Search Results - "Jaehnig, Eric"

WebGestalt 2019: gene set analysis toolkit with revamped UIs and APIs by Liao, Yuxing, Wang, Jing, Jaehnig, Eric J, Shi, Zhiao, Zhang, Bing

“…WebGestalt is a popular tool for the interpretation of gene lists derived from large scale -omics studies. In the 2019 update, WebGestalt supports 12…”
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OmicsEV: a tool for comprehensive quality evaluation of omics data tables by Wen, Bo, Jaehnig, Eric J, Zhang, Bing

“…RNA-Seq and mass spectrometry-based studies generate omics data tables with measurements for tens of thousands of genes across all samples in a study. The…”
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Deep Learning Prediction Boosts Phosphoproteomics-Based Discoveries Through Improved Phosphopeptide Identification by Yi, Xinpei, Wen, Bo, Ji, Shuyi, Saltzman, Alexander B., Jaehnig, Eric J., Lei, Jonathan T., Gao, Qiang, Zhang, Bing

“…Shotgun phosphoproteomics enables high-throughput analysis of phosphopeptides in biological samples. One of the primary challenges associated with this…”
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IDPpub: Illuminating the Dark Phosphoproteome Through PubMed Mining by Savage, Sara R., Zhang, Yaoyun, Jaehnig, Eric J., Liao, Yuxing, Shi, Zhiao, Pham, Huy Anh, Xu, Hua, Zhang, Bing

“…Global phosphoproteomics experiments quantify tens of thousands of phosphorylation sites. However, data interpretation is hampered by our limited knowledge on…”
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Rewiring of Genetic Networks in Response to DNA Damage by Bandyopadhyay, Sourav, Mehta, Monika, Kuo, Dwight, Sung, Min-Kyung, Chuang, Ryan, Jaehnig, Eric J, Bodenmiller, Bernd, Licon, Katherine, Copeland, Wilbert, Shales, Michael, Fiedler, Dorothea, Dutkowski, Janusz, Guénolé, Aude, van Attikum, Haico, Shokat, Kevan M, Kolodner, Richard D, Huh, Won-Ki, Aebersold, Ruedi, Keogh, Michael-Christopher, Krogan, Nevan J, Ideker, Trey

“…Although cellular behaviors are dynamic, the networks that govern these behaviors have been mapped primarily as static snapshots. Using an approach called…”
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Pan-cancer proteogenomics expands the landscape of therapeutic targets by Savage, Sara R, Yi, Xinpei, Lei, Jonathan T, Wen, Bo, Zhao, Hongwei, Liao, Yuxing, Jaehnig, Eric J, Somes, Lauren K, Shafer, Paul W, Lee, Tobie D, Fu, Zile, Dou, Yongchao, Shi, Zhiao, Gao, Daming, Hoyos, Valentina, Gao, Qiang, Zhang, Bing

“…Fewer than 200 proteins are targeted by cancer drugs approved by the Food and Drug Administration (FDA). We integrate Clinical Proteomic Tumor Analysis…”
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Checkpoint Kinases Regulate a Global Network of Transcription Factors in Response to DNA Damage by Jaehnig, Eric J., Kuo, Dwight, Hombauer, Hans, Ideker, Trey G., Kolodner, Richard D.

“…DNA damage activates checkpoint kinases that induce several downstream events, including widespread changes in transcription. However, the specific connections…”
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Proteogenomic Markers of Chemotherapy Resistance and Response in Triple-Negative Breast Cancer by Anurag, Meenakshi, Jaehnig, Eric J, Krug, Karsten, Lei, Jonathan T, Bergstrom, Erik J, Kim, Beom-Jun, Vashist, Tanmayi D, Huynh, Anh Minh Tran, Dou, Yongchao, Gou, Xuxu, Huang, Chen, Shi, Zhiao, Wen, Bo, Korchina, Viktoriya, Gibbs, Richard A, Muzny, Donna M, Doddapaneni, Harshavardhan, Dobrolecki, Lacey E, Rodriguez, Henry, Robles, Ana I, Hiltke, Tara, Lewis, Michael T, Nangia, Julie R, Nemati Shafaee, Maryam, Li, Shunqiang, Hagemann, Ian S, Hoog, Jeremy, Lim, Bora, Osborne, C Kent, Mani, D R, Gillette, Michael A, Zhang, Bing, Echeverria, Gloria V, Miles, George, Rimawi, Mothaffar F, Carr, Steven A, Ademuyiwa, Foluso O, Satpathy, Shankha, Ellis, Matthew J

“…Microscaled proteogenomics was deployed to probe the molecular basis for differential response to neoadjuvant carboplatin and docetaxel combination…”
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Cell-autonomous activation of Hedgehog signaling inhibits brown adipose tissue development by Nosavanh, LaGina, Yu, Da-Hai, Jaehnig, Eric J., Tong, Qiang, Shen, Lanlan, Chen, Miao-Hsueh

“…Significance The function of brown adipose tissue (BAT), which converts chemical energy into heat, has been widely characterized, but how BAT forms and what…”
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MEF2C regulates outflow tract alignment and transcriptional control of Tdgf1 by Barnes, Ralston M, Harris, Ian S, Jaehnig, Eric J, Sauls, Kimberly, Sinha, Tanvi, Rojas, Anabel, Schachterle, William, McCulley, David J, Norris, Russell A, Black, Brian L

“…Congenital heart defects are the most common birth defects in humans, and those that affect the proper alignment of the outflow tracts and septation of the…”
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Kinase inhibitor pulldown assay (KiP) for clinical proteomics by Saltzman, Alexander B, Chan, Doug W, Holt, Matthew V, Wang, Junkai, Jaehnig, Eric J, Anurag, Meenakshi, Singh, Purba, Malovannaya, Anna, Kim, Beom-Jun, Ellis, Matthew J

“…Protein kinases are frequently dysregulated and/or mutated in cancer and represent essential targets for therapy. Accurate quantification is essential. For…”
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Perspectives on the DNA damage and replication checkpoint responses in Saccharomyces cerevisiae by Putnam, Christopher D., Jaehnig, Eric J., Kolodner, Richard D.

“…The DNA damage and replication checkpoints are believed to primarily slow the progression of the cell cycle to allow DNA repair to occur. Here we summarize…”
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Kinase Inhibitor Pulldown Assay Identifies a Chemotherapy Response Signature in Triple-negative Breast Cancer Based on Purine-binding Proteins by Wang, Junkai, Saltzman, Alexander B, Jaehnig, Eric J, Lei, Jonathan T, Malovannaya, Anna, Holt, Matthew V, Young, Meggie N, Rimawi, Mothaffar F, Ademuyiwa, Foluso O, Anurag, Meenakshi, Kim, Beom-Jun, Ellis, Matthew J

“…Triple-negative breast cancer (TNBC) constitutes 10%-15% of all breast tumors. The current standard of care is multiagent chemotherapy, which is effective in…”
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Identification and characterization of a supraclavicular brown adipose tissue in mice by Mo, Qianxing, Salley, Jordan, Roshan, Tony, Baer, Lisa A, May, Francis J, Jaehnig, Eric J, Lehnig, Adam C, Guo, Xin, Tong, Qiang, Nuotio-Antar, Alli M, Shamsi, Farnaz, Tseng, Yu-Hua, Stanford, Kristin I, Chen, Miao-Hsueh

“…A fundamental challenge to our understanding of brown adipose tissue (BAT) is the lack of an animal model that faithfully represents human BAT. Such a model is…”
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Chemogenetic profiling identifies RAD17 as synthetically lethal with checkpoint kinase inhibition by Shen, John Paul, Srivas, Rohith, Gross, Andrew, Li, Jianfeng, Jaehnig, Eric J, Sun, Su Ming, Bojorquez-Gomez, Ana, Licon, Katherine, Sivaganesh, Vignesh, Xu, Jia L, Klepper, Kristin, Yeerna, Huwate, Pekin, Daniel, Qiu, Chu Ping, van Attikum, Haico, Sobol, Robert W, Ideker, Trey

“…Chemical inhibitors of the checkpoint kinases have shown promise in the treatment of cancer, yet their clinical utility may be limited by a lack of molecular…”
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Increased Susceptibility to Isoproterenol-Induced Cardiac Hypertrophy and Impaired Weight Gain in Mice Lacking the Histidine-Rich Calcium-Binding Protein by Jaehnig, Eric J., Heidt, Analeah B., Greene, Stephanie B., Cornelissen, Ivo, Black, Brian L.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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HRC Is a Direct Transcriptional Target of MEF2 during Cardiac, Skeletal, and Arterial Smooth Muscle Development In Vivo by Anderson, Joshua P., Dodou, Evdokia, Heidt, Analeah B., De Val, Sarah J., Jaehnig, Eric J., Greene, Stephanie B., Olson, Eric N., Black, Brian L.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Abstract 4385: Proteogenomics-driven synthetic lethality discovery to predict targetable protein dependencies induced by somatic deletions by Lei, Jonathan T., Jaehnig, Eric, Zhang, Bing

“…Abstract Computational prediction of synthetic lethality has been shown as a promising approach to identify therapeutic vulnerabilities in many cancer types…”
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Proteogenomic and metabolomic characterization of human glioblastoma by Gritsenko, Marina A., Kyle, Jennifer E., Cao, Song, Rykunov, Dmitry, Cornwell, MacIntosh, Petralia, Francesca, Wu, Yige, Reva, Boris, Kawaler, Emily, Olsen, Lindsey K., Liang, Wen-Wei, Wendl, Michael C., Caravan, Wagma, Ji, Jiayi, Petyuk, Vladislav A., Moon, Jamie, Moore, Ronald J., Krek, Azra, Zhu, Houxiang, McMichael, Joshua F., Lu, Shuangjia, Baral, Jessika, Yao, Lijun, Zink, Erika, Bloodsworth, Kent J., Satpathy, Shankha, Boca, Simina M., Chen, Feng, Ketchum, Karen A., Boja, Emily S., Hiltke, Tara, Mani, D.R., Chen, Xi S., Li, Qing Kay, Kim, Albert H., Fenyö, David, Mesri, Mehdi, Resnick, Adam C., Wang, Pei, Chheda, Milan G., Barnholtz-Sloan, Jill S., Rodland, Karin D., Liu, Tao, Ding, Li, Bauer, Thomas, Borucki, Melissa, Burke, Meghan C., Cai, Shuang, Calinawan, Anna P., Carr, Steven A., Chan, Daniel W., Charamut, Alyssa, Chesla, David, Chowdhury, Shrabanti, Cieślik, Marcin P., Culpepper, Houston, Demir, Emek, Dhir, Rajiv, Duffy, Elizabeth, Edwards, Robert, Gabriel, Stacey, Gabrovski, Nikolay, Garofano, Luciano, Gillette, Michael A., Hannick, Linda I., Hindenach, Barbara, Hoadley, Katherine A., Hostetter, Galen, Huang, Chen, Jaehnig, Eric, Ji, Nan, Jones, Corbin D., Kaspera, Wojciech, Lei, Jonathan, Li, Kai, Liu, Hongwei, Lubínski, Jan, Malc, Ewa, Malovannaya, Anna, McGarvey, Peter B., McGee, John, Mieczkowski, Piotr, Modugno, Francesmary, Ozbek, Umut, Paulovich, Amanda G., Piehowski, Paul D., Polonskaya, Larisa, Pruetz, Barbara, Ramkissoon, Shakti, Riggins, Gregory, Stawicki, Jakub, Tabor, Dave, Tansil, Darlene, Traer, Elie, Vatanian, Negin, Webster, Alex, Wen, Bo, Whiteaker, Jeffrey R., Zhang, Liwei, Zhao, Grace

“…Glioblastoma (GBM) is the most aggressive nervous system cancer. Understanding its molecular pathogenesis is crucial to improving diagnosis and treatment…”
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Abstract 5467: Outlier analysis to identify determinants of therapeutic resistance in breast cancer by Jaehnig, Eric James, Anurag, Meenakshi, Lei, Jonathan T., Zhang, Bing

“…Abstract Tumors are typically characterized by variable responses to targeted therapy driven by the heterogeneity of drivers among tumors. Inter-tumor…”
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