Chronic urticaria associated with Blastocystis hominis infection

Urticaria is a skin rash with several etiologic factors, including infectious agents. Blastocystis hominis is an intestinal protozoan parasite that has been linked to urticaria and skin lesions. The aim of this work was to investigate the association between B. hominis infection and chronic urticari...

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Published in:	Archives of dermatological research Vol. 316; no. 7; p. 413
Main Authors:	Jafari, Arya, Bahrami, Fares, Nasiri-Kalmarzi, Rasoul, Abdoli, Amir
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Springer Berlin Heidelberg 16-06-2024 Springer Nature B.V
Subjects:	Adolescent Adult Aged Blastocystis hominis Blastocystis hominis - isolation & purification Blastocystis Infections - complications Blastocystis Infections - diagnosis Blastocystis Infections - epidemiology Blastocystis Infections - parasitology Case-Control Studies Chronic infection Chronic Urticaria - diagnosis Chronic Urticaria - parasitology Dermatology Feces - parasitology Female Humans Infections Male Medicine Medicine & Public Health Middle Aged Original Paper Polymerase chain reaction rRNA Severity of Illness Index Skin diseases Skin lesions Statistical analysis Urticaria Urticaria - parasitology Young Adult Iran Subtypes Chronic urticaria Blastocystis hominis
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Summary:	Urticaria is a skin rash with several etiologic factors, including infectious agents. Blastocystis hominis is an intestinal protozoan parasite that has been linked to urticaria and skin lesions. The aim of this work was to investigate the association between B. hominis infection and chronic urticaria. In a case-control study, stool samples were obtained from 94 patients with chronic urticaria as case group and 285 healthy individuals as control group. Urticaria activity score 7 (UAS7) was used to score the severity of urticaria, classified as mild, moderate and intense. All stool samples underwent routine stool examinations, as well as polymerase chain reaction (PCR) for the detection of B. hominis . Molecular detection was carried out using the small subunit ribosomal RNA (SSU-rRNA) gene and the parasite subtypes were determined by sequencing. The rate of B. hominis infection was 21.3% (20 out of 94) and 17.2% (49 out of 285) between the case and control groups, respectively ( p = 0.463). Three subtypes of B. hominis , including ST-1, ST-2 and ST-3, were detected in the case and control groups (ST-1 = 30% vs. 8.3%, ST-2 = 40% vs. 25% and ST-3 = 30% vs. 66.6% in the case and control group, respectively), which was statistically significant ( p = 0.00001). However, no statistical differences were found between the severity of the urticaria and the B. hominis subtypes ( p = 0.533). This study revealed a higher prevalence (but not significant) of B. hominis infection among patients with urticaria than healthy individuals. However, the results did not find a significant association between the subtypes of B. hominis and the severity of urticaria.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1432-069X 0340-3696 1432-069X
DOI:	10.1007/s00403-024-03019-8