Search Results - "Jadhav, Unmesh"

Epigenetic Regulation of Intestinal Stem Cells and Disease: A Balancing Act of DNA and Histone Methylation by Lorzadeh, Alireza, Romero-Wolf, Maile, Goel, Ajay, Jadhav, Unmesh

“…Genetic mutations or regulatory failures underlie cellular malfunction in many diseases, including colorectal cancer and inflammatory bowel diseases. However,…”
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Replicational Dilution of H3K27me3 in Mammalian Cells and the Role of Poised Promoters by Jadhav, Unmesh, Manieri, Elisa, Nalapareddy, Kodandaramireddy, Madha, Shariq, Chakrabarti, Shaon, Wucherpfennig, Kai, Barefoot, Megan, Shivdasani, Ramesh A.

“…Polycomb repressive complex 2 (PRC2) places H3K27me3 at developmental genes and is causally implicated in keeping bivalent genes silent. It is unclear if that…”
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Acquired Tissue-Specific Promoter Bivalency Is a Basis for PRC2 Necessity in Adult Cells by Jadhav, Unmesh, Nalapareddy, Kodandaramireddy, Saxena, Madhurima, O’Neill, Nicholas K., Pinello, Luca, Yuan, Guo-Cheng, Orkin, Stuart H., Shivdasani, Ramesh A.

“…Bivalent promoters in embryonic stem cells (ESCs) carry methylation marks on two lysine residues, K4 and K27, in histone3 (H3). K4me2/3 is generally considered…”
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Extensive Recovery of Embryonic Enhancer and Gene Memory Stored in Hypomethylated Enhancer DNA by Jadhav, Unmesh, Cavazza, Alessia, Banerjee, Kushal K., Xie, Huafeng, O’Neill, Nicholas K., Saenz-Vash, Veronica, Herbert, Zachary, Madha, Shariq, Orkin, Stuart H., Zhai, Huili, Shivdasani, Ramesh A.

“…Developing and adult tissues use different cis-regulatory elements. Although DNA at some decommissioned embryonic enhancers is hypomethylated in adult cells,…”
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Creb5 establishes the competence for Prg4 expression in articular cartilage by Zhang, Cheng-Hai, Gao, Yao, Jadhav, Unmesh, Hung, Han-Hwa, Holton, Kristina M., Grodzinsky, Alan J., Shivdasani, Ramesh A., Lassar, Andrew B.

“…A hallmark of cells comprising the superficial zone of articular cartilage is their expression of lubricin, encoded by the Prg4 gene, that lubricates the joint…”
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Single-Cell Transcript Profiles Reveal Multilineage Priming in Early Progenitors Derived from Lgr5+ Intestinal Stem Cells by Kim, Tae-Hee, Saadatpour, Assieh, Guo, Guoji, Saxena, Madhurima, Cavazza, Alessia, Desai, Niyati, Jadhav, Unmesh, Jiang, Lan, Rivera, Miguel N., Orkin, Stuart H., Yuan, Guo-Cheng, Shivdasani, Ramesh A.

“…Lgr5+ intestinal stem cells (ISCs) drive epithelial self-renewal, and their immediate progeny—intestinal bipotential progenitors—produce absorptive and…”
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Response of neuroblastoma cells to ionizing radiation : Modulation of in vitro invasiveness and angiogenesis of human microvascular endothelial cells by JADHAV, Unmesh, MOHANAM, Sanjeeva

“…Neuroblastomas are the most common extra-cranial tumors of childhood and well known for their heterogeneous clinical behavior associated with certain genetic…”
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Natural Selection, Crypt Fitness, and Pol III Dependency in the Intestine by Jadhav, Unmesh, PhD, Shivdasani, Ramesh A., MD, PhD

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Inhibition of matrix metalloproteinase-9 reduces in vitro invasion and angiogenesis in human microvascular endothelial cells by Jadhav, Unmesh, Chigurupati, Srinivasulu, Lakka, Sajani S, Mohanam, Sanjeeva

“…The expression of matrix metalloproteinases (MMPs), particularly MMP-9, is significantly increased during tumor progression and is thought to play a major role…”
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Dietary Isothiocyanate Iberin Inhibits Growth and Induces Apoptosis in Human Glioblastoma Cells by Jadhav, Unmesh, Ezhilarasan, Ravesanker, Smith, Steven F., Smith, Mark A., Mohanam, Sanjeeva

“…In this study, we evaluated the antiproliferative and proapoptotic effects of the isothiocyanate iberin, a bioactive agent in Brassicaceae species, in human…”
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Ascl2-Dependent Cell Dedifferentiation Drives Regeneration of Ablated Intestinal Stem Cells by Murata, Kazutaka, Jadhav, Unmesh, Madha, Shariq, van Es, Johan, Dean, Justin, Cavazza, Alessia, Wucherpfennig, Kai, Michor, Franziska, Clevers, Hans, Shivdasani, Ramesh A.

“…Ablation of LGR5+ intestinal stem cells (ISCs) is associated with rapid restoration of the ISC compartment. Different intestinal crypt populations…”
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Dynamic Reorganization of Chromatin Accessibility Signatures during Dedifferentiation of Secretory Precursors into Lgr5+ Intestinal Stem Cells by Jadhav, Unmesh, Saxena, Madhurima, O’Neill, Nicholas K., Saadatpour, Assieh, Yuan, Guo-Cheng, Herbert, Zachary, Murata, Kazutaka, Shivdasani, Ramesh A.

“…Replicating Lgr5+ stem cells and quiescent Bmi1+ cells behave as intestinal stem cells (ISCs) in vivo. Disrupting Lgr5+ ISCs triggers epithelial renewal from…”
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Dissecting Cell Lineages: From Microscope to Kaleidoscope by Jadhav, Unmesh, Shivdasani, Ramesh A.

“…Single-cell transcriptomics coupled with dynamic two-color fluorescence are used by Gehart et al. (2019) to elucidate adult mammalian cell trajectories in real…”
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Abstract 2456: Distinct metabolic dependencies in pancreatic cancer by Kalaany, Nada, Lee, Min-Sik, Dennis, Courtney, Lorzadeh, Alireza, Hoffman, Megan, Mino-Kenudson, Mari, Dougan, Stephanie, Jadhav, Unmesh, Clish, Clary

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Ornithine aminotransferase supports polyamine synthesis in pancreatic cancer by Lee, Min-Sik, Dennis, Courtney, Naqvi, Insia, Dailey, Lucas, Lorzadeh, Alireza, Ye, George, Zaytouni, Tamara, Adler, Ashley, Hitchcock, Daniel S., Lin, Lin, Hoffman, Megan T., Bhuiyan, Aladdin M., Barth, Jaimie L., Machacek, Miranda E., Mino-Kenudson, Mari, Dougan, Stephanie K., Jadhav, Unmesh, Clish, Clary B., Kalaany, Nada Y.

“…There is a need to develop effective therapies for pancreatic ductal adenocarcinoma (PDA), a highly lethal malignancy with increasing incidence 1 and poor…”
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Hypogonadotropic hypogonadism in subjects with DAX1 mutations by Jadhav, Unmesh, Harris, Rebecca M., Jameson, J. Larry

“…► In humans, mutations in DAX1 cause adrenal hypoplasia congenita and hypogonadotropic hypogonadism. ► Hypogonadotropic hypogonadism involves a combined…”
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Abstract PO-028: Pancreatic ductal adenocarcinoma is dependent on an unconventional pathway for polyamine synthesis by Lee, Min-Sik, Naqvi, Insia, Dennis, Courtney, Dailey, Lucas, Lorzadeh, Alireza, Zaytouni, Tamara, Adler, Ashley, Hitchcock, Daniel S., Lin, Lin, Jadhav, Unmesh, Clish, Clary B., Kalaany, Nada Y.

“…Abstract Targeting altered metabolism in pancreatic ductal adenocarcinoma (PDAC) has been an area of extensive investigation for over a decade now. A major…”
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Steroidogenic Factor-1 (SF-1)-Driven Differentiation of Murine Embryonic Stem (ES) Cells into a Gonadal Lineage by Jadhav, Unmesh, Jameson, J. Larry

“…Steroidogenic factor 1 (SF-1) is essential for the development and function of steroidogenic tissues. Stable incorporation of SF-1 into embryonic stem cells…”
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Transcription factor-dependent 'anti-repressive' mammalian enhancers exclude H3K27me3 from extended genomic domains by Saxena, Madhurima, Roman, Adrianna K San, O'Neill, Nicholas K, Sulahian, Rita, Jadhav, Unmesh, Shivdasani, Ramesh A

“…Compacted chromatin and nucleosomes are known barriers to gene expression; the nature and relative importance of other transcriptional constraints remain…”
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Adaptation of pancreatic cancer cells to nutrient deprivation is reversible and requires glutamine synthetase stabilization by mTORC1 by Tsai, Pei-Yun, Lee, Min-Sik, Jadhav, Unmesh, Naqvi, Insia, Madha, Shariq, Adler, Ashley, Mistry, Meeta, Naumenko, Sergey, Lewis, Caroline A., Hitchcock, Daniel S., Roberts, Frederick R., DelNero, Peter, Hank, Thomas, Honselmann, Kim C., Oyarvide, Vicente Morales, Mino-Kenudson, Mari, Clish, Clary B., Shivdasani, Ramesh A., Kalaany, Nada Y.

“…Pancreatic ductal adenocarcinoma (PDA) is a lethal, therapy-resistant cancer that thrives in a highly desmoplastic, nutrient-deprived microenvironment. Several…”
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