Breast cancer biobank from a single institutional cohort in an urban setting in india: Tumor characteristics and survival outcomes

•Breast cancer biobank sourced from the practice of an oncoplastic surgeon.•Contains 434 IDC tissues with associated 3 year average followup.•Spearheading research on profiling of tumours and novel prognostic markers. A breast cancer biobank with retrospectively collected patient data and FFPE tissu...

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Published in:	Cancer treatment and research communications Vol. 28; p. 100409
Main Authors:	Busheri, Laleh, Dixit, Santosh, Nare, Smeeta, Alhat, Rashmi, Thomas, George, Jagtap, Mangal, Navgire, Ruth, Shinde, Priya, Banale, Rituja, Unde, Rohini, Reddy, Ruhi, Shaikh, Shahin, Konnur, Aishwarya, Namewar, Namrata, Bapat, Ashwini, Patil, Ankita, Johari, Rateeka, Kushwaha, Roli, Kumari, Wimpy, Varghese, Beenu, Deshpande, Pooja, Deshmukh, Chetan, Kelkar, Devaki A., Shashidhara, L S, Koppiker, Chaitanyanand B, Kulkarni, Madhura
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 2021 Elsevier
Subjects:	Breast Cancer Biobank Breast Neoplasms - mortality Cohort Studies Female Humans India Indian Cohort Middle Aged Single Surgeon – Cohort Survival Analysis Tissue Banks - standards India Single Surgeon – Cohort Breast Cancer Biobank Indian Cohort
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Summary:	•Breast cancer biobank sourced from the practice of an oncoplastic surgeon.•Contains 434 IDC tissues with associated 3 year average followup.•Spearheading research on profiling of tumours and novel prognostic markers. A breast cancer biobank with retrospectively collected patient data and FFPE tissue samples was established in 2018 at Prashanti Cancer Care Mission, Pune, India. It runs a cancer care clinic with support from a single surgeon's breast cancer practice. The clinical data and tissue sample collection is undertaken with appropriate patient consent following ethical approval and guidelines. The biobank holds clinical history, diagnostic reports, treatment and follow-up information along with FFPE tumor tissue specimens, adjacent normal and, in few cases, contralateral normal breast tissue. Detailed family history and germline mutational profiles of eligible and consenting patients and their relatives are also deposited in the biobank. Here, we report the first audit of the biobank. A total number of 994 patients with breast disease have deposited consented clinical records in the biobank. The majority of the records (80%, n = 799) are of patients with infiltrating ductal carcinoma (IDC). Of 799 IDC patients, 434 (55%) have deposited tumor tissue in the biobank with consent. In addition, germline mutation profiles of 84 patients and their family members are deposited. Follow-up information is available for 85% of the 434 IDC patients with an average follow-up of 3 years. The biobank has aided the initiation of translational research at our center in collaboration with eminent institutes like IISER Pune and SJRI Bangalore to evaluate profiles of breast cancer in an Indian cohort. The biobank will be a valuable resource to the breast cancer research community, especially to understand South Asian profiles of breast cancer.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2468-2942 2468-2942
DOI:	10.1016/j.ctarc.2021.100409