Search Results - "Jacomo, Rafael"

Presence of SARS-CoV-2 RNA in Semen—Cohort Study in the United States COVID-19 Positive Patients by Machado, Bruno, Barcelos Barra, Gustavo, Scherzer, Nickolas, Massey, Jack, dos Santos Luz, Hemerson, Henrique Jacomo, Rafael, Herinques Santa Rita, Ticiane, Davis, Rodney

“…On 31 December 2019, China informed the World Health Organization they were facing a viral pneumonia epidemic of a new type of Coronavirus. Currently, 10…”
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Analytical Sensitivity and Specificity of Two RT-qPCR Protocols for SARS-CoV-2 Detection Performed in an Automated Workflow by Barra, Gustavo Barcelos, Santa Rita, Ticiane Henriques, Mesquita, Pedro Góes, Jácomo, Rafael Henriques, Nery, Lídia Freire Abdalla

“…WHO declared the novel coronavirus (COVID-19) outbreak a global pandemic on 11 March 2020. The establishment of standardized RT-qPCR protocols for respiratory…”
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Improving acute promyelocytic leukemia (APL) outcome in developing countries through networking, results of the International Consortium on APL by Rego, Eduardo M., Kim, Haesook T., Ruiz-Argüelles, Guillermo J., Undurraga, Maria Soledad, Uriarte, Maria del Rosario, Jacomo, Rafael H., Gutiérrez-Aguirre, Homero, Melo, Raul A.M., Bittencourt, Rosane, Pasquini, Ricardo, Pagnano, Katia, Fagundes, Evandro M., Chauffaille, Maria de Lourdes, Chiattone, Carlos S., Martinez, Lem, Meillón, Luis A., Gómez-Almaguer, David, Kwaan, Hau C., Garcés-Eisele, Javier, Gallagher, Robert, Niemeyer, Charlotte M., Schrier, Stanley L., Tallman, Martin, Grimwade, David, Ganser, Arnold, Berliner, Nancy, Ribeiro, Raul C., Lo-Coco, Francesco, Löwenberg, Bob, Sanz, Miguel A.

“…Thanks to modern treatment with all-trans retinoic acid and chemotherapy, acute promyelocytic leukemia (APL) is now the most curable type of leukemia. However,…”
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The experience of the International Consortium on Acute Promyelocytic Leukemia in monitoring minimal residual disease in acute promyelocytic leukaemia by Lange, Ana P., Lima, Ana S., Lucena‐Araujo, Antonio R., Jácomo, Rafael H., Melo, Raul A., Bittencourt, Rosane I., Pasquini, Ricardo, Pagnano, Katia, Fagundes, Evandro M., Chauffaille, Maria L., Chiattone, Carlos S., Sanz, Miguel A., Lo‐Coco, Francesco, Grimwade, David, Rego, Eduardo M.

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Methionine-induced hyperhomocysteinemia reverts fibrinolytic pathway activation in a murine model of acute promyelocytic leukemia by Jácomo, Rafael H., Santana-Lemos, Barbara A., Lima, Ana Silvia G., Assis, Patricia A., Lange, Ana Paula A., Figueiredo-Pontes, Lorena L., Oliveira, Luciana O., Bassi, Sarah C., Benício, Mariana T.L., Baggio, Márcia S., Garcia, Aglair B., Falcão, Roberto P., Rego, Eduardo M.

“…Increased fibrinolysis is an important component of acute promyelocytic leukemia (APL) bleeding diathesis. APL blasts overexpress annexin II (ANXII), a…”
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High ΔNp73/TAp73 ratio is associated with poor prognosis in acute promyelocytic leukemia by Lucena-Araujo, Antonio R., Kim, Haesook T., Thomé, Carolina, Jacomo, Rafael H., Melo, Raul A., Bittencourt, Rosane, Pasquini, Ricardo, Pagnano, Katia, Glória, Ana Beatriz F., Chauffaille, Maria de Lourdes, Athayde, Melina, Chiattone, Carlos S., Mito, Ingrid, Bendlin, Rodrigo, Souza, Carmino, Bortolheiro, Cristina, Coelho-Silva, Juan L., Schrier, Stanley L., Tallman, Martin S., Grimwade, David, Ganser, Arnold, Berliner, Nancy, Ribeiro, Raul C., Lo-Coco, Francesco, Löwenberg, Bob, Sanz, Miguel A., Rego, Eduardo M.

“…The TP73 gene transcript is alternatively spliced and translated into the transcriptionally active (TAp73) or inactive (ΔNp73) isoforms, with opposite effects…”
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Internal tandem duplication of the FLT3 gene confers poor overall survival in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and anthracycline-based chemotherapy: an International Consortium on Acute Promyelocytic Leukemia study by Lucena-Araujo, Antonio R., Kim, Haesook T., Jacomo, Rafael H., Melo, Raul A., Bittencourt, Rosane, Pasquini, Ricardo, Pagnano, Katia, Fagundes, Evandro M., Chauffaille, Maria de Lourdes, Chiattone, Carlos S., Lima, Ana Silvia, Ruiz-Argüelles, Guillermo, Undurraga, Maria Soledad, Martinez, Lem, Kwaan, Hau C., Gallagher, Robert, Niemeyer, Charlotte M., Schrier, Stanley L., Tallman, Martin S., Grimwade, David, Ganser, Arnold, Berliner, Nancy, Ribeiro, Raul C., Lo-Coco, Francesco, Löwenberg, Bob, Sanz, Miguel A., Rego, Eduardo M.

“…Activating internal tandem duplication (ITD) mutations in the fms - like tyrosine kinase 3 ( FLT3 ) gene ( FLT3 -ITD) are associated with poor outcome in acute…”
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The presence of CD56/CD16 in T‐cell acute lymphoblastic leukaemia correlates with the expression of cytotoxic molecules and is associated with worse response to treatment by Dalmazzo, Leandro F. F., Jácomo, Rafael H., Marinato, André F., Figueiredo‐Pontes, Lorena L., Cunha, Renato L. G., Garcia, Aglair B., Rego, Eduardo M., Falcão, Roberto P.

“…Summary Some cases of T‐cell acute lymphoblastic leukaemia (ALL) express markers found in natural‐killer (NK) cells, such as CD56 and CD16. Out of 84 T‐cell…”
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Genotyping of Single Nucleotide Polymorphisms Using Allele-Specific qPCR Producing Amplicons of Small Sizes Directly from Crude Serum Isolated from Capillary Blood by a Hand-Powered Paper Centrifuge by Barra, Gustavo Barcelos, Santa Rita, Ticiane Henriques, Jardim, Daniella Paniago, Mesquita, Pedro Góes, Nobre, Camila Santos, Jácomo, Rafael Henriques, Abdalla Nery, Lídia Freire

“…The cell-free genomic DNA (gDNA) concentration in serum ranges from 1500 to 7500 copies/mL within 2 h after phlebotomy (6⁻24 times the concentration observed…”
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Antibody-targeted horseradish peroxidase associated with indole-3-acetic acid induces apoptosis in vitro in hematological malignancies by Dalmazzo, Leandro F.F, Santana-Lemos, Bárbara A, Jácomo, Rafael H, Garcia, Aglair B, Rego, Eduardo M, da Fonseca, Luiz M, Falcão, Roberto P

“…Abstract Indole-3-acetic acid (IAA), when oxidized by horseradish peroxidase (HRP), is transformed into cytotoxic molecules capable of inducing cell injury…”
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All-trans retinoic acid with daunorubicin or idarubicin for risk-adapted treatment of acute promyelocytic leukaemia: a matched-pair analysis of the PETHEMA LPA-2005 and IC-APL studies by Sanz, Miguel A., Montesinos, Pau, Kim, Haesook T., Ruiz-Argüelles, Guillermo J., Undurraga, María S., Uriarte, María R., Martínez, Lem, Jacomo, Rafael H., Gutiérrez-Aguirre, Homero, Melo, Raul A. M., Bittencourt, Rosane, Pasquini, Ricardo, Pagnano, Katia, Fagundes, Evandro M., Vellenga, Edo, Holowiecka, Alexandra, González-Huerta, Ana J., Fernández, Pascual, De la Serna, Javier, Brunet, Salut, De Lisa, Elena, González-Campos, José, Ribera, José M., Krsnik, Isabel, Ganser, Arnold, Berliner, Nancy, Ribeiro, Raul C., Lo-Coco, Francesco, Löwenberg, Bob, Rego, Eduardo M.

“…Front-line treatment of acute promyelocytic leukaemia (APL) consists of all- trans retinoic acid (ATRA) and anthracycline-based chemotherapy. In this setting,…”
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Prognostic impact of KMT2E transcript levels on outcome of patients with acute promyelocytic leukaemia treated with all‐trans retinoic acid and anthracycline‐based chemotherapy: an International Consortium on Acute Promyelocytic Leukaemia study by Lucena‐Araujo, Antonio R., Kim, Haesook T., Jacomo, Rafael H., Melo, Raul A., Bittencourt, Rosane, Pasquini, Ricardo, Pagnano, Katia, Fagundes, Evandro M., Chauffaille, Maria, Chiattone, Carlos S., Lima, Ana S., Kwaan, Hau C., Gallagher, Robert, Niemeyer, Charlotte M., Schrier, Stanley L., Tallman, Martin S., Grimwade, David, Ganser, Arnold, Berliner, Nancy, Ribeiro, Raul C., Lo‐Coco, Francesco, Löwenberg, Bob, Sanz, Miguel A., Rego, Eduardo M.

“…Summary The KMT2E (MLL5) gene encodes a histone methyltransferase implicated in the positive control of genes related to haematopoiesis. Its close relationship…”
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Effect size and inferential statistical techniques coupled with machine learning for assessing the association between prolactin concentration and metabolic homeostasis by Dias, Alan Carvalho, Jácomo, Rafael Henriques, Nery, Lidia Freire Abdalla, Naves, Luciana Ansaneli

“…Recent guidelines classify low prolactin levels as low as <7 ng/mL and high levels as >25 ng/mL, while the "Homeostatically Functionally Increased Transient…”
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The expression of ΔNTP73, TATP73 and TP53 genes in acute myeloid leukaemia is associated with recurrent cytogenetic abnormalities and in vitro susceptibility to cytarabine cytotoxicity by Lucena‐Araujo, Antonio R., Panepucci, Rodrigo A., Dos Santos, Guilherme A. S., Jácomo, Rafael H., Santana‐Lemos, Bárbara A. A., Lima, Ana S. G., Garcia, Aglair B., Araújo, Amélia G., Falcão, Roberto P., Rego, Eduardo M.

“…Summary TP73 encodes for two proteins: full‐length TAp73 and ΔNp73, which have little transcriptional activity and exert dominant‐negative function towards…”
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The association of ICAM-1 Exon 6 (E469K) but not of ICAM-1 Exon 4 (G241R) and PECAM-1 Exon 3 (L125V) polymorphisms with the development of differentiation syndrome in acute promyelocytic leukemia by Adriana I. Dore, Barbara A. A. Santana-Lemos, Virginia M. Coser, Flávia L. S. Santos, Leandro F. Dalmazzo, Ana S. G. Lima, Rafael H. Jacomo, Jorge Elias, Jr, Roberto Passetto Falcão, Waldir V. Pereira, Eduardo M. Rego

“…The use of all trans‐retinoic acid (ATRA) is the basis of treatment of acute promyelocytic leukemia (APL) and represents the paradigm of differentiation…”
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Halofuginone has anti-proliferative effects in acute promyelocytic leukemia by modulating the transforming growth factor beta signaling pathway by de Figueiredo-Pontes, Lorena L, Assis, Patricia A, Santana-Lemos, Bárbara A A, Jácomo, Rafael H, Lima, Ana Sílvia G, Garcia, Aglair B, Thomé, Carolina H, Araújo, Amélia G, Panepucci, Rodrigo A, Zago, Marco A, Nagler, Arnon, Falcão, Roberto P, Rego, Eduardo M

“…Promyelocytic leukemia-retinoic acid receptor alpha (PML-RARα) expression in acute promyelocytic leukemia (APL) impairs transforming growth factor beta (TGFβ)…”
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Results of FLT3 mutation screening and correlations with immunophenotyping in 169 Brazilian patients with acute myeloid leukemia by Lucena-Araujo, Antonio R, Souza, Danielle L, de Oliveira, Fabio Morato, Benicio, Mariana Tereza Lira, Figueiredo-Pontes, Lorena L, Santana-Lemos, Barbara A, dos Santos, Guilherme A, Jacomo, Rafael H, Dinarte-Santos, Anemari R, Yamamoto, Mihoko, Silva-Jr, Wilson A, de Lourdes Chauffaille, Maria, Rego, Eduardo M

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The impact of medical education and networking on the outcome of leukemia treatment in developing countries. The experience of International Consortium on Acute Promyelocytic Leukemia (IC-APL) by Rego, Eduardo M, Kim, Haesook T, Ruiz-Argüelles, Guillermo J, Uriarte, Maria del Rosario, Jacomo, Rafael H, Gutiérrez-Aguirre, Homero, Melo, Raul A M, Bittencourt, Rosane, Pasquini, Ricardo, Pagnano, Katia, Fagundes, Evandro M, Chauffaille, Maria de Lourdes, Chiattone, Carlos, Martinez, Lem, Meillón, Luis A, Gómez-Almaguer, David, Kwaan, Hau, Garcés-Eisele, Javier, Gallagher, Robert, Niemeyer, Charlotte M, Lowenberg, Bob, Ribeiro, Raul, LoCoco, Francesco, Sanz, Miguel A

“…Several clinical trials conducted in Europe and US reported favorable outcomes of patients with APL treated with the combination of all trans retinoic acid…”
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Overcoming Supply Shortage for SARS-CoV-2 Detection by RT-qPCR by Barra, Gustavo Barcelos, Santa Rita, Ticiane Henriques, Mesquita, Pedro Góes, Jácomo, Rafael Henriques, Nery, Lídia Freire Abdalla

“…In February 2020, our laboratory started to offer a RT-qPCR assay for the qualitative detection of severe acute respiratory syndrome coronavirus 2. A few…”
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Noninvasive fetal sex determination by analysis of cell‐free fetal DNA in maternal capillary blood obtained by fingertip puncture by Santa Rita, Ticiane Henriques, Nobre, Camila Santos, Jácomo, Rafael Henriques, Nery, Lídia Freire Abdalla, Barra, Gustavo Barcelos

“…What's already known about this topic? Noninvasive fetal sex determination searches for Y‐chromosome sequences in maternal plasma isolated from venous blood…”
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