Search Results - "Jacobson, Tyler B."

Negative interactions determine Clostridioides difficile growth in synthetic human gut communities by Hromada, Susan, Qian, Yili, Jacobson, Tyler B, Clark, Ryan L, Watson, Lauren, Safdar, Nasia, Amador‐Noguez, Daniel, Venturelli, Ophelia S

“…Understanding the principles of colonization resistance of the gut microbiome to the pathogen Clostridioides difficile will enable the design of defined…”
Get full text

Expression of Phosphofructokinase Is Not Sufficient to Enable Embden-Meyerhof-Parnas Glycolysis in Zymomonas mobilis ZM4 by Felczak, Magdalena M., Jacobson, Tyler B., Ong, Wai Kit, Amador-Noguez, Daniel, TerAvest, Michaela A.

“…Zymomonas mobilis is a bacterium that produces ethanol from glucose at up to 97% of theoretical efficiency on a carbon basis. One factor contributing to the…”
Get full text

Autotrophic and mixotrophic metabolism of an anammox bacterium revealed by in vivo 13C and 2H metabolic network mapping by Lawson, Christopher E., Nuijten, Guylaine H. L., de Graaf, Rob M., Jacobson, Tyler B., Pabst, Martin, Stevenson, David. M., Jetten, Mike S. M., Noguera, Daniel R., McMahon, Katherine D., Amador-Noguez, Daniel, Lücker, Sebastian

“…Anaerobic ammonium-oxidizing (anammox) bacteria mediate a key step in the biogeochemical nitrogen cycle and have been applied worldwide for the…”
Get full text

Near-equilibrium glycolysis supports metabolic homeostasis and energy yield by Park, Junyoung O., Tanner, Lukas B., Wei, Monica H., Khana, Daven B., Jacobson, Tyler B., Zhang, Zheyun, Rubin, Sara A., Li, Sophia Hsin-Jung, Higgins, Meytal B., Stevenson, David M., Amador-Noguez, Daniel, Rabinowitz, Joshua D.

Get full text

Metabolic Remodeling during Nitrogen Fixation in Zymomonas mobilis by Martien, Julia I, Trujillo, Edna A, Jacobson, Tyler B, Tatli, Mehmet, Hebert, Alexander S, Stevenson, David M, Coon, Joshua J, Amador-Noguez, Daniel

“…Zymomonas mobilis is an ethanologenic bacterium currently being developed for production of advanced biofuels. Recent studies have shown that Z. mobilis can…”
Get full text

Comparative functional genomics identifies an iron-limited bottleneck in a Saccharomyces cerevisiae strain with a cytosolic-localized isobutanol pathway by Gambacorta, Francesca V., Wagner, Ellen R., Jacobson, Tyler B., Tremaine, Mary, Muehlbauer, Laura K., McGee, Mick A., Baerwald, Justin J., Wrobel, Russell L., Wolters, John F., Place, Mike, Dietrich, Joshua J., Xie, Dan, Serate, Jose, Gajbhiye, Shabda, Liu, Lisa, Vang-Smith, Maikayeng, Coon, Joshua J., Zhang, Yaoping, Gasch, Audrey P., Amador-Noguez, Daniel, Hittinger, Chris Todd, Sato, Trey K., Pfleger, Brian F.

“…Metabolic engineering strategies have been successfully implemented to improve the production of isobutanol, a next-generation biofuel, in Saccharomyces…”
Get full text

Hostile Takeover: How Viruses Reprogram Prokaryotic Metabolism by Jacobson, Tyler B, Callaghan, Melanie M, Amador-Noguez, Daniel

“…To reproduce, prokaryotic viruses must hijack the cellular machinery of their hosts and redirect it toward the production of viral particles. While takeover of…”
Get full text

Investigating the Chemolithoautotrophic and Formate Metabolism of Nitrospira moscoviensis by Constraint-Based Metabolic Modeling and 13C-Tracer Analysis by Lawson, Christopher E, Mundinger, Aniela B, Koch, Hanna, Jacobson, Tyler B, Weathersby, Coty A, Jetten, Mike S. M, Pabst, Martin, Amador-Noguez, Daniel, Noguera, Daniel R, McMahon, Katherine, Lücker, Sebastian

“…Nitrite-oxidizing bacteria belonging to the genus Nitrospira mediate a key step in nitrification and play important roles in the biogeochemical nitrogen cycle…”
Get full text

Near-equilibrium glycolysis supports metabolic homeostasis and energy yield by Park, Junyoung O., Tanner, Lukas B., Wei, Monica H., Khana, Daven B., Jacobson, Tyler B., Zhang, Zheyun, Rubin, Sara A., Li, Sophia Hsin-Jung, Higgins, Meytal B., Stevenson, David M., Amador-Noguez, Daniel, Rabinowitz, Joshua D.

“…Glycolysis plays a central role in producing ATP and biomass. Its control principles, however, remain incompletely understood. Here, we develop a method that…”
Get full text

Stepwise genetic engineering of Pseudomonas putida enables robust heterologous production of prodigiosin and glidobactin A by Cook, Taylor B., Jacobson, Tyler B., Venkataraman, Maya V., Hofstetter, Heike, Amador-Noguez, Daniel, Thomas, Michael G., Pfleger, Brian F.

“…Polyketide synthases (PKS) and nonribosomal peptide synthetases (NRPS) comprise biosynthetic pathways that provide access to diverse, often bioactive natural…”
Get full text

Assessing the impact of substrate-level enzyme regulations limiting ethanol titer in Clostridium thermocellum using a core kinetic model by Foster, Charles, Boorla, Veda Sheersh, Dash, Satyakam, Gopalakrishnan, Saratram, Jacobson, Tyler B., Olson, Daniel G., Amador-Noguez, Daniel, Lynd, Lee R., Maranas, Costas D.

“…Clostridium thermocellum is a promising candidate for consolidated bioprocessing because it can directly ferment cellulose to ethanol. Despite significant…”
Get full text

Phenolic Amides Are Potent Inhibitors of De Novo Nucleotide Biosynthesis by Pisithkul, Tippapha, Jacobson, Tyler B, O'Brien, Thomas J, Stevenson, David M, Amador-Noguez, Daniel

“…An outstanding challenge toward efficient production of biofuels and value-added chemicals from plant biomass is the impact that lignocellulose-derived…”
Get full text

Evaluation of 1,2-diacyl-3-acetyl triacylglycerol production in Yarrowia lipolytica by Yan, Qiang, Jacobson, Tyler B., Ye, Zhou, Cortés-Pena, Yoel R., Bhagwat, Sarang S., Hubbard, Susan, Cordell, William T., Oleniczak, Rebecca E., Gambacorta, Francesca V., Vazquez, Julio Rivera, Shusta, Eric V., Amador-Noguez, Daniel, Guest, Jeremy S., Pfleger, Brian F.

“…Plants produce many high-value oleochemical molecules. While oil-crop agriculture is performed at industrial scales, suitable land is not available to meet…”
Get full text

2H and 13C metabolic flux analysis elucidates in vivo thermodynamics of the ED pathway in Zymomonas mobilis by Jacobson, Tyler B., Adamczyk, Paul A., Stevenson, David M., Regner, Matthew, Ralph, John, Reed, Jennifer L., Amador-Noguez, Daniel

“…Zymomonas mobilis is an industrially relevant bacterium notable for its ability to rapidly ferment simple sugars to ethanol using the Entner-Doudoroff (ED)…”
Get full text

Investigating the Chemolithoautotrophic and Formate Metabolism of Nitrospira moscoviensis by Constraint-Based Metabolic Modeling and 13 C-Tracer Analysis by Lawson, Christopher E., Mundinger, Aniela B., Koch, Hanna, Jacobson, Tyler B., Weathersby, Coty A., Jetten, Mike S. M., Pabst, Martin, Amador-Noguez, Daniel, Noguera, Daniel R., McMahon, Katherine, Lücker, Sebastian

“…Nitrospira spp. are globally abundant nitrifying bacteria in soil and aquatic ecosystems and in wastewater treatment plants, where they control the oxidation…”
Get full text

In Vivo Thermodynamic Analysis of Glycolysis in Clostridium thermocellum and Thermoanaerobacterium saccharolyticum Using 13C and 2H Tracers by Jacobson, Tyler B, Korosh, Travis K, Stevenson, David M, Foster, Charles, Maranas Costas, Olson, Daniel G, Lynd, Lee R, Amador-Noguez, Daniel

“…ABSTRACTClostridium thermocellum and Thermoanaerobacterium saccharolyticum are thermophilic anaerobic bacteria with complementary metabolic capabilities that…”
Get full text

In Vivo Thermodynamic Analysis of Glycolysis in Clostridium thermocellum and Thermoanaerobacterium saccharolyticum Using 13 C and 2 H Tracers by Jacobson, Tyler B, Korosh, Travis K, Stevenson, David M, Foster, Charles, Maranas, Costas, Olson, Daniel G, Lynd, Lee R, Amador-Noguez, Daniel

“…and are thermophilic anaerobic bacteria with complementary metabolic capabilities that utilize distinct glycolytic pathways for the conversion of cellulosic…”
Get full text

Relative Activities of the β‑Ketoacyl-CoA and Acyl-CoA Reductases Influence the Product Profile and Flux in a Reversed β‑Oxidation Pathway by Courtney, Dylan K., Su, Yun, Jacobson, Tyler B., Khana, Daven B., Ailiani, Aditya, Amador-Noguez, Daniel, Pfleger, Brian F.

“…The β-oxidation pathway, normally involved in the catabolism of fatty acids, can be functionally made to act as a fermentative, iterative, elongation pathway…”
Get full text

Metabolic Remodeling during Nitrogen Fixation in Zymomonas mobilis by Martien, Julia I., Trujillo, Edna A., Jacobson, Tyler B., Tatli, Mehmet, Hebert, Alexander S., Stevenson, David M., Coon, Joshua J., Amador-Noguez, Daniel, Vickers, Claudia

“…Biofuels and bioproducts have the potential to serve as environmentally sustainable replacements for petroleum-derived fuels and commodity molecules. Advanced…”
Get full text

In Vivo Thermodynamic Analysis of Metabolic Networks by Jacobson, Tyler B

“…Zymomonas mobilis, Clostridium thermocellum, and Thermoanaerobacterium saccharolyticum are industrially-relevant bacteria currently being developed for the…”
Get full text