Search Results - "Jagadish, Swamy"

Phytochemicals as Invaluable Sources of Potent Antimicrobial Agents to Combat Antibiotic Resistance by Jadimurthy, Ragi, Jagadish, Swamy, Nayak, Siddaiah Chandra, Kumar, Sumana, Mohan, Chakrabhavi Dhananjaya, Rangappa, Kanchugarakoppal S

“…Plants have been used for therapeutic purposes against various human ailments for several centuries. Plant-derived natural compounds have been implemented in…”
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DNase 1 Protects From Increased Thrombin Generation and Venous Thrombosis During Aging: Cross-Sectional Study in Mice and Humans by Kumar, Rahul, Sonkar, Vijay K, Swamy, Jagadish, Ahmed, Azaj, Sharathkumar, Anjali A, Pierce, Gary L, Dayal, Sanjana

“…Background Human aging is associated with increased risk of thrombosis, but the mechanisms are poorly defined. We hypothesized that aging induces…”
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A new ibuprofen derivative inhibits platelet aggregation and ROS mediated platelet apoptosis by Rakesh, Kodagahalli S, Jagadish, Swamy, Vinayaka, Ajjampura C, Hemshekhar, Mahadevappa, Paul, Manoj, Thushara, Ram M, Sundaram, Mahalingam S, Swaroop, Toreshettahally R, Mohan, Chakrabhavi D, Basappa, Sadashiva, Marilinganadoddi P, Kemparaju, Kempaiah, Girish, Kesturu S, Rangappa, Kanchugarakoppal S

“…Thrombocytopenia is a serious issue connected with the pathogenesis of several human diseases including chronic inflammation, arthritis, Alzheimer's disease,…”
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Novel benzoxazine-based aglycones block glucose uptake in vivo by inhibiting glycosidases by Bharathkumar, Hanumantharayappa, Sundaram, Mahalingam S, Jagadish, Swamy, Paricharak, Shardul, Hemshekhar, Mahadevappa, Mason, Daniel, Kemparaju, Kempaiah, Girish, Kesturu S, Basappa, Bender, Andreas, Rangappa, Kanchugarakoppal S

“…Glycoside hydrolases catalyze the selective hydrolysis of glycosidic bonds in oligosaccharides, polysaccharides, and their conjugates. β-glucosidases occur in…”
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Anti-Cancer Activity of 2,4-Disubstituted Thiophene Derivatives: Dual Inhibitors of Lipoxygenase and Cyclooxygenase by Rakesh, Kodagahalli S, Jagadish, Swamy, Swaroop, Toreshettahally R, Mohan, Chakrabhavi D, Ashwini, Nanjundaswamy, Harsha, Kachigere B, Zameer, Farhan, Girish, Kesturu S, Rangappa, Kanchugarakoppal S

“…2,4-Disubstituted thiophene derivatives were synthesized and assessed for antiinflammatory and anti-cancer activities by targeting two important enzymes of the…”
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Melatonin restores neutrophil functions and prevents apoptosis amid dysfunctional glutathione redox system by NaveenKumar, Somanathapura K., Hemshekhar, Mahadevappa, Jagadish, Swamy, Manikanta, Kurnegala, Vishalakshi, Gopalapura J., Kemparaju, Kempaiah, Girish, Kesturu S.

“…Melatonin is a chronobiotic hormone, which can regulate human diseases like cancer, atherosclerosis, respiratory disorders, and microbial infections by…”
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Abstract 4136786: Prediabetes increases platelet activation and thrombotic susceptibility via mitochondrial oxidants by Ahmed, Azaj, jensen, melissa, Geasland, Katharine, Swamy, Jagadish, Spitz, Douglas, Abel, E. Dale, Jalal, Diana, Dayal, Sanjana

“…Abstract only Recent studies suggest that prediabetes is not only a prelude to diabetes, but also is an independent risk factor for cardiovascular thrombotic…”
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Abstract 238: Prediabetes Increases Platelet Activation Via Sod2 In Young And Middle-aged Veterans by Ahmed, Azaj, Eustes, Alicia, Geasland, Katharine, Swamy, Jagadish, Spitz, Douglas, Jalal, Diana, Dayal, Sanjana

“…Abstract only Aging is a risk factor for thrombotic cardiovascular diseases and presence of a risk factor may aggravate the outcome. Due to the increase in…”
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Endogenous SOD2 (Superoxide Dismutase) Regulates Platelet-Dependent Thrombin Generation and Thrombosis During Aging by Sonkar, Vijay K., Eustes, Alicia S., Ahmed, Azaj, Jensen, Melissa, Solanki, Mitali V., Swamy, Jagadish, Kumar, Rahul, Fidler, Trevor P., Houtman, Jon C.D., Allen, Bryan G., Spitz, Douglas R., Abel, E. Dale, Dayal, Sanjana

“…Reactive oxygen species (ROS) contribute to platelet hyperactivation during aging. Several oxidative pathways and antioxidant enzymes have been implicated;…”
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Abstract MP03: Histone-mediated Platelet Activation And Microvesicle-induced Thrombin Generation In COVID-19 by Eustes, Alicia S, Swamy, Jagadish, jensen, melissa, Wilson, Katina M, Kudchadkar, Shibani M, Perepu, Usha, Miller, Francis J, Lentz, Steven R, Dayal, Sanjana

“…Abstract only Background: Severe COVID-19 leads to inflammation and coagulopathy with progression to multiple organ failure. Several prothrombotic mechanisms…”
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Endogenous SOD2 (Superoxide Dismutase) Regulates Platelet-Dependent Thrombin Generation and Thrombosis During Aging by Sonkar, Vijay K., Eustes, Alicia S., Ahmed, Azaj, Jensen, Melissa, Solanki, Mitali V., Swamy, Jagadish, Kumar, Rahul, Fidler, Trevor P., Houtman, Jon C.D., Allen, Bryan G., Spitz, Douglas R., Abel, E. Dale, Dayal, Sanjana

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Extracellular histones: a unifying mechanism driving platelet-dependent extracellular vesicle release and thrombus formation in COVID-19 by Eustes, Alicia S., Ahmed, Azaj, Swamy, Jagadish, Patil, Gokul, Jensen, Melissa, Wilson, Katina M., Kudchadkar, Shibani, Wahab, Abdul, Perepu, Usha, Miller, Francis J., Lentz, Steven R., Dayal, Sanjana

“…COVID-19 can cause profound inflammation and coagulopathy, and while many mechanisms have been proposed, there is no known common pathway leading to a…”
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Novel oxolane derivative DMTD mitigates high glucose-induced erythrocyte apoptosis by regulating oxidative stress by Jagadish, Swamy, Hemshekhar, Mahadevappa, NaveenKumar, Somanathapura K., Sharath Kumar, Kothanahally S., Sundaram, Mahalingam S., Basappa, Girish, Kesturu S., Rangappa, Kanchugarakoppal S.

“…Chronic hyperglycemia is one of the characteristic conditions associated with Diabetes Mellitus (DM), which often exerts deleterious effects on erythrocyte…”
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Novel synthetic bisbenzimidazole that targets angiogenesis in Ehrlich ascites carcinoma bearing mice by Roopashree, Rangaswamy, Mohan, Chakrabhavi Dhananjaya, Swaroop, Toreshettahally Ramesh, Jagadish, Swamy, Raghava, Byregowda, Balaji, Kyathegowdanadoddi Srinivas, Jayarama, Shankar, Basappa, Rangappa, Kanchugarakoppal Subbegowda

“…[Display omitted] Cancer is a leading cause of death in developed countries and second cause in developing countries. Herein we are reporting the synthesis of…”
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Bisphenol AF elevates procoagulant platelets by inducing necroptosis via RIPK1-inflammasome axis by Vishalakshi, Gopalapura J., Hemshekhar, Mahadevappa, Sandesha, Vaddaragudisalu D., Prashanth, Kunthurumole S., Jagadish, Swamy, Paul, Manoj, Kemparaju, Kempaiah, Girish, Kesturu S.

“…Bisphenol AF, an analogue of Bisphenol A, is an important raw material used in the production of plastic and rubber substances like plastic bottles and…”
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3,5-Disubstituted Isoxazole Derivatives: Potential Inhibitors of Inflammation and Cancer by Rakesh, Kodagahalli Sathya, Jagadish, Swamy, Balaji, Kyathegowdanadoddi Srinivas, Zameer, Farhan, Swaroop, Toreshettahally Ramesh, Mohan, Chakrabhavi Dhanajaya, Jayarama, Shankar, Rangappa, Kanchugarakoppal Subbegowda

“…The products of arachidonic acid metabolism by lipoxygenase (LOX) and cyclooxygenase (COX) significantly contribute to inflammation and carcinogenesis…”
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Synthesis and characterization of novel oxazines and demonstration that they specifically target cyclooxygenase 2 by Srinivas, V., Mohan, Chakrabhavi Dhananjaya, Baburajeev, C.P., Rangappa, Shobith, Jagadish, Swamy, Fuchs, Julian E., Sukhorukov, Alexey Yu, Chandra, Mason, Daniel J., Sharath Kumar, Kothanahally Shivaramu, Madegowda, Mahendra, Bender, Andreas, Basappa, Rangappa, Kanchugarakoppal Subbegowda

“…[Display omitted] In the present study, we used solution combustion synthesis-bismuth oxide (Bi2O3) as catalyst for the simple and efficient synthesis of…”
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Development of Novel Triazolo-Thiadiazoles from Heterogeneous “Green” Catalysis as Protein Tyrosine Phosphatase 1B Inhibitors by Baburajeev, C. P., Dhananjaya Mohan, Chakrabhavi, Ananda, Hanumappa, Rangappa, Shobith, Fuchs, Julian E., Jagadish, Swamy, Sivaraman Siveen, Kodappully, Chinnathambi, Arunachalam, Ali Alharbi, Sulaiman, Zayed, M. E., Zhang, Jingwen, Li, Feng, Sethi, Gautam, Girish, Kesturu S., Bender, Andreas, Basappa, Rangappa, Kanchugarakoppal S.

“…Condensed-bicyclic triazolo-thiadiazoles were synthesized via an efficient “green” catalyst strategy and identified as effective inhibitors of PTP1B in vitro …”
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Platelet protective efficacy of 3,4,5 trisubstituted isoxazole analogue by inhibiting ROS-mediated apoptosis and platelet aggregation by Jagadish, Swamy, Rajeev, Narasimhamurthy, NaveenKumar, Somanathapura K., Sharath Kumar, Kothanahally S., Paul, Manoj, Hegde, Mahesh, Basappa, Sadashiva, Marilinganadoddi P., Girish, Kesturu S., Rangappa, Kanchugarakoppal S.

“…Thrombocytopenia is a major hematological concern in oxidative stress-associated pathologies and chronic clinical disorders, where premature platelet…”
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Synthesis and characterization of novel 1,2-oxazine-based small molecules that targets acetylcholinesterase by Sukhorukov, Alexey Yu, Nirvanappa, Anilkumar C, Swamy, Jagadish, Ioffe, Sema L, Nanjunda Swamy, Shivananju, Basappa, Rangappa, Kanchugarakoppal S

“…Thirteen 2-oxazine-based small molecules were synthesized targeting 5-lipoxygenase (LOX), and acetylcholinesterase (AChE). The test revealed that the newly…”
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