Search Results - "Jaffrezou, Jean Pierre"

Rituximab antiproliferative effect in B-lymphoma cells is associated with acid-sphingomyelinase activation in raft microdomains by Bezombes, Christine, Grazide, Solène, Garret, Céline, Fabre, Claire, Quillet-Mary, Anne, Müller, Sabina, Jaffrézou, Jean-Pierre, Laurent, Guy

“…Rituximab is a chimeric human immunoglobulin G1 (IgG1) anti-CD20 monoclonal antibody with significant activity against CD20+ malignant B cells. Rituximab is…”
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PKCζ protects against UV-C-induced apoptosis by inhibiting acid sphingomyelinase-dependent ceramide production by Charruyer, Alexandra, Jean, Christine, Colomba, Audrey, Jaffrézou, Jean-Pierre, Quillet-Mary, Anne, Laurent, Guy, Bezombes, Christine

“…In a recent study, we described that UV-C irradiation resulted in redox-dependent activation and relocalization of A-SMase (acid sphingomyelinase) to the…”
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Sphingolipids as modulators of cancer cell death: Potential therapeutic targets by Ségui, Bruno, Andrieu-Abadie, Nathalie, Jaffrézou, Jean-Pierre, Benoist, Hervé, Levade, Thierry

“…Through modifications in the fine membrane structure, cell–cell or cell–matrix interactions, and/or modulation of intracellular signaling pathways,…”
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Signaling pathways activated by daunorubicin by Laurent, Guy, Jaffrézou, Jean-Pierre

“…The anthracycline daunorubicin is widely used in the treatment of acute nonlymphocytic leukemia. The drug has, of course, been the object of intense basic…”
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Positive feedback control of neutral sphingomyelinase activity by ceramide by Jaffrezou, Jean‐Pierre, Maestre, Nicolas, Mas‐Mansat, Veronique, Bezombes, Christine, Levade, Thierry, Laurent, Guy

“…ABSTRACT While ceramide has emerged as a potent signal transducer, inconsistencies in the kinetics of ceramide generation, or its absence, in response to…”
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UV-C Light Induces Raft-associated Acid Sphingomyelinase and JNK Activation and Translocation Independently on a Nuclear Signal by Charruyer, Alexandra, Grazide, Solène, Bezombes, Christine, Müller, Sabina, Laurent, Guy, Jaffrézou, Jean-Pierre

“…The initiation of UV light-induced signaling in mammalian cells is largely considered to be subsequent to DNA damage. Several studies have also described…”
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Implication of Mitochondrial Hydrogen Peroxide Generation in Ceramide-induced Apoptosis by Quillet-Mary, Anne, Jaffrézou, Jean-Pierre, Mansat, Véronique, Bordier, Christine, Naval, Javier, Laurent, Guy

“…The key events implicated in ceramide-triggered apoptosis remain unknown. In this study we show that 25 μm C6-ceramide induced significant H2O2 production…”
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Genomic stability at the coding regions of the multidrug transporter gene ABCB1 : insights into the development of alternative drug resistance mechanisms in human leukemia cells by Chen, Kevin G, Duran, George E, Mogul, Mark J, Wang, Yan C, Ross, Kevin L, Jaffrézou, Jean-Pierre, Huff, Lyn M, Johnson, Kory R, Fojo, Tito, Lacayo, Norman J, Sikic, Branimir I

“…Despite considerable efforts to reverse clinical multidrug resistance (MDR), targeting the predominant multidrug transporter ABCB1/P-glycoprotein (P-gp) using…”
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L‐carnitine prevents doxorubicin‐induced apoptosis of cardiac myocytes: role of inhibition of ceramide generation by Andrieu‐Abadie, Nathalie, Jaffrézou, Jean‐Pierre, Hatem, Stéphane, Laurent, Guy, Levade, Thierry, Mercadier, Jean‐Jacques

“…ABSTRACTBesides the well‐documented effect of the chemotherapeutic drug doxorubicin on free radical generation, the exact signaling mechanisms by which it…”
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Kit signaling inhibits the sphingomyelin-ceramide pathway through PLCγ1: implication in stem cell factor radioprotective effect by Maddens, Stéphane, Charruyer, Alexandra, Plo, Isabelle, Dubreuil, Patrice, Berger, Stuart, Salles, Bernard, Laurent, Guy, Jaffrézou, Jean-Pierre

“…Previous studies demonstrated that Kit activation confers radioprotection. However, the mechanism by which Kit signaling interferes with cellular response to…”
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Ara‐C‐ and daunorubicin‐induced recruitment of Lyn in sphingomyelinase‐enriched membrane rafts by Grazide, Solène, Maestre, Nicolas, Veldman, Robert Jan, Bezombes, Christine, Maddens, Stéphane, Levade, Thierry, Laurent, Guy, Jaffrézou, Jean‐pierre

“…ABSTRACT Induction of apoptosis by DNA‐damaging agents such as 1‐β‐D‐arabinofuranosylcytosine (Ara‐C) includes the activation of Lyn protein tyrosine kinase…”
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Cytoprotective Effect of Glucosylceramide Synthase Inhibition against Daunorubicin-induced Apoptosis in Human Leukemic Cell Lines by Grazide, Solène, Terrisse, Anne-Dominique, Lerouge, Sandra, Laurent, Guy, Jaffrézou, Jean-Pierre

“…Several studies have shown that ceramide (CER) glucosylation contributes to drug resistance in multidrug-resistant cells and that inhibition of…”
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Cell surface-directed interaction of anthracyclines leads to cytotoxicity and nuclear factor κB activation but not apoptosis signaling by MAESTRE, Nicolas, TRITTON, Thomas R, LAURENT, Guy, JAFFREZOU, Jean-Pierre

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Protein kinase Cζ mediated Raf-1/extracellular-regulated kinase activation by daunorubicin by Mas, Véronique Mansat-De, Hernandez, Hélène, Plo, Isabelle, Bezombes, Christine, Maestre, Nicolas, Quillet-Mary, Anne, Filomenko, Rodolphe, Demur, Cécile, Jaffrézou, Jean-Pierre, Laurent, Guy

“…In light of the emerging concept of a protective function of the mitogen-activated protein kinase (MAPK) pathway under stress conditions, we investigated the…”
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Ceramide : A New Target in Anticancer Research? by Jaffrezou, Jean-Pierre, Laurent, Guy

“…An astute observer of chemotherapeutic progress concedes that anticancer research is, in effect, often more empirical that rational, and there are those who…”
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Implication of raft microdomains in drug induced apoptosis by Bezombes, Christine, Laurent, Guy, Jaffrézou, Jean-Pierre

“…DNA damaging agents such as 1-beta-D-arabinofuranosylcytosine (Ara-C) and daunorubicin (DNR) are widely used in the treatment of acute nonlymphocytic leukemia…”
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Resistance to microtubule-targeted cytotoxins in a K562 leukemia cell variant associated with altered tubulin expression and polymerization by Dumontet, Charles, Jaffrezou, Jean-Pierre, Tsuchiya, Etsuko, Duran, George E, Chen, Kevin Gang, Derry, W Brent, Wilson, Leslie, Jordan, Mary Ann, Sikic, Branimir I

“…A vinblastine resistant cell line, KCVB2, was established by co-selecting the parental erythroleukemic cell line K562 with step-wise increased concentrations…”
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Signalling sphingomyelinases: which, where, how and why? by Levade, Thierry, Jaffrézou, Jean-Pierre

“…A major lipid signalling pathway in mammalian cells implicates the activation of sphingomyelinase (SMase), which upon cell stimulation hydrolyses the…”
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Potential Role for Ceramide in Mitogen-activated Protein Kinase Activation and Proliferation of Vascular Smooth Muscle Cells Induced by Oxidized Low Density Lipoprotein by Augé, Nathalie, Escargueil-Blanc, Isabelle, Lajoie-Mazenc, Isabelle, Suc, Isabelle, Andrieu-Abadie, Nathalie, Pieraggi, Marie-Thérése, Chatelut, Martine, Thiers, Jean-Claude, Jaffrézou, Jean-Pierre, Laurent, Guy, Levade, Thierry, Négre-Salvayre, Anne, Salvayre, Robert

“…Proliferation of vascular smooth muscle cells (SMC) is a hallmark in the pathogenesis of atherosclerotic lesions. Mildly oxidized low density lipoproteins…”
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Serine protease inhibitors block neutral sphingomyelinase activation, ceramide generation, and apoptosis triggered by daunorubicin by Mansat, Veronique, Bettaïeb, Ali, Levade, Thierry, Laurent, Guy, Jaffrézou, Jean‐Pierre

“…To address the role of a plausible protease cascade in daunorubicin‐triggered apoptosis, we evaluated the effect of cell‐permeant protease inhibitors on its…”
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