Search Results - "Jadhav, Rohit R."

Arachidonic acid-regulated calcium signaling in T cells from patients with rheumatoid arthritis promotes synovial inflammation by Ye, Zhongde, Shen, Yi, Jin, Ke, Qiu, Jingtao, Hu, Bin, Jadhav, Rohit R., Sheth, Khushboo, Weyand, Cornelia M., Goronzy, Jörg J.

“…Rheumatoid arthritis (RA) and psoriatic arthritis (PsA) are two distinct autoimmune diseases that manifest with chronic synovial inflammation. Here, we show…”
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Regulation of miR-181a expression in T cell aging by Ye, Zhongde, Li, Guangjin, Kim, Chulwoo, Hu, Bin, Jadhav, Rohit R., Weyand, Cornelia M., Goronzy, Jörg J.

“…MicroRNAs have emerged as key regulators in T cell development, activation, and differentiation, with miR-181a having a prominent function. By targeting…”
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Activation of miR-21-Regulated Pathways in Immune Aging Selects against Signatures Characteristic of Memory T Cells by Kim, Chulwoo, Hu, Bin, Jadhav, Rohit R., Jin, Jun, Zhang, Huimin, Cavanagh, Mary M., Akondy, Rama S., Ahmed, Rafi, Weyand, Cornelia M., Goronzy, Jörg J.

“…Induction of protective vaccine responses, governed by the successful generation of antigen-specific antibodies and long-lived memory T cells, is increasingly…”
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Distinct Age-Related Epigenetic Signatures in CD4 and CD8 T Cells by Hu, Bin, Jadhav, Rohit R, Gustafson, Claire E, Le Saux, Sabine, Ye, Zhongde, Li, Xuanying, Tian, Lu, Weyand, Cornelia M, Goronzy, Jörg J

“…Healthy immune aging is in part determined by how well the sizes of naïve T cell compartments are being maintained with advancing age. Throughout adult life,…”
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Single-cell analysis of circulating tumor cells identifies cumulative expression patterns of EMT-related genes in metastatic prostate cancer by Chen, Chun-Liang, Mahalingam, Devalingam, Osmulski, Pawel, Jadhav, Rohit R., Wang, Chiou-Miin, Leach, Robin J., Chang, Tien-Cheng, Weitman, Steven D., Kumar, Addanki Pratap, Sun, LuZhe, Gaczynska, Maria E., Thompson, Ian M., Huang, Tim Hui-Ming

“…BACKGROUND Prostate tumors shed circulating tumor cells (CTCs) into the blood stream. Increased evidence shows that CTCs are often present in metastatic…”
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TRIB2 safeguards naive T cell homeostasis during aging by Cao, Wenqiang, Sturmlechner, Ines, Zhang, Huimin, Jin, Jun, Hu, Bin, Jadhav, Rohit R., Fang, Fengqin, Weyand, Cornelia M., Goronzy, Jörg J.

“…Naive CD4+ T cells are more resistant to age-related loss than naive CD8+ T cells, suggesting mechanisms that preferentially protect naive CD4+ T cells during…”
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Defects in Antiviral T Cell Responses Inflicted by Aging-Associated miR-181a Deficiency by Kim, Chulwoo, Jadhav, Rohit R., Gustafson, Claire E., Smithey, Megan J., Hirsch, Alec J., Uhrlaub, Jennifer L., Hildebrand, William H., Nikolich-Žugich, Janko, Weyand, Cornelia M., Goronzy, Jörg J.

“…Generation of protective immunity to infections and vaccinations declines with age. Studies in healthy individuals have implicated reduced miR-181a expression…”
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Corrigendum: Distinct Age-Related Epigenetic Signatures in CD4 and CD8 T Cells by Hu, Bin, Jadhav, Rohit R, Gustafson, Claire E, Le Saux, Sabine, Ye, Zhongde, Li, Xuanying, Tian, Lu, Weyand, Cornelia M, Goronzy, Jörg J

“…[This corrects the article DOI: 10.3389/fimmu.2020.585168.]…”
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Reduced chromatin accessibility to CD4 T cell super-enhancers encompassing susceptibility loci of rheumatoid arthritis by Jadhav, Rohit R., Hu, Bin, Ye, Zhongde, Sheth, Khushboo, Li, Xuanying, Greenleaf, William J., Weyand, Cornelia M., Goronzy, Jörg J.

“…Rheumatoid arthritis (RA) is an inflammatory disease that manifests as a preclinical stage of systemic autoimmunity followed by chronic progressive synovitis…”
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Promoter Hypomethylation of EpCAM-Regulated Bone Morphogenetic Protein Gene Family in Recurrent Endometrial Cancer by HSU, Ya-Ting, FEI GU, MUTCH, David G, GOODFELLOW, Paul J, THOMPSON, Ian M, KIRMA, Nameer B, HUANG, Tim Hui-Ming, HUANG, Yi-Wen, LIU, Joseph, JIANHUA RUAN, HUANG, Rui-Lan, WANG, Chiou-Miin, CHEN, Chun-Liang, JADHAV, Rohit R, LAI, Hung-Cheng

“…Epigenetic regulation by promoter methylation plays a key role in tumorigenesis. Our goal was to investigate whether altered DNA methylation signatures…”
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Epigenetic signature of PD-1+ TCF1+ CD8 T cells that act as resource cells during chronic viral infection and respond to PD-1 blockade by Jadhav, Rohit R., Im, Se Jin, Hu, Bin, Hashimoto, Masao, Li, Peng, Lin, Jian-Xin, Leonard, Warren J., Greenleaf, William J., Ahmed, Rafi, Goronzy, Jorg J.

“…We have recently defined a novel population of PD-1 (programmed cell death 1)+ TCF1 (T cell factor 1)+ virus-specific CD8 T cells that function as resource…”
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DNA methylation screening of primary prostate tumors identifies SRD5A2 and CYP11A1 as candidate markers for assessing risk of biochemical recurrence by Horning, Aaron M., Awe, Julius A., Wang, Chiou-Miin, Liu, Joseph, Lai, Zhao, Wang, Vickie Yao, Jadhav, Rohit R., Louie, Anna D., Lin, Chun-Lin, Kroczak, Tad, Chen, Yidong, Jin, Victor X., Abboud-Werner, Sherry L., Leach, Robin J., Hernandez, Javior, Thompson, Ian M., Saranchuk, Jeff, Drachenberg, Darrel, Chen, Chun-Liang, Mai, Sabine, Huang, Tim Hui-Ming

“…BACKGROUND Altered DNA methylation in CpG islands of gene promoters has been implicated in prostate cancer (PCa) progression and can be used to predict disease…”
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PD-1 combination therapy with IL-2 modifies CD8+ T cell exhaustion program by Hashimoto, Masao, Araki, Koichi, Cardenas, Maria A., Li, Peng, Jadhav, Rohit R., Kissick, Haydn T., Hudson, William H., McGuire, Donald J., Obeng, Rebecca C., Wieland, Andreas, Lee, Judong, McManus, Daniel T., Ross, James L., Im, Se Jin, Lee, Junghwa, Lin, Jian-Xin, Hu, Bin, West, Erin E., Scharer, Christopher D., Freeman, Gordon J., Sharpe, Arlene H., Ramalingam, Suresh S., Pellerin, Alex, Teichgräber, Volker, Greenleaf, William J., Klein, Christian, Goronzy, Jorg J., Umaña, Pablo, Leonard, Warren J., Smith, Kendall A., Ahmed, Rafi

“…Combination therapy with PD-1 blockade and IL-2 is highly effective during chronic lymphocytic choriomeningitis virus infection 1 . Here we examine the…”
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Epigenetics of T cell aging by Goronzy, Jörg J., Hu, Bin, Kim, Chulwoo, Jadhav, Rohit R., Weyand, Cornelia M.

“…T cells are a heterogeneous population of cells that differ in their differentiation stages. Functional states are reflected in the epigenome that confers…”
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Aging-associated HELIOS deficiency in naive CD4+ T cells alters chromatin remodeling and promotes effector cell responses by Zhang, Huimin, Jadhav, Rohit R., Cao, Wenqiang, Goronzy, Isabel N., Zhao, Tuantuan V., Jin, Jun, Ohtsuki, Shozo, Hu, Zhaolan, Morales, Jose, Greenleaf, William J., Weyand, Cornelia M., Goronzy, Jörg J.

“…Immune aging combines cellular defects in adaptive immunity with the activation of pathways causing a low-inflammatory state. Here we examined the influence of…”
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Histone deficiency and accelerated replication stress in T cell aging by Kim, Chulwoo, Jin, Jun, Ye, Zhongde, Jadhav, Rohit R, Gustafson, Claire E, Hu, Bin, Cao, Wenqiang, Tian, Lu, Weyand, Cornelia M, Goronzy, Jörg J

“…With increasing age, individuals are more vulnerable to viral infections such as with influenza or the SARS-CoV-2 virus. One age-associated defect in human T…”
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Single-Cell RNA-seq Reveals a Subpopulation of Prostate Cancer Cells with Enhanced Cell-Cycle-Related Transcription and Attenuated Androgen Response by Horning, Aaron M, Wang, Yao, Lin, Che-Kuang, Louie, Anna D, Jadhav, Rohit R, Hung, Chia-Nung, Wang, Chiou-Miin, Lin, Chun-Lin, Kirma, Nameer B, Liss, Michael A, Kumar, Addanki P, Sun, LuZhe, Liu, Zhijie, Chao, Wei-Ting, Wang, Qianben, Jin, Victor X, Chen, Chun-Liang, Huang, Tim H-M

“…Increasing evidence suggests the presence of minor cell subpopulations in prostate cancer that are androgen independent and poised for selection as dominant…”
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CISH impairs lysosomal function in activated T cells resulting in mitochondrial DNA release and inflammaging by Jin, Jun, Mu, Yunmei, Zhang, Huimin, Sturmlechner, Ines, Wang, Chenyao, Jadhav, Rohit R, Xia, Qiong, Weyand, Cornelia M, Goronzy, Jorg J

“…Chronic systemic inflammation is one of the hallmarks of the aging immune system. Here we show that activated T cells from older adults contribute to…”
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PREX1 improves homeostatic proliferation to maintain a naive CD4+ T cell compartment in older age by Zhang, Huimin, Okuyama, Hirohisa, Jain, Abhinav, Jadhav, Rohit R, Wu, Bowen, Sturmlechner, Ines, Morales, Jose, Ohtsuki, Shozo, Weyand, Cornelia M, Goronzy, Jӧrg J

“…The human adult immune system maintains normal T cell counts and compensates for T cell loss throughout life, mainly through peripheral homeostatic…”
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DNA Methylation Targets Influenced by Bisphenol A and/or Genistein Are Associated with Survival Outcomes in Breast Cancer Patients by Jadhav, Rohit R, Santucci-Pereira, Julia, Wang, Yao V, Liu, Joseph, Nguyen, Theresa D, Wang, Jun, Jenkins, Sarah, Russo, Jose, Huang, Tim H-M, Jin, Victor X, Lamartiniere, Coral A

“…Early postnatal exposures to Bisphenol A (BPA) and genistein (GEN) have been reported to predispose for and against mammary cancer, respectively, in adult…”
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