Search Results - "Jaffe, Iris Z."

Sex as a Biological Variable in Atherosclerosis by Man, Joshua J., Beckman, Joshua A., Jaffe, Iris Z.

“…Atherosclerosis is a chronic inflammatory vascular disease and the predominant cause of heart attack and ischemic stroke. Despite the well-known sexual…”
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Sex differences in mechanisms of arterial stiffness by DuPont, Jennifer J., Kenney, Rachel M., Patel, Ayan R., Jaffe, Iris Z.

“…Arterial stiffness progressively increases with aging and is an independent predictor of cardiovascular disease (CVD) risk. Evidence supports that there are…”
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Mineralocorticoid receptors in vascular function and disease by McCurley, Amy, Jaffe, Iris Z.

“…► Mineralocorticoid receptors are expressed in vascular smooth muscle and endothelial cells. ► MR-activation promotes vascular oxidative stress and vascular…”
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The endothelial mineralocorticoid receptor: Contributions to sex differences in cardiovascular disease by Moss, M. Elizabeth, Carvajal, Brigett, Jaffe, Iris Z.

“…Cardiovascular disease remains the leading cause of death for both men and women. The observation that premenopausal women are protected from cardiovascular…”
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Left Ventricular Unloading Before Reperfusion Promotes Functional Recovery After Acute Myocardial Infarction by Esposito, Michele L., Zhang, Yali, Qiao, Xiaoying, Reyelt, Lara, Paruchuri, Vikram, Schnitzler, Gavin R., Morine, Kevin J., Annamalai, Shiva K., Bogins, Courtney, Natov, Peter S., Pedicini, Robert, Breton, Catalina, Mullin, Andrew, Mackey, Emily E., Patel, Ayan, Rowin, Ethan, Jaffe, Iris Z., Karas, Richard H., Kapur, Navin K.

“…Heart failure after an acute myocardial infarction (AMI) is a major cause of morbidity and mortality worldwide. We recently reported that activation of a…”
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Direct regulation of blood pressure by smooth muscle cell mineralocorticoid receptors by McCurley, Amy, Pires, Paulo W, Bender, Shawn B, Aronovitz, Mark, Zhao, Michelle J, Metzger, Daniel, Chambon, Pierre, Hill, Michael A, Dorrance, Anne M, Mendelsohn, Michael E, Jaffe, Iris Z

“…The mineralocorticoid receptor, targeted by drugs commonly used to treat hypertension, is generally thought to contribute to hypertension by altering kidney…”
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Aldosterone Promotes Vascular Remodeling by Direct Effects on Smooth Muscle Cell Mineralocorticoid Receptors by Pruthi, Dafina, McCurley, Amy, Aronovitz, Mark, Galayda, Carol, Karumanchi, S Ananth, Jaffe, Iris Z

“…OBJECTIVE—Vascular remodeling occurs after endothelial injury, resulting in smooth muscle cell (SMC) proliferation and vascular fibrosis. We previously…”
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Endothelial Mineralocorticoid Receptors Contribute to Vascular Inflammation in Atherosclerosis in a Sex-Specific Manner by Moss, M. Elizabeth, Lu, Qing, Iyer, Surabhi L., Engelbertsen, Daniel, Marzolla, Vincenzo, Caprio, Massimiliano, Lichtman, Andrew H., Jaffe, Iris Z.

“…MR (mineralocorticoid receptor) activation is associated with cardiovascular ischemia in humans. This study explores the role of the MR in atherosclerotic mice…”
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Endothelial Mineralocorticoid Receptor Mediates Diet-Induced Aortic Stiffness in Females by Jia, Guanghong, Habibi, Javad, Aroor, Annayya R, Martinez-Lemus, Luis A, DeMarco, Vincent G, Ramirez-Perez, Francisco I, Sun, Zhe, Hayden, Melvin R, Meininger, Gerald A, Mueller, Katelee Barrett, Jaffe, Iris Z, Sowers, James R

“…RATIONALE:Enhanced activation of the mineralocorticoid receptors (MRs) in cardiovascular tissues increases oxidative stress, maladaptive immune responses, and…”
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Essential role of ICAM-1 in aldosterone-induced atherosclerosis by Marzolla, Vincenzo, Armani, Andrea, Mammi, Caterina, Moss, Mary E, Pagliarini, Vittoria, Pontecorvo, Laura, Antelmi, Antonella, Fabbri, Andrea, Rosano, Giuseppe, Jaffe, Iris Z, Caprio, Massimiliano

“…Abstract Objective Elevated aldosterone is associated with increased risk of atherosclerosis complications, whereas treatment with mineralocorticoid receptor…”
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Inhibition of the histone methyltransferase EZH2 induces vascular stiffness by Ibarrola, Jaime, Xiang, Rachel R, Sun, Zhe, Lu, Qing, Hill, Michael A, Jaffe, Iris Z

“…Vascular stiffness increases with aging, obesity and hypertension and predicts cardiovascular risk. The levels of histone H3-lysine-27 methylation (H3K27me)…”
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Endothelial Mineralocorticoid Receptors Differentially Contribute to Coronary and Mesenteric Vascular Function Without Modulating Blood Pressure by Mueller, Katelee Barrett, Bender, Shawn B, Hong, Kwangseok, Yang, Yan, Aronovitz, Mark, Jaisser, Frederic, Hill, Michael A, Jaffe, Iris Z

“…Arteriolar vasoreactivity tightly regulates tissue-specific blood flow and contributes to systemic blood pressure (BP) but becomes dysfunctional in the setting…”
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Role of Aldosterone and Mineralocorticoid Receptor in Cardiovascular Aging by Gorini, Stefania, Kim, Seung Kyum, Infante, Marco, Mammi, Caterina, La Vignera, Sandro, Fabbri, Andrea, Jaffe, Iris Z, Caprio, Massimiliano

“…The mineralocorticoid receptor (MR) was originally identified as a regulator of blood pressure, able to modulate renal sodium handling in response to its…”
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Endothelial Mineralocorticoid Receptor Deletion Prevents Diet-Induced Cardiac Diastolic Dysfunction in Females by Jia, Guanghong, Habibi, Javad, DeMarco, Vincent G, Martinez-Lemus, Luis A, Ma, Lixin, Whaley-Connell, Adam T, Aroor, Annayya R, Domeier, Timothy L, Zhu, Yi, Meininger, Gerald A, Mueller, Katelee Barrett, Jaffe, Iris Z, Sowers, James R

“…Overnutrition and insulin resistance are especially prominent risk factors for the development of cardiac diastolic dysfunction in females. We recently…”
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Differential vascular endothelial cell toxicity of established and novel BCR-ABL tyrosine kinase inhibitors by Wang, Yihua, Travers, Richard J, Farrell, Alanna, Lu, Qing, Bays, Jennifer L, Stepanian, Alec, Chen, Christopher, Jaffe, Iris Z

“…BCR-ABL tyrosine kinase inhibitors (TKIs) have dramatically improved survival in Philadelphia chromosome-positive leukemias. Newer BCR-ABL TKIs provide…”
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Smooth Muscle Cell Mineralocorticoid Receptors Are Mandatory for Aldosterone–Salt to Induce Vascular Stiffness by Galmiche, Guillaume, Pizard, Anne, Gueret, Alexandre, El Moghrabi, Soumaya, Ouvrard-Pascaud, Antoine, Berger, Stefan, Challande, Pascal, Jaffe, Iris Z., Labat, Carlos, Lacolley, Patrick, Jaisser, Frédéric

“…Arterial stiffness is recognized as a risk factor for many cardiovascular diseases. Aldosterone via its binding to and activation of the mineralocorticoid…”
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Progesterone Predisposes Females to Obesity-Associated Leptin-Mediated Endothelial Dysfunction via Upregulating Endothelial MR (Mineralocorticoid Receptor) Expression by Faulkner, Jessica L, Kennard, Simone, Huby, Anne-Cecile, Antonova, Galina, Lu, Qing, Jaffe, Iris Z, Patel, Vijay S, Fulton, David J.R, Belin de Chantemèle, Eric J

“…Compelling clinical evidence indicates that obesity and its associated metabolic abnormalities supersede the protective effects of female sex-hormones and…”
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Biological Sex Modulates the Adrenal and Blood Pressure Responses to Angiotensin II by Shukri, Mohammad Zaki, Tan, Jia Wei, Manosroi, Worapaka, Pojoga, Luminita H, Rivera, Alicia, Williams, Jonathan S, Seely, Ellen W, Adler, Gail K, Jaffe, Iris Z, Karas, Richard H, Williams, Gordon H, Romero, Jose R

“…The relationship between biological sex and aldosterone on blood pressure (BP) is unclear. We hypothesized that sex would modify the interaction between…”
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Molecular mechanisms for vascular complications of targeted cancer therapies by Gopal, Srila, Miller, Kenneth B, Jaffe, Iris Z

“…Molecularly targeted anti-cancer therapies have revolutionized cancer treatment by improving both quality of life and survival in cancer patients. However,…”
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Mineralocorticoid receptors in immune cells: Emerging role in cardiovascular disease by Bene, Nicholas C., Alcaide, Pilar, Wortis, Henry H., Jaffe, Iris Z.

“…•MR is expressed in macrophages, dendritic cells, and T and B lymphocytes.•MR promotes the pro-inflammatory M1 macrophage phenotype.•Macrophage MR contributes…”
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