Search Results - "Jacobsen, Johanne T."

Germinal Center Selection and Affinity Maturation Require Dynamic Regulation of mTORC1 Kinase by Ersching, Jonatan, Efeyan, Alejo, Mesin, Luka, Jacobsen, Johanne T., Pasqual, Giulia, Grabiner, Brian C., Dominguez-Sola, David, Sabatini, David M., Victora, Gabriel D.

“…During antibody affinity maturation, germinal center (GC) B cells cycle between affinity-driven selection in the light zone (LZ) and proliferation and somatic…”
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Visualizing antibody affinity maturation in germinal centers by Tas, Jeroen M. J., Mesin, Luka, Pasqual, Giulia, Targ, Sasha, Jacobsen, Johanne T., Mano, Yasuko M., Chen, Casie S., Weill, Jean-Claude, Reynaud, Claude-Agnès, Browne, Edward P., Meyer-Hermann, Michael, Victora, Gabriel D.

“…Antibodies somatically mutate to attain high affinity in germinal centers (GCs). There, competition between B cell clones and among somatic mutants of each…”
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Universal recording of immune cell interactions in vivo by Nakandakari-Higa, Sandra, Walker, Sarah, Canesso, Maria C. C., van der Heide, Verena, Chudnovskiy, Aleksey, Kim, Dong-Yoon, Jacobsen, Johanne T., Parsa, Roham, Bilanovic, Jana, Parigi, S. Martina, Fiedorczuk, Karol, Fuchs, Elaine, Bilate, Angelina M., Pasqual, Giulia, Mucida, Daniel, Kamphorst, Alice O., Pritykin, Yuri, Victora, Gabriel D.

“…Immune cells rely on transient physical interactions with other immune and non-immune populations to regulate their function 1 . To study these ‘kiss-and-run’…”
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Cytotoxic Escherichia coli strains encoding colibactin isolated from immunocompromised mice with urosepsis and meningitis by Bakthavatchalu, Vasudevan, Wert, Katherine J, Feng, Yan, Mannion, Anthony, Ge, Zhongming, Garcia, Alexis, Scott, Kathleen E, Caron, Tyler J, Madden, Carolyn M, Jacobsen, Johanne T, Victora, Gabriel, Jaenisch, Rudolf, Fox, James G

“…Immune-compromised mouse models allow for testing the preclinical efficacy of human cell transplantations and gene therapy strategies before moving forward to…”
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Enhanced germinal center reaction by targeting vaccine antigen to major histocompatibility complex class II molecules by Andersen, Tor Kristian, Huszthy, Peter C., Gopalakrishnan, Ramakrishna P., Jacobsen, Johanne T., Fauskanger, Marte, Tveita, Anders A., Grødeland, Gunnveig, Bogen, Bjarne

“…Enhancing the germinal center (GC) reaction is a prime objective in vaccine development. Targeting of antigen to MHCII on APCs has previously been shown to…”
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In Vivo Imaging of Tfh Cells by Nakandakari-Higa, Sandra, Jacobsen, Johanne T

“…Germinal centers (GCs) are microanatomical structures in secondary lymphoid organs where B cells undergo affinity maturation for antigen during the course of…”
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Imaging the different timescales of germinal center selection by Pae, Juhee, Jacobsen, Johanne T., Victora, Gabriel D.

“…Germinal centers (GCs) are the site of antibody affinity maturation, a fundamental immunological process that increases the potency of antibodies and thereby…”
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Expression of Foxp3 by T follicular helper cells in end-stage germinal centers by Jacobsen, Johanne T, Hu, Wei, R Castro, Tiago B, Solem, Sigrid, Galante, Alice, Lin, Zeran, Allon, Samuel J, Mesin, Luka, Bilate, Angelina M, Schiepers, Ariën, Shalek, Alex K, Rudensky, Alexander Y, Victora, Gabriel D

“…Germinal centers (GCs) are the site of immunoglobulin somatic hypermutation and affinity maturation, processes essential to an effective antibody response. The…”
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Clonal replacement sustains long-lived germinal centers primed by respiratory viruses by de Carvalho, Renan V.H., Ersching, Jonatan, Barbulescu, Alexandru, Hobbs, Alvaro, Castro, Tiago B.R., Mesin, Luka, Jacobsen, Johanne T., Phillips, Brooke K., Hoffmann, Hans-Heinrich, Parsa, Roham, Canesso, Maria Cecilia C., Nowosad, Carla R., Feng, Allan, Leist, Sarah R., Baric, Ralph S., Yang, Emily, Utz, P.J., Victora, Gabriel D.

“…Germinal centers (GCs) form in secondary lymphoid organs in response to infection and immunization and are the source of affinity-matured B cells. The duration…”
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Noninvasive Imaging of Human Immune Responses in a Human Xenograft Model of Graft-Versus-Host Disease by Van Elssen, Catharina H M J, Rashidian, Mohammad, Vrbanac, Vladimir, Wucherpfennig, Kai W, Habre, Zeina El, Sticht, Jana, Freund, Christian, Jacobsen, Johanne T, Cragnolini, Juanjo, Ingram, Jessica, Plaisier, Loes, Spierings, Eric, Tager, Andrew M, Ploegh, Hidde L

“…The immune system plays a crucial role in many diseases. Activation or suppression of immunity is often related to clinical outcome. Methods to explore the…”
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Enzyme-Mediated Modification of Single-Domain Antibodies for Imaging Modalities with Different Characteristics by Rashidian, Mohammad, Wang, Lu, Edens, Jerre G., Jacobsen, Johanne T., Hossain, Intekhab, Wang, Qifan, Victora, Gabriel D., Vasdev, Neil, Ploegh, Hidde, Liang, Steven H.

“…Antibodies are currently the fastest‐growing class of therapeutics. Although naked antibodies have proven valuable as pharmaceutical agents, they have some…”
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One-step generation of monoclonal B cell receptor mice capable of isotype switching and somatic hypermutation by Jacobsen, Johanne T, Mesin, Luka, Markoulaki, Styliani, Schiepers, Ariën, Cavazzoni, Cecília B, Bousbaine, Djenet, Jaenisch, Rudolf, Victora, Gabriel D

“…We developed a method for rapid generation of B cell receptor (BCR) monoclonal mice expressing prerearranged and chains monoallelically from the locus by…”
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Microanatomical Labeling of Germinal Center Structures for Flow Cytometry Using Photoactivation by Jacobsen, Johanne T, Victora, Gabriel D

“…Germinal centers (GCs) are inducible microanatomical structures required for the generation of high-affinity antibodies. Migration of B and T cells within and…”
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Use of 18F‑2-Fluorodeoxyglucose to Label Antibody Fragments for Immuno-Positron Emission Tomography of Pancreatic Cancer by Rashidian, Mohammad, Keliher, Edmund J, Dougan, Michael, Juras, Patrick K, Cavallari, Marco, Wojtkiewicz, Gregory R, Jacobsen, Johanne T, Edens, Jerre G, Tas, Jeroen M. J, Victora, Gabriel, Weissleder, Ralph, Ploegh, Hidde

“…We generated 18F-labeled antibody fragments for positron emission tomography (PET) imaging using a sortase-mediated reaction to install a…”
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B‐cell tolerance to the B‐cell receptor variable regions by Jacobsen, Johanne T., Sundvold‐Gjerstad, Vibeke, Skjeldal, Frode M., Andersen, Jan‐Terje, Abrahamsen, Greger, Bakke, Oddmund, Spurkland, Anne, Bogen, Bjarne

“…An enormous number of B cells with different B‐cell receptors (BCRs) are continuously produced in the bone marrow. BCRs are further diversified during the…”
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The cellular mechanism by which complementary Id and anti-Id antibodies communicate: T cells integrated into idiotypic regulation by Jacobsen, Johanne T, Lunde, Elin, Sundvold‐Gjerstad, Vibeke, Munthe, Ludvig A, Bogen, Bjarne

“…The V region antigenic determinants (idiotopes (Ids)) of antibodies (Abs) have been suggested to be involved in regulating the immune system. Certain diseases…”
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Enzyme-Mediated Modification of Single-Domain Antibodies for Imaging Modalities with Different Characteristics by Rashidian, Mohammad, Wang, Lu, Edens, Jerre G., Jacobsen, Johanne T., Hossain, Intekhab, Wang, Qifan, Victora, Gabriel D., Vasdev, Neil, Ploegh, Hidde, Liang, Steven H.

“…Antibodies are currently the fastest‐growing class of therapeutics. Although naked antibodies have proven valuable as pharmaceutical agents, they have some…”
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Use of 18 F-2-Fluorodeoxyglucose to Label Antibody Fragments for Immuno-Positron Emission Tomography of Pancreatic Cancer by Rashidian, Mohammad, Keliher, Edmund J., Dougan, Michael, Juras, Patrick K., Cavallari, Marco, Wojtkiewicz, Gregory R., Jacobsen, Johanne T., Edens, Jerre G., Tas, Jeroen M. J., Victora, Gabriel, Weissleder, Ralph, Ploegh, Hidde

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