Search Results - "Jaffee, Elizabeth"

Tumor Mutational Burden and Response Rate to PD-1 Inhibition by Yarchoan, Mark, Hopkins, Alexander, Jaffee, Elizabeth M

“…In a survey of the spectrum of mutational burdens in 27 types of cancers, there was a correlation between an increased mutational burden and the response to…”
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The tumour microenvironment in pancreatic cancer — clinical challenges and opportunities by Ho, Won Jin, Jaffee, Elizabeth M., Zheng, Lei

“…Metastatic pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal solid tumours despite the use of multi-agent conventional chemotherapy regimens…”
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Emerging strategies for combination checkpoint modulators in cancer immunotherapy by Popovic, Aleksandra, Jaffee, Elizabeth M, Zaidi, Neeha

“…Current immune checkpoint-modulating agents have demonstrated clinical efficacy in certain tumor types, particularly those with a high burden of tumor-specific…”
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Pancreatic Cancer: Pathogenesis, Screening, Diagnosis and Treatment by Wood, Laura D., Canto, Marcia Irene, Jaffee, Elizabeth M., Simeone, Diane M.

“…Pancreatic ductal adenocarcinoma (PDAC) is a clinically challenging cancer, due to both its late stage at diagnosis and its resistance to chemotherapy…”
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Macrophage-Targeting by CSF1/1R Blockade in Pancreatic Cancers by Ho, Won Jin, Jaffee, Elizabeth M

“…Published in in 2014, Zhu and colleagues achieved a mechanistic leap in our understanding of cancer-associated macrophage biology with their proof-of-concept…”
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Mesothelin Immunotherapy for Cancer: Ready for Prime Time? by Hassan, Raffit, Thomas, Anish, Alewine, Christine, Le, Dung T, Jaffee, Elizabeth M, Pastan, Ira

“…Mesothelin is a tumor antigen that is highly expressed in many human cancers, including malignant mesothelioma and pancreatic, ovarian, and lung…”
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The determinants of tumour immunogenicity by Blankenstein, Thomas, Coulie, Pierre G., Gilboa, Eli, Jaffee, Elizabeth M.

“…Four leading tumour immunologists provide their opinions on the determinants of immunogenicity and how we might therapeutically improve tumour immunogenicity…”
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Role of Immune Cells and Immune-Based Therapies in Pancreatitis and Pancreatic Ductal Adenocarcinoma by Zheng, Lei, Xue, Jing, Jaffee, Elizabeth M, Habtezion, Aida

“…Immune cells are important in the pathogenesis of acute pancreatitis and determine disease severity. Results from cytokine-based clinical trials for acute…”
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Targeting neoantigens to augment antitumour immunity by Yarchoan, Mark, Johnson, Burles A., Lutz, Eric R., Laheru, Daniel A., Jaffee, Elizabeth M.

“…Key Points Somatic mutations can cause tumours to express mutant proteins that are tumour specific and not expressed on normal cells (neoantigens). In the…”
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Immunotherapy transforms cancer treatment by Zaidi, Neeha, Jaffee, Elizabeth M

“…James Allison of the University of Texas MD Anderson Cancer Center and Tasuko Honjo of Kyoto University were jointly awarded the 2018 Nobel Prize in Physiology…”
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Cross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated Fibroblasts by Elyada, Ela, Bolisetty, Mohan, Laise, Pasquale, Flynn, William F, Courtois, Elise T, Burkhart, Richard A, Teinor, Jonathan A, Belleau, Pascal, Biffi, Giulia, Lucito, Matthew S, Sivajothi, Santhosh, Armstrong, Todd D, Engle, Dannielle D, Yu, Kenneth H, Hao, Yuan, Wolfgang, Christopher L, Park, Youngkyu, Preall, Jonathan, Jaffee, Elizabeth M, Califano, Andrea, Robson, Paul, Tuveson, David A

“…Cancer-associated fibroblasts (CAF) are major players in the progression and drug resistance of pancreatic ductal adenocarcinoma (PDAC). CAFs constitute a…”
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Targeting neoantigens to augment antitumour immunity by Yarchoan, Mark, Johnson, 3rd, Burles A, Lutz, Eric R, Laheru, Daniel A, Jaffee, Elizabeth M

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Oncogenic Kras Activates a Hematopoietic-to-Epithelial IL-17 Signaling Axis in Preinvasive Pancreatic Neoplasia by McAllister, Florencia, Bailey, Jennifer M., Alsina, Janivette, Nirschl, Christopher J., Sharma, Rajni, Fan, Hongni, Rattigan, Yanique, Roeser, Jeffrey C., Lankapalli, Rachana H., Zhang, Hao, Jaffee, Elizabeth M., Drake, Charles G., Housseau, Franck, Maitra, Anirban, Kolls, Jay K., Sears, Cynthia L., Pardoll, Drew M., Leach, Steven D.

“…Many human cancers are dramatically accelerated by chronic inflammation. However, the specific cellular and molecular elements mediating this effect remain…”
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Regulatory T-cell Modulation Using Cyclophosphamide in Vaccine Approaches: A Current Perspective by LE, Dung T, JAFFEE, Elizabeth M

“…Regulatory T cells (Treg) have become an important player in regulating anticancer immune responses. In fact, published studies describe a correlation between…”
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Transcriptional profiling identifies novel regulators of macrophage polarization by Gerrick, Kimberline Y, Gerrick, Elias R, Gupta, Anuj, Wheelan, Sarah J, Yegnasubramanian, Srinivasan, Jaffee, Elizabeth M

“…Macrophages are key inflammatory immune cells that display dynamic phenotypes and functions in response to their local microenvironment. Major advances have…”
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Tumor Antigen–Targeted, Monoclonal Antibody–Based Immunotherapy: Clinical Response, Cellular Immunity, and Immunoescape by FERRIS, Robert L, JAFFEE, Elizabeth M, FERRONE, Soldano

“…Tumor antigen (TA) -targeted monoclonal antibodies (mAb), rituximab, trastuzumab, and cetuximab, are clinically effective for some advanced malignancies,…”
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Immune cells track hard-to-target tumours by Zaidi, Neeha, Jaffee, Elizabeth M

“…The personalized vaccine induced CD4+ T-cell responses targeting neo-antigens in 8 out of 10 people who received the personalized vaccine and generated immune…”
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Cancer cells educate natural killer cells to a metastasis-promoting cell state by Chan, Isaac S, Knútsdóttir, Hildur, Ramakrishnan, Gayathri, Padmanaban, Veena, Warrier, Manisha, Ramirez, Juan Carlos, Dunworth, Matthew, Zhang, Hao, Jaffee, Elizabeth M, Bader, Joel S, Ewald, Andrew Josef

“…Natural killer (NK) cells have potent antitumor and antimetastatic activity. It is incompletely understood how cancer cells escape NK cell surveillance. Using…”
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Disrupting a converging metabolic target turns up the immunologic-heat in pancreatic tumors by Ho, Won Jin, Jaffee, Elizabeth M

“…Pancreatic ductal adenocarcinomas (PDACs) are classically immunologically cold tumors that have failed to demonstrate a significant response to…”
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Immune cells track hard-to-target brain tumours by Zaidi, Neeha, Jaffee, Elizabeth M.

“…Clinical trials reveal that personalized vaccines can boost immune-cell responses to brain tumours that don’t usually respond to immunotherapy. The findings…”
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