Search Results - "Jacobs, T."

Mitochondria are physiologically maintained at close to 50 °C by Chrétien, Dominique, Bénit, Paule, Ha, Hyung-Ho, Keipert, Susanne, El-Khoury, Riyad, Chang, Young-Tae, Jastroch, Martin, Jacobs, Howard T, Rustin, Pierre, Rak, Malgorzata

“…In endothermic species, heat released as a product of metabolism ensures stable internal temperature throughout the organism, despite varying environmental…”
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Post-acute sequelae of COVID-19 in a non-hospitalized cohort: Results from the Arizona CoVHORT by Bell, Melanie L, Catalfamo, Collin J, Farland, Leslie V, Ernst, Kacey C, Jacobs, Elizabeth T, Klimentidis, Yann C, Jehn, Megan, Pogreba-Brown, Kristen

“…Clinical presentation, outcomes, and duration of COVID-19 has ranged dramatically. While some individuals recover quickly, others suffer from persistent…”
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Allogeneic natural killer cell therapy by Berrien-Elliott, Melissa M., Jacobs, Miriam T., Fehniger, Todd A.

“…[Display omitted] Interest in adoptive cell therapy for treating cancer is exploding owing to early clinical successes of autologous chimeric antigen receptor…”
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Design of structurally distinct proteins using strategies inspired by evolution by Jacobs, T. M., Williams, B., Williams, T., Xu, X., Eletsky, A., Federizon, J. F., Szyperski, T., Kuhlman, B.

“…Natural recombination combines pieces of preexisting proteins to create new tertiary structures and functions. We describe a computational protocol, called…”
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Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages by Mills, Evanna L., Kelly, Beth, Logan, Angela, Costa, Ana S.H., Varma, Mukund, Bryant, Clare E., Tourlomousis, Panagiotis, Däbritz, J. Henry M., Gottlieb, Eyal, Latorre, Isabel, Corr, Sinéad C., McManus, Gavin, Ryan, Dylan, Jacobs, Howard T., Szibor, Marten, Xavier, Ramnik J., Braun, Thomas, Frezza, Christian, Murphy, Michael P., O’Neill, Luke A.

“…Activated macrophages undergo metabolic reprogramming, which drives their pro-inflammatory phenotype, but the mechanistic basis for this remains obscure. Here,…”
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State of the art in African trypanosome drug discovery by Jacobs, Robert T, Nare, Bakela, Phillips, Margaret A

“…African sleeping sickness is endemic in sub-Saharan Africa where the WHO estimates that 60 million people are at risk for the disease. Human African…”
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Incomplete influenza A virus genomes occur frequently but are readily complemented during localized viral spread by Jacobs, Nathan T., Onuoha, Nina O., Antia, Alice, Steel, John, Antia, Rustom, Lowen, Anice C.

“…Segmentation of viral genomes into multiple RNAs creates the potential for replication of incomplete viral genomes (IVGs). Here we use a single-cell approach…”
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YOUNG "DIPPER" STARS IN UPPER SCO AND OPH OBSERVED BY K2 by Ansdell, M., Gaidos, E., Rappaport, S. A., Jacobs, T. L., LaCourse, D. M., Jek, K. J., Mann, A. W., Wyatt, M. C., Kennedy, G., Williams, J. P., Boyajian, T. S.

“…ABSTRACT We present ten young ( 10 Myr) late-K and M dwarf stars observed in K2 Campaign 2 that host protoplanetary disks and exhibit quasi-periodic or…”
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Hard-material Adhesion: Which Scales of Roughness Matter? by Thimons, L. A., Gujrati, A., Sanner, A., Pastewka, L., Jacobs, T. D. B.

“…Background Surface topography strongly modifies adhesion of hard-material contacts, yet roughness of real surfaces typically exists over many length scales,…”
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A Mitochondrial Ribosomal and RNA Decay Pathway Blocks Cell Proliferation by Richter, Uwe, Lahtinen, Taina, Marttinen, Paula, Myöhänen, Maarit, Greco, Dario, Cannino, Giuseppe, Jacobs, Howard T., Lietzén, Niina, Nyman, Tuula A., Battersby, Brendan J.

“…Proliferating cells require coordinated gene expression between the nucleus and mitochondria in order to divide, ensuring sufficient organelle number in…”
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Which asperity scales matter for true contact area? A multi-scale and statistical investigation by Jackson, R.L., Jacobs, T.D.B.

“…The true contact area between two surfaces is only a small fraction of the apparent macroscopic contact area; it governs many interfacial properties such as…”
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Strong absorption and selective emission from engineered metals with dielectric coatings by Streyer, W, Law, S, Rooney, G, Jacobs, T, Wasserman, D

“…We demonstrate strong-to-perfect absorption across a wide range of mid-infrared wavelengths (5-12µm) using a two-layer system consisting of heavily-doped…”
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Regulation of growth in Drosophila melanogaster: the roles of mitochondrial metabolism by Jacobs, Howard T, George, Jack, Kemppainen, Esko

“…Mitochondrial functions are often considered purely from the standpoint of catabolism, but in growing cells they are mainly dedicated to anabolic processes,…”
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Drug mixtures and infusion technology by Lyons, S., Kidd, L., Jacobs, T.

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Likely transiting exocomets detected by Kepler by Rappaport, S., Vanderburg, A., Jacobs, T., LaCourse, D., Jenkins, J., Kraus, A., Rizzuto, A., Latham, D. W., Bieryla, A., Lazarevic, M., Schmitt, A.

“…Abstract We present the first good evidence for exocomet transits of a host star in continuum light in data from the Kepler mission. The Kepler star in…”
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The single-sided pulsator CO Camelopardalis by Kurtz, D W, Handler, G, Rappaport, S A, Saio, H, Fuller, J, Jacobs, T, Schmitt, A, Jones, D, Vanderburg, A, LaCourse, D, Nelson, L, Kahraman Aliçavuş, F, Giarrusso, M

“…ABSTRACT CO Cam (TIC 160268882) is the second ‘single-sided pulsator’ to be discovered. These are stars where one hemisphere pulsates with a significantly…”
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Stereotypic generation of axial tenocytes from bipartite sclerotome domains in zebrafish by Ma, Roger C, Jacobs, Craig T, Sharma, Priyanka, Kocha, Katrinka M, Huang, Peng

“…Development of a functional musculoskeletal system requires coordinated generation of muscles, bones, and tendons. However, how axial tendon cells (tenocytes)…”
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Notch signalling maintains Hedgehog responsiveness via a Gli-dependent mechanism during spinal cord patterning in zebrafish by Jacobs, Craig T, Huang, Peng

“…Spinal cord patterning is orchestrated by multiple cell signalling pathways. Neural progenitors are maintained by Notch signalling, whereas ventral neural…”
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HSF1-mediated BAG3 Expression Attenuates Apoptosis in 4-Hydroxynonenal-treated Colon Cancer Cells via Stabilization of Anti-apoptotic Bcl-2 Proteins by Jacobs, Aaron T., Marnett, Lawrence J.

“…4-Hydroxynonenal (HNE) is a pro-apoptotic electrophile generated during the spontaneous decomposition of oxidized lipids. We have previously shown that HNE…”
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The compact triply eclipsing triple star TIC 209409435 discovered with TESS by Borkovits, T, Rappaport, S A, Tan, T G, Gagliano, R, Jacobs, T, Huang, X, Mitnyan, T, Hambsch, F-J, Kaye, T, Maxted, P F L, Pál, A, Schmitt, A R

“…ABSTRACT We report the discovery in TESS Sectors 3 and 4 of a compact triply eclipsing triple star system. TIC 209409435 is a previously unknown eclipsing…”
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