Search Results - "Jacquemin, Marc G."

Factor VIII-Fc Activates Natural Killer Cells via Fc-Mediated Interactions With CD16 by Lagassé, H.A. Daniel, Hopkins, Louis B., Jankowski, Wojciech, Jacquemin, Marc G., Sauna, Zuben E., Golding, Basil

“…The most challenging complication associated with Factor VIII (FVIII) replacement therapy is the development of neutralizing anti-drug antibodies, or…”
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Increased synapse formation obtained by T cell epitopes containing a CxxC motif in flanking residues convert CD4+ T cells into cytolytic effectors by Carlier, Vincent A, VanderElst, Luc, Janssens, Wim, Jacquemin, Marc G, Saint-Remy, Jean-Marie R

“…The nature of MHC class II-binding epitopes not only determines the specificity of T cell responses, but may also alter effector cell functions. Cytolytic CD4+…”
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Antigenicity of putative phospholipid membrane-binding residues in factor VIII by Barrow, Rachel T., Healey, John F., Jacquemin, Marc G., Saint-Remy, Jean-Marie R., Lollar, Pete

“…Most inhibitory antibodies to human factor VIII (fVIII) bind to epitopes in the A2, ap-A3, or C2 domains. The anticoagulant action of antibodies to the C2…”
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The concentration of GPIbα magnetic particles is a critical parameter occasionally responsible for poor reproducibility of the VWF:GPIbR chemiluminescent immunoassay by Calcoen, Bas, Van Horenbeeck, Isa, Debasse, Mirjam, Toelen, Jelle, Vanlinthout, Ingrid, Schoeters, Joke, Peerlinck, Kathelijne, Jacquemin, Marc G.

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CD4+CD25+ T Cells Lyse Antigen-Presenting B Cells by Fas-Fas Ligand Interaction in an Epitope-Specific Manner by Janssens, Wim, Carlier, Vincent, Wu, Bo, VanderElst, Luc, Jacquemin, Marc G, Saint-Remy, Jean-Marie R

“…Suppression by regulatory T cells is now acknowledged to play a key role in the down-regulation of T cell responses to foreign and self Ags. In addition to the…”
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In vivo neutralization of a C2 domain–specific human anti–Factor VIII inhibitor by an anti-idiotypic antibody by Gilles, Jean Guy G., Grailly, Sabrina C., De Maeyer, Marc, Jacquemin, Marc G., VanderElst, Luc P., Saint-Remy, Jean-Marie R.

“…Factor VIII (FVIII) administration elicits specific inhibitory antibodies (Abs) in about 25% of patients with hemophilia A. The majority of such Abs reacts…”
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Factor VIII alloantibodies in hemophilia by Jacquemin, Marc G, Saint-Remy, Jean-Marie R

“…PURPOSE OF REVIEWThe development of an inhibitory response to factor VIII (FVIII) remains a puzzling challenge both for clinicians and scientists, not to…”
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The Dermatophagoides pteronyssinus Group 2 Allergen Contains a Universally Immunogenic T Cell Epitope by Wu, Bo, Elst, Luc Vander, Carlier, Vincent, Jacquemin, Marc G, Saint-Remy, Jean-Marie R

“…The use of T cell epitope-containing peptides for the induction of anergy in allergen sensitization is limited by genetic restriction that could be…”
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Some factor VIII (FVIII) inhibitors recognise a FVIII epitope(s) that is present only on FVIII-vWF complexes by Gilles, J G, Lavend'homme, R, Peerlinck, K, Jacquemin, M G, Hoylaerts, M, Jorieux, S, Mazurier, C, Vermylen, J, Saint-Remy, J M

“…A mild haemophilia A patient (LE) with an Arg2150His mutation in the C1 domain of the factor VIII (FVIII) light chain was shown to have anti-FVIII antibodies…”
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Factor VIII inhibitors by Gilles, J G, Jacquemin, M G, Saint-Remy, J M

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Mechanism and Kinetics of Factor VIII Inactivation: Study With an IgG4 Monoclonal Antibody Derived From a Hemophilia A Patient With Inhibitor by Jacquemin, Marc G., Desqueper, Benoı̂t G., Benhida, Abdellah, Vander Elst, Luc, Hoylaerts, Marc F., Bakkus, Marleen, Thielemans, Kris, Arnout, Jef, Peerlinck, Kathelijne, Gilles, Jean Guy G., Vermylen, Jos, Saint-Remy, Jean-Marie R.

“…The development of an immune response towards factor VIII (fVIII) remains a major complication for hemophilia A patients receiving fVIII infusions. The design…”
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A Limited Number of Anti-Idiotypic Antibodies Is Required To Maintain FVIII Function in Presence of Polyclonal Anti-FVIII Antibodies of Haemophilia A Patients with Inhibitors by Gilles, Jean Guy G., Grailly, Sabrina E., Jacquemin, Marc G., Saint-Remy, Jean Marie M.

“…Replacement therapy using either plasma-derived or recombinant FVIII elicits FVIII-specific Abs in about 25% of the patients. The majority of such antibodies…”
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Antifactor VIII Antibody Inhibiting Allogeneic but not Autologous Factor VIII in Patients With Mild Hemophilia A by Peerlinck, Kathelijne, Jacquemin, Marc G., Arnout, Jef, Hoylaerts, Marc F., Gilles, Jean Guy G., Lavend’homme, Renaud, Johnson, Karen M., Freson, Kathleen, Scandella, Dorothea, Saint-Remy, Jean-Marie R., Vermylen, Jos

“…Two unrelated patients with the same Arg2150His mutation in the factor VIII (FVIII) C1 domain, a residual FVIII activity of 0.09 IU/mL, and inhibitor titres of…”
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Immune Tolerance Induction by High Doses FVIII in Hemophilia A Patients with Inhibitor Does Not Require Deletion of FVIII-Specific T Cells by Jacquemin, Marc G., Lavend'homme, Renaud, Tinot, Thérèse, Peerlinck, Kathelijne, Saint-Remy, Jean Marie, Pautard, Brigitte

“…In patients with hemophilia A and FVIII inhibitor, tolerance to FVIII can frequently be restored by prolonged administration of FVIII (immune tolerance…”
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Mechanism and Kinetics of Factor VIII Inactivation: Study With an IgG4 Monoclonal Antibody Derived From a Hemophilia A Patient With Inhibitor by Jacquemin, Marc G., Desqueper, Benoı̂t G., Benhida, Abdellah, Vander Elst, Luc, Hoylaerts, Marc F., Bakkus, Marleen, Thielemans, Kris, Arnout, Jef, Peerlinck, Kathelijne, Gilles, Jean Guy G., Vermylen, Jos, Saint-Remy, Jean-Marie R.

“…The development of an immune response towards factor VIII (fVIII) remains a major complication for hemophilia A patients receiving fVIII infusions. The design…”
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Tolerance induction: a job for B cells? by Saint-Remy, Jean-Marie R., Jacquemin, Marc G.

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Factor VIII alloantibodies in hemophilia: Hemostasis and thrombosis by JACQUEMIN, Marc G, SAINT-REMY, Jean-Marie R

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The Determination of the Inhibitory Activity of Some Factor VIII Type II Inhibitor Antibodies Is Biased by the Type of Factor VIII Assay by Jacquemin, Marc G., Lamprecht, Seb, Lavend'homme, Renaud, Roodt, Jan, Chatelain, Bernard, Deneys, Veronique, Dewaele, Jeroen, Stassen, Jean-Marie, Meiring, Muriel, Saint-Remy, Jean Marie, Pieters, Henry, Badenhorst, Philip

“…Although type II Factor VIII (FVIII) inhibitor antibodies inhibit only partially FVIII activity, even when such antibodies are in very large excess over FVIII,…”
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Rupture of T Cell Tolerance to Self Factor VIII in Mild/Moderate Hemophilia A by Jacquemin, Marc G., Lavend'homme, Renaud, Abdellah, Benhida, Peerlinck, Kathelijne, Vermylen, Jos, Deneys, Véronique, Saint-Remy, Jean-Marie, Hermans, Cédric

“…Some patients with mild/moderate hemophilia A develop anti-Factor VIII (FVIII) antibodies following treatment with FVIII. In rare cases, the patient antibodies…”
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Major T cell epitope‐containing peptides can elicit strong antibody responses by Wu, Bo, Toussaint, Gaëlle, Vander Elst, Luc, Granier, Claude, Jacquemin, Marc G., Saint‐Remy, Jean‐Marie R.

“…Peptides containing major T cell epitopes have the capacity to induce T cell anergy and have therefore been proposed for the treatment of allergic and…”
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