Search Results - "Jae-Kyung Jung"

Anti-Inflammatory and Anti-Migratory Activities of Isoquinoline-1-Carboxamide Derivatives in LPS-Treated BV2 Microglial Cells via Inhibition of MAPKs/NF-κB Pathway by Do, Ha Thi Thu, Bui, Bich Phuong, Sim, Seongrak, Jung, Jae-Kyung, Lee, Heesoon, Cho, Jungsook

“…Eleven novel isoquinoline-1-carboxamides (HSR1101~1111) were synthesized and evaluated for their effects on lipopolysaccharide (LPS)-induced production of…”
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Organocatalytic and Regiodivergent Mannich Reaction of Ketones with Benzoxazinones by Viji, Mayavan, Sim, Jaeuk, Li, Siyuan, Lee, Heesoon, Oh, Kyungsoo, Jung, Jae‐Kyung

“…Abstract In this study, we have developed solvent‐controlled regioselective Mannich reaction of cyclicimines (benzoxazinones) with various ketones by using…”
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Microwave-Promoted Total Synthesis of Puniceloid D for Modulating the Liver X Receptor by Jung, Young Jin, Hosseininasab, Narges, Park, Jungjin, Hyun, Soonsil, Jung, Jae-Kyung, Kwak, Jae-Hwan

“…A growing global health concern is metabolic syndrome, which is defined by low HDL, diabetes, hypertension, and abdominal obesity. Nuclear receptors are…”
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K284-6111 prevents the amyloid beta-induced neuroinflammation and impairment of recognition memory through inhibition of NF-κB-mediated CHI3L1 expression by Choi, Ji Yeon, Yeo, In Jun, Kim, Ki Cheon, Choi, Won Rack, Jung, Jae-Kyung, Han, Sang-Bae, Hong, Jin Tae

“…Alzheimer's disease, which is pathologically characterized by an excessive accumulation of amyloid beta (Aβ) fibrils, is a degenerative brain disease and the…”
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Microwave-Mediated, Catalyst-Free Synthesis of 1,2,4-Triazolo[1,5- a ]pyridines from Enaminonitriles by Lee, Kwanghee, Kim, Young-Ah, Jung, Chanhyun, Sim, Jaeuk, Rajasekar, Shanmugam, Kwak, Jae-Hwan, Viji, Mayavan, Jung, Jae-Kyung

“…A catalyst-free, additive-free, and eco-friendly method for synthesizing 1,2,4-triazolo[1,5- ]pyridines under microwave conditions has been established. This…”
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γ‐Functionalization of α,β‐Unsaturated Nitriles under Mild Conditions: Versatile Synthesis of 4‐Aryl‐2‐Bromopyridines by Sim, Jaeuk, Viji, Mayavan, Rhee, Jeongtae, Jo, Hyeju, Cho, Suk Joon, Park, Yunjeong, Seo, Seung‐Yong, Jung, Kwan‐Young, Lee, Heesoon, Jung, Jae‐Kyung

“…This report describes the synthesis of 4‐aryl‐2‐halopyridines via γ‐functionalization of α,β‐unsaturated nitriles, which were obtained by the HWE reaction with…”
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A small molecule targeting CHI3L1 inhibits lung metastasis by blocking IL‐13Rα2‐mediated JNK‐AP‐1 signals by Lee, Yong Sun, Yu, Ji Eun, Kim, Ki Cheon, Lee, Dong Hun, Son, Dong Ju, Lee, Hee Pom, Jung, Jae‐kyung, Kim, Nam Du, Ham, Young Wan, Yun, Jaesuk, Han, Sang‐Bae, Hong, Jin Tae

“…Our previous big data analyses showed a high level of association between chitinase 3 like1 (CHI3L1) expression and lung tumor development. In the present…”
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Rapid, Operationally Simple, and Metal‐free NBS Mediated One‐pot Synthesis of 1,2‐Naphthoquinone from 2‐Naphthol by Sim, Jaeuk, Jo, Hyeju, Viji, Mayavan, Choi, Minho, Jung, Jin‐Ah, Lee, Heesoon, Jung, Jae‐Kyung

“…A metal‐free, one‐pot synthesis of 1,2‐naphthoquinone was accomplished from 2‐naphthol by utilizing economically cheap NBS under open air conditions. Initial…”
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Neurotrophic isoindolinones from the fruiting bodies of Hericium erinaceus by Ryu, Se Hwan, Hong, Seong Min, Khan, Zahra, Lee, Seul Ki, Vishwanath, Manjunatha, Turk, Ayman, Yeon, Sang Won, Jo, Yang Hee, Lee, Dae Hee, Lee, Jae Kang, Hwang, Bang Yeon, Jung, Jae-Kyung, Kim, Sun Yeou, Lee, Mi Kyeong

“…[Display omitted] Four compounds, hericerin (1), isohericerinol A (2), N-de-phenylethyl isohericerin (3) and corallocin A (4) were isolated from the fruiting…”
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The p21-activated kinase 4-Slug transcription factor axis promotes epithelial−mesenchymal transition and worsens prognosis in prostate cancer by Park, Jung-Jin, Park, Mee-Hee, Oh, Eun Hye, Soung, Nak-Kyun, Lee, Soo Jae, Jung, Jae-Kyung, Lee, Ok-Jun, Yun, Seok Joong, Kim, Wun-Jae, Shin, Eun-Young, Kim, Eung-Gook

“…Epithelial−mesenchymal transition (EMT) facilitates cancer invasion and metastasis and thus accelerates cancer progression. p21-activated kinase 4 (PAK4) is a…”
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Total synthesis of agastaquinone, a diterpenoid quinone isolated from Agastache rugosa by Lee, Sangku, Yoo, Jisu, Jung, Jae-Kyung, Kim, Jae Nyoung, Yoon, Myeong Sik

“…Agastaquinone is a tricyclic diterpenoid isolated from Agastache rugose. The first total synthesis of agastaquinone was accomplished based on intramolecular…”
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Regiodivergent Organocatalytic Reactions by Mayavan Viji, Srinu Lanka, Jaeuk Sim, Chanhyun Jung, Heesoon Lee, Manjunatha Vishwanath, Jae-Kyung Jung

“…Organocatalysts are abundantly used for various transformations, particularly to obtain highly enantio- and diastereomeric pure products by controlling the…”
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Synthesis and anti-neuroinflammatory activity of N-heterocyclic analogs based on natural biphenyl-neolignan honokiol by Yuan, Yue, Subedi, Lalita, Lim, Daesung, Jung, Jae-Kyung, Kim, Sun Yeou, Seo, Seung-Yong

“…[Display omitted] •Isoxazole and pyrazole analogs in B ring of honokiol.•Isoxazole and pyrazole were constructed by nitrile oxide cycloaddition and…”
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Targeting phosphorylation circuits on CREB and CRTCs as the strategy to prevent acquired skin hyperpigmentation by Kim, Song-Hee, Na, Changseon, Yun, Cheng-Yong, Kim, Jun Gu, Baek, Seung Tae, An, Hyun Jin, Lee, Jae Duk, Lee, Seung Wha, Jung, Jae-Kyung, Hwang, Bang Yeon, Han, Sang-Bae, Kim, Youngoo

“…The cAMP response element-binding protein (CREB) and CREB-regulated transcription coactivators (CRTCs) cooperate in the transcriptional activation of…”
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Design, Synthesis, and Cytotoxicity and Topoisomerase I/IIα Inhibition Activity of Pyrazolo[4,3- f ]quinoline Derivatives by Chaudhary, Chhabi Lal, Ko, Seungyun, Lee, Chaerim, Kim, Yerin, Jung, Chanhyun, Hyun, Soonsil, Kwon, Youngjoo, Kang, Jong-Soon, Jung, Jae-Kyung, Lee, Heesoon

“…With the several targets of cancer treatment, inhibition of DNA topoisomerase activity is one of the well-known focuses in cancer chemotherapy. Here, we…”
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Metal-free approach for the ʟ-proline mediated synthesis of nitrones from nitrosobenzene by Choi, Minho, Viji, Mayavan, Kim, Donghwan, Lee, Young Hee, Sim, Jaeuk, Kwak, Young-Shin, Lee, Kiho, Lee, Heesoon, Jung, Jae-Kyung

“…An efficient, and metal-free approach for the ʟ-proline mediated synthesis of nitrones from nitrosobenzene and benzaldehydes has been established. The reaction…”
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Targeting IKKβ Activity to Limit Sterile Inflammation in Acetaminophen-Induced Hepatotoxicity in Mice by Kim, Song-Hee, Jung, Da-Eun, Song, Jin Yong, Jung, Jihye, Jung, Jae-Kyung, Lee, Heesoon, Roh, Eunmiri, Hong, Jin Tae, Han, Sang-Bae, Kim, Youngsoo

“…The kinase activity of inhibitory κB kinase β (IKKβ) acts as a signal transducer in the activating pathway of nuclear factor-κB (NF-κB), a master regulator of…”
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Recent Advances and Challenges in Controlling the Spatiotemporal Release of Combinatorial Anticancer Drugs from Nanoparticles by Yoon, Moon Sup, Lee, Yu Jin, Shin, Hee Ji, Park, Chun-Woong, Han, Sang-Bae, Jung, Jae-Kyung, Kim, Jin-Seok, Shin, Dae Hwan

“…To overcome cancer, various chemotherapeutic studies are in progress; among these, studies on nano-formulated combinatorial drugs (NFCDs) are being actively…”
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A Novel Way of Preventing Postoperative Pancreatic Fistula by Directly Injecting Profibrogenic Materials into the Pancreatic Parenchyma by Lee, Sang Chul, Hong, Tae Ho, Kim, Ok-Hee, Cho, Suk Joon, Kim, Kee-Hwan, Song, Jin Sook, Hwang, Kyu-Seok, Jung, Jae-Kyung, Hong, Ha-Eun, Seo, Haeyeon, Choi, Ho Joong, Ahn, Joseph, Lee, Tae Yoon, Rim, Eunyoung, Jung, Kwan-Young, Kim, Say-June

“…This paper aims to validate if intrapancreatic injection of penicillin G can enhance hardness and suture holding capacity (SHC) of the pancreas through…”
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Myeloid differentiation 2 as a therapeutic target of inflammatory disorders by Park, Sun Hong, Kim, Nam Doo, Jung, Jae-Kyung, Lee, Chong-Kil, Han, Sang-Bae, Kim, Youngsoo

“…Lipopolysaccharide (LPS), an endotoxin of Gram-negative bacteria, activates the innate immunity system through a receptor complex of myeloid differentiation 2…”
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