Search Results - "Jacot, JL"

Discovery of 3-[(4,5,7-Trifluorobenzothiazol-2-yl)methyl]indole-N-acetic Acid (Lidorestat) and Congeners as Highly Potent and Selective Inhibitors of Aldose Reductase for Treatment of Chronic Diabetic Complications by Van Zandt, Michael C, Jones, Michael L, Gunn, David E, Geraci, Leo S, Jones, J. Howard, Sawicki, Diane R, Sredy, Janet, Jacot, Jorge L, DiCioccio, A. Thomas, Petrova, Tatiana, Mitschler, Andre, Podjarny, Alberto D

“…Recent efforts to identify treatments for chronic diabetic complications have resulted in the discovery of a novel series of highly potent and selective…”
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Diabetic-like retinopathy: early and late intervention therapies in galactose-fed rats by Robison, WG, Jr, Jacot, JL, Glover, JP, Basso, MD, Hohman, TC

“…To determine whether the diabetic-like thickening of retinal capillary basement membrane (RCBM) that develops in the galactose-fed rat model of diabetic ocular…”
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Retinal vascular changes induced by the oxidative stress of alpha-tocopherol deficiency contrasted with diabetic microangiopathy by Robison, Jr, W G, Jacot, J L, Katz, M L, Glover, J P

“…It has been proposed that oxidative tissue damage is involved in the development of diabetic angiopathies. To evaluate this hypothesis, experiments were…”
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Sorbinil prevention of diabetic-like retinopathy in the galactose-fed rat model by Robison, WG, Jr, Laver, NM, Jacot, JL, Glover, JP

“…To determine if the retinal microangiopathies of the galactose-fed rat model of diabetic retinopathy can be prevented with the aldose reductase inhibitor…”
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Diabetic-like retinopathy ameliorated with the aldose reductase inhibitor WAY-121,509 by Robinson, WG, Jr, Laver, NM, Jacot, JL, Glover, JP, Basso, MD, Blouin, P, Hohman, TC

“…To evaluate the efficacy of WAY-121,509, a potent new aldose reductase inhibitor (ARI), in preventing the retinopathy that develops in the galactose-fed rat…”
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Nitric oxide modulation of retinal, choroidal, and anterior uveal blood flow in newborn piglets by Jacot, J L, O'Neill, J T, Scandling, D M, West, S D, McKenzie, J E

“…The purpose of the present study was to investigate the role of nitric oxide (NO) in modulating the resting vascular tone of the choroidal and anterior uveal…”
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Efficacy of treatment after measurable diabeticlike retinopathy in galactose-fed rats by Robison, WG, Jr, Laver, NM, Jacot, JL, Chandler, ML, York, BM, Glover, JP

“…To determine whether the diabeticlike retinal microangiopathies of the galactose-fed rat model could be ameliorated if intervention by withdrawal of the…”
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Computer analysis of corneal innervation density using a novel double stain in rat corneal whole mounts by JACOT, JORGE L., GLOVER, JOEL P., ROBISON, W. GERALD

“…Computerised morphometry and a double stain technique were utilised to examine the corneal nerves in whole mounts. This novel stain combines the nonspecific…”
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Diabetic-like corneal sensitivity loss in galactose-fed rats ameliorated with aldose reductase inhibitors by Jacot, J L, Hosotani, H, Glover, J P, Lois, N, Robison, Jr, W G

“…This study investigated whether diabetic-like corneal sensory deficits occur in the galactose-fed rat model of diabetic ocular complications and if such…”
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Retinal capillary dilation: early diabetic-like retinopathy in the galactose-fed rat model by Glover, J P, Jacot, J L, Basso, M D, Hohman, T C, Robison, Jr, W G

“…The purpose of this study was to determine whether capillary dilation is one of the earliest structural changes in the diabetic-like retinopathy of the…”
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Histological evaluation of the canine retinal vasculature following chronic systemic administration of basic fibroblast growth factor by Jacot, J L, Laver, N M, Glover, J P, Lazarous, D F, Unger, E F, Robison, Jr, W G

“…The purpose of the present study was to determine if prolonged systemic arterial administration of basic fibroblast growth factor (bFGF) at a dose sufficient…”
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Improved gold chloride procedure for nerve staining in whole mounts of rat corneas by Jacot, J L, Glover, J P, Robison, Jr, W G

“…The purpose of this study was to modify the gold chloride procedure for studies of total innervation in corneal whole mounts to provide a decrease in…”
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