gabel, Frank, Hennig, Janosch

“…Abstract A key regulatory process during Drosophila development is the localized suppression of the hunchback mRNA translation at the posterior, which gives…”
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Switching the Post-translational Modification of Translation Elongation Factor EF-P by Volkwein, Wolfram, Krafczyk, Ralph, Jagtap, Pravin Kumar Ankush, Parr, Marina, Mankina, Elena, Macošek, Jakub, Guo, Zhenghuan, Fürst, Maximilian Josef Ludwig Johannes, Pfab, Miriam, Frishman, Dmitrij, Hennig, Janosch, Jung, Kirsten, Lassak, Jürgen

“…Tripeptides with two consecutive prolines are the shortest and most frequent sequences causing ribosome stalling. The bacterial translation elongation factor P…”
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Structural Basis for EarP-Mediated Arginine Glycosylation of Translation Elongation Factor EF-P by Krafczyk, Ralph, Macošek, Jakub, Jagtap, Pravin Kumar Ankush, Gast, Daniel, Wunder, Swetlana, Mitra, Prithiba, Jha, Amit Kumar, Rohr, Jürgen, Hoffmann-Röder, Anja, Jung, Kirsten, Hennig, Janosch, Lassak, Jürgen

“…Glycosylation is a universal strategy to posttranslationally modify proteins. The recently discovered arginine rhamnosylation activates the…”
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Substrate-bound Crystal Structures Reveal Features Unique to Mycobacterium tuberculosis N-Acetyl-glucosamine 1-Phosphate Uridyltransferase and a Catalytic Mechanism for Acetyl Transfer by Jagtap, Pravin Kumar Ankush, Soni, Vijay, Vithani, Neha, Jhingan, Gagan Deep, Bais, Vaibhav Singh, Nandicoori, Vinay Kumar, Prakash, Balaji

“…N-Acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), a bifunctional enzyme involved in bacterial cell wall synthesis is exclusive to prokaryotes. GlmU,…”
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Berichtigung: Selective Inhibitors of FKBP51 Employ Conformational Selection of Dynamic Invisible States by Jagtap, Pravin Kumar Ankush, Asami, Sam, Sippel, Claudia, Kaila, Ville R. I., Hausch, Felix, Sattler, Michael

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