Characterization of goat prions demonstrates geographical variation of scrapie strains in Europe and reveals the composite nature of prion strains

Bovine Spongiform Encephalopathy (BSE) is the only animal prion which has been recognized as a zoonotic agent so far. The identification of BSE in two goats raised the need to reliably identify BSE in small ruminants. However, our understanding of scrapie strain diversity in small ruminants remains...

Full description

Saved in:

Bibliographic Details
Published in:	Scientific reports Vol. 10; no. 1; p. 19
Main Authors:	Nonno, Romolo, Marin-Moreno, Alba, Carlos Espinosa, Juan, Fast, Christine, Van Keulen, Lucien, Spiropoulos, John, Lantier, Isabelle, Andreoletti, Olivier, Pirisinu, Laura, Di Bari, Michele A., Aguilar-Calvo, Patricia, Sklaviadis, Theodoros, Papasavva-Stylianou, Penelope, Acutis, Pier Luigi, Acin, Cristina, Bossers, Alex, Jacobs, Jorge G., Vaccari, Gabriele, D’Agostino, Claudia, Chiappini, Barbara, Lantier, Frederic, Groschup, Martin H., Agrimi, Umberto, Maria Torres, Juan, Langeveld, Jan P. M.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 08-01-2020 Nature Publishing Group
Subjects:	631/378/1689/364 64 64/110 64/60 692/308/1426 692/617/375/1937 692/699/255 82/1 82/29 82/51 Animal biology Animal models Animals Biological properties Bovine spongiform encephalopathy Cattle Encephalopathy, Bovine Spongiform - transmission Europe Geographical distribution Geographical variations Goat Diseases - transmission Goats Humanities and Social Sciences Life Sciences Mice multidisciplinary Prion Diseases - transmission Prion protein Prion Proteins - genetics Prion Proteins - metabolism Prions - classification Prions - genetics Prions - pathogenicity Science Science (multidisciplinary) Scrapie Scrapie - transmission Veterinary medicine and animal Health Europe
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Bovine Spongiform Encephalopathy (BSE) is the only animal prion which has been recognized as a zoonotic agent so far. The identification of BSE in two goats raised the need to reliably identify BSE in small ruminants. However, our understanding of scrapie strain diversity in small ruminants remains ill-defined, thus limiting the accuracy of BSE surveillance and spreading fear that BSE might lurk unrecognized in goats. We investigated prion strain diversity in a large panel of European goats by a novel experimental approach that, instead of assessing the neuropathological profile after serial transmissions in a single animal model, was based on the direct interaction of prion isolates with several recipient rodent models expressing small ruminants or heterologous prion proteins. The findings show that the biological properties of scrapie isolates display different patterns of geographical distribution in Europe and suggest that goat BSE could be reliably discriminated from a wide range of biologically and geographically diverse goat prion isolates. Finally, most field prion isolates showed composite strain features, with discrete strain components or sub-strains being present in different proportions in individual goats or tissues. This has important implications for understanding the nature and evolution of scrapie strains and their transmissibility to other species, including humans.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-019-57005-6