Search Results - "Jaehnig, Eric J"

Rewiring of Genetic Networks in Response to DNA Damage by Bandyopadhyay, Sourav, Mehta, Monika, Kuo, Dwight, Sung, Min-Kyung, Chuang, Ryan, Jaehnig, Eric J, Bodenmiller, Bernd, Licon, Katherine, Copeland, Wilbert, Shales, Michael, Fiedler, Dorothea, Dutkowski, Janusz, Guénolé, Aude, van Attikum, Haico, Shokat, Kevan M, Kolodner, Richard D, Huh, Won-Ki, Aebersold, Ruedi, Keogh, Michael-Christopher, Krogan, Nevan J, Ideker, Trey

“…Although cellular behaviors are dynamic, the networks that govern these behaviors have been mapped primarily as static snapshots. Using an approach called…”
Get full text

WebGestalt 2019: gene set analysis toolkit with revamped UIs and APIs by Liao, Yuxing, Wang, Jing, Jaehnig, Eric J, Shi, Zhiao, Zhang, Bing

“…WebGestalt is a popular tool for the interpretation of gene lists derived from large scale -omics studies. In the 2019 update, WebGestalt supports 12…”
Get full text

Checkpoint Kinases Regulate a Global Network of Transcription Factors in Response to DNA Damage by Jaehnig, Eric J., Kuo, Dwight, Hombauer, Hans, Ideker, Trey G., Kolodner, Richard D.

“…DNA damage activates checkpoint kinases that induce several downstream events, including widespread changes in transcription. However, the specific connections…”
Get full text

Cell-autonomous activation of Hedgehog signaling inhibits brown adipose tissue development by Nosavanh, LaGina, Yu, Da-Hai, Jaehnig, Eric J., Tong, Qiang, Shen, Lanlan, Chen, Miao-Hsueh

“…Significance The function of brown adipose tissue (BAT), which converts chemical energy into heat, has been widely characterized, but how BAT forms and what…”
Get full text

Perspectives on the DNA damage and replication checkpoint responses in Saccharomyces cerevisiae by Putnam, Christopher D., Jaehnig, Eric J., Kolodner, Richard D.

“…The DNA damage and replication checkpoints are believed to primarily slow the progression of the cell cycle to allow DNA repair to occur. Here we summarize…”
Get full text

OmicsEV: a tool for comprehensive quality evaluation of omics data tables by Wen, Bo, Jaehnig, Eric J, Zhang, Bing

“…RNA-Seq and mass spectrometry-based studies generate omics data tables with measurements for tens of thousands of genes across all samples in a study. The…”
Get full text

Deep Learning Prediction Boosts Phosphoproteomics-Based Discoveries Through Improved Phosphopeptide Identification by Yi, Xinpei, Wen, Bo, Ji, Shuyi, Saltzman, Alexander B., Jaehnig, Eric J., Lei, Jonathan T., Gao, Qiang, Zhang, Bing

“…Shotgun phosphoproteomics enables high-throughput analysis of phosphopeptides in biological samples. One of the primary challenges associated with this…”
Get full text

IDPpub: Illuminating the Dark Phosphoproteome Through PubMed Mining by Savage, Sara R., Zhang, Yaoyun, Jaehnig, Eric J., Liao, Yuxing, Shi, Zhiao, Pham, Huy Anh, Xu, Hua, Zhang, Bing

“…Global phosphoproteomics experiments quantify tens of thousands of phosphorylation sites. However, data interpretation is hampered by our limited knowledge on…”
Get full text

Pan-cancer proteogenomics expands the landscape of therapeutic targets by Savage, Sara R, Yi, Xinpei, Lei, Jonathan T, Wen, Bo, Zhao, Hongwei, Liao, Yuxing, Jaehnig, Eric J, Somes, Lauren K, Shafer, Paul W, Lee, Tobie D, Fu, Zile, Dou, Yongchao, Shi, Zhiao, Gao, Daming, Hoyos, Valentina, Gao, Qiang, Zhang, Bing

“…Fewer than 200 proteins are targeted by cancer drugs approved by the Food and Drug Administration (FDA). We integrate Clinical Proteomic Tumor Analysis…”
Get more information

Increased Susceptibility to Isoproterenol-Induced Cardiac Hypertrophy and Impaired Weight Gain in Mice Lacking the Histidine-Rich Calcium-Binding Protein by Jaehnig, Eric J., Heidt, Analeah B., Greene, Stephanie B., Cornelissen, Ivo, Black, Brian L.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Proteogenomic Markers of Chemotherapy Resistance and Response in Triple-Negative Breast Cancer by Anurag, Meenakshi, Jaehnig, Eric J, Krug, Karsten, Lei, Jonathan T, Bergstrom, Erik J, Kim, Beom-Jun, Vashist, Tanmayi D, Huynh, Anh Minh Tran, Dou, Yongchao, Gou, Xuxu, Huang, Chen, Shi, Zhiao, Wen, Bo, Korchina, Viktoriya, Gibbs, Richard A, Muzny, Donna M, Doddapaneni, Harshavardhan, Dobrolecki, Lacey E, Rodriguez, Henry, Robles, Ana I, Hiltke, Tara, Lewis, Michael T, Nangia, Julie R, Nemati Shafaee, Maryam, Li, Shunqiang, Hagemann, Ian S, Hoog, Jeremy, Lim, Bora, Osborne, C Kent, Mani, D R, Gillette, Michael A, Zhang, Bing, Echeverria, Gloria V, Miles, George, Rimawi, Mothaffar F, Carr, Steven A, Ademuyiwa, Foluso O, Satpathy, Shankha, Ellis, Matthew J

“…Microscaled proteogenomics was deployed to probe the molecular basis for differential response to neoadjuvant carboplatin and docetaxel combination…”
Get more information

HRC Is a Direct Transcriptional Target of MEF2 during Cardiac, Skeletal, and Arterial Smooth Muscle Development In Vivo by Anderson, Joshua P., Dodou, Evdokia, Heidt, Analeah B., De Val, Sarah J., Jaehnig, Eric J., Greene, Stephanie B., Olson, Eric N., Black, Brian L.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

MEF2C regulates outflow tract alignment and transcriptional control of Tdgf1 by Barnes, Ralston M, Harris, Ian S, Jaehnig, Eric J, Sauls, Kimberly, Sinha, Tanvi, Rojas, Anabel, Schachterle, William, McCulley, David J, Norris, Russell A, Black, Brian L

“…Congenital heart defects are the most common birth defects in humans, and those that affect the proper alignment of the outflow tracts and septation of the…”
Get full text

Kinase inhibitor pulldown assay (KiP) for clinical proteomics by Saltzman, Alexander B, Chan, Doug W, Holt, Matthew V, Wang, Junkai, Jaehnig, Eric J, Anurag, Meenakshi, Singh, Purba, Malovannaya, Anna, Kim, Beom-Jun, Ellis, Matthew J

“…Protein kinases are frequently dysregulated and/or mutated in cancer and represent essential targets for therapy. Accurate quantification is essential. For…”
Get full text

Kinase Inhibitor Pulldown Assay Identifies a Chemotherapy Response Signature in Triple-negative Breast Cancer Based on Purine-binding Proteins by Wang, Junkai, Saltzman, Alexander B, Jaehnig, Eric J, Lei, Jonathan T, Malovannaya, Anna, Holt, Matthew V, Young, Meggie N, Rimawi, Mothaffar F, Ademuyiwa, Foluso O, Anurag, Meenakshi, Kim, Beom-Jun, Ellis, Matthew J

“…Triple-negative breast cancer (TNBC) constitutes 10%-15% of all breast tumors. The current standard of care is multiagent chemotherapy, which is effective in…”
Get full text

Identification and characterization of a supraclavicular brown adipose tissue in mice by Mo, Qianxing, Salley, Jordan, Roshan, Tony, Baer, Lisa A, May, Francis J, Jaehnig, Eric J, Lehnig, Adam C, Guo, Xin, Tong, Qiang, Nuotio-Antar, Alli M, Shamsi, Farnaz, Tseng, Yu-Hua, Stanford, Kristin I, Chen, Miao-Hsueh

“…A fundamental challenge to our understanding of brown adipose tissue (BAT) is the lack of an animal model that faithfully represents human BAT. Such a model is…”
Get full text

Chemogenetic profiling identifies RAD17 as synthetically lethal with checkpoint kinase inhibition by Shen, John Paul, Srivas, Rohith, Gross, Andrew, Li, Jianfeng, Jaehnig, Eric J, Sun, Su Ming, Bojorquez-Gomez, Ana, Licon, Katherine, Sivaganesh, Vignesh, Xu, Jia L, Klepper, Kristin, Yeerna, Huwate, Pekin, Daniel, Qiu, Chu Ping, van Attikum, Haico, Sobol, Robert W, Ideker, Trey

“…Chemical inhibitors of the checkpoint kinases have shown promise in the treatment of cancer, yet their clinical utility may be limited by a lack of molecular…”
Get full text

Microscaled proteogenomic methods for precision oncology by Satpathy, Shankha, Jaehnig, Eric J., Krug, Karsten, Kim, Beom-Jun, Saltzman, Alexander B., Chan, Doug W., Holloway, Kimberly R., Anurag, Meenakshi, Huang, Chen, Singh, Purba, Gao, Ari, Namai, Noel, Dou, Yongchao, Wen, Bo, Vasaikar, Suhas V., Mutch, David, Watson, Mark A., Ma, Cynthia, Ademuyiwa, Foluso O., Rimawi, Mothaffar F., Schiff, Rachel, Hoog, Jeremy, Jacobs, Samuel, Malovannaya, Anna, Hyslop, Terry, Clauser, Karl R., Mani, D. R., Perou, Charles M., Miles, George, Zhang, Bing, Gillette, Michael A., Carr, Steven A., Ellis, Matthew J.

“…Cancer proteogenomics promises new insights into cancer biology and treatment efficacy by integrating genomics, transcriptomics and protein profiling including…”
Get full text

Abstract 1460: Co-expression network analysis reveals male breast cancer specific transcriptional module by Gou, Xuxu, Wang, Junkai, Lei, Jonathan T., Jaehnig, Eric J., Anurag, Meenakshi

“…Abstract Introduction: According to the American Cancer Society, An estimated 2,710 men are diagnosed with breast cancer annually of which about 530 die due to…”
Get full text

Abstract P5-02-36: Proteogenomic profiling of fresh frozen core biopsies from CALGB 40601 by Jaehnig, Eric J., Fernandez-Martinez, Aranzazu, Vashist, Tanmayi, Holt, Matthew V., Williams, LaTerrica, Lei, Jonathan, Kim, Beom-Jun, Dou, Yongchao, Korchina, Viktoriya, Gibbs, Richard, Muzny, Donna, Doddapaneni, Harshavardhan, Rodriguez, Henry, Robles, Ana, Hiltke, Tara, Mani, DR, Gillette, Michael, Hyslop, Terry, Wen, Yujia, McCart, Linda, Miles, George, Carr, Steven, Zhang, Bing, Satpathy, Shankha, Ellis, Matthew, Anurag, Meenakshi

“…Abstract Background: Targeted therapy for HER2+ breast cancer has significantly improved outcomes for this aggressive subtype. However, a subset of patients do…”
Get full text