Search Results - "Jacobs, K. B"

Genome Scan of Human Systemic Lupus Erythematosus by Regression Modeling: Evidence of Linkage and Epistasis at 4p16-15.2 by Gray-McGuire, C., Moser, K.L., Gaffney, P.M., Kelly, J., Yu, H., Olson, J.M., Jedrey, C.M., Jacobs, K.B., Kimberly, R.P., Neas, B.R., Rich, S.S., Behrens, T.W., Harley, J.B.

“…Systemic lupus erythematosus (SLE) is a complex autoimmune disorder involving at least hormonal, environmental, and genetic factors. Familial aggregation, a…”
Get full text

Haseman and Elston revisited by Elston, Robert C., Buxbaum, Sarah, Jacobs, Kevin B., Olson, Jane M.

“…Haseman and Elston (H‐E) [1972] proposed a method to detect quantitative trait loci by linkage to a marker. The squared sib‐pair trait difference is regressed…”
Get full text

Pooling Analysis of Genetic Data: The Association of Leptin Receptor (LEPR) Polymorphisms With Variables Related to Human Adiposity by Heo, M, Leibel, R. L, Boyer, B. B, Chung, W. K, Koulu, M, Karvonen, M. K, Pesonen, U, Rissanen, A, Laakso, M, Uusitupa, M. I. J, Chagnon, Y, Bouchard, C, Donohoue, P. A, Burns, T. L, Shuldiner, A. R, Silver, K, Andersen, R. E, Pedersen, O, Echwald, S, Sorensen, T. I. A, Behn, P, Permutt, M. A, Jacobs, K. B, Elston, R. C, Hoffman, D. J, Allison, D. B

“…Analysis of raw pooled data from distinct studies of a single question generates a single statistical conclusion with greater power and precision than…”
Get full text

Multilocus Linkage Tests Based on Affected Relative Pairs by Cordell, Heather J., Wedig, Geoffrey C., Jacobs, Kevin B., Elston, Robert C.

“…For complex diseases, recent interest has focused on methods that take into account joint effects at interacting loci. Conditioning on effects of disease loci…”
Get full text

Modeling and dissection of longitudinal blood pressure and hypertension phenotypes in genetic epidemiological studies by Bickeböller, H., Barrett, J.H., Jacobs, K.B., Rosenberger, A.

“…We discuss analyses of the Genetic Analysis Workshop 13 data from the Framingham Heart Study and simulations based on this study. We summarize analyses that…”
Get full text

Exact transmission-disequilibrium tests with multiallelic markers by Cleves, Mario A., Olson, Jane M., Jacobs, Kevin B.

“…The transmission‐disequilibrium (TD) test is a powerful method for detecting linkage between marker and disease loci in the presence of linkage disequilibrium…”
Get full text

meta-analytic investigation of linkage and association of common leptin receptor (LEPR) polymorphisms with body mass index and waist circumference by Heo, M, Leibel, R.L, Fontaine, K.R, Boyer, B.B, Chung, W.K, Koulu, M, Karvonen, M.K, Pesonen, U, Rissanen, A, Laakso, M, Uusitupa, M.I.J, Chagnon, Y, Bouchard, C, Donohoue, P.A, Burns, T.L, Shuldiner, A.R

“…Methods: We analyzed data pooled from nine studies on the human leptin receptor (LEPR) gene for the association of three alleles (K109R, Q223R and K656N) of…”
Get full text

Improved Evidence for Linkage on 6p and 5p with Retrospective Pooling of Data from Three Asthma Genome Screens by Iyengar, Sudha K., Jacobs, Kevin B., Palmer, Lyle J.

“…To improve our ability to identify genes for complex diseases, evaluation of new methods that retrospectively pool genotype and phenotype data collected by…”
Get full text

Pooling Data and Linkage Analysis in the Chromosome 5q Candidate Region for Asthma by Jacobs, Kevin B., Burton, Paul R., Iyengar, Sudha K., Elston, Robert C., Palmer, Lyle J.

“…We investigated a variety of methods for pooling data from eight data sets (n = 5,424 subjects) to validate evidence for linkage of markers in the cytokine…”
Get full text

A tournament of linkage tests in complex inheritance by Zhang, W, Tapper, W, Collins, A, Jacobs, K B, Elston, R C, Morton, N E

“…The performance of some weakly parametric linkage tests in common use was compared on 200 replicates of oligogenic inheritance from Genetic Analysis Workshop…”
Get more information

Genomewide meta‐analysis identifies loci associated with IGF‐I and IGFBP‐3 levels with impact on age‐related traits by Teumer, Alexander, Qi, Qibin, Nethander, Maria, Aschard, Hugues, Bandinelli, Stefania, Beekman, Marian, Berndt, Sonja I., Bidlingmaier, Martin, Broer, Linda, Cappola, Anne, Ceda, Gian Paolo, Chanock, Stephen, Chen, Ming‐Huei, Chen, Tai C., Chen, Yii‐Der Ida, Chung, Jonathan, Del Greco Miglianico, Fabiola, Eriksson, Joel, Ferrucci, Luigi, Friedrich, Nele, Gnewuch, Carsten, Goodarzi, Mark O., Grarup, Niels, Guo, Tingwei, Hammer, Elke, Hayes, Richard B., Hicks, Andrew A., Hofman, Albert, Houwing‐Duistermaat, Jeanine J., Hu, Frank, Hunter, David J., Husemoen, Lise L., Isaacs, Aaron, Jacobs, Kevin B., Janssen, Joop A. M. J. L., Jansson, John‐Olov, Jehmlich, Nico, Johnson, Simon, Juul, Anders, Karlsson, Magnus, Kilpelainen, Tuomas O., Kovacs, Peter, Kraft, Peter, Li, Chao, Linneberg, Allan, Liu, Yongmei, Loos, Ruth J. F., Lorentzon, Mattias, Lu, Yingchang, Maggio, Marcello, Magi, Reedik, Meigs, James, Mellström, Dan, Nauck, Matthias, Newman, Anne B., Pollak, Michael N., Pramstaller, Peter P., Prokopenko, Inga, Psaty, Bruce M., Reincke, Martin, Rimm, Eric B., Rotter, Jerome I., Saint Pierre, Aude, Schurmann, Claudia, Seshadri, Sudha, Sjögren, Klara, Slagboom, P. Eline, Strickler, Howard D., Stumvoll, Michael, Suh, Yousin, Sun, Qi, Zhang, Cuilin, Svensson, Johan, Tanaka, Toshiko, Tare, Archana, Tönjes, Anke, Uh, Hae‐Won, van Duijn, Cornelia M., Heemst, Diana, Vandenput, Liesbeth, Vasan, Ramachandran S., Völker, Uwe, Willems, Sara M., Ohlsson, Claes, Wallaschofski, Henri, Kaplan, Robert C.

“…Summary The growth hormone/insulin‐like growth factor (IGF) axis can be manipulated in animal models to promote longevity, and IGF‐related proteins including…”
Get full text

Haseman and Elston revisited: The effects of ascertainment and residual familial correlations on power to detect linkage by Palmer, Lyle J., Jacobs, Kevin B., Elston, Robert C.

Get full text

Diabetes and risk of pancreatic cancer: a pooled analysis from the pancreatic cancer cohort consortium by Elena, Joanne W., Steplowski, Emily, Yu, Kai, Hartge, Patricia, Tobias, Geoffrey S., Brotzman, Michelle J., Chanock, Stephen J., Stolzenberg-Solomon, Rachael Z., Arslan, Alan A., Bueno-de-Mesquita, H. Bas, Helzlsouer, Kathy, Jacobs, Eric J., LaCroix, Andrea, Petersen, Gloria, Zheng, Wei, Albanes, Demetrius, Allen, Naomi E., Amundadottir, Laufey, Bao, Ying, Boeing, Heiner, Boutron-Ruault, Marie-Christine, Buring, Julie E., Gaziano, J. Michael, Giovannucci, Edward L., Duell, Eric J., Hallmans, Göran, Howard, Barbara V., Hunter, David J., Hutchinson, Amy, Jacobs, Kevin B., Kooperberg, Charles, Kraft, Peter, Mendelsohn, Julie B., Michaud, Dominique S., Palli, Domenico, Phillips, Lawrence S., Overvad, Kim, Patel, Alpa V., Sansbury, Leah, Shu, Xiao–Ou, Simon, Michael S., Slimani, Nadia, Trichopoulos, Dimitrios, Visvanathan, Kala, Virtamo, Jarmo, Wolpin, Brian M., Zeleniuch-Jacquotte, Anne, Fuchs, Charles S., Hoover, Robert N., Gross, Myron

“…Purpose: Diabetes is a suspected risk factor for pancreatic cancer, but questions remain about whether it is a risk factor or a result of the disease. This…”
Get full text

Riprap Stability Under Wave Action by Kobayashi, Nobuhisa, Jacobs, Brian K

“…A mathematical model is developed to predict the flow characteristics in the downrush of regular waves and the critical condition for initiation of movement of…”
Get full text

A genome-wide association study identifies a novel susceptibility locus for renal cell carcinoma on 12p11.23 by Wu, Xifeng, Scelo, Ghislaine, Purdue, Mark P., Rothman, Nathaniel, Johansson, Mattias, Ye, Yuanqing, Wang, Zhaoming, Zelenika, Diana, Moore, Lee E., Wood, Christopher G., Prokhortchouk, Egor, Gaborieau, Valerie, Jacobs, Kevin B., Chow, Wong-Ho, Toro, Jorge R., Zaridze, David, Lin, Jie, Lubinski, Jan, Trubicka, Joanna, Szeszenia-Dabrowska, Neonilia, Lissowska, Jolanta, Rudnai, Peter, Fabianova, Eleonora, Mates, Dana, Jinga, Viorel, Bencko, Vladimir, Slamova, Alena, Holcatova, Ivana, Navratilova, Marie, Janout, Vladimir, Boffetta, Paolo, Colt, Joanne S., Davis, Faith G., Schwartz, Kendra L., Banks, Rosamonde E., Selby, Peter J., Harnden, Patricia, Berg, Christine D., Hsing, Ann W., Grubb, Robert L., Boeing, Heiner, Vineis, Paolo, Clavel-Chapelon, Françoise, Palli, Domenico, Tumino, Rosario, Krogh, Vittorio, Panico, Salvatore, Duell, Eric J., Quirós, José Ramón, Sanchez, Maria-José, Navarro, Carmen, Ardanaz, Eva, Dorronsoro, Miren, Khaw, Kay-Tee, Allen, Naomi E., Bueno-de-Mesquita, H. Bas, Peeters, Petra H.M., Trichopoulos, Dimitrios, Linseisen, Jakob, Ljungberg, Börje, Overvad, Kim, Tjønneland, Anne, Romieu, Isabelle, Riboli, Elio, Stevens, Victoria L, Thun, Michael J, Diver, W. Ryan, Gapstur, Susan M., Pharoah, Paul D., Easton, Douglas F., Albanes, Demetrius, Virtamo, Jarmo, Vatten, Lars, Hveem, Kristian, Fletcher, Tony, Koppova, Kvetoslava, Cussenot, Olivier, Cancel-Tassin, Geraldine, Benhamou, Simone, Hildebrandt, Michelle A., Pu, Xia, Foglio, Mario, Lechner, Doris, Hutchinson, Amy, Yeager, Meredith, Fraumeni, Joseph F., Lathrop, Mark, Skryabin, Konstantin G., McKay, James D., Gu, Jian, Brennan, Paul, Chanock, Stephen J.

“…Renal cell carcinoma (RCC) is the most lethal urologic cancer. Only two common susceptibility loci for RCC have been confirmed to date. To identify additional…”
Get full text

Testicular germ cell tumor susceptibility associated with the UCK2 locus on chromosome 1q23 by Schumacher, Fredrick R, Wang, Zhaoming, Skotheim, Rolf I, Koster, Roelof, Chung, Charles C, Hildebrandt, Michelle A T, Kratz, Christian P, Bakken, Anne C, Bishop, D Timothy, Cook, Michael B, Erickson, R Loren, Fosså, Sophie D, Greene, Mark H, Jacobs, Kevin B, Kanetsky, Peter A, Kolonel, Laurence N, Loud, Jennifer T, Korde, Larissa A, Le Marchand, Loic, Lewinger, Juan Pablo, Lothe, Ragnhild A, Pike, Malcolm C, Rahman, Nazneen, Rubertone, Mark V, Schwartz, Stephen M, Siegmund, Kimberly D, Skinner, Eila C, Turnbull, Clare, Van Den Berg, David J, Wu, Xifeng, Yeager, Meredith, Nathanson, Katherine L, Chanock, Stephen J, Cortessis, Victoria K, McGlynn, Katherine A

“…Genome-wide association studies (GWASs) have identified multiple common genetic variants associated with an increased risk of testicular germ cell tumors…”
Get full text

Stability of Armor Units on Composite Slopes by Kobayashi, Nobuhisa, Jacobs, Brian K

“…Riprap and sandbag model tests are conducted in a wave flume to investigate the effects of berm-type slopes on the stability of armor units and wave runup as…”
Get full text

Meta-analysis for linkage to asthma and atopy in the chromosome 5q31-33 candidate region by PALMER, Lyle J, BARNES, Kathleen C, WJST, Matthias, BURTON, Paul R, HONG CHEN, COOKSON, William O. C. M, DEICHMANN, Klaus A, ELSTON, Robert C, HOLLOWAY, John W, JACOBS, Kevin B, LAITINEN, Tarja

“…Asthma is a common, complex human disease. Gene discovery in asthma has been complicated by substantial etiological heterogeneity, the possibility of genes of…”
Get full text

Improving the power for disease locus detection in affected-sib-pair studies by using two-locus analysis and multiple regression methods by Cordell, Heather J., Jacobs, Kevin B., Wedig, Geoffrey C., Elston, Robert C.

“…In this paper we present a summary of an analysis of the simulated data (Problem 2) for GAW11. We used sib‐pair and affected‐sib‐pair (ASP) methods to evaluate…”
Get full text

Model-based and model-free multipoint genome-wide linkage analysis of alcoholism by Jacobs, Kevin B., Wedig, Geoffrey C., Schnell, Audrey H., Witte, John S., Elston, Robert C.

“…We analyzed a subset of the Collaborative Study on the Genetics of Alcoholism (COGA) data set as provided by the 11th Genetic Analysis Workshop (GAW11)…”
Get full text