Search Results - "Jacobsen, P.R"

Effects of Serotonin and Slow-Release 5-Hydroxytryptophan on Gastrointestinal Motility in a Mouse Model of Depression by Israelyan, Narek, Del Colle, Andrew, Li, Zhishan, Park, Yeji, Xing, Albert, Jacobsen, Jacob P.R., Luna, Ruth Ann, Jensen, Dane D., Madra, Moneek, Saurman, Virginia, Rahim, Ray, Latorre, Rocco, Law, Kimberly, Carson, William, Bunnett, Nigel W., Caron, Marc G., Margolis, Kara G.

“…Mood disorders and constipation are often comorbid, yet their shared etiologies have rarely been explored. The neurotransmitter serotonin (5-HT) regulates…”
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Adjunctive 5-Hydroxytryptophan Slow-Release for Treatment-Resistant Depression: Clinical and Preclinical Rationale by Jacobsen, Jacob P.R, Krystal, Andrew D, Krishnan, K. Ranga R, Caron, Marc G

“…Serotonin transporter (SERT) inhibitors treat depression by elevating brain extracellular 5-hydroxytryptamine (5-HTExt ). However, only one-third of patients…”
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Cholinergic dysfunction in the dorsal striatum promotes habit formation and maladaptive eating by Favier, Mathieu, Janickova, Helena, Justo, Damian, Kljakic, Ornela, Runtz, Léonie, Natsheh, Joman Y, Pascoal, Tharick A, Germann, Jurgen, Gallino, Daniel, Kang, Jun-Ii, Meng, Xiang Qi, Antinora, Christina, Raulic, Sanda, Jacobsen, Jacob Pr, Moquin, Luc, Vigneault, Erika, Gratton, Alain, Caron, Marc G, Duriez, Philibert, Brandon, Mark P, Neto, Pedro Rosa, Chakravarty, M Mallar, Herzallah, Mohammad M, Gorwood, Philip, Prado, Marco Am, Prado, Vania F, El Mestikawy, Salah

“…Dysregulation of habit formation has been recently proposed as pivotal to eating disorders. Here, we report that a subset of patients suffering from…”
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The interaction of escitalopram and R-citalopram at the human serotonin transporter investigated in the mouse by Jacobsen, Jacob P. R., Plenge, Per, Sachs, Benjamin D., Pehrson, Alan L., Cajina, Manuel, Du, Yunzhi, Roberts, Wendy, Rudder, Meghan L., Dalvi, Prachiti, Robinson, Taylor J., O’Neill, Sharon P., Khoo, King S., Morillo, Connie Sanchez, Zhang, Xiaodong, Caron, Marc G.

“…Rationale Escitalopram appears to be a superior antidepressant to racemic citalopram. It has been hypothesized that binding of R-citalopram to the serotonin…”
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Premature reproductive aging in female rats after developmental exposure to mixtures of endocrine disrupters by Jacobsen, P.R., Axelstad, M., Christiansen, S., Boberg, J., Hass, U.

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Combined exposure to endocrine disrupting pesticides impairs parturition, causes pup mortality and affects sexual differentiation in rats by Jacobsen, P.R, Christiansen, S, Boberg, J, Nellemann, C, Hass, U

“…Risk assessment is currently based on the no observed adverse effect levels (NOAELs) for single compounds. Humans are exposed to a mixture of chemicals and…”
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Daytime spikes in dopaminergic activity drive rapid mood-cycling in mice by Sidor, M M, Spencer, S M, Dzirasa, K, Parekh, P K, Tye, K M, Warden, M R, Arey, R N, Enwright, J F, Jacobsen, J P R, Kumar, S, Remillard, E M, Caron, M G, Deisseroth, K, McClung, C A

“…Disruptions in circadian rhythms and dopaminergic activity are involved in the pathophysiology of bipolar disorder, though their interaction remains unclear…”
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Adjunctive 5-hydroxytryptophan slow-release for treatment-resistant depression: Clinical and pre-clinical rationale by Jacobsen, Jacob P.R., Krystal, Andrew D., Krishnan, K. Ranga R., Caron, Marc G.

“…Serotonin transporter (SERT) inhibitors treat depression by elevating brain extracellular 5-hydroxytryptamine (5-HT Ext ). However, only one-third of patients…”
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Deletion of GSK3β in D2R-expressing neurons reveals distinct roles for β-arrestin signaling in antipsychotic and lithium action by Urs, Nikhil M., Snyder, Joshua C., Jacobsen, Jacob P. R., Peterson, Sean M., Caron, Marc G.

“…Several studies in rodent models have shown that glycogen synthase kinase 3 β (GSK3β) plays an important role in the actions of antispychotics and mood…”
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Deficient serotonin neurotransmission and depression-like serotonin biomarker alterations in tryptophan hydroxylase 2 (Tph2) loss-of-function mice by Jacobsen, J P R, Siesser, W B, Sachs, B D, Peterson, S, Cools, M J, Setola, V, Folgering, J H A, Flik, G, Caron, M G

“…Probably the foremost hypothesis of depression is the 5-hydroxytryptamine (5-HT, serotonin) deficiency hypothesis. Accordingly, anomalies in putative 5-HT…”
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Effects of Serotonin and Slow-release 5-HTP on Gastrointestinal Motility in a Mouse Model of Depression by Israelyan, Narek, Colle, Andrew Del, Li, Zhishan, Park, Yeji, Xing, Albert, Jacobsen, Jacob P.R., Luna, Ruth Ann, Jensen, Dane D., Madra, Moneek, Saurman, Virginia, Rahim, Ray, Latorre, Rocco, Law, Kimberly, Carson, William, Bunnett, Nigel W., Caron, Marc G., Margolis, Kara G.

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Slow-release delivery enhances the pharmacological properties of oral 5-hydroxytryptophan: mouse proof-of-concept by Jacobsen, Jacob P R, Oh, Adrianna, Bangle, Rachel, Roberts, Wendy L, Royer, Elizabeth L, Modesto, Nathan, Windermere, Sonora A, Yi, Zixuan, Vernon, Rebecca, Cajina, Manuel, Urs, Nikhil M, Snyder, Joshua C, Nicholls, Peter J, Sachs, Benjamin D, Caron, Marc G

“…5-hydroxytryptophan (5-HTP) has shown therapeutic promise in a range of human CNS disorders. But native 5-HTP immediate release (IR) is poorly druggable, as…”
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SSRI Augmentation by 5-Hydroxytryptophan Slow Release: Mouse Pharmacodynamic Proof of Concept by Jacobsen, Jacob Pr, Rudder, Meghan L, Roberts, Wendy, Royer, Elizabeth L, Robinson, Taylor J, Oh, Adrianna, Spasojevic, Ivan, Sachs, Benjamin D, Caron, Marc G

“…Drugs, notably SSRIs, that elevate brain extracellular 5-HT (5-HTExt) are antidepressants. Unfortunately, most patients fail to remit. Multipronged clinical…”
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Chronic corticosterone decreases brain-derived neurotrophic factor (BDNF) mRNA and protein in the hippocampus, but not in the frontal cortex, of the rat by Jacobsen, Jacob P.R., Mørk, Arne

“…This study examined the effects of chronic corticosterone (32 mg/kg/day, s.c., 21 days) on brain-derived neurotrophic factor (BDNF) mRNA and protein in the…”
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The effects of brain serotonin deficiency on behavioural disinhibition and anxiety-like behaviour following mild early life stress by Sachs, Benjamin D., Rodriguiz, Ramona M., Siesser, William B., Kenan, Alexander, Royer, Elizabeth L., Jacobsen, Jacob P. R., Wetsel, William C., Caron, Marc G.

“…Aberrant serotonin (5-HT) signalling and exposure to early life stress have both been suggested to play a role in anxiety- and impulsivity-related behaviours…”
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The effects of congenital brain serotonin deficiency on responses to chronic fluoxetine by Sachs, B D, Jacobsen, J P R, Thomas, T L, Siesser, W B, Roberts, W L, Caron, M G

“…The importance of reversing brain serotonin (5-HT) deficiency and promoting hippocampal neurogenesis in the mechanisms of action for antidepressants remain…”
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Tryptophan hydroxylase 2 genotype determines brain serotonin synthesis but not tissue content in C57Bl/6 and BALB/c congenic mice by Siesser, William B., Zhang, Xiaodong, Jacobsen, Jacob P.R., Sotnikova, Tatyana D., Gainetdinov, Raul R., Caron, Marc G.

“…▶ The C1473G SNP in mouse tryptophan hydroxylase 2 affects 5-HT synthesis rate. ▶ BALB/c congenics with the C allele have increased 5-HT synthesis and…”
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Selective cognitive deficits and reduced hippocampal brain-derived neurotrophic factor mRNA expression in small-conductance calcium-activated K+ channel deficient mice by Jacobsen, J.P.R, Redrobe, J.P, Hansen, H.H, Petersen, S, Bond, C.T, Adelman, J.P, Mikkelsen, J.D, Mirza, N.R

“…Abstract Small-conductance calcium-activated K+ channels 1–3 (SK1-3) are important for neuronal firing regulation and are considered putative CNS drug targets…”
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Insensitivity of NMRI mice to selective serotonin reuptake inhibitors in the tail suspension test can be reversed by co-treatment with 5-hydroxytryptophan by Jacobsen, Jacob P. R., Nielsen, Elsebet Ø., Hummel, Rene, Redrobe, John Paul, Mirza, Naheed, Weikop, Pia

“…Rationale Exploring differences between mouse strains in drug effects in models of antidepressant-like activity may provide clues to the neurobiology of…”
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Differential psychostimulant-induced activation of neural circuits in dopamine transporter knockout and wild type mice by TRINH, J. V, NEHRENBERG, D. L, JACOBSEN, J. P. R, CARON, M. G, WETSEL, W. C

“…Dopamine (DA) is a neurotransmitter that has been implicated in a wide variety of psychiatric disorders that include attention deficit-hyperactivity disorder…”
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