Search Results - "Jacobsen, Britta"

Progesterone receptors, their isoforms and progesterone regulated transcription by Jacobsen, Britta M., Horwitz, Kathryn B.

“…► Progesterone receptor (PR) levels are regulated by estrogen-dependent and independent pathways. ► PR mediated gene regulation as studied by expression…”
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Mucin 2 (MUC2) modulates the aggressiveness of breast cancer by Astashchanka, Anna, Shroka, Thomas M., Jacobsen, Britta M.

“…Purpose Tumors that secrete large volumes of mucus are chemotherapy resistant, however, mechanisms underlying this resistance are unknown. One protein highly…”
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Biological and clinical impact of imbalanced progesterone receptor isoform ratios in breast cancer by Lamb, Caroline A, Fabris, Victoria T, Jacobsen, Britta M, Molinolo, Alfredo, Lanari, Claudia

“…There is a consensus that progestins and thus their cognate receptor molecules, the progesterone receptors (PRs), are essential in the development of the adult…”
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Multiple molecular subtypes of triple-negative breast cancer critically rely on androgen receptor and respond to enzalutamide in vivo by Barton, Valerie N, D'Amato, Nicholas C, Gordon, Michael A, Lind, Hanne T, Spoelstra, Nicole S, Babbs, Beatrice L, Heinz, Richard E, Elias, Anthony, Jedlicka, Paul, Jacobsen, Britta M, Richer, Jennifer K

“…Triple-negative breast cancer (TNBC) has the lowest 5-year survival rate of invasive breast carcinomas, and currently there are no approved targeted therapies…”
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DNA profiling analysis of endometrial and ovarian cell lines reveals misidentification, redundancy and contamination by Korch, Christopher, Spillman, Monique A, Jackson, Twila A, Jacobsen, Britta M, Murphy, Susan K, Lessey, Bruce A, Jordan, V. Craig, Bradford, Andrew P

“…Abstract Objectives Cell lines derived from human ovarian and endometrial cancers, and their immortalized non-malignant counterparts, are critical tools to…”
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Role of the androgen receptor in breast cancer and preclinical analysis of enzalutamide by Cochrane, Dawn R, Bernales, Sebastián, Jacobsen, Britta M, Cittelly, Diana M, Howe, Erin N, D'Amato, Nicholas C, Spoelstra, Nicole S, Edgerton, Susan M, Jean, Annie, Guerrero, Javier, Gómez, Francisco, Medicherla, Satyanarayana, Alfaro, Iván E, McCullagh, Emma, Jedlicka, Paul, Torkko, Kathleen C, Thor, Ann D, Elias, Anthony D, Protter, Andrew A, Richer, Jennifer K

“…The androgen receptor (AR) is widely expressed in breast cancers and has been proposed as a therapeutic target in estrogen receptor alpha (ER) negative breast…”
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New generation breast cancer cell lines developed from patient-derived xenografts by Finlay-Schultz, Jessica, Jacobsen, Britta M, Riley, Duncan, Paul, Kiran V, Turner, Scott, Ferreira-Gonzalez, Andrea, Harrell, J Chuck, Kabos, Peter, Sartorius, Carol A

“…Breast cancer is a highly heterogeneous disease characterized by multiple histologic and molecular subtypes. While a myriad of breast cancer cell lines have…”
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Loss of E-cadherin Enhances IGF1-IGF1R Pathway Activation and Sensitizes Breast Cancers to Anti-IGF1R/InsR Inhibitors by Nagle, Alison M, Levine, Kevin M, Tasdemir, Nilgun, Scott, Julie A, Burlbaugh, Kara, Kehm, Justin, Katz, Tiffany A, Boone, David N, Jacobsen, Britta M, Atkinson, Jennifer M, Oesterreich, Steffi, Lee, Adrian V

“…Insulin-like growth factor 1 (IGF1) signaling regulates breast cancer initiation and progression and associated cancer phenotypes. We previously identified…”
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Cooperative Dynamics of AR and ER Activity in Breast Cancer by D'Amato, Nicholas C, Gordon, Michael A, Babbs, Beatrice, Spoelstra, Nicole S, Carson Butterfield, Kiel T, Torkko, Kathleen C, Phan, Vernon T, Barton, Valerie N, Rogers, Thomas J, Sartorius, Carol A, Elias, Anthony, Gertz, Jason, Jacobsen, Britta M, Richer, Jennifer K

“…Androgen receptor (AR) is expressed in 90% of estrogen receptor alpha-positive (ER ) breast tumors, but its role in tumor growth and progression remains…”
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Malignant stroma increases luminal breast cancer cell proliferation and angiogenesis through platelet-derived growth factor signaling by Pinto, Mauricio P, Dye, Wendy W, Jacobsen, Britta M, Horwitz, Kathryn B

“…Luminal, estrogen receptor-positive breast cancers represent more than 70% of cases. Despite initial good prognoses one third of Luminal cancers eventually…”
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Comprehensive Phenotypic Characterization of Human Invasive Lobular Carcinoma Cell Lines in 2D and 3D Cultures by Tasdemir, Nilgun, Bossart, Emily A, Li, Zheqi, Zhu, Li, Sikora, Matthew J, Levine, Kevin M, Jacobsen, Britta M, Tseng, George C, Davidson, Nancy E, Oesterreich, Steffi

“…Invasive lobular carcinoma (ILC) is the second most common subtype of breast cancer following invasive ductal carcinoma (IDC) and characterized by the loss of…”
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Steroid Hormone Receptor and Infiltrating Immune Cell Status Reveals Therapeutic Vulnerabilities of ESR1 -Mutant Breast Cancer by Williams, Michelle M, Spoelstra, Nicole S, Arnesen, Spencer, O'Neill, Kathleen I, Christenson, Jessica L, Reese, Jordan, Torkko, Kathleen C, Goodspeed, Andrew, Rosas, Emmanuel, Hanamura, Toru, Sams, Sharon B, Li, Zheqi, Oesterreich, Steffi, Riggins, Rebecca B, Jacobsen, Britta M, Elias, Anthony, Gertz, Jason, Richer, Jennifer K

“…Mutations in that confer constitutive estrogen receptor alpha (ER) activity in the absence of ligand are acquired by ≥40% of metastatic breast cancers (MBC)…”
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FGF2 induces breast cancer growth through ligand‐independent activation and recruitment of ERα and PRBΔ4 isoform to MYC regulatory sequences by Giulianelli, Sebastián, Riggio, Marina, Guillardoy, Tomas, Pérez Piñero, Cecilia, Gorostiaga, María A., Sequeira, Gonzalo, Pataccini, Gabriela, Abascal, María F., Toledo, María F., Jacobsen, Britta M., Guerreiro, Ana C., Barros, António, Novaro, Virginia, Monteiro, Fátima L., Amado, Francisco, Gass, Hugo, Abba, Martin, Helguero, Luisa A., Lanari, Claudia

“…Progression to hormone‐independent growth leading to endocrine therapy resistance occurs in a high proportion of patients with estrogen receptor alpha (ERα)…”
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Breast Cancer Suppression by Progesterone Receptors Is Mediated by Their Modulation of Estrogen Receptors and RNA Polymerase III by Finlay-Schultz, Jessica, Gillen, Austin E, Brechbuhl, Heather M, Ivie, Joshua J, Matthews, Shawna B, Jacobsen, Britta M, Bentley, David L, Kabos, Peter, Sartorius, Carol A

“…Greater than 50% of estrogen receptor (ER)-positive breast cancers coexpress the progesterone receptor (PR), which can directly and globally modify ER action…”
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WNT4 mediates estrogen receptor signaling and endocrine resistance in invasive lobular carcinoma cell lines by Sikora, Matthew J, Jacobsen, Britta M, Levine, Kevin, Chen, Jian, Davidson, Nancy E, Lee, Adrian V, Alexander, Caroline M, Oesterreich, Steffi

“…Invasive lobular carcinoma (ILC) of the breast typically presents with clinical biomarkers consistent with a favorable response to endocrine therapies, and…”
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Exogenous Thyroid Hormone Is Associated with Shortened Survival and Upregulation of High-Risk Gene Expression Profiles in Steroid Receptor-Positive Breast Cancers by Wahdan-Alaswad, Reema S, Edgerton, Susan M, Salem, Hiba, Kim, Hyun Min, Tan, Aik Choon, Finlay-Schultz, Jessica, Wellberg, Elizabeth A, Sartorius, Carol A, Jacobsen, Britta M, Haugen, Bryan R, Liu, Bolin, Thor, Ann D

“…Thyroid disease is a frequent comorbidity in women with breast cancer, and many require thyroid hormone replacement therapy (THRT). We postulated that THRT has…”
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SNAIL is induced by tamoxifen and leads to growth inhibition in invasive lobular breast carcinoma by Bossart, Emily A., Tasdemir, Nilgun, Sikora, Matthew J., Bahreini, Amir, Levine, Kevin M., Chen, Jian, Basudan, Ahmed, Jacobsen, Britta M., Burns, Timothy F., Oesterreich, Steffi

“…Purpose Invasive lobular carcinoma (ILC) is a histological subtype of breast cancer that is predominantly estrogen receptor alpha (ER)-positive (+) and is thus…”
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Progestin modulates the lipid profile and sensitivity of breast cancer cells to docetaxel by Schlaepfer, Isabel R., Hitz, Carolyn A., Gijón, Miguel A., Bergman, Bryan C., Eckel, Robert H., Jacobsen, Britta M.

“…► Progestins decrease sensitivity to docetaxel in breast cancer cells. ► Blocking lipid droplet formation increases docetaxel sensitivity. ► Docetaxel is…”
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Differential Gene Regulation by the Two Progesterone Receptor Isoforms in Human Breast Cancer Cells by Richer, Jennifer K, Jacobsen, Britta M, Manning, Nicole G, Abel, M Greg, Wolf, Douglas M, Horwitz, Kathryn B

“…The PR-A and PR-B isoforms of progesterone receptors (PR) have different physiological functions, and their ratio varies widely in breast cancers. To determine…”
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Progestin regulated miRNAs that mediate progesterone receptor action in breast cancer by Cochrane, Dawn R., Jacobsen, Britta M., Connaghan, Keith D., Howe, Erin N., Bain, David L., Richer, Jennifer K.

“…► Progestin stimulates rapid regulation of miRNAs. ► ATP1B1 is upregulated by progesterone receptor at its promoter. ► ATP1B1 is repressed by miR-29, a…”
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