Search Results - "Jacobse, Justin"

Intestinal Regulatory T Cells as Specialized Tissue-Restricted Immune Cells in Intestinal Immune Homeostasis and Disease by Jacobse, Justin, Li, Jing, Rings, Edmond H H M, Samsom, Janneke N, Goettel, Jeremy A

“…FOXP3 regulatory T cells (Treg cells) are a specialized population of CD4 T cells that restrict immune activation and are essential to prevent systemic…”
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SELENOP modifies sporadic colorectal carcinogenesis and WNT signaling activity through LRP5/6 interactions by Pilat, Jennifer M, Brown, Rachel E, Chen, Zhengyi, Berle, Nathaniel J, Othon, Adrian P, Washington, M Kay, Anant, Shruti A, Kurokawa, Suguru, Ng, Victoria H, Thompson, Joshua J, Jacobse, Justin, Goettel, Jeremy A, Lee, Ethan, Choksi, Yash A, Lau, Ken S, Short, Sarah P, Williams, Christopher S

“…Although selenium deficiency correlates with colorectal cancer (CRC) risk, the roles of the selenium-rich antioxidant selenoprotein P (SELENOP) in CRC remain…”
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HLA-Restriction of Human Treg Cells Is Not Required for Therapeutic Efficacy of Low-Dose IL-2 in Humanized Mice by Tyagi, Rajeev K, Jacobse, Justin, Li, Jing, Allaman, Margret M, Otipoby, Kevin L, Sampson, Erik R, Wilson, Keith T, Goettel, Jeremy A

“…Regulatory T (T ) cells are essential to maintain immune homeostasis in the intestine and T cell dysfunction is associated with several inflammatory and…”
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Myeloid deletion of talin-1 reduces mucosal macrophages and protects mice from colonic inflammation by Latour, Yvonne L., McNamara, Kara M., Allaman, Margaret M., Barry, Daniel P., Smith, Thaddeus M., Asim, Mohammad, Williams, Kamery J., Hawkins, Caroline V., Jacobse, Justin, Goettel, Jeremy A., Delgado, Alberto G., Piazuelo, M. Blanca, Washington, M. Kay, Gobert, Alain P., Wilson, Keith T.

“…The intestinal immune response is crucial in maintaining a healthy gut, but the enhanced migration of macrophages in response to pathogens is a major…”
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The Yin and Yang of Memory Consolidation: Hippocampal and Neocortical by Genzel, Lisa, Rossato, Janine I, Jacobse, Justin, Grieves, Roddy M, Spooner, Patrick A, Battaglia, Francesco P, Fernández, Guillen, Morris, Richard G M

“…While hippocampal and cortical mechanisms of memory consolidation have long been studied, their interaction is poorly understood. We sought to investigate…”
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Distinct roles for interleukin-23 receptor signaling in regulatory T cells in sporadic and inflammation-associated carcinogenesis by Jacobse, Justin, Pilat, Jennifer M, Li, Jing, Brown, Rachel E, Kwag, Aaron, Buendia, Matthew A, Choksi, Yash A, Washington, M Kay, Williams, Christopher S, Markham, Nicholas O, Short, Sarah P, Goettel, Jeremy A

“…The pro-inflammatory cytokine interleukin-23 (IL-23) has been implicated in colorectal cancer (CRC). Yet, the cell-specific contributions of IL-23 receptor…”
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Epithelial talin-1 protects mice from Citrobacter rodentium-induced colitis by restricting bacterial crypt intrusion and enhancing T cell immunity by Latour, Yvonne L., Allaman, Margaret M., Barry, Daniel P., Smith, Thaddeus M., Williams, Kamery J., McNamara, Kara M., Jacobse, Justin, Goettel, Jeremy A., Delgado, Alberto G., Piazuelo, M. Blanca, Zhao, Shilin, Gobert, Alain P., Wilson, Keith T.

“…Pathogenic enteric Escherichia coli present a significant burden to global health. Food-borne enteropathogenic E. coli (EPEC) and Shiga toxin-producing E. coli…”
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MTG16 regulates colonic epithelial differentiation, colitis, and tumorigenesis by repressing E protein transcription factors by Brown, Rachel E, Jacobse, Justin, Anant, Shruti A, Blunt, Koral M, Chen, Bob, Vega, Paige N, Jones, Chase T, Pilat, Jennifer M, Revetta, Frank, Gorby, Aidan H, Stengel, Kristy R, Choksi, Yash A, Palin, Kimmo, Piazuelo, M Blanca, Washington, Mary Kay, Lau, Ken S, Goettel, Jeremy A, Hiebert, Scott W, Short, Sarah P, Williams, Christopher S

“…Aberrant epithelial differentiation and regeneration contribute to colon pathologies, including inflammatory bowel disease (IBD) and colitis-associated cancer…”
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Cystathionine γ-lyase exacerbates Helicobacter pylori immunopathogenesis by promoting macrophage metabolic remodeling and activation by Latour, Yvonne L., Sierra, Johanna C., Finley, Jordan L., Asim, Mohammad, Barry, Daniel P., Allaman, Margaret M., Smith, Thaddeus M., McNamara, Kara M., Luis, Paula B., Schneider, Claus, Jacobse, Justin, Goettel, Jeremy A., Calcutt, M. Wade, Rose, Kristie L., Schey, Kevin L., Milne, Ginger L., Delgado, Alberto G., Piazuelo, M. Blanca, Paul, Bindu D., Snyder, Solomon H., Gobert, Alain P., Wilson, Keith T.

“…Macrophages play a crucial role in the inflammatory response to the human stomach pathogen Helicobacter pylori , which infects half of the world’s population…”
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FOXP3+ Tregs require WASP to restrain Th2-mediated food allergy by Lexmond, Willem S., Goettel, Jeremy A., Lyons, Jonathan J., Jacobse, Justin, Deken, Marion M., Lawrence, Monica G., DiMaggio, Thomas H., Kotlarz, Daniel, Garabedian, Elizabeth, Sackstein, Paul, Nelson, Celeste C., Jones, Nina, Stone, Kelly D., Candotti, Fabio, Rings, Edmond H.H.M., Thrasher, Adrian J., Milner, Joshua D., Snapper, Scott B., Fiebiger, Edda

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ILC3s restrict intestinal inflammation via IL-10 production by Li, Jing, Jacobse, Justin, Goettel, Jeremy Allen, Washington, Mary Kay

“…Abstract In this study, we investigated the role of IL-10 production by group 3 innate lymphoid cells (ILC3s) in regulating intestinal immunity. Prior work has…”
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23: ILC3S RESTRICT INTESTINAL INFLAMMATION VIA IL-10 PRODUCTION by Li, Jing, Jacobse, Justin, Washington, Kay, Goettel, Jeremy A.

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A method for scoring 4-nitroquinoline 1-oxide-induced murine esophageal squamous neoplasia by Aziz, Zaryab, Washington, Mary Kay, Jacobse, Justin, Choksi, Yash

“…A mouse model for esophageal squamous cell carcinoma (ESCC) is induced by oral administration of the carcinogen 4-nitroquinoline 1-oxide (4-NQO). There is not…”
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Su1278 ALTERED BASAL CELL NUCLEAR SHAPE DISTINGUISHES EOE FROM GERD AND OCCURS THROUGH STAT6 ACTIVATION by Kwag, Aaron, Buendia, Matthew A., Pilat, Jennifer M., Jacobse, Justin, Hiremath, Girish, Choksi, Yash A.

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Animal models of eosinophilic esophagitis by Pilat, Jennifer M, Jacobse, Justin, Buendia, Matthew A, Choksi, Yash A

“…Eosinophilic esophagitis is a chronic inflammatory disorder of the esophagus. Over the past 25 yr, great strides have been made toward understanding its…”
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GPX3 IS REQUIRED TO MEDIATE PROTECTIVE EFFECTS OF GPX1 LOSS IN COLITIS by Blunt, Koral, Jacobse, Justin, Allaman, Margaret, Washington, Mary, Goettel, Jeremy, Wilson, Keith, Williams, Christopher, Short, Sarah

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1242 N-ACETYLCYSTEINE MAY ATTENUATE HISTOPATHOLOGICAL FINDINGS OF EOSINOPHILIC ESOPHAGITIS BY REDUCING STAT6 ACTIVATION by Buendia, Matthew A., Jacobse, Justin, Kwag, Aaron, Wimbiscus, Mae A., Hiremath, Girish, Williams, Christopher S., Choksi, Yash A.

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725 INTERLEUKIN-23 RECEPTOR SIGNALLING IMPAIRS COLONIC REGULATORY T CELL SUPPRESSIVE CAPACITY IN VITRO AND DESTABILIZES COLONIC TREGS IN VIVO by Jacobse, Justin, Li, Jing, Washington, Mary K., Rings, Edmond H.H.M., Samsom, Janneke N., Goettel, Jeremy A.

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Children with eosinophilic esophagitis non‐responsive to combination therapy have distinct esophageal transcriptomic and microbiome profile by Hiremath, Girish, Choksi, Yash, Correa, Hernan, Jacobse, Justin, Das, Suman R., Ma, Siyuan, Goettel, Jeremy A., Rajagopala, Seesandra V.

“…Background A combination of proton‐pump inhibitors (PPI) and topical steroids (TS) is used to treat children with eosinophilic esophagitis (EoE). However, a…”
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GPX3 IS REQUIRED TO MEDIATE PROTECTIVE EFFECTS OF GPX1 LOSS IN COLITIS by Blunt, Koral, Jacobse, Justin, Allaman, Margaret, Washington, Mary, Goettel, Jeremy, Wilson, Keith, Williams, Christopher, Short, Sarah

“…Abstract Reactive oxygen species (ROS) have long been known to contribute to the development and severity of Inflammatory Bowel Disease. However, more recent…”
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