Search Results - "Jacquin, C."

A transcription factor helps Plasmodium falciparum gametocytogenesis take shape by McLean, Kyle Jarrod, Niles, Jacquin C.

“…The recent study by Campelo Morillo et al. has shown that one of the small number of non-ApiAP2 DNA-binding proteins in the Plasmodium falciparum genome acts…”
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Synthetic RNA–protein modules integrated with native translation mechanisms to control gene expression in malaria parasites by Ganesan, Suresh M., Falla, Alejandra, Goldfless, Stephen J., Nasamu, Armiyaw S., Niles, Jacquin C.

“…Synthetic posttranscriptional regulation of gene expression is important for understanding fundamental biology and programming new cellular processes in…”
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A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes by Sidik, Saima M., Huet, Diego, Ganesan, Suresh M., Huynh, My-Hang, Wang, Tim, Nasamu, Armiyaw S., Thiru, Prathapan, Saeij, Jeroen P.J., Carruthers, Vern B., Niles, Jacquin C., Lourido, Sebastian

“…Apicomplexan parasites are leading causes of human and livestock diseases such as malaria and toxoplasmosis, yet most of their genes remain uncharacterized…”
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Efficient CRISPR-Cas9–mediated genome editing in Plasmodium falciparum by Wagner, Jeffrey C, Platt, Randall J, Goldfless, Stephen J, Zhang, Feng, Niles, Jacquin C

“…Single guide RNAs driven by a T7 promoter target Cas9 to two endogenous loci, leading to fast and efficient genome editing in the malaria parasite P…”
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An integrated platform for genome engineering and gene expression perturbation in Plasmodium falciparum by Nasamu, Armiyaw S., Falla, Alejandra, Pasaje, Charisse Flerida A., Wall, Bridget A., Wagner, Jeffrey C., Ganesan, Suresh M., Goldfless, Stephen J., Niles, Jacquin C.

“…Establishing robust genome engineering methods in the malarial parasite, Plasmodium falciparum , has the potential to substantially improve the efficiency with…”
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Efficiency and stability evaluation of Cu2O/MWCNTs filters for virus removal from water by Domagała, K., Jacquin, C., Borlaf, M., Sinnet, B., Julian, T., Kata, D., Graule, T.

“…Both multi-walled carbon nanotubes (MWCNTs) and metal or metal oxides have demonstrated virus removal efficacy in drinking water applications. In this study,…”
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Plasmodium Niemann-Pick type C1-related protein is a druggable target required for parasite membrane homeostasis by Istvan, Eva S, Das, Sudipta, Bhatnagar, Suyash, Beck, Josh R, Owen, Edward, Llinas, Manuel, Ganesan, Suresh M, Niles, Jacquin C, Winzeler, Elizabeth, Vaidya, Akhil B, Goldberg, Daniel E

“…parasites possess a protein with homology to Niemann-Pick Type C1 proteins (Niemann-Pick Type C1-Related protein, NCR1). We isolated parasites with…”
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Functional genomics of RAP proteins and their role in mitoribosome regulation in Plasmodium falciparum by Hollin, Thomas, Abel, Steven, Falla, Alejandra, Pasaje, Charisse Flerida A., Bhatia, Anil, Hur, Manhoi, Kirkwood, Jay S., Saraf, Anita, Prudhomme, Jacques, De Souza, Amancio, Florens, Laurence, Niles, Jacquin C., Le Roch, Karine G.

“…The RAP (RNA-binding domain abundant in Apicomplexans) protein family has been identified in various organisms. Despite expansion of this protein family in…”
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ATG8 Is Essential Specifically for an Autophagy-Independent Function in Apicoplast Biogenesis in Blood-Stage Malaria Parasites by Walczak, Marta, Ganesan, Suresh M, Niles, Jacquin C, Yeh, Ellen

“…parasites and related pathogens contain an essential nonphotosynthetic plastid organelle, the apicoplast, derived from secondary endosymbiosis. Intriguingly, a…”
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Plasmepsins IX and X are essential and druggable mediators of malaria parasite egress and invasion by Nasamu, Armiyaw S., Glushakova, Svetlana, Russo, Ilaria, Vaupel, Barbara, Oksman, Anna, Kim, Arthur S., Fremont, Daved H., Tolia, Niraj, Beck, Josh R., Meyers, Marvin J., Niles, Jacquin C., Zimmerberg, Joshua, Goldberg, Daniel E.

“…Proteases of the malaria parasite Plasmodium falciparum have long been investigated as drug targets. The P. falciparum genome encodes 10 aspartic proteases…”
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Quantification of labile heme in live malaria parasites using a genetically encoded biosensor by Abshire, James R., Rowlands, Christopher J., Ganesan, Suresh M., So, Peter T. C., Niles, Jacquin C.

“…Heme is ubiquitous, yet relatively little is known about the maintenance of labile pools of this cofactor, which likely ensures its timely bioavailability for…”
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Selective expression of variant surface antigens enables Plasmodium falciparum to evade immune clearance in vivo by Chew, Marvin, Ye, Weijian, Omelianczyk, Radoslaw Igor, Pasaje, Charisse Flerida, Hoo, Regina, Chen, Qingfeng, Niles, Jacquin C., Chen, Jianzhu, Preiser, Peter

“…Plasmodium falciparum has developed extensive mechanisms to evade host immune clearance. Currently, most of our understanding is based on in vitro studies of…”
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Small molecule inhibition of apicomplexan FtsH1 disrupts plastid biogenesis in human pathogens by Amberg-Johnson, Katherine, Hari, Sanjay B, Ganesan, Suresh M, Lorenzi, Hernan A, Sauer, Robert T, Niles, Jacquin C, Yeh, Ellen

“…The malaria parasite and related apicomplexan pathogens contain an essential plastid organelle, the apicoplast, which is a key anti-parasitic target. Derived…”
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A microfabricated deformability-based flow cytometer with application to malaria by Bow, Hansen, Pivkin, Igor V, Diez-Silva, Monica, Goldfless, Stephen J, Dao, Ming, Niles, Jacquin C, Suresh, Subra, Han, Jongyoon

“…Malaria resulting from Plasmodium falciparum infection is a major cause of human suffering and mortality. Red blood cell (RBC) deformability plays a major role…”
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Identification of malaria parasite-infected red blood cell surface aptamers by inertial microfluidic SELEX (I-SELEX) by Birch, Christina M., Hou, Han Wei, Han, Jongyoon, Niles, Jacquin C.

“…Plasmodium falciparum malaria parasites invade and remodel human red blood cells (RBCs) by trafficking parasite-synthesized proteins to the RBC surface. While…”
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EXP2 is a nutrient-permeable channel in the vacuolar membrane of Plasmodium and is essential for protein export via PTEX by Garten, Matthias, Nasamu, Armiyaw S., Niles, Jacquin C., Zimmerberg, Joshua, Goldberg, Daniel E., Beck, Josh R.

“…Intraerythrocytic malaria parasites reside within a parasitophorous vacuolar membrane (PVM) generated during host cell invasion 1 . Erythrocyte remodelling and…”
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The chaperonin TRiC forms an oligomeric complex in the malaria parasite cytosol by Spillman, Natalie J., Beck, Josh R., Ganesan, Suresh M., Niles, Jacquin C., Goldberg, Daniel E.

“…The malaria parasite exports numerous proteins into its host red blood cell (RBC). The trafficking of these exported effectors is complex. Proteins are first…”
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Complex nutrient channel phenotypes despite Mendelian inheritance in a Plasmodium falciparum genetic cross by Gupta, Ankit, Bokhari, Abdullah A B, Pillai, Ajay D, Crater, Anna K, Gezelle, Jeanine, Saggu, Gagandeep, Nasamu, Armiyaw S, Ganesan, Suresh M, Niles, Jacquin C, Desai, Sanjay A

“…Malaria parasites activate a broad-selectivity ion channel on their host erythrocyte membrane to obtain essential nutrients from the bloodstream. This…”
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MalDA, Accelerating Malaria Drug Discovery by Yang, Tuo, Ottilie, Sabine, Istvan, Eva S., Godinez-Macias, Karla P., Lukens, Amanda K., Baragaña, Beatriz, Campo, Brice, Walpole, Chris, Niles, Jacquin C., Chibale, Kelly, Dechering, Koen J., Llinás, Manuel, Lee, Marcus C.S., Kato, Nobutaka, Wyllie, Susan, McNamara, Case W., Gamo, Francisco Javier, Burrows, Jeremy, Fidock, David A., Goldberg, Daniel E., Gilbert, Ian H., Wirth, Dyann F., Winzeler, Elizabeth A.

“…The Malaria Drug Accelerator (MalDA) is a consortium of 15 leading scientific laboratories. The aim of MalDA is to improve and accelerate the early…”
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Inhibitors of ApiAP2 protein DNA binding exhibit multistage activity against Plasmodium parasites by Russell, Timothy James, De Silva, Erandi K, Crowley, Valerie M, Shaw-Saliba, Kathryn, Dube, Namita, Josling, Gabrielle, Pasaje, Charisse Flerida A, Kouskoumvekaki, Irene, Panagiotou, Gianni, Niles, Jacquin C, Jacobs-Lorena, Marcelo, Denise Okafor, C, Gamo, Francisco-Javier, Llinás, Manuel

“…Plasmodium parasites are reliant on the Apicomplexan AP2 (ApiAP2) transcription factor family to regulate gene expression programs. AP2 DNA binding domains…”
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