Search Results - "Jaeger, Mariane"

A logical model of Ewing sarcoma cell epithelial-to-mesenchymal transition supports the existence of hybrid cellular phenotypes by Silveira, Daner A, Gupta, Shantanu, da Cunha Jaeger, Mariane, Brunetto de Farias, Caroline, Mombach, José Carlos Merino, Sinigaglia, Marialva

“…Ewing sarcoma (ES) is a highly aggressive pediatric tumor driven by the RNA-binding protein EWS (EWS)/friend leukemia integration 1 transcription factor (FLI1)…”
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HDAC and MAPK/ERK Inhibitors Cooperate To Reduce Viability and Stemness in Medulloblastoma by da Cunha Jaeger, Mariane, Ghisleni, Eduarda Chiesa, Cardoso, Paula Schoproni, Siniglaglia, Marialva, Falcon, Tiago, Brunetto, André T., Brunetto, Algemir L., de Farias, Caroline Brunetto, Taylor, Michael D., Nör, Carolina, Ramaswamy, Vijay, Roesler, Rafael

“…Medulloblastoma (MB), which originates from embryonic neural stem cells (NSCs) or neural precursors in the developing cerebellum, is the most common malignant…”
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Oncogenic functions of ZEB1 in pediatric solid cancers: interplays with microRNAs and long noncoding RNAs by Fratini, Lívia, Jaeger, Mariane, de Farias, Caroline Brunetto, Brunetto, André T., Brunetto, Algemir L., Shaw, Lisa, Roesler, Rafael

“…The transcription factor Zinc finger E-box binding 1 (ZEB1) displays a range of regulatory activities in cell function and embryonic development, including…”
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EHMT2/G9a as an Epigenetic Target in Pediatric and Adult Brain Tumors by Souza, Barbara Kunzler, Freire, Natalia Hogetop, Jaeger, Mariane, de Farias, Caroline Brunetto, Brunetto, Algemir L, Brunetto, André T, Roesler, Rafael

“…Epigenetic mechanisms, including post-translational modifications of DNA and histones that influence chromatin structure, regulate gene expression during…”
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Cancer Stem Cells and Chemoresistance in Ewing Sarcoma by Dos Santos, Rafael Pereira, Roesler, Rafael, Gregianin, Lauro, Brunetto, André T, da Cunha Jaeger, Mariane, Lunardi Brunetto, Algemir, de Farias, Caroline Brunetto

“…Resistance to chemotherapy poses a major challenge for cancer treatment. Reactivating a stem cell program resembling that seen in embryonic development can…”
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Modulation of Viability, Proliferation, and Stemness by Rosmarinic Acid in Medulloblastoma Cells: Involvement of HDACs and EGFR by Laschuk Herlinger, Alice, Lovatto Michaelsen, Gustavo, Sinigaglia, Marialva, Fratini, Lívia, Nogueira Debom, Gabriela, Braganhol, Elizandra, Brunetto de Farias, Caroline, Lunardi Brunetto, Algemir, Tesainer Brunetto, André, da Cunha Jaeger, Mariane, Roesler, Rafael

“…Medulloblastoma (MB) is a heterogeneous group of malignant pediatric brain tumors, divided into molecular groups with distinct biological features and…”
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Histone Methyltransferases G9a/Ehmt2 and GLP/Ehmt1 Are Associated with Cell Viability and Poorer Prognosis in Neuroblastoma and Ewing Sarcoma by Souza, Barbara Kunzler, Freire, Natalia Hogetop, Monteiro, Thiago Santos, Herlinger, Alice Laschuk, Jaeger, Mariane, Dalmolin, Matheus G. S., de Farias, Caroline Brunetto, Gregianin, Lauro, Brunetto, André T., Brunetto, Algemir L., Thiele, Carol J., Roesler, Rafael

“…Changes in epigenetic programming have been proposed as being key events in the initiation and progression of childhood cancers. HMT euchromatic histone lysine…”
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Convergence of BMI1 and CHD7 on ERK Signaling in Medulloblastoma by Badodi, Sara, Dubuc, Adrian, Zhang, Xinyu, Rosser, Gabriel, Da Cunha Jaeger, Mariane, Kameda-Smith, Michelle M., Morrissy, Anca Sorana, Guilhamon, Paul, Suetterlin, Philipp, Li, Xiao-Nan, Guglielmi, Loredana, Merve, Ashirwad, Farooq, Hamza, Lupien, Mathieu, Singh, Sheila K., Basson, M. Albert, Taylor, Michael D., Marino, Silvia

“…We describe molecular convergence between BMI1 and CHD7 in the initiation of medulloblastoma. Identified in a functional genomic screen in mouse models, a…”
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Reverse Engineering of Ewing Sarcoma Regulatory Network Uncovers PAX7 and RUNX3 as Master Regulators Associated with Good Prognosis by Ribeiro-Dantas, Marcel da Câmara, Oliveira Imparato, Danilo, Dalmolin, Matheus Gibeke Siqueira, de Farias, Caroline Brunetto, Brunetto, André Tesainer, da Cunha Jaeger, Mariane, Roesler, Rafael, Sinigaglia, Marialva, Siqueira Dalmolin, Rodrigo Juliani

“…Ewing Sarcoma (ES) is a rare malignant tumor occurring most frequently in adolescents and young adults. The ES hallmark is a chromosomal translocation between…”
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Stemness and Cell Cycle Regulators and Their Modulation by Retinoic Acid in Ewing Sarcoma by Battistella, Maria Eduarda, Freire, Natália Hogetop, Toson, Bruno, Dalmolin, Matheus, Fernandes, Marcelo A C, Tassinari, Isadora D, Jaeger, Mariane, Brunetto, André T, Brunetto, Algemir L, Gregianin, Lauro, de Farias, Caroline Brunetto, Roesler, Rafael

“…Retinoic acid (RA) regulates stemness and differentiation in human embryonic stem cells (ESCs). Ewing sarcoma (ES) is a pediatric tumor that may arise from the…”
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Histone Deacetylase Inhibitors in Pediatric Brain Cancers: Biological Activities and Therapeutic Potential by Perla, Alexandre, Fratini, Lívia, Cardoso, Paula S., Nör, Carolina, Brunetto, André T., Brunetto, Algemir L., de Farias, Caroline Brunetto, Jaeger, Mariane, Roesler, Rafael

“…Brain cancers are the leading cause of cancer-related deaths in children. Biological changes in these tumors likely include epigenetic deregulation during…”
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Antitumor Activities and Cellular Changes Induced by TrkB Inhibition in Medulloblastoma by Thomaz, Amanda, Pinheiro, Kelly de Vargas, Souza, Bárbara Kunzler, Gregianin, Lauro, Brunetto, Algemir L, Brunetto, André T, de Farias, Caroline Brunetto, Jaeger, Mariane da Cunha, Ramaswamy, Vijay, Nör, Carolina, Taylor, Michael D, Roesler, Rafael

“…Neurotrophins are critically involved in regulating normal neural development and plasticity. Brain-derived neurotrophic factor (BDNF), a neurotrophin that…”
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Expression and pharmacological inhibition of TrkB and EGFR in glioblastoma by Pinheiro, Kelly V., Thomaz, Amanda, Souza, Bárbara Kunzler, Metcalfe, Victoria Anne, Freire, Natália Hogetop, Brunetto, André Tesainer, de Farias, Caroline Brunetto, Jaeger, Mariane, Bambini, Victorio, Smith, Christopher G. S., Shaw, Lisa, Roesler, Rafael

“…A member of the Trk family of neurotrophin receptors, tropomyosin receptor kinase B (TrkB, encoded by the NTRK2 gene) is an increasingly important target in…”
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Olfactory and respiratory lamina propria transplantation after spinal cord transection in rats: Effects on functional recovery and axonal regeneration by Centenaro, Lígia Aline, Jaeger, Mariane da Cunha, Ilha, Jocemar, de Souza, Marcelo Alves, Kalil-Gaspar, Pedro Ivo, Cunha, Núbia Broetto, Marcuzzo, Simone, Achaval, Matilde

“…Abstract Spinal cord injury (SCI) has very poor clinical prospects, resulting in irreversible loss of function below the injury site. Although applied in…”
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Implications of Olfactory Lamina Propria Transplantation on Hyperreflexia and Myelinated Fiber Regeneration in Rats with Complete Spinal Cord Transection by Centenaro, Lígia Aline, da Cunha Jaeger, Mariane, Ilha, Jocemar, de Souza, Marcelo Alves, Balbinot, Luciane Fachin, do Nascimento, Patrícia Severo, Marcuzzo, Simone, Achaval, Matilde

“…Transplantation with olfactory ensheathing cells (OECs) has been adopted after several models of spinal cord injury (SCI) with the purpose of creating a…”
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The Beneficial Effects of Treadmill Step Training on Activity-Dependent Synaptic and Cellular Plasticity Markers After Complete Spinal Cord Injury by Ilha, Jocemar, Centenaro, Lígia A., Broetto Cunha, Núbia, de Souza, Daniela F., Jaeger, Mariane, do Nascimento, Patrícia S., Kolling, Janaína, Ben, Juliana, Marcuzzo, Simone, Wyse, Angela T. S., Gottfried, Carmem, Achaval, Matilde

“…Several studies have shown that treadmill training improves neurological outcomes and promotes plasticity in lumbar spinal cord of spinal animals. The…”
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Treadmill step training-induced adaptive muscular plasticity in a chronic paraplegia model by Ilha, Jocemar, da Cunha, Núbia B., Jaeger, Mariane, de Souza, Daniela F., Nascimento, Patrícia S. do, Marcuzzo, Simone, Figueiró, Micheli, Gottfried, Carmem, Achaval, Matilde

“…► SCI causes severe skeletal muscle atrophy in soleus. ► Step training promotes partial recovery the muscular atrophy in chronic paralyzed soleus muscle. ► The…”
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Toll-like Receptors 2, 3, and 4 in Childhood Acute Lymphocytic Leukemia by Cruz, Matheus Loureiro da Silva, Santos, Rafael Pereira dos, Souza, Barbara Kunzler, Jaeger, Mariane da Cunha, Silva, Camila Alves da, Gregianin, Lauro José, Loss, Jiseh Fagundes, Marques, Rebeca Ferreira, Brunetto, Algemir Lunardi, Brunetto, André Tesainer, Roesler, Rafael, Farias, Caroline Brunetto de

“…Introduction: Acute lymphocytic leukemia (ALL) is the most common cancer type in children and accounts for 80% of pediatric leukemias. Novel targets are…”
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Primary cells derived from Tuberous Sclerosis Complex patients show autophagy alteration in the haploinsufficiency state by Rosset, Clévia, Jaeger, Mariane da Cunha, Filippi-Chiela, Eduardo, Reis, Larissa Brussa, Sartor, Ivaine Taís Sauthier, Oliveira Netto, Cristina Brinckmann, Farias, Caroline Brunetto de, Roesler, Rafael, Ashton-Prolla, Patricia

“…Tuberous sclerosis complex (TSC) is an autosomal dominant cancer predisposition disorder caused by heterozygous mutations in TSC1 or TSC2 genes and…”
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Targeting the epigenome of cancer stem cells in pediatric nervous system tumors by Freire, Natália Hogetop, Jaeger, Mariane da Cunha, de Farias, Caroline Brunetto, Nör, Carolina, Souza, Barbara Kunzler, Gregianin, Lauro, Brunetto, André Tesainer, Roesler, Rafael

“…Medulloblastoma, neuroblastoma, and pediatric glioma account for almost 30% of all cases of pediatric cancers. Recent evidence indicates that pediatric nervous…”
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