Search Results - "Jaffrey, Samie R"

Highly efficient expression of circular RNA aptamers in cells using autocatalytic transcripts by Litke, Jacob L., Jaffrey, Samie R.

“…RNA aptamers and RNA aptamer-based devices can be genetically encoded and expressed in cells to probe and manipulate cellular function. However, their…”
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Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons by Meyer, Kate D., Saletore, Yogesh, Zumbo, Paul, Elemento, Olivier, Mason, Christopher E., Jaffrey, Samie R.

“…Methylation of the N6 position of adenosine (m6A) is a posttranscriptional modification of RNA with poorly understood prevalence and physiological relevance…”
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mRNA ageing shapes the Cap2 methylome in mammalian mRNA by Despic, Vladimir, Jaffrey, Samie R.

“…The mRNA cap structure is a major site of dynamic mRNA methylation. mRNA caps exist in either the Cap1 or Cap2 form, depending on the presence of 2′- O…”
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Nonsense-mediated RNA decay in the brain: emerging modulator of neural development and disease by Jaffrey, Samie R., Wilkinson, Miles F.

“…Steady-state RNA levels are controlled by the balance between RNA synthesis and RNA turnover. A selective RNA turnover mechanism that has received recent…”
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Molecular basis for the specific and multivariant recognitions of RNA substrates by human hnRNP A2/B1 by Wu, Baixing, Su, Shichen, Patil, Deepak P., Liu, Hehua, Gan, Jianhua, Jaffrey, Samie R., Ma, Jinbiao

“…Human hnRNP A2/B1 is an RNA-binding protein that plays important roles in many biological processes, including maturation, transport, and metabolism of mRNA,…”
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RNA modifications: what have we learned and where are we headed? by Frye, Michaela, Jaffrey, Samie R., Pan, Tao, Rechavi, Gideon, Suzuki, Tsutomu

“…Five experts discuss topical aspects of RNA modifications, highlighting where the research field stands, recommendations for best practices and visions for the…”
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Regulation of Axon Guidance by Compartmentalized Nonsense-Mediated mRNA Decay by Colak, Dilek, Ji, Sheng-Jian, Porse, Bo T., Jaffrey, Samie R.

“…Growth cones enable axons to navigate toward their targets by responding to extracellular signaling molecules. Growth-cone responses are mediated in part by…”
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Broccoli: Rapid Selection of an RNA Mimic of Green Fluorescent Protein by Fluorescence-Based Selection and Directed Evolution by Filonov, Grigory S, Moon, Jared D, Svensen, Nina, Jaffrey, Samie R

“…Genetically encoded fluorescent ribonucleic acids (RNAs) have diverse applications, including imaging RNA trafficking and as a component of RNA-based sensors…”
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Distinguishing RNA modifications from noise in epitranscriptome maps by Grozhik, Anya V, Jaffrey, Samie R

“…Messenger RNA (mRNA) and long noncoding RNA (lncRNA) can be subjected to a variety of post-transcriptional modifications that markedly influence their fate and…”
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A superfolding Spinach2 reveals the dynamic nature of trinucleotide repeat–containing RNA by Strack, Rita L, Disney, Matthew D, Jaffrey, Samie R

“…The Spinach2 RNA aptamer provides substantially improved imaging over its predecessor Spinach, enabling live-cell imaging of many tagged RNA species including…”
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Structure and Mechanism of RNA Mimics of Green Fluorescent Protein by You, Mingxu, Jaffrey, Samie R

“…RNAs have highly complex and dynamic cellular localization patterns. Technologies for imaging RNA in living cells are important for uncovering their function…”
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Expanding the epitranscriptome: Dihydrouridine in mRNA by Dixit, Sameer, Jaffrey, Samie R

“…Nucleotide modifications can markedly influence mRNA processing and metabolism. New studies, one in PLOS Biology, show that approximately 130 yeast mRNAs…”
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Activation of SIRT3 by the NAD+ Precursor Nicotinamide Riboside Protects from Noise-Induced Hearing Loss by Brown, Kevin D., Maqsood, Sadia, Huang, Jing-Yi, Pan, Yong, Harkcom, William, Li, Wei, Sauve, Anthony, Verdin, Eric, Jaffrey, Samie R.

“…Intense noise exposure causes hearing loss by inducing degeneration of spiral ganglia neurites that innervate cochlear hair cells. Nicotinamide adenine…”
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Imaging metabolite dynamics in living cells using a Spinach-based riboswitch by You, Mingxu, Litke, Jacob L., Jaffrey, Samie R.

“…Riboswitches are natural ligand-sensing RNAs typically that are found in the 5′ UTRs of mRNA. Numerous classes of riboswitches have been discovered, enabling…”
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Plug-and-Play Fluorophores Extend the Spectral Properties of Spinach by Song, Wenjiao, Strack, Rita L, Svensen, Nina, Jaffrey, Samie R

“…Spinach and Spinach2 are RNA aptamers that can be used for the genetic encoding of fluorescent RNA. Spinach2 binds and activates the fluorescence of…”
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RNA Mimics of Green Fluorescent Protein by Paige, Jeremy S., Wu, Karen Y., Jaffrey, Samie R.

“…Green fluorescent protein (GFP) and its derivatives have transformed the use and analysis of proteins for diverse applications. Like proteins, RNA has complex…”
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Global analysis of lysine ubiquitination by ubiquitin remnant immunoaffinity profiling by Jaffrey, Samie R, Xu, Guoqiang, Paige, Jeremy S

“…Protein ubiquitination is a post-translational modification (PTM) that regulates various aspects of protein function by different mechanisms. Characterization…”
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Fluorescent RNA Aptamers as a Tool to Study RNA-Modifying Enzymes by Svensen, Nina, Jaffrey, Samie R

“…RNA-modifying enzymes are difficult to assay due to the absence of fluorometric substrates. Here we show that the Broccoli, a previously reported fluorescent…”
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Engineering Fluorophore Recycling in a Fluorogenic RNA Aptamer by Li, Xing, Wu, Jiahui, Jaffrey, Samie R.

“…Fluorogenic aptamers can potentially show minimal photobleaching during continuous irradiation since any photobleached fluorophore can exchange with…”
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Defining the location of promoter-associated R-loops at near-nucleotide resolution using bisDRIP-seq by Dumelie, Jason G, Jaffrey, Samie R

“…R-loops are features of chromatin consisting of a strand of DNA hybridized to RNA, as well as the expelled complementary DNA strand. R-loops are enriched at…”
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