Search Results - "Jae-Gook Shin"

Clinical Implementation of Pharmacogenomics for Personalized Precision Medicine: Barriers and Solutions by Klein, Michelle E, Parvez, Md Masud, Shin, Jae-Gook

“…Clinical implementation of pharmacogenomics (PGx) leads to personalized medicine, which improves the efficacy, safety, and cost-effectiveness of treatments…”
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Comparison of multivariate linear regression and a machine learning algorithm developed for prediction of precision warfarin dosing in a Korean population by Nguyen, Van Lam, Nguyen, Hoang Dat, Cho, Yong‐Soon, Kim, Ho‐Sook, Han, Il‐Yong, Kim, Dae‐Kyeong, Ahn, Sangzin, Shin, Jae‐Gook

“…Background Personalized warfarin dosing is influenced by various factors including genetic and non‐genetic factors. Multiple linear regression (LR) is known as…”
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Pharmacokinetics of Single Doses of BI 425809 in Healthy Chinese and Japanese Subjects: A Randomized Study by Tsuda, Yasuhiro, Ugai, Hiroyuki, Wunderlich, Glen, Shin, Jae-Gook

“…This study's primary goal was to evaluate the safety profile, tolerability, pharmacokinetics, and dose proportionality of BI 425809, a potent and selective…”
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Pharmacokinetics and Pharmacodynamics of Tegoprazan Coadministered With Amoxicillin and Clarithromycin in Healthy Subjects by Ghim, Jong‐Lyul, Chin, May Chien, Jung, Jinah, Lee, Jiwon, Kim, Seokuee, Kim, Bongtae, Song, Geun Seog, Choi, Young‐Kyung, Shin, Jae‐Gook

“…This clinical trial was conducted to evaluate the pharmacokinetics and pharmacodynamics of tegoprazan when coadministered with amoxicillin/clarithromycin in…”
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Isoniazid Population Pharmacokinetics and Dose Recommendation for Korean Patients With Tuberculosis Based on Target Attainment Analysis by Cho, Yong‐Soon, Jang, Tae Won, Kim, Hyo‐Jung, Oh, Jee Youn, Lee, Hyun‐Kyung, Park, Hye Kyeong, Ghim, Jong‐Lyul, Long, Nguyen Phuoc, Park, Yumi, Choi, Young‐Kyung, Phuong, Nguyen Thi Thu, Shin, Jae‐Gook

“…The wide variability of isoniazid (INH) pharmacokinetics is mainly attributed to the trimodal N‐acetyltransferase 2 (NAT2) acetylator phenotype, that is,…”
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Prediction of Drug–Drug Interaction between Tacrolimus and Principal Ingredients of Wuzhi Capsule in Chinese Healthy Volunteers Using Physiologically‐Based Pharmacokinetic Modelling by Zhang, Hongyan, Bu, Fengjiao, Li, Lei, Jiao, Zheng, Ma, Guo, Cai, Weimin, Zhuang, Xiaomei, Lin, Hai‐Shu, Shin, Jae‐Gook, Xiang, Xiaoqiang

“…Schisantherin A and schisandrin A, the most abundant active ingredients of Wuzhi capsule, are known to inhibit tacrolimus metabolism by inhibiting CYP3A4/5. We…”
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Identification and functional characterization of CYP4V2 genetic variants exhibiting decreased activity of lauric acid metabolism by Jarrar, Yazun Bashir, Shin, Jae‐Gook, Lee, Su‐Jun

“…The objectives of the present study were to identify CYP4V2 genetic variants and characterize their functional consequences. A total of 26CYP4V2 genetic…”
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Comprehensive lipid and lipid-related gene investigations of host immune responses to characterize metabolism-centric biomarkers for pulmonary tuberculosis by Long, Nguyen Phuoc, Anh, Nguyen Ky, Yen, Nguyen Thi Hai, Phat, Nguyen Ky, Park, Seongoh, Thu, Vo Thuy Anh, Cho, Yong-Soon, Shin, Jae-Gook, Oh, Jee Youn, Kim, Dong Hyun

“…Despite remarkable success in the prevention and treatment of tuberculosis (TB), it remains one of the most devastating infectious diseases worldwide…”
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Warfarin pharmacogenetics: a single VKORC1 polymorphism is predictive of dose across 3 racial groups by Limdi, Nita A., Wadelius, Mia, Cavallari, Larisa, Eriksson, Niclas, Crawford, Dana C., Lee, Ming-Ta M., Chen, Chien-Hsiun, Motsinger-Reif, Alison, Sagreiya, Hersh, Liu, Nianjun, Wu, Alan H.B., Gage, Brian F., Jorgensen, Andrea, Pirmohamed, Munir, Shin, Jae-Gook, Suarez-Kurtz, Guilherme, Kimmel, Stephen E., Johnson, Julie A., Klein, Teri E., Wagner, Michael J.

“…Warfarin-dosing algorithms incorporating CYP2C9 and VKORC1 −1639G>A improve dose prediction compared with algorithms based solely on clinical and demographic…”
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A new population pharmacokinetic model for vancomycin in patients with variable renal function: Therapeutic drug monitoring based on extended covariate model using CKD‐EPI estimation by Kim, Dong‐Jin, Lee, Dong‐Hwan, Ahn, Sangzin, Jung, Jinah, Kiem, Sungmin, Kim, So Won, Shin, Jae‐Gook

“…What is known and objective Although patients may have received vancomycin therapy with therapeutic drug monitoring (TDM), those treated with high‐strength and…”
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Inhibitory Interaction Potential of 22 Antituberculosis Drugs on Organic Anion and Cation Transporters of the SLC22A Family by Parvez, M Masud, Kaisar, Nazia, Shin, Ho Jung, Jung, Jin Ah, Shin, Jae-Gook

“…Twenty-two currently marketed antituberculosis drugs were comprehensively evaluated for their inhibitory effect on organic anionic transporter (OAT)- and…”
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Molecular perturbations in pulmonary tuberculosis patients identified by pathway-level analysis of plasma metabolic features by Phuoc Long, Nguyen, Heo, Da Young, Park, Seongoh, Thi Hai Yen, Nguyen, Cho, Yong-Soon, Shin, Jae-Gook, Oh, Jee Youn, Kim, Dong-Hyun

“…Insight into the metabolic biosignature of tuberculosis (TB) may inform clinical care, reduce adverse effects, and facilitate metabolism-informed therapeutic…”
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Para‐aminosalicylic acid significantly reduced tenofovir exposure in human subjects: Mismatched findings from in vitro to in vivo translational research by Parvez, Md Masud, Kalkisim, Said, Nguyen, Phuong Thi Thu, Jung, Jin Ah, Park, Jeong‐Kon, Ghim, Jong‐Lyul, Kim, Eun‐Young, Cho, Yong‐Soon, Babaoglu, Melih O., Shin, Jae‐Gook

“…Aims Tenofovir and para‐aminosalicylic acid (PAS) may be coprescribed to treat patients with concomitant infections of human immunodeficiency virus and…”
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Identification and functional study of genetic polymorphisms in cyclic nucleotide phosphodiesterase 3A (PDE3A) by Kim, You Ran, Yi, MyeongJin, Cho, Sun‐Ah, Kim, Woo‐Young, Min, JungKi, Shin, Jae‐Gook, Lee, Su‐Jun

“…Phosphodiesterase 3A (PDE3A) is an enzyme that plays an important role in the regulation of cyclic adenosine monophosphate (cAMP)–mediated intracellular…”
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Comprehensive lipid profiles investigation reveals host metabolic and immune alterations during anti-tuberculosis treatment: Implications for therapeutic monitoring by Anh, Nguyen Ky, Phat, Nguyen Ky, Yen, Nguyen Thi Hai, Jayanti, Rannissa Puspita, Thu, Vo Thuy Anh, Park, Young Jin, Cho, Yong-Soon, Shin, Jae-Gook, Kim, Dong Hyun, Oh, Jee Youn, Long, Nguyen Phuoc

“…In this study, we investigated the lipidome of tuberculosis patients during standard chemotherapy to discover biosignatures that could aid therapeutic…”
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Physiologically Based Pharmacokinetic Modeling Approach to Predict Drug‐Drug Interactions With Ethionamide Involving Impact of Genetic Polymorphism on FMO3 by Nguyen, Phuong Thi Thu, Parvez, Md Masud, Kim, Min Jung, Yoo, Sung Eun, Ahn, Sangzin, Ghim, Jong‐Lyul, Shin, Jae‐Gook

“…The widely used second‐line antituberculosis drug ethionamide shows wide interindividual variability in its disposition; however, the relevant factors…”
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Effect of rifampin on enantioselective disposition and anti‐hypertensive effect of benidipine by Sunwoo, Yu Eun, Nguyen, Phuong Thi Thu, Chien, Chin May, Ryu, Ji Young, Shon, Jihong, Shin, Jae‐Gook

“…Aims In vitro study showed that benidipine is exclusively metabolized by cytochrome P450 (CYP) 3A. This study evaluated the effect of rifampin on the…”
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Characterization of 22 Antituberculosis Drugs for Inhibitory Interaction Potential on Organic Anionic Transporter Polypeptide (OATP)-Mediated Uptake by Parvez, M Masud, Jung, Jin Ah, Shin, Ho Jung, Kim, Dong Hyun, Shin, Jae-Gook

“…We investigated the inhibitory interaction potential of 22 currently marketed antituberculosis (TB) drugs on organic anion-transporting polypeptide 1B1…”
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Quantitative Analysis of Isoniazid and Its Four Primary Metabolites in Plasma of Tuberculosis Patients Using LC-MS/MS by Ky Anh, Nguyen, My Tung, Pham, Kim, Min Jung, Phuoc Long, Nguyen, Cho, Yong-Soon, Kim, Dong-Hyun, Shin, Jae-Gook

“…Isoniazid and its metabolites are potentially associated with hepatotoxicity and treatment outcomes in patients who receive antituberculosis (TB) therapy. To…”
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Development of population pharmacokinetics model of isoniazid in Indonesian patients with tuberculosis by Soedarsono, Soedarsono, Jayanti, Rannissa Puspita, Mertaniasih, Ni Made, Kusmiati, Tutik, Permatasari, Ariani, Indrawanto, Dwi Wahyu, Charisma, Anita Nur, Yuliwulandari, Rika, Long, Nguyen Phuoc, Choi, Young-Kyung, Hoa, Pham Quang, Hoa, Pham Vinh, Cho, Yong-Soon, Shin, Jae-Gook

“…•This study reports the first population pharmacokinetics (PK) model for isoniazid (INH) in Indonesian patients with tuberculosis (TB).•The PK of INH in this…”
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