Search Results - "Jagdmann, Erik"

Small-Molecule Antagonists of the RIG‑I Innate Immune Receptor by Rawling, David C, Jagdmann, G. Erik, Potapova, Olga, Pyle, Anna Marie

“…The RIG-I receptor plays a key role in the vertebrate innate immune system, where it functions as a sensor for detecting infection by RNA viruses. Although…”
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Small molecules that target group II introns are potent antifungal agents by Fedorova, Olga, Jagdmann, G. Erik, Adams, Rebecca L., Yuan, Lin, Van Zandt, Michael C., Pyle, Anna Marie

“…Specific RNA structures control numerous metabolic processes that impact human health, and yet efforts to target RNA structures de novo have been limited. In…”
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Chemical Synthesis and Characterization of Epicatechin Glucuronides and Sulfates: Bioanalytical Standards for Epicatechin Metabolite Identification by Zhang, Mingbao, Jagdmann, G. Erik, Van Zandt, Michael, Sheeler, Ryan, Beckett, Paul, Schroeter, Hagen

“…The monoglucuronides and sulfates of epicatechin, 3′-O-methylepicatechin, and 4′-O-methylepicatechin, respectively, were synthesized as authentic bioanalytical…”
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Enantioselective synthesis of orthogonally protected (2R,3R)-(−)-epicatechin derivatives, key intermediates in the de novo chemical synthesis of (−)-epicatechin glucuronides and sulfates by Zhang, Mingbao, Erik Jagdmann, G., Van Zandt, Michael, Beckett, Paul, Schroeter, Hagen

“…Ten orthogonally protected (−)-epicatechin and 3′- or 4′-O-methyl-(−)-epicatechin derivatives were prepared in a regiospecific and enantioselective manner. For…”
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Discovery of (R)‑2-Amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic Acid and Congeners As Highly Potent Inhibitors of Human Arginases I and II for Treatment of Myocardial Reperfusion Injury by Van Zandt, Michael C, Whitehouse, Darren L, Golebiowski, Adam, Ji, Min Koo, Zhang, Mingbao, Beckett, R. Paul, Jagdmann, G. Erik, Ryder, Todd R, Sheeler, Ryan, Andreoli, Monica, Conway, Bruce, Mahboubi, Keyvan, D’Angelo, Gerard, Mitschler, Andre, Cousido-Siah, Alexandra, Ruiz, Francesc X, Howard, Eduardo I, Podjarny, Alberto D, Schroeter, Hagen

“…Recent efforts to identify treatments for myocardial ischemia reperfusion injury have resulted in the discovery of a novel series of highly potent…”
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Discovery of Allosteric Potentiators for the Metabotropic Glutamate 2 Receptor:  Synthesis and Subtype Selectivity of N-(4-(2-Methoxyphenoxy)phenyl)-N-(2,2,2− trifluoroethylsulfonyl)pyrid-3-ylmethylamine by Johnson, Michael P, Baez, Melvyn, Jagdmann, G. Erik, Britton, Thomas C, Large, Thomas H, Callagaro, David O, Tizzano, Joseph P, Monn, James A, Schoepp, Darryle D

“…This report describes recently discovered novel allosteric modulators of metabotropic glutamate2 (mGlu2) receptors. These pyridylmethylsulfonamides (e.g., 3)…”
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Metabotropic glutamate 2 receptor potentiators: receptor modulation, frequency-dependent synaptic activity, and efficacy in preclinical anxiety and psychosis model(s) by Johnson, Michael P, Barda, David, Britton, Thomas C, Emkey, Renee, Hornback, William J, Jagdmann, G Erik, McKinzie, David L, Nisenbaum, Eric S, Tizzano, Joseph P, Schoepp, Darryle D

“…To increase subtype selectivity and provide a novel means to alter receptor function, we discovered and characterization potentiators for the metabotropic…”
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Discovery of N‑Substituted 3‑Amino-4-(3-boronopropyl)pyrrolidine-3-carboxylic Acids as Highly Potent Third-Generation Inhibitors of Human Arginase I and II by Van Zandt, Michael C, Jagdmann, G. Erik, Whitehouse, Darren L, Ji, Minkoo, Savoy, Jennifer, Potapova, Olga, Cousido-Siah, Alexandra, Mitschler, Andre, Howard, Eduardo I, Pyle, Anna Marie, Podjarny, Alberto D

“…Recent efforts to identify new highly potent arginase inhibitors have resulted in the discovery of a novel family of…”
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Synthesis and Protein Kinase Inhibitory Activity of Balanol Analogues with Modified Benzophenone Subunits by Lampe, John W, Biggers, Christopher K, Defauw, Jean M, Foglesong, Robert J, Hall, Steven E, Heerding, Julia M, Hollinshead, Sean P, Hu, Hong, Hughes, Philip F, Jagdmann, G. Erik, Johnson, Mary George, Lai, Yen-Shi, Lowden, Christopher T, Lynch, Michael P, Mendoza, José S, Murphy, Marcia M, Wilson, Joseph W, Ballas, Lawrence M, Carter, Kiyomi, Darges, James W, Davis, Jefferson E, Hubbard, Frederick R, Stamper, Mark L

“…A series of analogues of the protein kinase C (PKC) inhibitory natural product balanol which bear modified benzophenone subunits are described. The analogues…”
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Synthesis of quaternary α-amino acid-based arginase inhibitors via the Ugi reaction by Golebiowski, Adam, Whitehouse, Darren, Beckett, R. Paul, Van Zandt, Michael, Ji, Min Koo, Ryder, Todd R., Jagdmann, Erik, Andreoli, Monica, Lee, Yung, Sheeler, Ryan, Conway, Bruce, Olczak, Jacek, Mazur, Marzena, Czestkowski, Wojciech, Piotrowska, Wieslawa, Cousido-Siah, Alexandra, Ruiz, Francesc X., Mitschler, Andre, Podjarny, Alberto, Schroeter, Hagen

“…The Ugi reaction has been successfully applied to the synthesis of novel arginase inhibitors. In an effort to decrease conformational flexibility of the…”
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SAR study of a subtype selective allosteric potentiator of metabotropic glutamate 2 receptor, N-(4-phenoxyphenyl)- N-(3-pyridinylmethyl)ethanesulfonamide by Barda, David A., Wang, Zhao-Qing, Britton, Thomas C., Henry, Steven S., Jagdmann, G.Erik, Coleman, Darrell S., Johnson, Michael P., Andis, Sherri L., Schoepp, Darryle D.

“…The structure–activity relationship of a subtype selective mGlu2 potentiator, LY181837 is explored. The major excitatory neurotransmitter in the Central…”
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2-Substituted-2-amino-6-boronohexanoic acids as arginase inhibitors by Golebiowski, Adam, Paul Beckett, R., Van Zandt, Michael, Ji, Min Koo, Whitehouse, Darren, Ryder, Todd R., Jagdmann, Erik, Andreoli, Monica, Mazur, Adam, Padmanilayam, Manyian, Cousido-Siah, Alexandra, Mitschler, Andre, Ruiz, Francesc X., Podjarny, Alberto, Schroeter, Hagen

“…Substitution at the alpha center of the known human arginase inhibitor 2-amino-6-boronohexanoic acid (ABH) is acceptable in the active site pockets of both…”
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Synthesis of quaternary I--amino acid-based arginase inhibitors via the Ugi reaction by Golebiowski, Adam, Whitehouse, Darren, Beckett, R, Zandt, Michael, Ji, Min, Ryder, Todd, Jagdmann, Erik, Andreoli, Monica, Lee, Yung, Sheeler, Ryan, Conway, Bruce, Olczak, Jacek, Mazur, Marzena, Czestkowski, Wojciech, Piotrowska, Wieslawa, Cousido-Siah, Alexandra, Ruiz, Francesc, Mitschler, Andre, Podjarny, Alberto, Schroeter, Hagen

“…The Ugi reaction has been successfully applied to the synthesis of novel arginase inhibitors. In an effort to decrease conformational flexibility of the…”
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alpha.-Amino carbanions. Preparation, metalation, and alkylation of enamidines. Synthesis of piperidine and pyrrolidine natural products and homologation of carbonyl compounds by Meyers, A. L, Edwards, Philip D, Bailey, Thomas R, Jagdmann, G. Erik

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Discovery of allosteric potentiators for the metabotropic glutamate 2 receptor : Synthesis and subtype selectivity of N-(4-(2-methoxyphenoxy)phenyl)-N-(2,2,2-trifluoroethylsulfonyl)pyrid-3-ylmethyl- amine by JOHNSON, Michael P, BAEZ, Melvyn, JAGDMANN, G. Erik, BRITTON, Thomas C, LARGE, Thomas H, CALLAGARO, David O, TIZZANO, Joseph P, MONN, James A, SCHOEPP, Darryle D

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Two efficient syntheses of (±)- anti-N-benzyl-3-amino-4-hydroxyhexahydroazepine by Hu, Hong, Erik Jagdmann, G., Hughes, Philip F., Nichols, Jeffrey B.

“…Functionalization of ε-caprolactam ( 3) or Beckmann rearrangement of the syn-oxime derivative of 3-ethoxy-2-cyclohexen-1-one ( 12) provided efficient and…”
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Thallium in organic synthesis. 60. 2,6-Diaryl-3,7-dioxabicyclo[3.3.0]octane-4,8-dione lignans by oxidative dimerization of 4-alkoxycinnamic acids with thallium(III) trifluoroacetate or cobalt(III) trifluoride by Taylor, Edward C, Andrade, Juan G, Rall, Gerhardus J. H, Steliou, Kosta, Jagdmann, G Erik, McKillop, Alexander

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Thallium in organic synthesis. 61. Intramolecular capture of radical cations from thallium(III) trifluoroacetate oxidation of arylalkanoic acids and arylalkanols. New routes to oxygen heterocycles by Taylor, Edward C, Andrade, Juan G, Rall, Gerhardus J. H, Turchi, Ignatius J, Steliou, Kosta, Jagdmann, G. Erik, McKillop, Alexander

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Synthesis and biological evaluation of conformationally constrained bicyclic and tricyclic balanol analogues as inhibitors of protein kinase C by Mendoza, JoséS., Erik Jagdmann, G., Gosnell, Paul A.

“…A series of conformationally constrained bicyclic ( 20–25 and 28) and tricyclic ( 26 and 27) balanol analogues was prepared and evaluated as inhibitors of…”
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Increasing the cellular PKC inhibitory activity of balanol: A study of ester analogs by Crane, Heidi M., Menaldino, David S., Erik Jagdmann, G., Darges, James W., Buben, John A.

“…As part of an effort to enhance the cellular activity of balanol analogs 2 and 3, we prepared a series of benzophenone ester analogs of varying steric size and…”
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